JP2007532582A5 - - Google Patents
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- Publication number
- JP2007532582A5 JP2007532582A5 JP2007507578A JP2007507578A JP2007532582A5 JP 2007532582 A5 JP2007532582 A5 JP 2007532582A5 JP 2007507578 A JP2007507578 A JP 2007507578A JP 2007507578 A JP2007507578 A JP 2007507578A JP 2007532582 A5 JP2007532582 A5 JP 2007532582A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- hydrogen
- optionally substituted
- halo
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001931 aliphatic group Chemical group 0.000 claims 82
- 239000001257 hydrogen Substances 0.000 claims 59
- 229910052739 hydrogen Inorganic materials 0.000 claims 59
- 125000005843 halogen group Chemical group 0.000 claims 47
- 125000000623 heterocyclic group Chemical group 0.000 claims 47
- 125000001072 heteroaryl group Chemical group 0.000 claims 32
- -1 —OR 7 Chemical group 0.000 claims 32
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 30
- 150000002431 hydrogen Chemical class 0.000 claims 25
- 125000004452 carbocyclyl group Chemical group 0.000 claims 24
- 125000003118 aryl group Chemical group 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 23
- 229910052757 nitrogen Inorganic materials 0.000 claims 23
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 19
- 125000001188 haloalkyl group Chemical group 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 13
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 13
- 125000002947 alkylene group Chemical group 0.000 claims 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 8
- 125000002950 monocyclic group Chemical group 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 6
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 5
- 125000004429 atom Chemical group 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 230000000010 osteolytic effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 0 CC1(C)OC[C@@](C(Nc2cc(Cl)cc3c2[n]c2cnccc32)=O)N(CC(Nc2cnccn2)=*)C1 Chemical compound CC1(C)OC[C@@](C(Nc2cc(Cl)cc3c2[n]c2cnccc32)=O)N(CC(Nc2cnccn2)=*)C1 0.000 description 2
- JQLQLGAJYLEICO-UHFFFAOYSA-O CC1(C)OCC(C(Nc2cc(Cl)cc-3c2[NH2+]c2cnccc-32)=O)N(CC(NC2CCNCC2)=O)C1 Chemical compound CC1(C)OCC(C(Nc2cc(Cl)cc-3c2[NH2+]c2cnccc-32)=O)N(CC(NC2CCNCC2)=O)C1 JQLQLGAJYLEICO-UHFFFAOYSA-O 0.000 description 1
- UYSYBZVVDDYMQT-UHFFFAOYSA-N CC1(C)OCC(C(Nc2cc(Cl)cc3c2[nH]c2c3C=CNC2)=O)N(CC(N(CC2)CCC2NC(C)=O)=O)C1 Chemical compound CC1(C)OCC(C(Nc2cc(Cl)cc3c2[nH]c2c3C=CNC2)=O)N(CC(N(CC2)CCC2NC(C)=O)=O)C1 UYSYBZVVDDYMQT-UHFFFAOYSA-N 0.000 description 1
- CAJKVRMMTHEDFG-UHFFFAOYSA-N CC1(C)OCC(C(Nc2cc(Cl)cc3c2[nH]c2cnccc32)=O)N(CC(N(CC2)CCC2C(F)(F)F)=O)C1 Chemical compound CC1(C)OCC(C(Nc2cc(Cl)cc3c2[nH]c2cnccc32)=O)N(CC(N(CC2)CCC2C(F)(F)F)=O)C1 CAJKVRMMTHEDFG-UHFFFAOYSA-N 0.000 description 1
- NHYQIFWNYYCDNI-UHFFFAOYSA-N CC1(C)OCC(C(Nc2cc(Cl)cc3c2[nH]c2cnccc32)=O)N(CC(NC(CC2)CCN2C(C)=O)=O)C1 Chemical compound CC1(C)OCC(C(Nc2cc(Cl)cc3c2[nH]c2cnccc32)=O)N(CC(NC(CC2)CCN2C(C)=O)=O)C1 NHYQIFWNYYCDNI-UHFFFAOYSA-N 0.000 description 1
- PLPDRQMNKXHSOB-DEOSSOPVSA-N CC1(C)OC[C@@H](C(Nc2cc(Cl)cc3c2[nH]c2cnccc32)=O)N(CC(N2CCC(C[N+](C)(C)[O-])CC2)=O)C1 Chemical compound CC1(C)OC[C@@H](C(Nc2cc(Cl)cc3c2[nH]c2cnccc32)=O)N(CC(N2CCC(C[N+](C)(C)[O-])CC2)=O)C1 PLPDRQMNKXHSOB-DEOSSOPVSA-N 0.000 description 1
- HWBCEOSXWUVELS-NRFANRHFSA-N CC1(C)OC[C@@H](C(Nc2cc(Cl)cc3c2[nH]c2cnccc32)=O)N(CC(NN2CCCCC2)=O)C1 Chemical compound CC1(C)OC[C@@H](C(Nc2cc(Cl)cc3c2[nH]c2cnccc32)=O)N(CC(NN2CCCCC2)=O)C1 HWBCEOSXWUVELS-NRFANRHFSA-N 0.000 description 1
- JXCMZOYCAKYXPM-JOCHJYFZSA-N CC1(C)OC[C@H](C(Nc2cc(Cl)cc3c2[nH]c2cnccc32)=O)N(CC[NH+](c(cn2)ccc2OC)[O-])C1 Chemical compound CC1(C)OC[C@H](C(Nc2cc(Cl)cc3c2[nH]c2cnccc32)=O)N(CC[NH+](c(cn2)ccc2OC)[O-])C1 JXCMZOYCAKYXPM-JOCHJYFZSA-N 0.000 description 1
- XBPSLHXWTIIWFA-QGZVFWFLSA-N CCOC(CN(C)C(CN1[C@H](C[NH+](c2cc(Cl)cc3c2[nH]c2cnccc32)[O-])COC(C)(C)C1)=O)=O Chemical compound CCOC(CN(C)C(CN1[C@H](C[NH+](c2cc(Cl)cc3c2[nH]c2cnccc32)[O-])COC(C)(C)C1)=O)=O XBPSLHXWTIIWFA-QGZVFWFLSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56089204P | 2004-04-09 | 2004-04-09 | |
| PCT/US2005/013812 WO2005111037A1 (en) | 2004-04-09 | 2005-04-08 | Beta-carbolines useful for treating inflammatory disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007532582A JP2007532582A (ja) | 2007-11-15 |
| JP2007532582A5 true JP2007532582A5 (https=) | 2008-03-13 |
Family
ID=35045213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007507578A Pending JP2007532582A (ja) | 2004-04-09 | 2005-04-08 | 炎症性疾患の処置に有用なβ−カルボリン |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7951801B2 (https=) |
| EP (2) | EP1735311B1 (https=) |
| JP (1) | JP2007532582A (https=) |
| KR (1) | KR20070014166A (https=) |
| CN (1) | CN1976931A (https=) |
| AT (1) | ATE462702T1 (https=) |
| AU (1) | AU2005243188A1 (https=) |
| BR (1) | BRPI0509660A (https=) |
| CA (1) | CA2561859A1 (https=) |
| CR (1) | CR8696A (https=) |
| DE (1) | DE602005020263D1 (https=) |
| EA (1) | EA010546B1 (https=) |
| EC (1) | ECSP066986A (https=) |
| IL (1) | IL178435A0 (https=) |
| MA (1) | MA28567B1 (https=) |
| MX (1) | MXPA06011545A (https=) |
| NO (1) | NO20064894L (https=) |
| RS (1) | RS20060584A (https=) |
| TN (1) | TNSN06321A1 (https=) |
| TW (1) | TW200539880A (https=) |
| UA (1) | UA88638C2 (https=) |
| WO (1) | WO2005111037A1 (https=) |
| ZA (1) | ZA200608956B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200630337A (en) * | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| WO2007110449A1 (en) * | 2006-03-29 | 2007-10-04 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use |
| US8937181B2 (en) * | 2006-04-13 | 2015-01-20 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| TW200815353A (en) * | 2006-04-13 | 2008-04-01 | Euro Celtique Sa | Benzenesulfonamide compounds and their use |
| CL2007002958A1 (es) * | 2006-10-12 | 2008-05-09 | Epix Delaware Inc | Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr |
| US8399486B2 (en) | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
| US8765736B2 (en) * | 2007-09-28 | 2014-07-01 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| US20090131422A1 (en) * | 2007-10-23 | 2009-05-21 | Millennium Pharmaceuticals, Inc. | Salts of an IKK inhibitor |
| WO2009054970A1 (en) * | 2007-10-23 | 2009-04-30 | Millennium Pharmaceuticals, Inc. | Mesylate salt of an ikk inhibitor |
| WO2009076512A1 (en) | 2007-12-11 | 2009-06-18 | Epix Delaware, Inc. | Carboxamidξ compounds and their use as chemokine receptor agonists |
| KR101831005B1 (ko) | 2010-07-06 | 2018-02-21 | 오노 야꾸힝 고교 가부시키가이샤 | 테트라히드로카르볼린 유도체 |
| ES2587856T3 (es) | 2011-03-18 | 2016-10-27 | Ono Pharmaceutical Co., Ltd. | Derivado de tetrahidrocarbolina |
| CN102416014B (zh) * | 2011-09-13 | 2012-11-21 | 河南中医学院 | 一种生物碱类成分组合物在制备抗甲型h1n1流感病毒药物中的应用 |
| CN108271369A (zh) | 2015-10-23 | 2018-07-10 | 法尔玛赞公司 | 用于制备色胺及其衍生物的新工艺 |
| NZ746011A (en) | 2016-03-03 | 2023-01-27 | Bill Elliot Cham | Glycoalkaloid combinations and various uses thereof |
| US11117893B2 (en) * | 2018-09-24 | 2021-09-14 | Union University | Methods for preparation of substituted pyridines and related novel compounds |
| CN117083274A (zh) * | 2021-04-23 | 2023-11-17 | 四川海思科制药有限公司 | 一种并环杂环衍生物及其在医药上的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3623448B2 (ja) | 1998-08-12 | 2005-02-23 | ファイザー・プロダクツ・インク | Ｔａｃｅインヒビター |
| DE19951360A1 (de) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
| HUP0300894A3 (en) | 2000-03-15 | 2008-05-28 | Sanofi Aventis Deutschland | Substituted beta-carbolines, process for their preparation, pharmaceutical compositions containing them and their use |
| WO2001068648A1 (en) * | 2000-03-15 | 2001-09-20 | Aventis Pharma Deutschland Gmbh | Substituted beta-carbolines with ikb-kinase inhibiting activity |
| ATE363473T1 (de) | 2001-09-19 | 2007-06-15 | Pharmacia Corp | Substituierte pyrazoloverbindungen zur behandlung von entzündungen |
| DE60217532T8 (de) | 2001-11-07 | 2008-02-07 | Millennium Pharmaceuticals, Inc., Cambridge | Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas |
| AU2004230952A1 (en) * | 2003-04-09 | 2004-10-28 | Millenium Pharmaceuticals, Inc. | Beta-carbolines useful for treating inflammatory disease |
-
2005
- 2005-04-08 MX MXPA06011545A patent/MXPA06011545A/es not_active Application Discontinuation
- 2005-04-08 EA EA200601884A patent/EA010546B1/ru not_active IP Right Cessation
- 2005-04-08 UA UAA200611756A patent/UA88638C2/ru unknown
- 2005-04-08 US US11/101,998 patent/US7951801B2/en not_active Expired - Lifetime
- 2005-04-08 EP EP05779267A patent/EP1735311B1/en not_active Expired - Lifetime
- 2005-04-08 AU AU2005243188A patent/AU2005243188A1/en not_active Withdrawn
- 2005-04-08 CN CNA2005800190147A patent/CN1976931A/zh active Pending
- 2005-04-08 RS RSP-2006/0584A patent/RS20060584A/sr unknown
- 2005-04-08 CA CA002561859A patent/CA2561859A1/en not_active Abandoned
- 2005-04-08 BR BRPI0509660-0A patent/BRPI0509660A/pt not_active IP Right Cessation
- 2005-04-08 DE DE602005020263T patent/DE602005020263D1/de not_active Expired - Fee Related
- 2005-04-08 JP JP2007507578A patent/JP2007532582A/ja active Pending
- 2005-04-08 TW TW094111190A patent/TW200539880A/zh unknown
- 2005-04-08 WO PCT/US2005/013812 patent/WO2005111037A1/en not_active Ceased
- 2005-04-08 EP EP10003450A patent/EP2206713A1/en not_active Withdrawn
- 2005-04-08 AT AT05779267T patent/ATE462702T1/de not_active IP Right Cessation
- 2005-04-08 KR KR1020067023401A patent/KR20070014166A/ko not_active Ceased
-
2006
- 2006-10-04 IL IL178435A patent/IL178435A0/en unknown
- 2006-10-06 TN TNP2006000321A patent/TNSN06321A1/en unknown
- 2006-10-19 CR CR8696A patent/CR8696A/es unknown
- 2006-10-26 NO NO20064894A patent/NO20064894L/no not_active Application Discontinuation
- 2006-10-27 ZA ZA200608956A patent/ZA200608956B/en unknown
- 2006-11-02 MA MA29431A patent/MA28567B1/fr unknown
- 2006-11-09 EC EC2006006986A patent/ECSP066986A/es unknown
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