JP2007531742A5 - - Google Patents
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- Publication number
- JP2007531742A5 JP2007531742A5 JP2007506364A JP2007506364A JP2007531742A5 JP 2007531742 A5 JP2007531742 A5 JP 2007531742A5 JP 2007506364 A JP2007506364 A JP 2007506364A JP 2007506364 A JP2007506364 A JP 2007506364A JP 2007531742 A5 JP2007531742 A5 JP 2007531742A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- alkylene
- group
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 OCCN(CC1)CCN1C(CC1(CC1)C(CCC1)N(*c(cc2)ccc2Cl)C1c1cc(F)cc(F)c1)=O Chemical compound OCCN(CC1)CCN1C(CC1(CC1)C(CCC1)N(*c(cc2)ccc2Cl)C1c1cc(F)cc(F)c1)=O 0.000 description 3
- OCCFKBSPALTXNO-ZMYBKAFPSA-N C=C(CCC(Cl)=C)S(N(C(CCC1)C2(CC(N(CC3)CC3O)=O)CC2)C1/C=C/C(/F)=C\C(F)=[IH])(=O)=O Chemical compound C=C(CCC(Cl)=C)S(N(C(CCC1)C2(CC(N(CC3)CC3O)=O)CC2)C1/C=C/C(/F)=C\C(F)=[IH])(=O)=O OCCFKBSPALTXNO-ZMYBKAFPSA-N 0.000 description 1
- DZVADAPXXFPQQD-UHFFFAOYSA-N CCCC(C1(CC(N2CCCCC2)=O)CC1)N(Cc1cc(C)cc(F)c1)C(CC1)=CC=C1Cl Chemical compound CCCC(C1(CC(N2CCCCC2)=O)CC1)N(Cc1cc(C)cc(F)c1)C(CC1)=CC=C1Cl DZVADAPXXFPQQD-UHFFFAOYSA-N 0.000 description 1
- IBIWRKOEBSUGFF-UHFFFAOYSA-N CCCCC(CCCCC(N(CC1)CCC1N1CCCCC1)=O)N(Cc1cc(C)cc(F)c1)S(c(cc1)ccc1Cl)(=O)=O Chemical compound CCCCC(CCCCC(N(CC1)CCC1N1CCCCC1)=O)N(Cc1cc(C)cc(F)c1)S(c(cc1)ccc1Cl)(=O)=O IBIWRKOEBSUGFF-UHFFFAOYSA-N 0.000 description 1
- AVVBQXBHUQDDGO-UHFFFAOYSA-N O=C(CC1(CC1)C(CCCC1c2cc(F)cc(F)c2)N1S(c(cc1)ccc1Cl)(=O)=O)N1CCCC1 Chemical compound O=C(CC1(CC1)C(CCCC1c2cc(F)cc(F)c2)N1S(c(cc1)ccc1Cl)(=O)=O)N1CCCC1 AVVBQXBHUQDDGO-UHFFFAOYSA-N 0.000 description 1
- GRFJCSQWTVDWAX-DOEKTCAHSA-N O[C@@H](C[C@H]1C2CC2)C[C@H](C2(CC(N(CC3)CCC3N3CCCCC3)=O)CC2)N1S(c(cc1)ccc1Cl)(=O)=O Chemical compound O[C@@H](C[C@H]1C2CC2)C[C@H](C2(CC(N(CC3)CCC3N3CCCCC3)=O)CC2)N1S(c(cc1)ccc1Cl)(=O)=O GRFJCSQWTVDWAX-DOEKTCAHSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55952904P | 2004-04-05 | 2004-04-05 | |
| PCT/US2005/011456 WO2005097768A2 (en) | 2004-04-05 | 2005-04-04 | Novel gamma secretase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007531742A JP2007531742A (ja) | 2007-11-08 |
| JP2007531742A5 true JP2007531742A5 (https=) | 2008-05-01 |
Family
ID=34965070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506364A Withdrawn JP2007531742A (ja) | 2004-04-05 | 2005-04-04 | 新規のγセクレターゼインヒビター |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060004004A1 (https=) |
| EP (1) | EP1740570A2 (https=) |
| JP (1) | JP2007531742A (https=) |
| KR (1) | KR20070010144A (https=) |
| CN (1) | CN1950358A (https=) |
| AR (1) | AR049377A1 (https=) |
| AU (1) | AU2005230681B2 (https=) |
| CA (1) | CA2563033A1 (https=) |
| IL (1) | IL178392A0 (https=) |
| PE (1) | PE20060165A1 (https=) |
| TW (1) | TWI300410B (https=) |
| WO (1) | WO2005097768A2 (https=) |
| ZA (1) | ZA200608274B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| PE20060481A1 (es) * | 2004-06-30 | 2006-06-19 | Schering Corp | N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas |
| WO2011053822A2 (en) | 2009-11-01 | 2011-05-05 | The Brigham And Women's Hospital, Inc. | Notch inhibition in the treatment and prevention of obesity and metabolic syndrome |
| WO2007103114A2 (en) | 2006-03-07 | 2007-09-13 | The Brigham & Women's Hospital, Inc. | Notch inhibition in the treatment or prevention of atherosclerosis |
| US9567396B2 (en) | 2006-03-07 | 2017-02-14 | Evonik Degussa Gmbh | Notch inhibition in the prevention of vein graft failure |
| DK2041181T3 (da) * | 2006-06-08 | 2011-08-29 | Helmholtz Zentrum Muenchen | Specifikke proteaseinhibitorer og deres anvendelse i cancerterapi |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| WO2009052126A1 (en) * | 2007-10-19 | 2009-04-23 | Janssen Pharmaceutica, N.V. | PIPERIDINYL AND PIPERAZINYL MODULATORS OF γ-SECRETASE |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| US9629891B2 (en) | 2011-10-17 | 2017-04-25 | Nationwide Children's Hospital, Inc. | Products and methods for aortic abdominal aneurysm |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| US12485126B2 (en) | 2018-07-19 | 2025-12-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination for treating cancer |
| US20230416830A1 (en) | 2020-11-16 | 2023-12-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for predicting and treating uveal melanoma |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6589978B2 (en) * | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
| US7122675B2 (en) * | 2001-08-03 | 2006-10-17 | Schering Corporation | Gamma secretase inhibitors |
| AR034390A1 (es) * | 2001-08-03 | 2004-02-25 | Schering Corp | Derivados de 1-sulfonil-tetrahidro quinolinas sustituidas, composiciones farmaceuticas y el uso de las mismas para la elaboracion de medicamentos como inhibidores de la gama secretasa |
| TW200302717A (en) * | 2002-02-06 | 2003-08-16 | Schering Corp | Novel gamma secretase inhibitors |
| US7256186B2 (en) * | 2002-02-06 | 2007-08-14 | Schering Corporation | Gamma secretase inhibitors |
| US20040171614A1 (en) * | 2002-02-06 | 2004-09-02 | Schering-Plough Corporation | Novel gamma secretase inhibitors |
| CN102702044A (zh) * | 2006-01-20 | 2012-10-03 | 先灵公司 | 作为γ分泌酶抑制剂的碳环和杂环芳基砜化合物 |
-
2005
- 2005-04-04 WO PCT/US2005/011456 patent/WO2005097768A2/en not_active Ceased
- 2005-04-04 TW TW094110746A patent/TWI300410B/zh active
- 2005-04-04 AR ARP050101319A patent/AR049377A1/es not_active Application Discontinuation
- 2005-04-04 US US11/098,745 patent/US20060004004A1/en not_active Abandoned
- 2005-04-04 JP JP2007506364A patent/JP2007531742A/ja not_active Withdrawn
- 2005-04-04 AU AU2005230681A patent/AU2005230681B2/en not_active Ceased
- 2005-04-04 KR KR1020067020621A patent/KR20070010144A/ko not_active Ceased
- 2005-04-04 EP EP05733367A patent/EP1740570A2/en not_active Withdrawn
- 2005-04-04 CA CA002563033A patent/CA2563033A1/en not_active Abandoned
- 2005-04-04 CN CNA2005800148332A patent/CN1950358A/zh active Pending
- 2005-04-05 PE PE2005000380A patent/PE20060165A1/es not_active Application Discontinuation
-
2006
- 2006-09-28 IL IL178392A patent/IL178392A0/en unknown
- 2006-10-04 ZA ZA200608274A patent/ZA200608274B/xx unknown
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