JP2007532697A5 - - Google Patents
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- Publication number
- JP2007532697A5 JP2007532697A5 JP2007509553A JP2007509553A JP2007532697A5 JP 2007532697 A5 JP2007532697 A5 JP 2007532697A5 JP 2007509553 A JP2007509553 A JP 2007509553A JP 2007509553 A JP2007509553 A JP 2007509553A JP 2007532697 A5 JP2007532697 A5 JP 2007532697A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- biophysical environment
- composition according
- delivery vehicle
- nitric oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000000203 mixture Substances 0.000 claims 56
- 239000002840 nitric oxide donor Substances 0.000 claims 15
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 8
- 230000002411 adverse Effects 0.000 claims 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 4
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 claims 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 4
- 235000019743 Choline chloride Nutrition 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 4
- 239000001110 calcium chloride Substances 0.000 claims 4
- 229910001628 calcium chloride Inorganic materials 0.000 claims 4
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 claims 4
- 229960003178 choline chloride Drugs 0.000 claims 4
- 229940075529 glyceryl stearate Drugs 0.000 claims 4
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 3
- 239000000654 additive Substances 0.000 claims 3
- 230000000996 additive effect Effects 0.000 claims 3
- 239000006071 cream Substances 0.000 claims 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 claims 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 2
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims 2
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 2
- 229930003316 Vitamin D Natural products 0.000 claims 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 2
- 235000014104 aloe vera supplement Nutrition 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 229960005188 collagen Drugs 0.000 claims 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 2
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 235000011147 magnesium chloride Nutrition 0.000 claims 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 2
- 229960002216 methylparaben Drugs 0.000 claims 2
- 239000002480 mineral oil Substances 0.000 claims 2
- 235000010446 mineral oil Nutrition 0.000 claims 2
- 229940042472 mineral oil Drugs 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 229960002969 oleic acid Drugs 0.000 claims 2
- 238000005192 partition Methods 0.000 claims 2
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims 2
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims 2
- 229940113124 polysorbate 60 Drugs 0.000 claims 2
- 239000001103 potassium chloride Substances 0.000 claims 2
- 235000011164 potassium chloride Nutrition 0.000 claims 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 2
- 229960003415 propylparaben Drugs 0.000 claims 2
- 235000002639 sodium chloride Nutrition 0.000 claims 2
- 229950011392 sorbitan stearate Drugs 0.000 claims 2
- 229940031439 squalene Drugs 0.000 claims 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- 229940042585 tocopherol acetate Drugs 0.000 claims 2
- 229960004418 trolamine Drugs 0.000 claims 2
- 235000019155 vitamin A Nutrition 0.000 claims 2
- 239000011719 vitamin A Substances 0.000 claims 2
- 235000019166 vitamin D Nutrition 0.000 claims 2
- 239000011710 vitamin D Substances 0.000 claims 2
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 2
- 229940045997 vitamin a Drugs 0.000 claims 2
- 229940046008 vitamin d Drugs 0.000 claims 2
- 229930064664 L-arginine Natural products 0.000 claims 1
- 235000014852 L-arginine Nutrition 0.000 claims 1
- ZDLDXNCMJBOYJV-YFKPBYRVSA-N L-arginine, methyl ester Chemical compound COC(=O)[C@@H](N)CCCN=C(N)N ZDLDXNCMJBOYJV-YFKPBYRVSA-N 0.000 claims 1
- 125000002059 L-arginyl group Chemical class O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 claims 1
- GWFGDXZQZYMSMJ-UHFFFAOYSA-N Octadecansaeure-heptadecylester Natural products CCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC GWFGDXZQZYMSMJ-UHFFFAOYSA-N 0.000 claims 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- UQTGZDUYNOOQRP-QMMMGPOBSA-N butyl (2s)-2-amino-5-(diaminomethylideneamino)pentanoate Chemical class CCCCOC(=O)[C@@H](N)CCCNC(N)=N UQTGZDUYNOOQRP-QMMMGPOBSA-N 0.000 claims 1
- 235000011148 calcium chloride Nutrition 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000030175 lameness Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- NKBWPOSQERPBFI-UHFFFAOYSA-N octadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC NKBWPOSQERPBFI-UHFFFAOYSA-N 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56356004P | 2004-04-19 | 2004-04-19 | |
| US56355104P | 2004-04-19 | 2004-04-19 | |
| US56355804P | 2004-04-19 | 2004-04-19 | |
| US56355204P | 2004-04-19 | 2004-04-19 | |
| US56357004P | 2004-04-19 | 2004-04-19 | |
| US56356604P | 2004-04-19 | 2004-04-19 | |
| US56355404P | 2004-04-19 | 2004-04-19 | |
| US56356504P | 2004-04-19 | 2004-04-19 | |
| US56355904P | 2004-04-19 | 2004-04-19 | |
| US56357504P | 2004-04-19 | 2004-04-19 | |
| US56357404P | 2004-04-19 | 2004-04-19 | |
| US56355604P | 2004-04-19 | 2004-04-19 | |
| US56356704P | 2004-04-19 | 2004-04-19 | |
| US56356404P | 2004-04-19 | 2004-04-19 | |
| US56357304P | 2004-04-19 | 2004-04-19 | |
| US56357204P | 2004-04-19 | 2004-04-19 | |
| US56356304P | 2004-04-19 | 2004-04-19 | |
| US56357604P | 2004-04-19 | 2004-04-19 | |
| US56356904P | 2004-04-19 | 2004-04-19 | |
| US56355704P | 2004-04-19 | 2004-04-19 | |
| US56356104P | 2004-04-19 | 2004-04-19 | |
| US56356204P | 2004-04-19 | 2004-04-19 | |
| US56357104P | 2004-04-19 | 2004-04-19 | |
| US56355504P | 2004-04-19 | 2004-04-19 | |
| US56355304P | 2004-04-19 | 2004-04-19 | |
| PCT/US2005/013230 WO2005102307A2 (en) | 2004-04-19 | 2005-04-19 | Beneficial effects of increasing local blood flow |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011093358A Division JP2011140525A (ja) | 2004-04-19 | 2011-04-19 | 局所的血流増大の有益な効果 |
| JP2011273409A Division JP2012056964A (ja) | 2004-04-19 | 2011-12-14 | 局所的血流増大の有益な効果 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007532697A JP2007532697A (ja) | 2007-11-15 |
| JP2007532697A5 true JP2007532697A5 (enExample) | 2008-05-22 |
Family
ID=35196712
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007509553A Withdrawn JP2007532697A (ja) | 2004-04-19 | 2005-04-19 | 局所的血流増大の有益な効果 |
| JP2007509552A Expired - Lifetime JP5630942B2 (ja) | 2004-04-19 | 2005-04-19 | 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達 |
| JP2011093358A Pending JP2011140525A (ja) | 2004-04-19 | 2011-04-19 | 局所的血流増大の有益な効果 |
| JP2011273409A Withdrawn JP2012056964A (ja) | 2004-04-19 | 2011-12-14 | 局所的血流増大の有益な効果 |
| JP2011283904A Pending JP2012062328A (ja) | 2004-04-19 | 2011-12-26 | 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達 |
| JP2012172904A Withdrawn JP2012211201A (ja) | 2004-04-19 | 2012-08-03 | 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達 |
| JP2015088079A Withdrawn JP2015164932A (ja) | 2004-04-19 | 2015-04-23 | 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達 |
| JP2015088080A Pending JP2015131861A (ja) | 2004-04-19 | 2015-04-23 | 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007509552A Expired - Lifetime JP5630942B2 (ja) | 2004-04-19 | 2005-04-19 | 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達 |
| JP2011093358A Pending JP2011140525A (ja) | 2004-04-19 | 2011-04-19 | 局所的血流増大の有益な効果 |
| JP2011273409A Withdrawn JP2012056964A (ja) | 2004-04-19 | 2011-12-14 | 局所的血流増大の有益な効果 |
| JP2011283904A Pending JP2012062328A (ja) | 2004-04-19 | 2011-12-26 | 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達 |
| JP2012172904A Withdrawn JP2012211201A (ja) | 2004-04-19 | 2012-08-03 | 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達 |
| JP2015088079A Withdrawn JP2015164932A (ja) | 2004-04-19 | 2015-04-23 | 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達 |
| JP2015088080A Pending JP2015131861A (ja) | 2004-04-19 | 2015-04-23 | 不利な生物物理学的環境によりもたらされる有益な物質の経皮送達 |
Country Status (7)
| Country | Link |
|---|---|
| US (10) | US9050365B2 (enExample) |
| EP (2) | EP1737441A4 (enExample) |
| JP (8) | JP2007532697A (enExample) |
| AU (2) | AU2005235308B2 (enExample) |
| CA (2) | CA2563670C (enExample) |
| ES (1) | ES2429443T3 (enExample) |
| WO (2) | WO2005102282A1 (enExample) |
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| US7914814B2 (en) | 1997-09-17 | 2011-03-29 | Strategic Science & Technologies, Llc | Topical delivery of arginine of cause beneficial effects |
| US7629384B2 (en) * | 1997-09-17 | 2009-12-08 | Strategic Science & Technologies, Llc | Topical delivery of L-arginine to cause beneficial effects |
| US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
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| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
| US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| JP2006505583A (ja) | 2002-10-25 | 2006-02-16 | フォーミックス エルティーディー． | 化粧剤および医薬用フォーム |
| US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
| US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
| US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
| WO2005081964A2 (en) * | 2004-02-23 | 2005-09-09 | Strategic Science & Technologies, Llc | Topical delivery of a nitric oxide donor to improve body and skin appearance |
| JP2007532697A (ja) * | 2004-04-19 | 2007-11-15 | ストラテジック サイエンス アンド テクノロジーズ， エルエルシー | 局所的血流増大の有益な効果 |
| US9226909B2 (en) | 2004-04-19 | 2016-01-05 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| US20110028548A1 (en) * | 2004-04-19 | 2011-02-03 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| HUP0401422A2 (en) * | 2004-07-15 | 2006-04-28 | G Laszlo Meszaros | Use of l-arginine as vasoaktive ingredient absorbing through skin for external application |
| CA2606565C (en) | 2005-05-27 | 2016-05-10 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
| US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
| WO2009090495A2 (en) | 2007-12-07 | 2009-07-23 | Foamix Ltd. | Oil and liquid silicone foamable carriers and formulations |
| WO2010041141A2 (en) | 2008-10-07 | 2010-04-15 | Foamix Ltd. | Oil-based foamable carriers and formulations |
| AU2009205314A1 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
| CA2727710C (en) | 2008-06-11 | 2016-11-01 | Biochemics, Inc. | Control of blood vessel physiology to treat skin disorders |
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-
2005
- 2005-04-19 JP JP2007509553A patent/JP2007532697A/ja not_active Withdrawn
- 2005-04-19 AU AU2005235308A patent/AU2005235308B2/en not_active Ceased
- 2005-04-19 WO PCT/US2005/013228 patent/WO2005102282A1/en not_active Ceased
- 2005-04-19 US US11/587,323 patent/US9050365B2/en active Active
- 2005-04-19 JP JP2007509552A patent/JP5630942B2/ja not_active Expired - Lifetime
- 2005-04-19 EP EP05737752A patent/EP1737441A4/en not_active Withdrawn
- 2005-04-19 AU AU2005235309A patent/AU2005235309B2/en not_active Ceased
- 2005-04-19 ES ES05737763T patent/ES2429443T3/es not_active Expired - Lifetime
- 2005-04-19 WO PCT/US2005/013230 patent/WO2005102307A2/en not_active Ceased
- 2005-04-19 EP EP05737763.2A patent/EP1737429B1/en not_active Expired - Lifetime
- 2005-04-19 CA CA2563670A patent/CA2563670C/en not_active Expired - Lifetime
- 2005-04-19 CA CA002563678A patent/CA2563678A1/en not_active Abandoned
-
2009
- 2009-01-16 US US12/355,754 patent/US20090123528A1/en not_active Abandoned
- 2009-05-12 US US12/464,124 patent/US20090221536A1/en not_active Abandoned
-
2010
- 2010-07-09 US US12/833,798 patent/US20100280122A1/en not_active Abandoned
-
2011
- 2011-04-19 JP JP2011093358A patent/JP2011140525A/ja active Pending
- 2011-11-29 US US13/306,129 patent/US20120108664A1/en not_active Abandoned
- 2011-12-14 JP JP2011273409A patent/JP2012056964A/ja not_active Withdrawn
- 2011-12-26 JP JP2011283904A patent/JP2012062328A/ja active Pending
-
2012
- 2012-08-03 JP JP2012172904A patent/JP2012211201A/ja not_active Withdrawn
- 2012-11-01 US US13/666,190 patent/US20130072498A1/en not_active Abandoned
-
2013
- 2013-10-30 US US14/067,238 patent/US20140066452A1/en not_active Abandoned
-
2014
- 2014-09-22 US US14/492,394 patent/US20150011570A1/en not_active Abandoned
- 2014-11-24 US US14/551,153 patent/US20150080470A1/en not_active Abandoned
-
2015
- 2015-04-09 US US14/682,211 patent/US20150342873A1/en not_active Abandoned
- 2015-04-23 JP JP2015088079A patent/JP2015164932A/ja not_active Withdrawn
- 2015-04-23 JP JP2015088080A patent/JP2015131861A/ja active Pending
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