JP2007530617A5 - - Google Patents
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- Publication number
- JP2007530617A5 JP2007530617A5 JP2007505453A JP2007505453A JP2007530617A5 JP 2007530617 A5 JP2007530617 A5 JP 2007530617A5 JP 2007505453 A JP2007505453 A JP 2007505453A JP 2007505453 A JP2007505453 A JP 2007505453A JP 2007530617 A5 JP2007530617 A5 JP 2007530617A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- amino
- alkenyl
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 salt hydrates Chemical class 0.000 claims 278
- 229910052757 nitrogen Inorganic materials 0.000 claims 97
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 83
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 64
- 150000003839 salts Chemical class 0.000 claims 61
- 229910052799 carbon Inorganic materials 0.000 claims 52
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 51
- 150000001721 carbon Chemical group 0.000 claims 50
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 claims 48
- KZOWNALBTMILAP-JBMRGDGGSA-N ancitabine hydrochloride Chemical compound Cl.N=C1C=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3OC2=N1 KZOWNALBTMILAP-JBMRGDGGSA-N 0.000 claims 45
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 39
- 125000001153 fluoro group Chemical group F* 0.000 claims 38
- 125000000623 heterocyclic group Chemical group 0.000 claims 36
- 125000004076 pyridyl group Chemical group 0.000 claims 33
- 150000001875 compounds Chemical class 0.000 claims 32
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 31
- 125000001424 substituent group Chemical group 0.000 claims 30
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 26
- 125000000217 alkyl group Chemical group 0.000 claims 26
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 25
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 25
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims 25
- 229910052731 fluorine Inorganic materials 0.000 claims 24
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 24
- 125000005843 halogen group Chemical group 0.000 claims 23
- 229910052736 halogen Inorganic materials 0.000 claims 22
- 150000002367 halogens Chemical class 0.000 claims 22
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 21
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 20
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 20
- 229910052801 chlorine Inorganic materials 0.000 claims 20
- 239000000460 chlorine Substances 0.000 claims 20
- 150000007522 mineralic acids Chemical class 0.000 claims 20
- 150000007524 organic acids Chemical class 0.000 claims 20
- 125000003342 alkenyl group Chemical group 0.000 claims 19
- 150000004677 hydrates Chemical class 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 19
- 235000005985 organic acids Nutrition 0.000 claims 19
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 17
- 239000003574 free electron Substances 0.000 claims 16
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 16
- 229910052717 sulfur Inorganic materials 0.000 claims 16
- 125000002950 monocyclic group Chemical group 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 14
- 125000005331 diazinyl group Chemical group N1=NC(=CC=C1)* 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 13
- 125000000304 alkynyl group Chemical group 0.000 claims 13
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 13
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 13
- 125000006559 (C1-C3) alkylamino group Chemical group 0.000 claims 12
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 claims 12
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 12
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 11
- 125000006239 protecting group Chemical group 0.000 claims 11
- 125000004434 sulfur atom Chemical group 0.000 claims 11
- 125000001544 thienyl group Chemical group 0.000 claims 11
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 10
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 10
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 10
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 10
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 10
- 229910052794 bromium Inorganic materials 0.000 claims 10
- 125000001309 chloro group Chemical group Cl* 0.000 claims 10
- 239000011737 fluorine Substances 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 229910052740 iodine Inorganic materials 0.000 claims 10
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 9
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 239000001301 oxygen Substances 0.000 claims 9
- 229920006395 saturated elastomer Polymers 0.000 claims 9
- 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 claims 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 8
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 8
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 8
- 125000004430 oxygen atom Chemical group O* 0.000 claims 8
- 125000006594 (C1-C3) alkylsulfony group Chemical group 0.000 claims 7
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 7
- 125000006598 aminocarbonylamino group Chemical group 0.000 claims 7
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 7
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims 7
- 125000006597 (C1-C3) alkylcarbonylamino group Chemical group 0.000 claims 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 6
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 6
- 238000006243 chemical reaction Methods 0.000 claims 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 5
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 5
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 5
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 5
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 5
- 125000006563 (C1-3) alkylaminocarbonyl group Chemical group 0.000 claims 4
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims 4
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 4
- 125000004484 1-methylpiperidin-4-yl group Chemical group CN1CCC(CC1)* 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000006576 di-(C1-C3-alkyl)-aminocarbonyl group Chemical group 0.000 claims 4
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 4
- 125000000524 functional group Chemical group 0.000 claims 4
- 125000000842 isoxazolyl group Chemical group 0.000 claims 4
- 125000003386 piperidinyl group Chemical group 0.000 claims 4
- 125000003226 pyrazolyl group Chemical group 0.000 claims 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
- 125000000168 pyrrolyl group Chemical group 0.000 claims 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 4
- 229920002554 vinyl polymer Polymers 0.000 claims 4
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 claims 3
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 3
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 3
- 125000005400 pyridylcarbonyl group Chemical group N1=C(C=CC=C1)C(=O)* 0.000 claims 3
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 3
- 125000005190 thiohydroxy group Chemical group 0.000 claims 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 3
- 125000006603 (C1-C3) alkylaminosulfonyl group Chemical group 0.000 claims 2
- 125000006595 (C1-C3) alkylsulfinyl group Chemical group 0.000 claims 2
- 125000004760 (C1-C4) alkylsulfonylamino group Chemical group 0.000 claims 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 2
- LISFMEBWQUVKPJ-FOQJRBATSA-N 1H-quinolin-2-one Chemical group C1=CC=C2N[14C](=O)C=CC2=C1 LISFMEBWQUVKPJ-FOQJRBATSA-N 0.000 claims 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 2
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 241000255925 Diptera Species 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000004566 azetidin-1-yl group Chemical group N1(CCC1)* 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 230000017531 blood circulation Effects 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 230000003449 preventive effect Effects 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 230000024883 vasodilation Effects 0.000 claims 2
- 125000004750 (C1-C6) alkylaminosulfonyl group Chemical group 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 208000013586 Complex regional pain syndrome type 1 Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000033830 Hot Flashes Diseases 0.000 claims 1
- 206010060800 Hot flush Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- FHLBDQHVLWHDJT-UHFFFAOYSA-N N1CNCC=2C1=CSC2 Chemical compound N1CNCC=2C1=CSC2 FHLBDQHVLWHDJT-UHFFFAOYSA-N 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010042496 Sunburn Diseases 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 206010047141 Vasodilatation Diseases 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- 125000004744 butyloxycarbonyl group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 231100001102 clostridial toxin Toxicity 0.000 claims 1
- 208000018912 cluster headache syndrome Diseases 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 1
- 125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 210000002200 mouth mucosa Anatomy 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 230000037380 skin damage Effects 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 1
- 0 CCN(*C)*(C)(C)*(*)*(*)(*)*C Chemical compound CCN(*C)*(C)(C)*(*)*(*)(*)*C 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004015723.5 | 2004-03-29 | ||
| DE102004015723A DE102004015723A1 (de) | 2004-03-29 | 2004-03-29 | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| PCT/EP2005/003094 WO2005092880A1 (de) | 2004-03-29 | 2005-03-23 | Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2007530617A JP2007530617A (ja) | 2007-11-01 |
| JP2007530617A6 JP2007530617A6 (ja) | 2008-02-14 |
| JP2007530617A5 true JP2007530617A5 (https=) | 2008-07-17 |
| JP4796567B2 JP4796567B2 (ja) | 2011-10-19 |
Family
ID=34967621
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007505453A Expired - Fee Related JP4796567B2 (ja) | 2004-03-29 | 2005-03-23 | 選択されたｃｇｒｐアンタゴニスト、その製造方法及びその薬物としての使用 |
| JP2008099425A Withdrawn JP2008189689A (ja) | 2004-03-29 | 2008-04-07 | Ｃｇｒｐアンタゴニストとして使用される２−オキソ−１，２，４，５−テトラヒドロ−１，３−ベンゾジアゼピン−３−イル−ピペリジン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008099425A Withdrawn JP2008189689A (ja) | 2004-03-29 | 2008-04-07 | Ｃｇｒｐアンタゴニストとして使用される２−オキソ−１，２，４，５−テトラヒドロ−１，３−ベンゾジアゼピン−３−イル−ピペリジン |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US7479488B2 (https=) |
| EP (2) | EP2108648A1 (https=) |
| JP (2) | JP4796567B2 (https=) |
| KR (1) | KR20070007867A (https=) |
| CN (1) | CN1976916A (https=) |
| AR (2) | AR049625A1 (https=) |
| AT (2) | ATE437868T1 (https=) |
| AU (1) | AU2005225539A1 (https=) |
| BR (2) | BRPI0509368A (https=) |
| CA (1) | CA2558889A1 (https=) |
| CY (2) | CY1108744T1 (https=) |
| DE (2) | DE102004015723A1 (https=) |
| DK (1) | DK1732917T3 (https=) |
| EA (1) | EA012111B1 (https=) |
| EC (1) | ECSP066898A (https=) |
| ES (1) | ES2330865T3 (https=) |
| HR (1) | HRP20090457T1 (https=) |
| IL (2) | IL178334A0 (https=) |
| MX (1) | MX2007011526A (https=) |
| MY (1) | MY141754A (https=) |
| NO (1) | NO20064166L (https=) |
| NZ (2) | NZ550774A (https=) |
| PE (2) | PE20091884A1 (https=) |
| PL (1) | PL1732917T3 (https=) |
| PT (1) | PT1732917E (https=) |
| RS (1) | RS51150B (https=) |
| SI (1) | SI1732917T1 (https=) |
| TW (1) | TW200602338A (https=) |
| UA (1) | UA88163C2 (https=) |
| UY (1) | UY29437A1 (https=) |
| WO (1) | WO2005092880A1 (https=) |
| ZA (2) | ZA200606056B (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0311812B8 (pt) * | 2002-06-05 | 2021-05-25 | Bristol Myers Squibb Co | antagonistas de receptor de peptídeo relacionado com o gene de calcitonina, composição farmacêutica e seu uso |
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