KR20070010144A - 신규한 감마 세크레타제 억제제 - Google Patents
신규한 감마 세크레타제 억제제 Download PDFInfo
- Publication number
- KR20070010144A KR20070010144A KR1020067020621A KR20067020621A KR20070010144A KR 20070010144 A KR20070010144 A KR 20070010144A KR 1020067020621 A KR1020067020621 A KR 1020067020621A KR 20067020621 A KR20067020621 A KR 20067020621A KR 20070010144 A KR20070010144 A KR 20070010144A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- alkylene
- substituted
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CCCCC(CCCC)N(*)S(c(cc1)ccc1Cl)(=O)=O Chemical compound CCCCC(CCCC)N(*)S(c(cc1)ccc1Cl)(=O)=O 0.000 description 11
- IAGZWJRBASNBNA-UHFFFAOYSA-N CC(CC1)=CC=C1Cl Chemical compound CC(CC1)=CC=C1Cl IAGZWJRBASNBNA-UHFFFAOYSA-N 0.000 description 2
- OKUHCFCESVOGFM-UHFFFAOYSA-N CC(C)(CO)N(CC1)CCN1C(CC1(CC(CCCC2CCCC3CC3)N2S(c(cc2)ccc2Cl)(=O)=O)CC1)=O Chemical compound CC(C)(CO)N(CC1)CCN1C(CC1(CC(CCCC2CCCC3CC3)N2S(c(cc2)ccc2Cl)(=O)=O)CC1)=O OKUHCFCESVOGFM-UHFFFAOYSA-N 0.000 description 1
- IPPKNEOMVCVEPJ-UHFFFAOYSA-N CC1N(C)CCN(CCO)C1 Chemical compound CC1N(C)CCN(CCO)C1 IPPKNEOMVCVEPJ-UHFFFAOYSA-N 0.000 description 1
- CQMSIUDXMNNCBA-UHFFFAOYSA-N CCC(C1)C=C(C(CCCC2C3(CS(N(CC4)CC4O)(=O)=O)CC3)N2S(c(cc2)ccc2Cl)(=O)=O)C=C1F Chemical compound CCC(C1)C=C(C(CCCC2C3(CS(N(CC4)CC4O)(=O)=O)CC3)N2S(c(cc2)ccc2Cl)(=O)=O)C=C1F CQMSIUDXMNNCBA-UHFFFAOYSA-N 0.000 description 1
- MTQUBXQPABESQB-UHFFFAOYSA-N CCC1(CC1)C(CCCC1C(C=C(C2)F)=CC2F)N1S(c(cc1)ccc1Cl)(=O)=O Chemical compound CCC1(CC1)C(CCCC1C(C=C(C2)F)=CC2F)N1S(c(cc1)ccc1Cl)(=O)=O MTQUBXQPABESQB-UHFFFAOYSA-N 0.000 description 1
- JFKXEXLVLCESPE-UHFFFAOYSA-N CCCC(CC1)(CCN1C(CC1CC1)=O)O Chemical compound CCCC(CC1)(CCN1C(CC1CC1)=O)O JFKXEXLVLCESPE-UHFFFAOYSA-N 0.000 description 1
- RFAWBKORCGRFAQ-UHFFFAOYSA-N CCCCC(CCCC1CC2(CC(N(CCCC)CCCCO)=O)CC2)N1S(c(cc1)ccc1Cl)(=O)=O Chemical compound CCCCC(CCCC1CC2(CC(N(CCCC)CCCCO)=O)CC2)N1S(c(cc1)ccc1Cl)(=O)=O RFAWBKORCGRFAQ-UHFFFAOYSA-N 0.000 description 1
- FMLUUWAFHUTCJK-UHFFFAOYSA-N CCCCCC(CC1CC2)(CC2N1C(CC1(CC1)SCC=S)=O)O Chemical compound CCCCCC(CC1CC2)(CC2N1C(CC1(CC1)SCC=S)=O)O FMLUUWAFHUTCJK-UHFFFAOYSA-N 0.000 description 1
- VCOJPHPOVDIRJK-UHFFFAOYSA-N CN1C(CO)CCC1 Chemical compound CN1C(CO)CCC1 VCOJPHPOVDIRJK-UHFFFAOYSA-N 0.000 description 1
- BKLJHZNEHATCBI-UHFFFAOYSA-N CN1CC(CC2)N(CCO)C2C1 Chemical compound CN1CC(CC2)N(CCO)C2C1 BKLJHZNEHATCBI-UHFFFAOYSA-N 0.000 description 1
- WILMUQFCDOPOGL-UHFFFAOYSA-N O=C(CC1CC1)N(CC1)CCC11NCC1 Chemical compound O=C(CC1CC1)N(CC1)CCC11NCC1 WILMUQFCDOPOGL-UHFFFAOYSA-N 0.000 description 1
- KULGRDAFNJICLE-UHFFFAOYSA-N OC(CC1CC1)N1CCC(CCC2[IH]CCCCC2)CC1 Chemical compound OC(CC1CC1)N1CCC(CCC2[IH]CCCCC2)CC1 KULGRDAFNJICLE-UHFFFAOYSA-N 0.000 description 1
- RHIVUIKINVRONT-UHFFFAOYSA-N OCCN(C(CC1)C2)C1CN2C(CC1(CS)CC1)=O Chemical compound OCCN(C(CC1)C2)C1CN2C(CC1(CS)CC1)=O RHIVUIKINVRONT-UHFFFAOYSA-N 0.000 description 1
- TVOFGXPRWRFKGH-JKJQWKFPSA-N OC[C@H](CCC1)N1C(C(C1(CC1)C(CCCC1CCCc2cc(F)cc(F)c2)N1S(c(cc1)ccc1Cl)(=O)=O)O)=O Chemical compound OC[C@H](CCC1)N1C(C(C1(CC1)C(CCCC1CCCc2cc(F)cc(F)c2)N1S(c(cc1)ccc1Cl)(=O)=O)O)=O TVOFGXPRWRFKGH-JKJQWKFPSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55952904P | 2004-04-05 | 2004-04-05 | |
| US60/559,529 | 2004-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20070010144A true KR20070010144A (ko) | 2007-01-22 |
Family
ID=34965070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067020621A Ceased KR20070010144A (ko) | 2004-04-05 | 2005-04-04 | 신규한 감마 세크레타제 억제제 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060004004A1 (https=) |
| EP (1) | EP1740570A2 (https=) |
| JP (1) | JP2007531742A (https=) |
| KR (1) | KR20070010144A (https=) |
| CN (1) | CN1950358A (https=) |
| AR (1) | AR049377A1 (https=) |
| AU (1) | AU2005230681B2 (https=) |
| CA (1) | CA2563033A1 (https=) |
| IL (1) | IL178392A0 (https=) |
| PE (1) | PE20060165A1 (https=) |
| TW (1) | TWI300410B (https=) |
| WO (1) | WO2005097768A2 (https=) |
| ZA (1) | ZA200608274B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| PE20060481A1 (es) * | 2004-06-30 | 2006-06-19 | Schering Corp | N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas |
| WO2011053822A2 (en) | 2009-11-01 | 2011-05-05 | The Brigham And Women's Hospital, Inc. | Notch inhibition in the treatment and prevention of obesity and metabolic syndrome |
| WO2007103114A2 (en) | 2006-03-07 | 2007-09-13 | The Brigham & Women's Hospital, Inc. | Notch inhibition in the treatment or prevention of atherosclerosis |
| US9567396B2 (en) | 2006-03-07 | 2017-02-14 | Evonik Degussa Gmbh | Notch inhibition in the prevention of vein graft failure |
| DK2041181T3 (da) * | 2006-06-08 | 2011-08-29 | Helmholtz Zentrum Muenchen | Specifikke proteaseinhibitorer og deres anvendelse i cancerterapi |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| WO2009052126A1 (en) * | 2007-10-19 | 2009-04-23 | Janssen Pharmaceutica, N.V. | PIPERIDINYL AND PIPERAZINYL MODULATORS OF γ-SECRETASE |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| US9629891B2 (en) | 2011-10-17 | 2017-04-25 | Nationwide Children's Hospital, Inc. | Products and methods for aortic abdominal aneurysm |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| US12485126B2 (en) | 2018-07-19 | 2025-12-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination for treating cancer |
| US20230416830A1 (en) | 2020-11-16 | 2023-12-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for predicting and treating uveal melanoma |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6589978B2 (en) * | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
| US7122675B2 (en) * | 2001-08-03 | 2006-10-17 | Schering Corporation | Gamma secretase inhibitors |
| AR034390A1 (es) * | 2001-08-03 | 2004-02-25 | Schering Corp | Derivados de 1-sulfonil-tetrahidro quinolinas sustituidas, composiciones farmaceuticas y el uso de las mismas para la elaboracion de medicamentos como inhibidores de la gama secretasa |
| TW200302717A (en) * | 2002-02-06 | 2003-08-16 | Schering Corp | Novel gamma secretase inhibitors |
| US7256186B2 (en) * | 2002-02-06 | 2007-08-14 | Schering Corporation | Gamma secretase inhibitors |
| US20040171614A1 (en) * | 2002-02-06 | 2004-09-02 | Schering-Plough Corporation | Novel gamma secretase inhibitors |
| CN102702044A (zh) * | 2006-01-20 | 2012-10-03 | 先灵公司 | 作为γ分泌酶抑制剂的碳环和杂环芳基砜化合物 |
-
2005
- 2005-04-04 WO PCT/US2005/011456 patent/WO2005097768A2/en not_active Ceased
- 2005-04-04 TW TW094110746A patent/TWI300410B/zh active
- 2005-04-04 AR ARP050101319A patent/AR049377A1/es not_active Application Discontinuation
- 2005-04-04 US US11/098,745 patent/US20060004004A1/en not_active Abandoned
- 2005-04-04 JP JP2007506364A patent/JP2007531742A/ja not_active Withdrawn
- 2005-04-04 AU AU2005230681A patent/AU2005230681B2/en not_active Ceased
- 2005-04-04 KR KR1020067020621A patent/KR20070010144A/ko not_active Ceased
- 2005-04-04 EP EP05733367A patent/EP1740570A2/en not_active Withdrawn
- 2005-04-04 CA CA002563033A patent/CA2563033A1/en not_active Abandoned
- 2005-04-04 CN CNA2005800148332A patent/CN1950358A/zh active Pending
- 2005-04-05 PE PE2005000380A patent/PE20060165A1/es not_active Application Discontinuation
-
2006
- 2006-09-28 IL IL178392A patent/IL178392A0/en unknown
- 2006-10-04 ZA ZA200608274A patent/ZA200608274B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200608274B (en) | 2008-08-27 |
| WO2005097768A3 (en) | 2005-12-15 |
| TWI300410B (en) | 2008-09-01 |
| CN1950358A (zh) | 2007-04-18 |
| WO2005097768A2 (en) | 2005-10-20 |
| AU2005230681B2 (en) | 2009-07-30 |
| JP2007531742A (ja) | 2007-11-08 |
| PE20060165A1 (es) | 2006-04-13 |
| IL178392A0 (en) | 2007-02-11 |
| EP1740570A2 (en) | 2007-01-10 |
| US20060004004A1 (en) | 2006-01-05 |
| AR049377A1 (es) | 2006-07-26 |
| AU2005230681A1 (en) | 2005-10-20 |
| TW200602050A (en) | 2006-01-16 |
| CA2563033A1 (en) | 2005-10-20 |
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