ZA200608956B - Beta-carbolines useful for treating inflammatory disease - Google Patents
Beta-carbolines useful for treating inflammatory disease Download PDFInfo
- Publication number
- ZA200608956B ZA200608956B ZA200608956A ZA200608956A ZA200608956B ZA 200608956 B ZA200608956 B ZA 200608956B ZA 200608956 A ZA200608956 A ZA 200608956A ZA 200608956 A ZA200608956 A ZA 200608956A ZA 200608956 B ZA200608956 B ZA 200608956B
- Authority
- ZA
- South Africa
- Prior art keywords
- aliphatic
- hydrogen
- optionally substituted
- halo
- heterocyclyl
- Prior art date
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- 208000027866 inflammatory disease Diseases 0.000 title claims abstract description 9
- AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 title abstract description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 45
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 10
- 201000011510 cancer Diseases 0.000 claims abstract description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 9
- 201000010099 disease Diseases 0.000 claims abstract description 8
- 125000001931 aliphatic group Chemical group 0.000 claims description 107
- -1 -OR’ Chemical group 0.000 claims description 97
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- 239000001257 hydrogen Substances 0.000 claims description 77
- 125000000623 heterocyclic group Chemical group 0.000 claims description 75
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- 125000004452 carbocyclyl group Chemical group 0.000 claims description 33
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- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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| EP (2) | EP1735311B1 (https=) |
| JP (1) | JP2007532582A (https=) |
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| CN (1) | CN1976931A (https=) |
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| UA (1) | UA88638C2 (https=) |
| WO (1) | WO2005111037A1 (https=) |
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| TW200630337A (en) * | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| WO2007110449A1 (en) * | 2006-03-29 | 2007-10-04 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use |
| US8937181B2 (en) * | 2006-04-13 | 2015-01-20 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| TW200815353A (en) * | 2006-04-13 | 2008-04-01 | Euro Celtique Sa | Benzenesulfonamide compounds and their use |
| CL2007002958A1 (es) * | 2006-10-12 | 2008-05-09 | Epix Delaware Inc | Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr |
| US8399486B2 (en) | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
| US8765736B2 (en) * | 2007-09-28 | 2014-07-01 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| US20090131422A1 (en) * | 2007-10-23 | 2009-05-21 | Millennium Pharmaceuticals, Inc. | Salts of an IKK inhibitor |
| WO2009054970A1 (en) * | 2007-10-23 | 2009-04-30 | Millennium Pharmaceuticals, Inc. | Mesylate salt of an ikk inhibitor |
| WO2009076512A1 (en) | 2007-12-11 | 2009-06-18 | Epix Delaware, Inc. | Carboxamidξ compounds and their use as chemokine receptor agonists |
| KR101831005B1 (ko) | 2010-07-06 | 2018-02-21 | 오노 야꾸힝 고교 가부시키가이샤 | 테트라히드로카르볼린 유도체 |
| ES2587856T3 (es) | 2011-03-18 | 2016-10-27 | Ono Pharmaceutical Co., Ltd. | Derivado de tetrahidrocarbolina |
| CN102416014B (zh) * | 2011-09-13 | 2012-11-21 | 河南中医学院 | 一种生物碱类成分组合物在制备抗甲型h1n1流感病毒药物中的应用 |
| CN108271369A (zh) | 2015-10-23 | 2018-07-10 | 法尔玛赞公司 | 用于制备色胺及其衍生物的新工艺 |
| NZ746011A (en) | 2016-03-03 | 2023-01-27 | Bill Elliot Cham | Glycoalkaloid combinations and various uses thereof |
| US11117893B2 (en) * | 2018-09-24 | 2021-09-14 | Union University | Methods for preparation of substituted pyridines and related novel compounds |
| CN117083274A (zh) * | 2021-04-23 | 2023-11-17 | 四川海思科制药有限公司 | 一种并环杂环衍生物及其在医药上的应用 |
Family Cites Families (7)
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| JP3623448B2 (ja) | 1998-08-12 | 2005-02-23 | ファイザー・プロダクツ・インク | Ｔａｃｅインヒビター |
| DE19951360A1 (de) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
| HUP0300894A3 (en) | 2000-03-15 | 2008-05-28 | Sanofi Aventis Deutschland | Substituted beta-carbolines, process for their preparation, pharmaceutical compositions containing them and their use |
| WO2001068648A1 (en) * | 2000-03-15 | 2001-09-20 | Aventis Pharma Deutschland Gmbh | Substituted beta-carbolines with ikb-kinase inhibiting activity |
| ATE363473T1 (de) | 2001-09-19 | 2007-06-15 | Pharmacia Corp | Substituierte pyrazoloverbindungen zur behandlung von entzündungen |
| DE60217532T8 (de) | 2001-11-07 | 2008-02-07 | Millennium Pharmaceuticals, Inc., Cambridge | Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas |
| AU2004230952A1 (en) * | 2003-04-09 | 2004-10-28 | Millenium Pharmaceuticals, Inc. | Beta-carbolines useful for treating inflammatory disease |
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- 2005-04-08 JP JP2007507578A patent/JP2007532582A/ja active Pending
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- 2006-10-27 ZA ZA200608956A patent/ZA200608956B/en unknown
- 2006-11-02 MA MA29431A patent/MA28567B1/fr unknown
- 2006-11-09 EC EC2006006986A patent/ECSP066986A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2206713A1 (en) | 2010-07-14 |
| EP1735311A1 (en) | 2006-12-27 |
| MA28567B1 (fr) | 2007-05-02 |
| CN1976931A (zh) | 2007-06-06 |
| BRPI0509660A (pt) | 2007-10-09 |
| DE602005020263D1 (de) | 2010-05-12 |
| TNSN06321A1 (en) | 2008-02-22 |
| AU2005243188A1 (en) | 2005-11-24 |
| JP2007532582A (ja) | 2007-11-15 |
| US7951801B2 (en) | 2011-05-31 |
| MXPA06011545A (es) | 2007-03-26 |
| KR20070014166A (ko) | 2007-01-31 |
| TW200539880A (en) | 2005-12-16 |
| WO2005111037A1 (en) | 2005-11-24 |
| EP1735311B1 (en) | 2010-03-31 |
| CA2561859A1 (en) | 2005-11-24 |
| EA010546B1 (ru) | 2008-10-30 |
| EA200601884A1 (ru) | 2007-04-27 |
| IL178435A0 (en) | 2007-02-11 |
| US20050239781A1 (en) | 2005-10-27 |
| NO20064894L (no) | 2007-01-03 |
| UA88638C2 (ru) | 2009-11-10 |
| RS20060584A (sr) | 2008-08-07 |
| CR8696A (es) | 2007-08-28 |
| ECSP066986A (es) | 2006-12-29 |
| ATE462702T1 (de) | 2010-04-15 |
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