JP2007532625A5 - - Google Patents
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- Publication number
- JP2007532625A5 JP2007532625A5 JP2007507864A JP2007507864A JP2007532625A5 JP 2007532625 A5 JP2007532625 A5 JP 2007532625A5 JP 2007507864 A JP2007507864 A JP 2007507864A JP 2007507864 A JP2007507864 A JP 2007507864A JP 2007532625 A5 JP2007532625 A5 JP 2007532625A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- groups
- aryl
- independently selected
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 85
- 125000003118 aryl group Chemical group 0.000 claims 69
- 229910052799 carbon Inorganic materials 0.000 claims 62
- 150000001875 compounds Chemical class 0.000 claims 55
- 229910052739 hydrogen Inorganic materials 0.000 claims 43
- 125000002947 alkylene group Chemical group 0.000 claims 32
- 125000003710 aryl alkyl group Chemical group 0.000 claims 30
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 22
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 16
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 15
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 15
- 125000000732 arylene group Chemical group 0.000 claims 14
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 14
- 229910052760 oxygen Inorganic materials 0.000 claims 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 13
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 13
- 125000002993 cycloalkylene group Chemical group 0.000 claims 12
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- 229910052717 sulfur Inorganic materials 0.000 claims 10
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 9
- 125000005549 heteroarylene group Chemical group 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 125000006587 (C5-C10) heteroarylene group Chemical group 0.000 claims 6
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 206010003736 Attention deficit/hyperactivity disease Diseases 0.000 claims 4
- 201000006287 attention deficit hyperactivity disease Diseases 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- -1 thiouronium compound Chemical class 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 206010001897 Alzheimer's disease Diseases 0.000 claims 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- 206010061536 Parkinson's disease Diseases 0.000 claims 2
- 206010041349 Somnolence Diseases 0.000 claims 2
- 201000003631 narcolepsy Diseases 0.000 claims 2
- 208000001797 Obstructive Sleep Apnea Diseases 0.000 claims 1
- 206010062519 Poor quality sleep Diseases 0.000 claims 1
- UMGDCJDMYOKAJW-UHFFFAOYSA-N Thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 230000000875 corresponding Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000000926 neurological Effects 0.000 claims 1
- 230000001590 oxidative Effects 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 239000003638 reducing agent Substances 0.000 claims 1
- 230000037321 sleepiness Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04290983.8 | 2004-04-13 | ||
| EP04290983A EP1586560A1 (en) | 2004-04-13 | 2004-04-13 | Thio-substituted arylmethanesulfinyl derivatives |
| US56899104P | 2004-05-07 | 2004-05-07 | |
| US60/568,991 | 2004-05-07 | ||
| US11/104,074 | 2005-04-12 | ||
| US11/104,074 US7297817B2 (en) | 2004-04-13 | 2005-04-12 | Thio-substituted arylmethanesulfinyl derivatives |
| PCT/IB2005/000964 WO2005100310A1 (en) | 2004-04-13 | 2005-04-13 | Thio-substituted arylmethanesulfinyl derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007532625A JP2007532625A (ja) | 2007-11-15 |
| JP2007532625A5 true JP2007532625A5 (US07652168-20100126-C00055.png) | 2008-06-26 |
| JP4972542B2 JP4972542B2 (ja) | 2012-07-11 |
Family
ID=34964553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007507864A Expired - Fee Related JP4972542B2 (ja) | 2004-04-13 | 2005-04-13 | チオ置換アリールメタンスルフィニル誘導体 |
Country Status (12)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7314875B2 (en) * | 2004-04-13 | 2008-01-01 | Cephalon, Inc. | Tricyclic aromatic and bis-phenyl sulfinyl derivatives |
| US7449481B2 (en) * | 2004-04-13 | 2008-11-11 | Cephalon, Inc. | Thio-substituted biaryl-methanesulfinyl derivatives |
| EP1702915A1 (en) * | 2005-03-14 | 2006-09-20 | Cephalon France | Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation |
| US20160083343A1 (en) | 2013-03-15 | 2016-03-24 | Global Blood Therapeutics, Inc | Compounds and uses thereof for the modulation of hemoglobin |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| HUE035104T2 (en) | 2014-08-13 | 2018-05-02 | Red Bull Gmbh | Heterocyclic compounds with activity memory stimulating activity |
| WO2016023997A1 (en) | 2014-08-13 | 2016-02-18 | Red Bull Gmbh | Heterocyclic compounds with working memory enhancing activity |
| WO2017223284A1 (en) | 2016-06-23 | 2017-12-28 | University Of Maryland, Baltimore | NON-CATALYTIC SUBSTRATE-SELECTIVE P38α-SPECIFIC MAPK INHIBITORS WITH ENDOTHELIAL-STABILIZING AND ANTI-INFLAMMATORY ACTIVITY, AND METHODS OF USE THEREOF |
| JP2022511555A (ja) | 2018-12-07 | 2022-01-31 | ユニバーシティ オブ メリーランド，ボルチモア | 非ＡＴＰ／触媒部位ｐ３８マイトジェン活性化プロテインキナーゼ阻害剤 |
| CN116406355A (zh) * | 2020-05-18 | 2023-07-07 | Gen1E生命科学公司 | P38α促分裂原活化蛋白激酶抑制剂 |
| CN116367838A (zh) | 2020-10-29 | 2023-06-30 | Gen1E生命科学公司 | 结晶5-(二甲基氨基)-n-(4-(吗啉代甲基)苯基)萘-1-磺酰胺二盐酸盐二水合物 |
| CN117120422A (zh) | 2021-03-23 | 2023-11-24 | Gen1E生命科学公司 | 取代的萘基P38α丝裂原活化的蛋白激酶抑制剂 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE150366C (US07652168-20100126-C00055.png) | ||||
| US3689567A (en) | 1966-08-01 | 1972-09-05 | Tsung Ying Shen | Benzyl methyl sulfones and process for preparing same |
| US3950542A (en) * | 1967-02-21 | 1976-04-13 | L'oreal | Cysteamine derivatives for oral treatment of seborrhea |
| US3976694A (en) | 1973-05-10 | 1976-08-24 | Smithkline Corporation | α-Aminoalkyl-4-hydroxy-3-alkylsulfonylmethylphenyl ketones |
| US4006183A (en) | 1975-07-08 | 1977-02-01 | Sandoz, Inc. | Substituted α-methylsulfinyl-o-toluidines |
| GB1520812A (en) | 1975-10-02 | 1978-08-09 | Lafon Labor | Benzhydrylsulphinyl derivatives |
| GB1570982A (en) | 1976-03-05 | 1980-07-09 | Shell Int Research | Substituted benzyl ethers and thioethers |
| GB1584462A (en) | 1977-03-31 | 1981-02-11 | Lafon Labor | N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them |
| GB1600840A (en) | 1978-05-30 | 1981-10-21 | Wellcome Found | Diphenylether derivatives useful as flukicidal agents |
| DE3100387A1 (de) * | 1981-01-09 | 1982-09-02 | Basf Ag, 6700 Ludwigshafen | Substituierte diphenylether, diese enthaltende herbizide und ihre anwendung als herbizide |
| FR2593809B1 (fr) | 1986-01-31 | 1988-07-22 | Lafon Labor | Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique |
| DE3872937T2 (de) | 1987-05-11 | 1993-01-21 | Ono Pharmaceutical Co | Benzoylaminophenoxybuttersaeure-derivate. |
| DE3851262T2 (de) | 1987-06-04 | 1995-02-02 | Ono Pharmaceutical Co | Benzoylaminophenoxybuttersäure-Derivate. |
| DE3901706A1 (de) * | 1988-05-17 | 1989-11-30 | Bayer Ag | Halogensubstituierte phenoxybenzyl(thi)ol-derivate |
| JPH02229175A (ja) * | 1989-03-02 | 1990-09-11 | Hokko Chem Ind Co Ltd | 環状アシルヒドロキシルアミン誘導体およびその製法 |
| FR2663225B1 (fr) | 1990-06-14 | 1994-11-04 | Lafon Labor | Nouvelle utilisation du modafinil. |
| CA2118907A1 (en) | 1991-09-13 | 1993-04-01 | Akira Yoshida | Tricyclic heterocyclic compound |
| FR2684875B1 (fr) | 1991-12-13 | 1995-05-24 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un medicament ayant un effet anti-ischemique. |
| WO1993013079A1 (en) * | 1991-12-20 | 1993-07-08 | Agouron Pharmaceuticals, Inc. | Antifolate quinazolines |
| FR2697162B1 (fr) | 1992-10-23 | 1995-01-13 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un médicament pour le traitement de l'incontinence urinaire et des troubles sphinctériens urétro vésicaux. |
| FR2706767B1 (US07652168-20100126-C00055.png) | 1993-06-22 | 1995-09-08 | Lafon Labor | |
| FR2708201B1 (fr) | 1993-06-30 | 1995-10-20 | Lafon Labor | Utilisation de dérivés d'acétamide pour la fabrication de médicaments. |
| FR2707637B1 (fr) | 1993-06-30 | 1995-10-06 | Lafon Labor | Nouveaux dérivés d'acétamide, leur procédé de préparation et leur utilisation en thérapeutique. |
| DE59603311D1 (de) * | 1995-01-30 | 1999-11-18 | Hoechst Ag | Basisch-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| EP0752421B1 (en) * | 1995-07-07 | 2005-10-12 | AstraZeneca AB | Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists |
| WO1997044044A1 (en) * | 1996-05-17 | 1997-11-27 | Magainin Pharmaceuticals Inc. | Therapeutic uses for an aminosterol compound |
| JP3608021B2 (ja) * | 1996-09-05 | 2005-01-05 | 参天製薬株式会社 | 新規含硫黄アミノ酸誘導体 |
| US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| AU8750298A (en) * | 1997-08-28 | 1999-03-22 | Ono Pharmaceutical Co. Ltd. | Peroxisome proliferator-activated receptor controllers |
| FR2771004B1 (fr) | 1997-11-19 | 2000-02-18 | Inst Curie | Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse |
| JP4345230B2 (ja) * | 1998-03-10 | 2009-10-14 | 小野薬品工業株式会社 | カルボン酸誘導体およびその誘導体を有効成分として含有する薬剤 |
| ATE368037T1 (de) * | 1999-04-28 | 2007-08-15 | Sanofi Aventis Deutschland | Di-aryl-säurederivate als ppar rezeptor liganden |
| US6346548B1 (en) | 1999-08-16 | 2002-02-12 | Cephalon, Inc. | Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue |
| US6455588B1 (en) | 1999-08-20 | 2002-09-24 | Cephalon, Inc. | Compositions including modafinil for treatment of eating disorders and for appetite stimulation |
| HN2001000008A (es) * | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| US6670358B2 (en) | 2000-05-16 | 2003-12-30 | Cephalon, Inc. | Substituted thioacetamides |
| US6492396B2 (en) | 2000-05-16 | 2002-12-10 | Cephalon, Inc. | Substituted thioacetamides |
| DK1309547T3 (da) | 2000-07-27 | 2007-05-21 | Teva Pharma | Krystallinsk og ren modafinil og fremgangsmåde til fremstilling af samme |
| JP2002212177A (ja) * | 2000-11-14 | 2002-07-31 | Takeda Chem Ind Ltd | 脂質代謝改善剤 |
| GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
| UA104987C2 (uk) * | 2001-06-12 | 2014-04-10 | Уеллстат Терепьютікс Корпорейшн | Похідні 3-(2,6-диметилбензилокси)фенілоцтової кислоти |
| KR20040015298A (ko) * | 2001-06-27 | 2004-02-18 | 스미스클라인 비참 코포레이션 | 디펩티딜 펩티다제 억제제로서의 플루오로피롤리딘 |
| AU2003261935A1 (en) * | 2002-09-06 | 2004-03-29 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| US7449481B2 (en) | 2004-04-13 | 2008-11-11 | Cephalon, Inc. | Thio-substituted biaryl-methanesulfinyl derivatives |
| US7119214B2 (en) | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| US7423176B2 (en) | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
| US7314875B2 (en) | 2004-04-13 | 2008-01-01 | Cephalon, Inc. | Tricyclic aromatic and bis-phenyl sulfinyl derivatives |
| EP1586560A1 (en) | 2004-04-13 | 2005-10-19 | Cephalon, Inc. | Thio-substituted arylmethanesulfinyl derivatives |
-
2005
- 2005-04-12 US US11/104,074 patent/US7297817B2/en active Active
- 2005-04-13 MX MXPA06011779A patent/MXPA06011779A/es active IP Right Grant
- 2005-04-13 ES ES05718427T patent/ES2373667T3/es active Active
- 2005-04-13 WO PCT/IB2005/000964 patent/WO2005100310A1/en active Application Filing
- 2005-04-13 AU AU2005232961A patent/AU2005232961B2/en not_active Ceased
- 2005-04-13 NZ NZ550583A patent/NZ550583A/en unknown
- 2005-04-13 AT AT05718427T patent/ATE524439T1/de not_active IP Right Cessation
- 2005-04-13 CA CA2562554A patent/CA2562554C/en not_active Expired - Fee Related
- 2005-04-13 CN CN2005800194167A patent/CN1972909B/zh not_active Expired - Fee Related
- 2005-04-13 EP EP05718427A patent/EP1740535B1/en active Active
- 2005-04-13 JP JP2007507864A patent/JP4972542B2/ja not_active Expired - Fee Related
-
2007
- 2007-04-04 HK HK07103642.9A patent/HK1097821A1/xx not_active IP Right Cessation
