NZ550774A - Selected CGRP antagonists, method for the production thereof and their use as medicaments - Google Patents

Info

Publication number

NZ550774A

NZ550774A NZ550774A NZ55077405A NZ550774A NZ 550774 A NZ550774 A NZ 550774A NZ 550774 A NZ550774 A NZ 550774A NZ 55077405 A NZ55077405 A NZ 55077405A NZ 550774 A NZ550774 A NZ 550774A

Authority

NZ

New Zealand

Prior art keywords

alkyl

group

amino

oxo

denotes

Prior art date

2004-03-29

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 title claims description 119
• 229940127597 CGRP antagonist Drugs 0.000 title claims description 28
• 238000004519 manufacturing process Methods 0.000 title claims description 5
• 239000003814 drug Substances 0.000 title description 2
• -1 1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one-3-yl Chemical group 0.000 claims abstract description 622
• 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 187
• 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 152
• 150000001875 compounds Chemical class 0.000 claims abstract description 119
• 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 claims abstract description 111
• 125000001424 substituent group Chemical group 0.000 claims abstract description 56
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 23
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 19
• 229910052760 oxygen Inorganic materials 0.000 claims abstract description 19
• 239000001301 oxygen Substances 0.000 claims abstract description 19
• 230000001154 acute effect Effects 0.000 claims abstract description 9
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
• 238000011321 prophylaxis Methods 0.000 claims abstract description 7
• 206010047141 Vasodilatation Diseases 0.000 claims abstract description 6
• BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims abstract description 6
• 238000011282 treatment Methods 0.000 claims abstract description 6
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract description 6
• 230000024883 vasodilation Effects 0.000 claims abstract description 6
• 229940088597 hormone Drugs 0.000 claims abstract description 5
• 239000005556 hormone Substances 0.000 claims abstract description 5
• 208000027866 inflammatory disease Diseases 0.000 claims abstract description 5
• 208000002193 Pain Diseases 0.000 claims abstract description 4
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 4
• 208000024172 Cardiovascular disease Diseases 0.000 claims abstract description 3
• 241000193403 Clostridium Species 0.000 claims abstract description 3
• 206010012735 Diarrhoea Diseases 0.000 claims abstract description 3
• 206010019233 Headaches Diseases 0.000 claims abstract description 3
• 206010027304 Menopausal symptoms Diseases 0.000 claims abstract description 3
• 230000017531 blood circulation Effects 0.000 claims abstract description 3
• 230000002950 deficient Effects 0.000 claims abstract description 3
• 239000000262 estrogen Substances 0.000 claims abstract description 3
• 231100000869 headache Toxicity 0.000 claims abstract description 3
• 229960005181 morphine Drugs 0.000 claims abstract description 3
• 230000003449 preventive effect Effects 0.000 claims abstract description 3
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• 208000024891 symptom Diseases 0.000 claims abstract description 3
• 230000001225 therapeutic effect Effects 0.000 claims abstract description 3
• 239000003053 toxin Substances 0.000 claims abstract description 3
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• 208000023890 Complex Regional Pain Syndromes Diseases 0.000 claims abstract 4
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• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 120
• 150000003839 salts Chemical class 0.000 claims description 112
• 229910052799 carbon Inorganic materials 0.000 claims description 97
• 239000000203 mixture Substances 0.000 claims description 95
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 88
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 87
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 80
• 238000006243 chemical reaction Methods 0.000 claims description 79
• 150000001721 carbon Chemical group 0.000 claims description 77
• 125000001153 fluoro group Chemical group F* 0.000 claims description 76
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 69
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 66
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 63
• 125000004076 pyridyl group Chemical group 0.000 claims description 63
• 229910052739 hydrogen Inorganic materials 0.000 claims description 62
• 125000000623 heterocyclic group Chemical group 0.000 claims description 56
• 229910052731 fluorine Inorganic materials 0.000 claims description 51
• 125000000217 alkyl group Chemical group 0.000 claims description 49
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 48
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 46
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 46
• 229910052801 chlorine Inorganic materials 0.000 claims description 46
• 239000001257 hydrogen Substances 0.000 claims description 46
• 239000000460 chlorine Substances 0.000 claims description 45
• 229910052736 halogen Inorganic materials 0.000 claims description 43
• 125000005843 halogen group Chemical group 0.000 claims description 43
• 150000002367 halogens Chemical class 0.000 claims description 43
• ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims description 43
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 40
• KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims description 36
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 33
• 125000003342 alkenyl group Chemical group 0.000 claims description 32
• 239000003574 free electron Substances 0.000 claims description 32
• 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 32
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 32
• 125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 31
• 125000002911 monocyclic heterocycle group Chemical group 0.000 claims description 31
• 125000006239 protecting group Chemical group 0.000 claims description 29
• 229920006395 saturated elastomer Polymers 0.000 claims description 28
• 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 25
• 150000001412 amines Chemical class 0.000 claims description 24
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 24
• 125000005331 diazinyl group Chemical group N1=NC(=CC=C1)* 0.000 claims description 24
• ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 23
• 229910052794 bromium Inorganic materials 0.000 claims description 23
• 229910052740 iodine Inorganic materials 0.000 claims description 23
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 21
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 21
• 239000011737 fluorine Substances 0.000 claims description 21
• 150000007522 mineralic acids Chemical class 0.000 claims description 19
• 125000003118 aryl group Chemical group 0.000 claims description 18
• 125000001072 heteroaryl group Chemical group 0.000 claims description 18
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 18
• 150000007524 organic acids Chemical class 0.000 claims description 18
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 17
• 125000000304 alkynyl group Chemical group 0.000 claims description 17
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 16
• 125000004430 oxygen atom Chemical group O* 0.000 claims description 16
• 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims description 15
• 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 14
• 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 14
• 125000006529 (C3-C6) alkyl group Chemical group 0.000 claims description 13
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 13
• 238000001816 cooling Methods 0.000 claims description 13
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 13
• 125000006598 aminocarbonylamino group Chemical group 0.000 claims description 12
• 229910052701 rubidium Inorganic materials 0.000 claims description 12
• 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims description 10
• 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 10
• 229910052705 radium Inorganic materials 0.000 claims description 10
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 10
• 229920002554 vinyl polymer Polymers 0.000 claims description 10
• 125000006592 (C2-C3) alkenyl group Chemical group 0.000 claims description 9
• 239000013543 active substance Substances 0.000 claims description 9
• 125000004432 carbon atom Chemical group C* 0.000 claims description 9
• 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims description 9
• 125000005842 heteroatom Chemical group 0.000 claims description 9
• 125000004484 1-methylpiperidin-4-yl group Chemical group CN1CCC(CC1)* 0.000 claims description 8
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 8
• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 8
• 125000004429 atom Chemical group 0.000 claims description 8
• 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 8
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 8
• 125000006593 (C2-C3) alkynyl group Chemical group 0.000 claims description 7
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 7
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 7
• 238000002360 preparation method Methods 0.000 claims description 7
• 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims description 7
• 239000000126 substance Substances 0.000 claims description 7
• 150000002431 hydrogen Chemical class 0.000 claims description 6
• HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims description 5
• 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 5
• 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
• 125000005400 pyridylcarbonyl group Chemical group N1=C(C=CC=C1)C(=O)* 0.000 claims description 5
• 125000005190 thiohydroxy group Chemical group 0.000 claims description 5
• 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 4
• 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims description 4
• 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 4
• 125000004566 azetidin-1-yl group Chemical group N1(CCC1)* 0.000 claims description 4
• 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims description 4
• 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 4
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• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 4
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• 238000009472 formulation Methods 0.000 claims description 4
• 229940116364 hard fat Drugs 0.000 claims description 4
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
• UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims description 4
• 208000019695 Migraine disease Diseases 0.000 claims description 3
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 3
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 3
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• DYTJDGVMTRZAKQ-JGCGQSQUSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 DYTJDGVMTRZAKQ-JGCGQSQUSA-N 0.000 description 3
• 229910052783 alkali metal Inorganic materials 0.000 description 3
• 150000001340 alkali metals Chemical class 0.000 description 3
• 239000005557 antagonist Substances 0.000 description 3
• 230000027455 binding Effects 0.000 description 3
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• 239000003638 chemical reducing agent Substances 0.000 description 3
• 125000001309 chloro group Chemical group Cl* 0.000 description 3
• 235000015165 citric acid Nutrition 0.000 description 3
• 229940113088 dimethylacetamide Drugs 0.000 description 3
• KKOIZINMLZXJKJ-UHFFFAOYSA-N ethyl 2-(4-piperidin-4-ylpiperidin-1-yl)acetate Chemical compound C1CN(CC(=O)OCC)CCC1C1CCNCC1 KKOIZINMLZXJKJ-UHFFFAOYSA-N 0.000 description 3
• VNGAMKUTWIFQJL-UHFFFAOYSA-N ethyl 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCC1N1C(=O)NC2=CC=CC=C2CC1 VNGAMKUTWIFQJL-UHFFFAOYSA-N 0.000 description 3
• 238000001914 filtration Methods 0.000 description 3
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
• 238000011534 incubation Methods 0.000 description 3
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• 125000001624 naphthyl group Chemical group 0.000 description 3
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• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 3
• 229910052708 sodium Inorganic materials 0.000 description 3
• 239000001632 sodium acetate Substances 0.000 description 3
• 235000017281 sodium acetate Nutrition 0.000 description 3
• 239000007787 solid Substances 0.000 description 3
• 238000001228 spectrum Methods 0.000 description 3
• 238000003756 stirring Methods 0.000 description 3
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• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 3
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• QAIHVUNTQCSPCF-PQHLKRTFSA-N (2r)-1-[1-[(2r)-3-(3-bromo-4-hydroxyphenyl)-2-[4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carbonyl]oxypropanoyl]piperidin-4-yl]pyrrolidine-2-carboxylic acid Chemical compound OC(=O)[C@H]1CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 QAIHVUNTQCSPCF-PQHLKRTFSA-N 0.000 description 2
• NUXPWWDYSUDWRH-ROJLCIKYSA-N (2r)-1-[1-[(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-2-[4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carbonyl]oxypropanoyl]piperidin-4-yl]piperidine-2-carboxylic acid Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2[C@H](CCCC2)C(O)=O)=C1 NUXPWWDYSUDWRH-ROJLCIKYSA-N 0.000 description 2
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• WADFYTZUQMPNRR-UHFFFAOYSA-N 3-(4-chloro-3,5-dimethylphenyl)-2-oxopropanoic acid Chemical compound CC1=CC(CC(=O)C(O)=O)=CC(C)=C1Cl WADFYTZUQMPNRR-UHFFFAOYSA-N 0.000 description 2
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• MNNFBHQEQQLQAK-JGCGQSQUSA-N 3-[4-[1-[(2r)-3-(3-bromo-4-hydroxyphenyl)-2-[4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carbonyl]oxypropanoyl]piperidin-4-yl]piperazin-1-yl]propanoic acid Chemical compound C1CN(CCC(=O)O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 MNNFBHQEQQLQAK-JGCGQSQUSA-N 0.000 description 2
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• DNHQVZUQRJWZCD-UUWRZZSWSA-N 3-[4-[1-[(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-2-[4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carbonyl]oxypropanoyl]piperidin-4-yl]piperidin-1-yl]propanoic acid Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)C2CCN(CCC(O)=O)CC2)=C1 DNHQVZUQRJWZCD-UUWRZZSWSA-N 0.000 description 2
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• DMRFACYVTPHAED-MGBGTMOVSA-N 3-[4-[4-[(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-2-[4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carbonyl]oxypropanoyl]piperazin-1-yl]piperidin-1-yl]propanoic acid Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCN(CC2)C2CCN(CCC(O)=O)CC2)=C1 DMRFACYVTPHAED-MGBGTMOVSA-N 0.000 description 2
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• JSBVPHFOYNEPKX-MGBGTMOVSA-N 4-[4-[1-[(2r)-3-(3-bromo-4-hydroxyphenyl)-2-[4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carbonyl]oxypropanoyl]piperidin-4-yl]piperidin-1-yl]-4-oxobutanoic acid Chemical compound C1CN(C(=O)CCC(=O)O)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 JSBVPHFOYNEPKX-MGBGTMOVSA-N 0.000 description 2
• KITQEUFCASDZBU-MGBGTMOVSA-N 4-[4-[1-[(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-2-[4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carbonyl]oxypropanoyl]piperidin-4-yl]piperazin-1-yl]-4-oxobutanoic acid Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCN(CC2)C(=O)CCC(O)=O)=C1 KITQEUFCASDZBU-MGBGTMOVSA-N 0.000 description 2
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• QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 2
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• 239000007995 HEPES buffer Substances 0.000 description 2
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• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
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• ASLGWNCQISUJMA-AREMUKBSSA-N [(2r)-1-(4-aminopiperidin-1-yl)-3-(3,4-dichlorophenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(N)CCN1C(=O)[C@H](OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)CC1=CC=C(Cl)C(Cl)=C1 ASLGWNCQISUJMA-AREMUKBSSA-N 0.000 description 2
• ADSWRBHRVYPUSF-MGBGTMOVSA-N [(2r)-1-(4-cycloheptylpiperazin-1-yl)-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCN(CC2)C2CCCCCC2)=C1 ADSWRBHRVYPUSF-MGBGTMOVSA-N 0.000 description 2
• TXNJSSZUQPSLBJ-JGCGQSQUSA-N [(2r)-1-(4-cyclohexylpiperazin-1-yl)-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCN(CC2)C2CCCCC2)=C1 TXNJSSZUQPSLBJ-JGCGQSQUSA-N 0.000 description 2
• BMWCOCHKVPWSSL-WJOKGBTCSA-N [(2r)-1-(4-cyclopentylpiperazin-1-yl)-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCN(CC2)C2CCCC2)=C1 BMWCOCHKVPWSSL-WJOKGBTCSA-N 0.000 description 2
• MDFXNWWWVQQQBG-WJOKGBTCSA-N [(2r)-1-[4-(1,4-diazepan-1-yl)piperidin-1-yl]-3-(3,4-dibromophenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(Br)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 MDFXNWWWVQQQBG-WJOKGBTCSA-N 0.000 description 2
• HMPXKROPOPPEKI-WJOKGBTCSA-N [(2r)-1-[4-(1,4-diazepan-1-yl)piperidin-1-yl]-3-(3,4-dichlorophenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(Cl)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 HMPXKROPOPPEKI-WJOKGBTCSA-N 0.000 description 2
• WJRAVJBRKMLSHC-SSEXGKCCSA-N [(2r)-1-[4-(1,4-diazepan-1-yl)piperidin-1-yl]-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 WJRAVJBRKMLSHC-SSEXGKCCSA-N 0.000 description 2
• DJCVVBMBHXWVAB-WJOKGBTCSA-N [(2r)-1-[4-(1,4-diazepan-1-yl)piperidin-1-yl]-3-(3,5-dibromo-4-methoxyphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(OC)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 DJCVVBMBHXWVAB-WJOKGBTCSA-N 0.000 description 2
• UOKXFASBGSHJHQ-WJOKGBTCSA-N [(2r)-1-[4-(1,4-diazepan-1-yl)piperidin-1-yl]-3-(3,5-dibromophenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound BrC1=CC(Br)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCNCCC2)=C1 UOKXFASBGSHJHQ-WJOKGBTCSA-N 0.000 description 2
• VIWVAIFTHBLOSZ-WJOKGBTCSA-N [(2r)-1-[4-(1,4-diazepan-1-yl)piperidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=CC(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 VIWVAIFTHBLOSZ-WJOKGBTCSA-N 0.000 description 2
• LLTNPLRNNRVRQP-MGBGTMOVSA-N [(2r)-1-[4-(1-cyclopropylsulfonylpiperidin-4-yl)piperidin-1-yl]-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)C1CCN(CC1)S(=O)(=O)C1CC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 LLTNPLRNNRVRQP-MGBGTMOVSA-N 0.000 description 2
• IYCFQOZRVDKEDN-PGUFJCEWSA-N [(2r)-1-[4-(1-cyclopropylsulfonylpiperidin-4-yl)piperidin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)C2CCN(CC2)S(=O)(=O)C2CC2)=C1 IYCFQOZRVDKEDN-PGUFJCEWSA-N 0.000 description 2
• UNCXCQWLBRSYAB-JGCGQSQUSA-N [(2r)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxo-3-[3-(trifluoromethyl)phenyl]propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(C=CC=2)C(F)(F)F)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 UNCXCQWLBRSYAB-JGCGQSQUSA-N 0.000 description 2
• SYYQXHZRKXEVRP-MGBGTMOVSA-N [(2r)-1-[4-(4,4-dimethylpiperidin-1-yl)piperidin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCC(C)(C)CC2)=C1 SYYQXHZRKXEVRP-MGBGTMOVSA-N 0.000 description 2
• ZUKYKNJEUVBMPD-SSEXGKCCSA-N [(2r)-1-[4-(4-amino-4-methylpiperidin-1-yl)piperidin-1-yl]-3-(3,5-dichloro-4-hydroxyphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(C)(N)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=C(Cl)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 ZUKYKNJEUVBMPD-SSEXGKCCSA-N 0.000 description 2
• TYHNCYOTAFEPNP-WJOKGBTCSA-N [(2r)-1-[4-(4-amino-4-methylpiperidin-1-yl)piperidin-1-yl]-3-(3-bromo-4-hydroxyphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(C)(N)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 TYHNCYOTAFEPNP-WJOKGBTCSA-N 0.000 description 2
• YTBUSFWMJKHEHE-JGCGQSQUSA-N [(2r)-1-[4-(4-amino-4-methylpiperidin-1-yl)piperidin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCC(C)(N)CC2)=C1 YTBUSFWMJKHEHE-JGCGQSQUSA-N 0.000 description 2
• URPIQZCSCRAYEW-WJOKGBTCSA-N [(2r)-1-[4-(4-amino-4-methylpiperidin-1-yl)piperidin-1-yl]-3-[3,5-bis(trifluoromethyl)phenyl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(C)(N)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 URPIQZCSCRAYEW-WJOKGBTCSA-N 0.000 description 2
• LRNJCGDGPUKBTD-MGBGTMOVSA-N [(2r)-1-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-3-(3,4-dibromophenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(Br)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCN(CC1)C1CC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 LRNJCGDGPUKBTD-MGBGTMOVSA-N 0.000 description 2
• KOHGGZOQUUBTLW-JGCGQSQUSA-N [(2r)-1-[4-(4-hydroxypiperidin-1-yl)piperidin-1-yl]-3-(3-methylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=CC=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCC(O)CC2)=C1 KOHGGZOQUUBTLW-JGCGQSQUSA-N 0.000 description 2
• ADVJSIFLUXPXRJ-GDLZYMKVSA-N [(2r)-1-[4-(dimethylamino)piperidin-1-yl]-3-(4,5-dimethylpyridin-2-yl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(N(C)C)CCN1C(=O)[C@H](OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)CC1=CC(C)=C(C)C=N1 ADVJSIFLUXPXRJ-GDLZYMKVSA-N 0.000 description 2
• DETXUWNNRZHHKR-PGUFJCEWSA-N [(2r)-1-[4-[1-(2-ethoxy-2-oxoethyl)piperidin-4-yl]piperidin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)OCC)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 DETXUWNNRZHHKR-PGUFJCEWSA-N 0.000 description 2
• JMQOKIUZDSPFFY-PSXMRANNSA-N [(2r)-1-[4-[1-(3-ethoxy-3-oxopropyl)piperidin-4-yl]piperidin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CCC(=O)OCC)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 JMQOKIUZDSPFFY-PSXMRANNSA-N 0.000 description 2
• NSCXTVXJOKCRFO-PGUFJCEWSA-N [(2r)-1-[4-[1-(4-ethoxy-4-oxobutanoyl)piperidin-4-yl]piperazin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)CCC(=O)OCC)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 NSCXTVXJOKCRFO-PGUFJCEWSA-N 0.000 description 2
• RZNASSCFBSDBRT-PSXMRANNSA-N [(2r)-1-[4-[1-(4-ethoxy-4-oxobutanoyl)piperidin-4-yl]piperidin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)CCC(=O)OCC)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 RZNASSCFBSDBRT-PSXMRANNSA-N 0.000 description 2
• QGVRSRUFRHCEIY-UUWRZZSWSA-N [(2r)-1-[4-[1-(dimethylsulfamoyl)piperidin-4-yl]piperidin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)N(C)C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 QGVRSRUFRHCEIY-UUWRZZSWSA-N 0.000 description 2
• UQYVBEYJAPRFJR-JGCGQSQUSA-N [(2r)-1-[4-[1-[2-(hydroxyamino)-2-oxoethyl]piperidin-4-yl]piperazin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCN(CC2)C2CCN(CC(=O)NO)CC2)=C1 UQYVBEYJAPRFJR-JGCGQSQUSA-N 0.000 description 2
• UWAJMPNHNFBKNA-MGBGTMOVSA-N [(2r)-1-[4-[1-[2-(hydroxyamino)-2-oxoethyl]piperidin-4-yl]piperidin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)C2CCN(CC(=O)NO)CC2)=C1 UWAJMPNHNFBKNA-MGBGTMOVSA-N 0.000 description 2
• FEXRMAALMJOUQO-PGUFJCEWSA-N [(2r)-1-[4-[4-(2-ethoxy-2-oxoethyl)piperidin-1-yl]piperidin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(CC(=O)OCC)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 FEXRMAALMJOUQO-PGUFJCEWSA-N 0.000 description 2
• UUJRQWPQTFMGNM-PGUFJCEWSA-N [(2r)-1-[4-[4-(3-ethoxy-3-oxopropyl)piperazin-1-yl]piperidin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CCC(=O)OCC)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 UUJRQWPQTFMGNM-PGUFJCEWSA-N 0.000 description 2
• SBDLPZMBXQFPBJ-UUWRZZSWSA-N [(2r)-1-[4-[4-(cyclopropylmethyl)piperazin-1-yl]piperidin-1-yl]-3-(3,4-dichlorophenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(Cl)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCN(CC2CC2)CC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 SBDLPZMBXQFPBJ-UUWRZZSWSA-N 0.000 description 2
• KBSXVABMNWVBLI-MGBGTMOVSA-N [(2r)-1-[4-[4-(dimethylsulfamoyl)piperazin-1-yl]piperidin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)N(C)C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 KBSXVABMNWVBLI-MGBGTMOVSA-N 0.000 description 2
• CGUGOEGUWAAPJI-JGCGQSQUSA-N [(2r)-1-[4-[4-[2-(hydroxyamino)-2-oxoethyl]piperazin-1-yl]piperidin-1-yl]-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCN(CC(=O)NO)CC2)=C1 CGUGOEGUWAAPJI-JGCGQSQUSA-N 0.000 description 2
• HNZCXVDSTVQRCD-SSEXGKCCSA-N [(2r)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)-3-[3-(trifluoromethyl)phenyl]propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound FC(F)(F)C1=CC=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCNCC2)=C1 HNZCXVDSTVQRCD-SSEXGKCCSA-N 0.000 description 2
• MFYXFNIHKOLAKT-UUWRZZSWSA-N [(2r)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)-3-(3,4,5-trimethylphenyl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(C)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCCCC2)=C1 MFYXFNIHKOLAKT-UUWRZZSWSA-N 0.000 description 2
• AKTZRPOTGJHYNE-WJOKGBTCSA-N [(2r)-3-(3,4-dibromophenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-1h-imidazo[4,5-c]quinolin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(Br)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=C4C=CC=CC4=NC=C32)=O)CC1 AKTZRPOTGJHYNE-WJOKGBTCSA-N 0.000 description 2
• RMZIEMKWDXRILW-WJOKGBTCSA-N [(2r)-3-(3,4-dibromophenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(Br)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 RMZIEMKWDXRILW-WJOKGBTCSA-N 0.000 description 2
• CARKOWOCZPVBPN-JGCGQSQUSA-N [(2r)-3-(3,4-dibromophenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(Br)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 CARKOWOCZPVBPN-JGCGQSQUSA-N 0.000 description 2
• DJOWEJYCLKZWIJ-JGCGQSQUSA-N [(2r)-3-(3,4-dibromophenyl)-1-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(Br)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 DJOWEJYCLKZWIJ-JGCGQSQUSA-N 0.000 description 2
• QLOCQPKLEFQBCY-JGCGQSQUSA-N [(2r)-3-(3,4-dibromophenyl)-1-[4-(4-fluorophenyl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=CC(F)=CC=C1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(Br)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 QLOCQPKLEFQBCY-JGCGQSQUSA-N 0.000 description 2
• XLKXHJTZFRJKOF-JGCGQSQUSA-N [(2r)-3-(3,4-dibromophenyl)-1-[4-(4-methyl-1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(Br)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 XLKXHJTZFRJKOF-JGCGQSQUSA-N 0.000 description 2
• GETSPAVVCMUSIM-WJOKGBTCSA-N [(2r)-3-(3,4-dibromophenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-1h-imidazo[4,5-c]quinolin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(Br)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=C4C=CC=CC4=NC=C32)=O)CC1 GETSPAVVCMUSIM-WJOKGBTCSA-N 0.000 description 2
• YSIJLNARNGTXKG-WJOKGBTCSA-N [(2r)-3-(3,4-dibromophenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(Br)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 YSIJLNARNGTXKG-WJOKGBTCSA-N 0.000 description 2
• WVNKRSBGTJXNLC-HHHXNRCGSA-N [(2r)-3-(3,4-dibromophenyl)-1-[4-(methylamino)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(NC)CCN1C(=O)[C@H](OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)CC1=CC=C(Br)C(Br)=C1 WVNKRSBGTJXNLC-HHHXNRCGSA-N 0.000 description 2
• KNDQTXBQPGUZLH-WJOKGBTCSA-N [(2r)-3-(3,4-dibromophenyl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(Br)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 KNDQTXBQPGUZLH-WJOKGBTCSA-N 0.000 description 2
• PADQYYLTBGRQQY-SSEXGKCCSA-N [(2r)-3-(3,4-dibromophenyl)-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(Br)=CC=C1C[C@H](C(=O)N1CCN(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 PADQYYLTBGRQQY-SSEXGKCCSA-N 0.000 description 2
• SVZWAWIYYLHCPP-WJOKGBTCSA-N [(2r)-3-(3,4-dibromophenyl)-1-oxo-1-(4-piperidin-4-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(Br)=CC=C1C[C@H](C(=O)N1CCC(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 SVZWAWIYYLHCPP-WJOKGBTCSA-N 0.000 description 2
• PSHAHVMMTVKFMU-JGCGQSQUSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(1-methylpiperidin-4-yl)-1,4-diazepan-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CCC1 PSHAHVMMTVKFMU-JGCGQSQUSA-N 0.000 description 2
• HDNOWWWHJHPWRG-SSEXGKCCSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3C2)=O)CC1 HDNOWWWHJHPWRG-SSEXGKCCSA-N 0.000 description 2
• NYVKFWPLDHYMAS-WJOKGBTCSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 NYVKFWPLDHYMAS-WJOKGBTCSA-N 0.000 description 2
• LLFBYKCFQJNPQY-JGCGQSQUSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(7-methoxy-2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C([C@@H](OC(=O)N1CCC(CC1)N1C(=O)NC2=CC=C(C=C2CC1)OC)C(=O)N1CCN(CC1)C1CCN(C)CC1)C1=CC=C(Cl)C(Cl)=C1 LLFBYKCFQJNPQY-JGCGQSQUSA-N 0.000 description 2
• WOPPASPQSQSNGS-SSEXGKCCSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(3-oxo-5-phenyl-1h-1,2,4-triazol-2-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC(=N2)C=2C=CC=CC=2)=O)CC1 WOPPASPQSQSNGS-SSEXGKCCSA-N 0.000 description 2
• APNIYOJPAUFUBU-MGBGTMOVSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(7-methoxy-2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C([C@@H](OC(=O)N1CCC(CC1)N1C(=O)NC2=CC=C(C=C2CC1)OC)C(=O)N1CCC(CC1)C1CCN(C)CC1)C1=CC=C(Cl)C(Cl)=C1 APNIYOJPAUFUBU-MGBGTMOVSA-N 0.000 description 2
• HKXVCYOJAWMKOJ-WJOKGBTCSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(4-fluorophenyl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=CC(F)=CC=C1N1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 HKXVCYOJAWMKOJ-WJOKGBTCSA-N 0.000 description 2
• HKOQSBQIXDUNLC-JGCGQSQUSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-1h-benzo[e]benzimidazol-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=C4C=CC=CC4=CC=C32)=O)CC1 HKOQSBQIXDUNLC-JGCGQSQUSA-N 0.000 description 2
• XEDRYMOLMRYBAK-WJOKGBTCSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-1h-imidazo[4,5-c]quinolin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=C4C=CC=CC4=NC=C32)=O)CC1 XEDRYMOLMRYBAK-WJOKGBTCSA-N 0.000 description 2
• GYDGECZHHRDYEZ-WJOKGBTCSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 GYDGECZHHRDYEZ-WJOKGBTCSA-N 0.000 description 2
• OIDUMOPNOMDOFF-JGCGQSQUSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(7-methoxy-2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C([C@@H](OC(=O)N1CCC(CC1)N1C(=O)NC2=CC=C(C=C2CC1)OC)C(=O)N1CCC(CC1)N1CCN(C)CC1)C1=CC=C(Cl)C(Cl)=C1 OIDUMOPNOMDOFF-JGCGQSQUSA-N 0.000 description 2
• VHJTVZCLAGXVFB-JGCGQSQUSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-[2-(diethylamino)ethyl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(CCN(CC)CC)CCN1C(=O)[C@H](OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)CC1=CC=C(Cl)C(Cl)=C1 VHJTVZCLAGXVFB-JGCGQSQUSA-N 0.000 description 2
• PRAMLFOBBUSDMQ-SSEXGKCCSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CCCN(C)C)CCN1C(=O)[C@H](OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)CC1=CC=C(Cl)C(Cl)=C1 PRAMLFOBBUSDMQ-SSEXGKCCSA-N 0.000 description 2
• VVKQPDOIMDVJNI-SSEXGKCCSA-N [(2r)-3-(3,4-dichlorophenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(Cl)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 VVKQPDOIMDVJNI-SSEXGKCCSA-N 0.000 description 2
• DOZZBNCWNXMASZ-SSEXGKCCSA-N [(2r)-3-(3,4-dichlorophenyl)-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(Cl)=CC=C1C[C@H](C(=O)N1CCN(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 DOZZBNCWNXMASZ-SSEXGKCCSA-N 0.000 description 2
• GOPJDZLSRRYKDH-WJOKGBTCSA-N [(2r)-3-(3,4-dichlorophenyl)-1-oxo-1-(4-pyridin-4-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(Cl)=CC=C1C[C@H](C(=O)N1CCC(CC1)C=1C=CN=CC=1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 GOPJDZLSRRYKDH-WJOKGBTCSA-N 0.000 description 2
• HLRLYVYOVJSQNU-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 HLRLYVYOVJSQNU-WJOKGBTCSA-N 0.000 description 2
• ZJQPARFWASKBEO-SSEXGKCCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-(1-methylsulfonylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 ZJQPARFWASKBEO-SSEXGKCCSA-N 0.000 description 2
• AWANYXNWQYNRQP-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-(1-methylsulfonylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 AWANYXNWQYNRQP-WJOKGBTCSA-N 0.000 description 2
• DUXVRVGVSGCWJH-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-(4,4-dimethylpiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(C)(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 DUXVRVGVSGCWJH-WJOKGBTCSA-N 0.000 description 2
• WRKQVHWXPTVOJS-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-(4-ethyl-4-hydroxypiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(CC)(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 WRKQVHWXPTVOJS-WJOKGBTCSA-N 0.000 description 2
• FZDRBTIMHLFSTA-SSEXGKCCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-(4-hydroxy-4-methylpiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(C)(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 FZDRBTIMHLFSTA-SSEXGKCCSA-N 0.000 description 2
• WFKOFQVYQCKMAZ-SSEXGKCCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-(4-hydroxypiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 WFKOFQVYQCKMAZ-SSEXGKCCSA-N 0.000 description 2
• LHEGBNDITZBFII-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-(4-methyl-1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 LHEGBNDITZBFII-WJOKGBTCSA-N 0.000 description 2
• NLRQLALRPMSFRX-SSEXGKCCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 NLRQLALRPMSFRX-SSEXGKCCSA-N 0.000 description 2
• JJGNYPIFCZCIGD-GDLZYMKVSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-(oxan-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=C(Br)C=C1C[C@H](C(=O)N1CCN(CC1)C1CCOCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 JJGNYPIFCZCIGD-GDLZYMKVSA-N 0.000 description 2
• IALUJLZGMSOPIY-XZWHSSHBSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[(2s)-2-methoxycarbonylpyrrolidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound COC(=O)[C@@H]1CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 IALUJLZGMSOPIY-XZWHSSHBSA-N 0.000 description 2
• DKGNFZBHGQMCLC-PDDLMNHVSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[(3r)-3-hydroxypiperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1[C@H](O)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 DKGNFZBHGQMCLC-PDDLMNHVSA-N 0.000 description 2
• DJSOWCWNWKBEKV-JGCGQSQUSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[1-(2-hydroxyethyl)piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CCO)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 DJSOWCWNWKBEKV-JGCGQSQUSA-N 0.000 description 2
• LFLBFOKHDFJSIG-MGBGTMOVSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[1-(3-ethoxy-3-oxopropyl)piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CCC(=O)OCC)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 LFLBFOKHDFJSIG-MGBGTMOVSA-N 0.000 description 2
• GNAXTUMUURRZIH-UUWRZZSWSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[1-(3-ethoxy-3-oxopropyl)piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CCC(=O)OCC)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 GNAXTUMUURRZIH-UUWRZZSWSA-N 0.000 description 2
• XPHYILKDRMYOIY-MGBGTMOVSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[1-(4-ethoxy-4-oxobutanoyl)piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)CCC(=O)OCC)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 XPHYILKDRMYOIY-MGBGTMOVSA-N 0.000 description 2
• HKOVMNDUTZQMDZ-JGCGQSQUSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[1-(dimethylsulfamoyl)piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)N(C)C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 HKOVMNDUTZQMDZ-JGCGQSQUSA-N 0.000 description 2
• XRPXWRBDWBRNLW-SSEXGKCCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[1-(methylsulfamoyl)piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)NC)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 XRPXWRBDWBRNLW-SSEXGKCCSA-N 0.000 description 2
• WBDJZKQZBWXAKD-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[1-[2-(hydroxyamino)-2-oxoethyl]piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)NO)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 WBDJZKQZBWXAKD-WJOKGBTCSA-N 0.000 description 2
• FOKKVMDTQNVGHY-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[1-[2-(methoxyamino)-2-oxoethyl]piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)NOC)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 FOKKVMDTQNVGHY-WJOKGBTCSA-N 0.000 description 2
• RWAZNXXRBKOFMZ-JGCGQSQUSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[1-[2-(methoxyamino)-2-oxoethyl]piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)NOC)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 RWAZNXXRBKOFMZ-JGCGQSQUSA-N 0.000 description 2
• NNJBOHFRXOGICE-JGCGQSQUSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[4-(1-hydroxycyclopropyl)piperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCC(CC1)C1(O)CC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 NNJBOHFRXOGICE-JGCGQSQUSA-N 0.000 description 2
• HMWZCHDMDDLALA-JGCGQSQUSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[4-(2-ethoxy-2-oxoethyl)piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)OCC)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 HMWZCHDMDDLALA-JGCGQSQUSA-N 0.000 description 2
• TUOCKODQPBWJTA-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[4-(2-hydroxyethyl)piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CCO)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 TUOCKODQPBWJTA-WJOKGBTCSA-N 0.000 description 2
• CJZDLHFZGNJQOK-MGBGTMOVSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[4-(4-ethoxy-4-oxobutanoyl)piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)CCC(=O)OCC)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 CJZDLHFZGNJQOK-MGBGTMOVSA-N 0.000 description 2
• HJXRGIXMWGYERU-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[4-(dimethylsulfamoyl)piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)N(C)C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 HJXRGIXMWGYERU-WJOKGBTCSA-N 0.000 description 2
• DTSPQDQZZWDQRM-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[4-(hydroxymethyl)piperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(CO)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 DTSPQDQZZWDQRM-WJOKGBTCSA-N 0.000 description 2
• JPVIGPCQYTXXGI-SSEXGKCCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[4-(methylsulfamoyl)piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)NC)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 JPVIGPCQYTXXGI-SSEXGKCCSA-N 0.000 description 2
• ZLTSYUNJFGNYMW-SSEXGKCCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[4-[2-(hydroxyamino)-2-oxoethyl]piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)NO)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 ZLTSYUNJFGNYMW-SSEXGKCCSA-N 0.000 description 2
• ROVSQJHFZNADHZ-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[4-[2-(methoxyamino)-2-oxoethyl]piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)NOC)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 ROVSQJHFZNADHZ-WJOKGBTCSA-N 0.000 description 2
• KWTLFWAOVWMLHK-SSEXGKCCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[4-hydroxy-4-(hydroxymethyl)piperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(CO)(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 KWTLFWAOVWMLHK-SSEXGKCCSA-N 0.000 description 2
• OHPSQOIUWBEABT-GDLZYMKVSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[4-hydroxy-4-(trifluoromethyl)piperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCC(O)(CC1)C(F)(F)F)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 OHPSQOIUWBEABT-GDLZYMKVSA-N 0.000 description 2
• HWMMHXHTMQSGMK-SSEXGKCCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 HWMMHXHTMQSGMK-SSEXGKCCSA-N 0.000 description 2
• BXEVRXGWCFSPDL-GDLZYMKVSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxo-1-[4-(1-sulfamoylpiperidin-4-yl)piperazin-1-yl]propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)N)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 BXEVRXGWCFSPDL-GDLZYMKVSA-N 0.000 description 2
• WADFOYDQNMCICY-SSEXGKCCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxo-1-[4-(1-sulfamoylpiperidin-4-yl)piperidin-1-yl]propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)N)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 WADFOYDQNMCICY-SSEXGKCCSA-N 0.000 description 2
• GBZWBPNAIUKLIV-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-methoxyphenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(OC)=C(Br)C=C1C[C@H](C(=O)N1CCN(CC1)C1CCN(C)CC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 GBZWBPNAIUKLIV-WJOKGBTCSA-N 0.000 description 2
• UDELVWHLJBLSHI-SSEXGKCCSA-N [(2r)-3-(3,5-dibromo-4-methoxyphenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(OC)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 UDELVWHLJBLSHI-SSEXGKCCSA-N 0.000 description 2
• IIEVAAOAVRVIFN-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-methoxyphenyl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(OC)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 IIEVAAOAVRVIFN-WJOKGBTCSA-N 0.000 description 2
• MHXFOQBLIAOWFU-SSEXGKCCSA-N [(2r)-3-(3,5-dibromo-4-methoxyphenyl)-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(OC)=C(Br)C=C1C[C@H](C(=O)N1CCN(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 MHXFOQBLIAOWFU-SSEXGKCCSA-N 0.000 description 2
• VBBAPFYPVZODOB-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-methoxyphenyl)-1-oxo-1-(4-piperidin-4-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(OC)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 VBBAPFYPVZODOB-WJOKGBTCSA-N 0.000 description 2
• RIOWFTGSSQPKFY-MGBGTMOVSA-N [(2r)-3-(3,5-dibromo-4-methylphenyl)-1-[4-(4-methyl-1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(C)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 RIOWFTGSSQPKFY-MGBGTMOVSA-N 0.000 description 2
• MJCRKZNNVWXVIU-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-methylphenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(C)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 MJCRKZNNVWXVIU-WJOKGBTCSA-N 0.000 description 2
• WUQOQSFFLDHTCT-JGCGQSQUSA-N [(2r)-3-(3,5-dibromo-4-methylphenyl)-1-oxo-1-(4-piperidin-4-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(C)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 WUQOQSFFLDHTCT-JGCGQSQUSA-N 0.000 description 2
• DGOBBTMMQALBSO-WJOKGBTCSA-N [(2r)-3-(3,5-dibromophenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 DGOBBTMMQALBSO-WJOKGBTCSA-N 0.000 description 2
• RBZNVZWKCNCDFZ-JGCGQSQUSA-N [(2r)-3-(3,5-dibromophenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 RBZNVZWKCNCDFZ-JGCGQSQUSA-N 0.000 description 2
• FIOHQPGGBKHQQL-JGCGQSQUSA-N [(2r)-3-(3,5-dibromophenyl)-1-[4-(4-methyl-1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 FIOHQPGGBKHQQL-JGCGQSQUSA-N 0.000 description 2
• VDVVIHIWSBKEGL-WJOKGBTCSA-N [(2r)-3-(3,5-dibromophenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 VDVVIHIWSBKEGL-WJOKGBTCSA-N 0.000 description 2
• SMWOXPZFFPTHFY-MUUNZHRXSA-N [(2r)-3-(3,5-dibromophenyl)-1-[4-(dimethylamino)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(N(C)C)CCN1C(=O)[C@H](OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)CC1=CC(Br)=CC(Br)=C1 SMWOXPZFFPTHFY-MUUNZHRXSA-N 0.000 description 2
• AOTJSJQDFXGQSU-SSEXGKCCSA-N [(2r)-3-(3,5-dibromophenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound BrC1=CC(Br)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCNCC2)=C1 AOTJSJQDFXGQSU-SSEXGKCCSA-N 0.000 description 2
• YSFBMMNESDLQTJ-GDLZYMKVSA-N [(2r)-3-(3,5-dichloro-4-hydroxyphenyl)-1-(4-morpholin-4-ylpiperidin-1-yl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCOCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 YSFBMMNESDLQTJ-GDLZYMKVSA-N 0.000 description 2
• IKSSXELBPROIPJ-SSEXGKCCSA-N [(2r)-3-(3,5-dichloro-4-hydroxyphenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=C(Cl)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 IKSSXELBPROIPJ-SSEXGKCCSA-N 0.000 description 2
• IVZKWKIENKLYNA-SSEXGKCCSA-N [(2r)-3-(3,5-dichloro-4-hydroxyphenyl)-1-[4-(1-methylsulfonylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=C(Cl)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 IVZKWKIENKLYNA-SSEXGKCCSA-N 0.000 description 2
• XLYWDIUTYPYZTK-WJOKGBTCSA-N [(2r)-3-(3,5-dichloro-4-hydroxyphenyl)-1-[4-(4,4-dimethylpiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(C)(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=C(Cl)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 XLYWDIUTYPYZTK-WJOKGBTCSA-N 0.000 description 2
• TYZFKKBYUAZTEW-SSEXGKCCSA-N [(2r)-3-(3,5-dichloro-4-hydroxyphenyl)-1-[4-(4-hydroxy-4-methylpiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(C)(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=C(Cl)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 TYZFKKBYUAZTEW-SSEXGKCCSA-N 0.000 description 2
• ZSMLILHAYHOYMY-MGBGTMOVSA-N [(2r)-3-(3,5-dichloro-4-hydroxyphenyl)-1-[4-[1-(2-ethoxy-2-oxoethyl)piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)OCC)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=C(Cl)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 ZSMLILHAYHOYMY-MGBGTMOVSA-N 0.000 description 2
• RCRKOJFWRCFOSI-GDLZYMKVSA-N [(2r)-3-(3,5-dichloro-4-hydroxyphenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 RCRKOJFWRCFOSI-GDLZYMKVSA-N 0.000 description 2
• BHJYMJVIBHNWDI-GDLZYMKVSA-N [(2r)-3-(3,5-dichloro-4-hydroxyphenyl)-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1C[C@H](C(=O)N1CCN(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 BHJYMJVIBHNWDI-GDLZYMKVSA-N 0.000 description 2
• JHRMIXAVLZCLAO-MGBGTMOVSA-N [(2r)-3-(3,5-dichloro-4-methylphenyl)-1-[4-(4-methyl-1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(C)=C(Cl)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 JHRMIXAVLZCLAO-MGBGTMOVSA-N 0.000 description 2
• HYZUVGURKGAQFH-JGCGQSQUSA-N [(2r)-3-(3,5-dichloro-4-methylphenyl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(C)=C(Cl)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 HYZUVGURKGAQFH-JGCGQSQUSA-N 0.000 description 2
• GYVMRCWXIGARST-WJOKGBTCSA-N [(2r)-3-(3,5-dichlorophenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C=C(Cl)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 GYVMRCWXIGARST-WJOKGBTCSA-N 0.000 description 2
• JYAVTZOQOSQJKD-MGBGTMOVSA-N [(2r)-3-(3,5-dimethylphenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(C)C=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 JYAVTZOQOSQJKD-MGBGTMOVSA-N 0.000 description 2
• HBLAHWBRNQYEPJ-JGCGQSQUSA-N [(2r)-3-(3,5-dimethylphenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=CC(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCNCC2)=C1 HBLAHWBRNQYEPJ-JGCGQSQUSA-N 0.000 description 2
• VGHNARVSEGUENU-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-(4-cycloheptylpiperazin-1-yl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=CC=C1C[C@H](C(=O)N1CCN(CC1)C1CCCCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 VGHNARVSEGUENU-JGCGQSQUSA-N 0.000 description 2
• NOCVAIACMXJROM-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-(4-cyclohexylpiperazin-1-yl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=CC=C1C[C@H](C(=O)N1CCN(CC1)C1CCCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 NOCVAIACMXJROM-WJOKGBTCSA-N 0.000 description 2
• LOWZCFQJQSKDAR-SSEXGKCCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-(4-cyclopentylpiperazin-1-yl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=CC=C1C[C@H](C(=O)N1CCN(CC1)C1CCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 LOWZCFQJQSKDAR-SSEXGKCCSA-N 0.000 description 2
• HBDVXSKOFAGOBF-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 HBDVXSKOFAGOBF-WJOKGBTCSA-N 0.000 description 2
• MDLHFOIGXYZODQ-UUWRZZSWSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(1-cyclopropylsulfonylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)C1CCN(CC1)S(=O)(=O)C1CC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 MDLHFOIGXYZODQ-UUWRZZSWSA-N 0.000 description 2
• RELUPHGBJDZKKO-MGBGTMOVSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(1-ethylsulfonylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)CC)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 RELUPHGBJDZKKO-MGBGTMOVSA-N 0.000 description 2
• HJRUTRRIVLPQMX-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(1-methylsulfonylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 HJRUTRRIVLPQMX-WJOKGBTCSA-N 0.000 description 2
• CVEWUYNAENZEKC-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(4,4-dimethylpiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(C)(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 CVEWUYNAENZEKC-JGCGQSQUSA-N 0.000 description 2
• AHTCEWOMFDKTRQ-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(4-ethyl-4-hydroxypiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(CC)(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 AHTCEWOMFDKTRQ-JGCGQSQUSA-N 0.000 description 2
• NEYCCPGLLSLDTQ-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(4-hydroxypiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 NEYCCPGLLSLDTQ-WJOKGBTCSA-N 0.000 description 2
• IZQRGEWJHSVGHU-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 IZQRGEWJHSVGHU-WJOKGBTCSA-N 0.000 description 2
• CBAQLEIOWSCRHS-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 CBAQLEIOWSCRHS-WJOKGBTCSA-N 0.000 description 2
• OLAQEMKRSFCQQA-MUUNZHRXSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(dimethylamino)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(N(C)C)CCN1C(=O)[C@H](OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)CC1=CC=C(O)C(Br)=C1 OLAQEMKRSFCQQA-MUUNZHRXSA-N 0.000 description 2
• OCXHSSOLPVDXRE-SSEXGKCCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(oxan-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=CC=C1C[C@H](C(=O)N1CCN(CC1)C1CCOCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 OCXHSSOLPVDXRE-SSEXGKCCSA-N 0.000 description 2
• OJHGYLYCZNLPPS-BVRKHOPBSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[(2r)-2-methoxycarbonylpyrrolidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound COC(=O)[C@H]1CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 OJHGYLYCZNLPPS-BVRKHOPBSA-N 0.000 description 2
• OJHGYLYCZNLPPS-IGYGKHONSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[(2s)-2-methoxycarbonylpyrrolidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound COC(=O)[C@@H]1CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 OJHGYLYCZNLPPS-IGYGKHONSA-N 0.000 description 2
• LPQYABDKXLYRQM-DLFZDVPBSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[(3r)-3-hydroxypiperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1[C@H](O)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 LPQYABDKXLYRQM-DLFZDVPBSA-N 0.000 description 2
• HNNVEQYCZXWYQA-PDDLMNHVSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[(3r)-3-hydroxypyrrolidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1[C@H](O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 HNNVEQYCZXWYQA-PDDLMNHVSA-N 0.000 description 2
• LPQYABDKXLYRQM-JTSJOTPCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[(3s)-3-hydroxypiperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1[C@@H](O)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 LPQYABDKXLYRQM-JTSJOTPCSA-N 0.000 description 2
• DRBVHSBRXFDPGB-MGBGTMOVSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-(2-ethoxy-2-oxoethyl)piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)OCC)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 DRBVHSBRXFDPGB-MGBGTMOVSA-N 0.000 description 2
• QULTTYMRJNYJOT-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-(2-hydroxyethyl)piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CCO)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 QULTTYMRJNYJOT-JGCGQSQUSA-N 0.000 description 2
• UNSWDCUPHDPHOO-MGBGTMOVSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-(2-hydroxyethyl)piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CCO)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 UNSWDCUPHDPHOO-MGBGTMOVSA-N 0.000 description 2
• SMUZEZVARCRABC-UUWRZZSWSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-(3-ethoxy-3-oxopropyl)piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CCC(=O)OCC)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 SMUZEZVARCRABC-UUWRZZSWSA-N 0.000 description 2
• NYUXBSQATHIMHS-UUWRZZSWSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-(4-ethoxy-4-oxobutanoyl)piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)CCC(=O)OCC)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 NYUXBSQATHIMHS-UUWRZZSWSA-N 0.000 description 2
• YUEWTRUKBDJZEI-PGUFJCEWSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-(4-ethoxy-4-oxobutanoyl)piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)CCC(=O)OCC)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 YUEWTRUKBDJZEI-PGUFJCEWSA-N 0.000 description 2
• DWNXWGWDMPXOBW-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-(dimethylsulfamoyl)piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)N(C)C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 DWNXWGWDMPXOBW-JGCGQSQUSA-N 0.000 description 2
• KQIZAOPAPHKQCV-MGBGTMOVSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-(dimethylsulfamoyl)piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)N(C)C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 KQIZAOPAPHKQCV-MGBGTMOVSA-N 0.000 description 2
• LZIDQVZFSSFYLH-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-(methylsulfamoyl)piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)NC)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 LZIDQVZFSSFYLH-WJOKGBTCSA-N 0.000 description 2
• OGSUOVCGVXARCK-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-(methylsulfamoyl)piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)NC)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 OGSUOVCGVXARCK-JGCGQSQUSA-N 0.000 description 2
• SLWHYACQWRBOOR-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-[2-(hydroxyamino)-2-oxoethyl]piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)NO)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 SLWHYACQWRBOOR-WJOKGBTCSA-N 0.000 description 2
• DDYDLLFOELLJMD-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-[2-(methoxyamino)-2-oxoethyl]piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)NOC)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 DDYDLLFOELLJMD-JGCGQSQUSA-N 0.000 description 2
• RDFYWJWYOQZXAA-MGBGTMOVSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-[2-(methoxyamino)-2-oxoethyl]piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)NOC)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 RDFYWJWYOQZXAA-MGBGTMOVSA-N 0.000 description 2
• QIHXRNWEVMUKQS-MGBGTMOVSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[1-[2-[hydroxy(methyl)amino]-2-oxoethyl]piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)N(O)C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 QIHXRNWEVMUKQS-MGBGTMOVSA-N 0.000 description 2
• OPLZPCGILOBJRD-MGBGTMOVSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[4-(1-hydroxycyclopropyl)piperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCC(CC1)C1(O)CC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 OPLZPCGILOBJRD-MGBGTMOVSA-N 0.000 description 2
• BBEKXBRXNQSJRC-MGBGTMOVSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[4-(2-ethoxy-2-oxoethyl)piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)OCC)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 BBEKXBRXNQSJRC-MGBGTMOVSA-N 0.000 description 2
• AAIUVKYQNJGXFD-UUWRZZSWSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[4-(2-ethoxy-2-oxoethyl)piperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(CC(=O)OCC)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 AAIUVKYQNJGXFD-UUWRZZSWSA-N 0.000 description 2
• COTHZTOAAFYQLE-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[4-(2-hydroxyethyl)piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CCO)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 COTHZTOAAFYQLE-JGCGQSQUSA-N 0.000 description 2
• LMFIOAFCQIQIPB-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[4-(dimethylsulfamoyl)piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)N(C)C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 LMFIOAFCQIQIPB-JGCGQSQUSA-N 0.000 description 2
• VESNWIHTHRFFMS-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[4-(hydroxymethyl)piperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(CO)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 VESNWIHTHRFFMS-JGCGQSQUSA-N 0.000 description 2
• POFDJPIEHCUYEA-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[4-[2-(hydroxyamino)-2-oxoethyl]piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)NO)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 POFDJPIEHCUYEA-WJOKGBTCSA-N 0.000 description 2
• VBANWZUVAZAYLB-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[4-[2-[hydroxy(methyl)amino]-2-oxoethyl]piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)N(O)C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 VBANWZUVAZAYLB-JGCGQSQUSA-N 0.000 description 2
• UCBDYZWSPCZJLZ-SSEXGKCCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 UCBDYZWSPCZJLZ-SSEXGKCCSA-N 0.000 description 2
• ZYXGTCZYLAUXRA-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 ZYXGTCZYLAUXRA-WJOKGBTCSA-N 0.000 description 2
• JGAKKFFDQLXDQN-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-oxo-1-(4-piperidin-4-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 JGAKKFFDQLXDQN-WJOKGBTCSA-N 0.000 description 2
• ICZWMVITFYLWKG-SSEXGKCCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-oxo-1-[4-(1-sulfamoylpiperidin-4-yl)piperazin-1-yl]propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)N)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 ICZWMVITFYLWKG-SSEXGKCCSA-N 0.000 description 2
• MUZWEIURUXQLRB-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-oxo-1-[4-[4-(3,3,3-trifluoro-2-oxopropyl)piperazin-1-yl]piperidin-1-yl]propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCN(CC(=O)C(F)(F)F)CC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 MUZWEIURUXQLRB-WJOKGBTCSA-N 0.000 description 2
• LZGSTJHTNZPMFI-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-methylphenyl)-1-[4-(1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(C)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 LZGSTJHTNZPMFI-JGCGQSQUSA-N 0.000 description 2
• IYHOPKPHPLJHOF-MGBGTMOVSA-N [(2r)-3-(3-bromo-4-methylphenyl)-1-[4-(4-methyl-1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(C)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 IYHOPKPHPLJHOF-MGBGTMOVSA-N 0.000 description 2
• QMJFIJQFIDZJGH-SSEXGKCCSA-N [(2r)-3-(3-chloro-4-hydroxyphenyl)-1-(4-morpholin-4-ylpiperidin-1-yl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCOCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 QMJFIJQFIDZJGH-SSEXGKCCSA-N 0.000 description 2
• VXBISINLPVCMRQ-WJOKGBTCSA-N [(2r)-3-(3-chloro-4-hydroxyphenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 VXBISINLPVCMRQ-WJOKGBTCSA-N 0.000 description 2
• XQSNGOPEAJMGGR-JGCGQSQUSA-N [(2r)-3-(3-chloro-4-hydroxyphenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 XQSNGOPEAJMGGR-JGCGQSQUSA-N 0.000 description 2
• XLWSORRJYMGZJV-WJOKGBTCSA-N [(2r)-3-(3-chloro-4-hydroxyphenyl)-1-[4-(1-methylsulfonylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 XLWSORRJYMGZJV-WJOKGBTCSA-N 0.000 description 2
• IBOUAQUTXOOTSO-JGCGQSQUSA-N [(2r)-3-(3-chloro-4-hydroxyphenyl)-1-[4-(4,4-dimethylpiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(C)(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 IBOUAQUTXOOTSO-JGCGQSQUSA-N 0.000 description 2
• RUKXIDMLINQBIK-WJOKGBTCSA-N [(2r)-3-(3-chloro-4-hydroxyphenyl)-1-[4-(4-hydroxy-4-methylpiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(C)(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 RUKXIDMLINQBIK-WJOKGBTCSA-N 0.000 description 2
• WVBUWCYPIWQIHC-WJOKGBTCSA-N [(2r)-3-(3-chloro-4-hydroxyphenyl)-1-[4-(4-hydroxypiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 WVBUWCYPIWQIHC-WJOKGBTCSA-N 0.000 description 2
• IZJFHFAATCMCPD-SSEXGKCCSA-N [(2r)-3-(3-chloro-4-hydroxyphenyl)-1-[4-(oxan-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(O)=CC=C1C[C@H](C(=O)N1CCN(CC1)C1CCOCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 IZJFHFAATCMCPD-SSEXGKCCSA-N 0.000 description 2
• QDLWPZPWCBEGEJ-WJOKGBTCSA-N [(2r)-3-(3-chloro-4-hydroxyphenyl)-1-[4-[4-hydroxy-4-(hydroxymethyl)piperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(CO)(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 QDLWPZPWCBEGEJ-WJOKGBTCSA-N 0.000 description 2
• DSKJMLGZVFYVHJ-WJOKGBTCSA-N [(2r)-3-(3-chloro-4-hydroxyphenyl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 DSKJMLGZVFYVHJ-WJOKGBTCSA-N 0.000 description 2
• HIKRFIHFNVROOF-SSEXGKCCSA-N [(2r)-3-(3-chloro-4-hydroxyphenyl)-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(O)=CC=C1C[C@H](C(=O)N1CCN(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 HIKRFIHFNVROOF-SSEXGKCCSA-N 0.000 description 2
• ANVACFLJUWSBHE-JGCGQSQUSA-N [(2r)-3-(3-chloro-4-methylphenyl)-1-[4-(1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(C)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 ANVACFLJUWSBHE-JGCGQSQUSA-N 0.000 description 2
• PBCXJNGRYVUAGL-MGBGTMOVSA-N [(2r)-3-(3-chloro-4-methylphenyl)-1-[4-(4-methyl-1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(C)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 PBCXJNGRYVUAGL-MGBGTMOVSA-N 0.000 description 2
• QOGQYHCCLRESLX-JGCGQSQUSA-N [(2r)-3-(3-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 QOGQYHCCLRESLX-JGCGQSQUSA-N 0.000 description 2
• BNBZGQDEHVPNDE-WJOKGBTCSA-N [(2r)-3-(3-methylphenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=CC=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCNCC2)=C1 BNBZGQDEHVPNDE-WJOKGBTCSA-N 0.000 description 2
• ALKMAJSCVAVEPZ-WJOKGBTCSA-N [(2r)-3-(3-methylphenyl)-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=CC=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCN(CC2)C2CCNCC2)=C1 ALKMAJSCVAVEPZ-WJOKGBTCSA-N 0.000 description 2
• DQMNJYPRUGCAAU-JGCGQSQUSA-N [(2r)-3-(3-methylphenyl)-1-oxo-1-(4-piperidin-4-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=CC=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)C2CCNCC2)=C1 DQMNJYPRUGCAAU-JGCGQSQUSA-N 0.000 description 2
• QEHWQPHZLSMYTG-MGBGTMOVSA-N [(2r)-3-(4,5-dimethylpyridin-2-yl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2N=CC(C)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 QEHWQPHZLSMYTG-MGBGTMOVSA-N 0.000 description 2
• OGFYYUPBLHYWEY-WJOKGBTCSA-N [(2r)-3-(4,5-dimethylpyridin-2-yl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(C)C(C)=CN=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 OGFYYUPBLHYWEY-WJOKGBTCSA-N 0.000 description 2
• SGHICGBNYSUCAR-WJOKGBTCSA-N [(2r)-3-(4,5-dimethylpyridin-2-yl)-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(C)C(C)=CN=C1C[C@H](C(=O)N1CCN(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 SGHICGBNYSUCAR-WJOKGBTCSA-N 0.000 description 2
• VASZOEXTWGDNRZ-SSEXGKCCSA-N [(2r)-3-(4-amino-3,5-dibromophenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(N)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 VASZOEXTWGDNRZ-SSEXGKCCSA-N 0.000 description 2
• IKRGPWCVEPUGRH-WJOKGBTCSA-N [(2r)-3-(4-amino-3,5-dibromophenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(N)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 IKRGPWCVEPUGRH-WJOKGBTCSA-N 0.000 description 2
• ZAQIVEJIWFAPAW-GDLZYMKVSA-N [(2r)-3-(4-amino-3,5-dibromophenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(N)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 ZAQIVEJIWFAPAW-GDLZYMKVSA-N 0.000 description 2
• ONUJFFJKSLAIIA-GDLZYMKVSA-N [(2r)-3-(4-amino-3,5-dibromophenyl)-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(N)=C(Br)C=C1C[C@H](C(=O)N1CCN(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 ONUJFFJKSLAIIA-GDLZYMKVSA-N 0.000 description 2
• DEDLTMODKPMMBO-JGCGQSQUSA-N [(2r)-3-(4-amino-3,5-dimethylphenyl)-1-[4-(1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(N)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCNCCC2)=C1 DEDLTMODKPMMBO-JGCGQSQUSA-N 0.000 description 2
• AQUBCWILFYJEOG-JGCGQSQUSA-N [(2r)-3-(4-amino-3,5-dimethylphenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(C)C(N)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 AQUBCWILFYJEOG-JGCGQSQUSA-N 0.000 description 2
• YGQRXADVMTXPNR-MGBGTMOVSA-N [(2r)-3-(4-amino-3,5-dimethylphenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(N)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 YGQRXADVMTXPNR-MGBGTMOVSA-N 0.000 description 2
• KUKLMKURBOIBIC-JGCGQSQUSA-N [(2r)-3-(4-amino-3,5-dimethylphenyl)-1-[4-(4-amino-4-methylpiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(N)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCC(C)(N)CC2)=C1 KUKLMKURBOIBIC-JGCGQSQUSA-N 0.000 description 2
• OVJHSWPUWWCMJM-MGBGTMOVSA-N [(2r)-3-(4-amino-3,5-dimethylphenyl)-1-[4-(4-methyl-1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(N)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 OVJHSWPUWWCMJM-MGBGTMOVSA-N 0.000 description 2
• LHZUUQBDCNPREA-WJOKGBTCSA-N [(2r)-3-(4-amino-3,5-dimethylphenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(N)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCNCC2)=C1 LHZUUQBDCNPREA-WJOKGBTCSA-N 0.000 description 2
• BXKJEQOSYVFTMS-JGCGQSQUSA-N [(2r)-3-(4-amino-3,5-dimethylphenyl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(N)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCCCC2)=C1 BXKJEQOSYVFTMS-JGCGQSQUSA-N 0.000 description 2
• PFRHUEFXUINTDB-SSEXGKCCSA-N [(2r)-3-(4-amino-3-bromophenyl)-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(N)=CC=C1C[C@H](C(=O)N1CCN(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 PFRHUEFXUINTDB-SSEXGKCCSA-N 0.000 description 2
• LIVQCELZPCDSDV-MUUNZHRXSA-N [(2r)-3-(4-aminophenyl)-1-[4-(dimethylamino)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(N(C)C)CCN1C(=O)[C@H](OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)CC1=CC=C(N)C=C1 LIVQCELZPCDSDV-MUUNZHRXSA-N 0.000 description 2
• UMSMDWNWCSNXKV-WJOKGBTCSA-N [(2r)-3-(4-aminophenyl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=CC(N)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 UMSMDWNWCSNXKV-WJOKGBTCSA-N 0.000 description 2
• OUHYMAJYQLFBKE-MGBGTMOVSA-N [(2r)-3-(4-bromo-3,5-dimethylphenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(Br)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 OUHYMAJYQLFBKE-MGBGTMOVSA-N 0.000 description 2
• XQDFBTVPBYVXCU-JGCGQSQUSA-N [(2r)-3-(4-bromo-3,5-dimethylphenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(Br)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 XQDFBTVPBYVXCU-JGCGQSQUSA-N 0.000 description 2
• MEBVPQUEIRSVSZ-GDLZYMKVSA-N [(2r)-3-(4-bromo-3,5-dimethylphenyl)-1-[4-(dimethylamino)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(N(C)C)CCN1C(=O)[C@H](OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)CC1=CC(C)=C(Br)C(C)=C1 MEBVPQUEIRSVSZ-GDLZYMKVSA-N 0.000 description 2
• SFEXLNDRSXKZPE-WJOKGBTCSA-N [(2r)-3-(4-bromo-3,5-dimethylphenyl)-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(Br)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCN(CC2)C2CCNCC2)=C1 SFEXLNDRSXKZPE-WJOKGBTCSA-N 0.000 description 2
• KXXQADGWENHUCA-JGCGQSQUSA-N [(2r)-3-(4-chloro-3,5-dimethylphenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(C)C(Cl)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 KXXQADGWENHUCA-JGCGQSQUSA-N 0.000 description 2
• ZXDFXOKDJRUDOO-JGCGQSQUSA-N [(2r)-3-(4-chloro-3,5-dimethylphenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(Cl)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 ZXDFXOKDJRUDOO-JGCGQSQUSA-N 0.000 description 2
• VNLKNTNJFDIXCU-JGCGQSQUSA-N [(2r)-3-(4-chloro-3,5-dimethylphenyl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(Cl)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCCCC2)=C1 VNLKNTNJFDIXCU-JGCGQSQUSA-N 0.000 description 2
• UMKMTFHHRBBUQE-WJOKGBTCSA-N [(2r)-3-(4-chloro-3,5-dimethylphenyl)-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(Cl)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCN(CC2)C2CCNCC2)=C1 UMKMTFHHRBBUQE-WJOKGBTCSA-N 0.000 description 2
• HWFSBULEKYYKOW-JGCGQSQUSA-N [(2r)-3-(4-chloro-3,5-dimethylphenyl)-1-oxo-1-(4-piperidin-4-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(Cl)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)C2CCNCC2)=C1 HWFSBULEKYYKOW-JGCGQSQUSA-N 0.000 description 2
• LQNBDEBOXCRBBN-MGBGTMOVSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 LQNBDEBOXCRBBN-MGBGTMOVSA-N 0.000 description 2
• LWGBPQMBWWKQAK-JGCGQSQUSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(1-methylsulfonylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCN(CC2)C2CCN(CC2)S(C)(=O)=O)=C1 LWGBPQMBWWKQAK-JGCGQSQUSA-N 0.000 description 2
• LKXTVCSGKJTHCO-JGCGQSQUSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(4-hydroxy-1-methylsulfonylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)C2(O)CCN(CC2)S(C)(=O)=O)=C1 LKXTVCSGKJTHCO-JGCGQSQUSA-N 0.000 description 2
• NDLVSGOKPPDGRP-JGCGQSQUSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(4-hydroxypiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCC(O)CC2)=C1 NDLVSGOKPPDGRP-JGCGQSQUSA-N 0.000 description 2
• UKAMREZDQHDNJE-MGBGTMOVSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(4-methyl-1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 UKAMREZDQHDNJE-MGBGTMOVSA-N 0.000 description 2
• WJIPSCJAASNZPP-JGCGQSQUSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 WJIPSCJAASNZPP-JGCGQSQUSA-N 0.000 description 2
• BYNNUMCOXRGYNE-JGCGQSQUSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCN(CC2)S(C)(=O)=O)=C1 BYNNUMCOXRGYNE-JGCGQSQUSA-N 0.000 description 2
• UQLBAHOLZZPYPV-WJOKGBTCSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(oxan-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCN(CC2)C2CCOCC2)=C1 UQLBAHOLZZPYPV-WJOKGBTCSA-N 0.000 description 2
• QDYWZBNWSIAQDG-ROJLCIKYSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-[(2r)-2-methoxycarbonylpyrrolidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound COC(=O)[C@H]1CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 QDYWZBNWSIAQDG-ROJLCIKYSA-N 0.000 description 2
• UIOSZGZVEUHLRY-XLJNKUFUSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-[(3r)-3-hydroxypiperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2C[C@H](O)CCC2)=C1 UIOSZGZVEUHLRY-XLJNKUFUSA-N 0.000 description 2
• FHBCXIRSFUBTME-BVRKHOPBSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-[(3r)-3-hydroxypyrrolidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2C[C@H](O)CC2)=C1 FHBCXIRSFUBTME-BVRKHOPBSA-N 0.000 description 2
• FHBCXIRSFUBTME-IGYGKHONSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-[(3s)-3-hydroxypyrrolidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2C[C@@H](O)CC2)=C1 FHBCXIRSFUBTME-IGYGKHONSA-N 0.000 description 2
• CGENFMMZZSCYFK-UUWRZZSWSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-[1-(2-hydroxyethyl)piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)C2CCN(CCO)CC2)=C1 CGENFMMZZSCYFK-UUWRZZSWSA-N 0.000 description 2
• SSCRJIXTMNDFRR-JGCGQSQUSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-[1-(methylsulfamoyl)piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)NC)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 SSCRJIXTMNDFRR-JGCGQSQUSA-N 0.000 description 2
• PBZPQUCBWXKTBE-MGBGTMOVSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-[1-(methylsulfamoyl)piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)NC)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 PBZPQUCBWXKTBE-MGBGTMOVSA-N 0.000 description 2
• ICBNWSSWSHNZMF-MGBGTMOVSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-[4-(2-hydroxyethyl)piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCN(CCO)CC2)=C1 ICBNWSSWSHNZMF-MGBGTMOVSA-N 0.000 description 2
• WUXFRSGHYDAJDI-JGCGQSQUSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCCCC2)=C1 WUXFRSGHYDAJDI-JGCGQSQUSA-N 0.000 description 2
• COBFUXMQQSLDQD-WJOKGBTCSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCN(CC2)C2CCNCC2)=C1 COBFUXMQQSLDQD-WJOKGBTCSA-N 0.000 description 2
• JOUAUAGOYGTXNU-JGCGQSQUSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxo-1-(4-piperidin-4-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)C2CCNCC2)=C1 JOUAUAGOYGTXNU-JGCGQSQUSA-N 0.000 description 2
• BHDGMWZHMYRAOE-WJOKGBTCSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxo-1-[4-(1-sulfamoylpiperidin-4-yl)piperazin-1-yl]propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCN(CC2)C2CCN(CC2)S(N)(=O)=O)=C1 BHDGMWZHMYRAOE-WJOKGBTCSA-N 0.000 description 2
• VDXJMLPKKLIBRM-JGCGQSQUSA-N [(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-1-oxo-1-[4-[4-(3,3,3-trifluoro-2-oxopropyl)piperazin-1-yl]piperidin-1-yl]propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound CC1=C(O)C(C)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCN(CC(=O)C(F)(F)F)CC2)=C1 VDXJMLPKKLIBRM-JGCGQSQUSA-N 0.000 description 2
• CWJUFPMIYQRJCY-JGCGQSQUSA-N [(2r)-3-(4-hydroxyphenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=CC(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 CWJUFPMIYQRJCY-JGCGQSQUSA-N 0.000 description 2
• NHWOZBVQFSBGMO-WJOKGBTCSA-N [(2r)-3-(4-hydroxyphenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=CC(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 NHWOZBVQFSBGMO-WJOKGBTCSA-N 0.000 description 2
• AISQMYCMHKTHHN-SSEXGKCCSA-N [(2r)-3-(4-hydroxyphenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=CC(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 AISQMYCMHKTHHN-SSEXGKCCSA-N 0.000 description 2
• XGWUSBMPVHLFIV-WJOKGBTCSA-N [(2r)-3-(4-hydroxyphenyl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=CC(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 XGWUSBMPVHLFIV-WJOKGBTCSA-N 0.000 description 2
• YVBXQLXOGWRGTK-WJOKGBTCSA-N [(2r)-3-(4-hydroxyphenyl)-1-oxo-1-(4-piperidin-4-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=CC(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 YVBXQLXOGWRGTK-WJOKGBTCSA-N 0.000 description 2
• PMBNWMKPDAHJSZ-UUWRZZSWSA-N [(2r)-3-(4-methoxy-3,5-dimethylphenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(C)C(OC)=C(C)C=C1C[C@H](C(=O)N1CCC(CC1)C1CCN(C)CC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 PMBNWMKPDAHJSZ-UUWRZZSWSA-N 0.000 description 2
• IKNVJVKFOLWYQO-UUWRZZSWSA-N [(2r)-3-(4-methoxy-3,5-dimethylphenyl)-1-[4-(4-methyl-1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(C)C(OC)=C(C)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCN(C)CCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 IKNVJVKFOLWYQO-UUWRZZSWSA-N 0.000 description 2
• LQKOPYUYZQBPJO-JGCGQSQUSA-N [(2r)-3-(4-methoxy-3,5-dimethylphenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(C)C(OC)=C(C)C=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 LQKOPYUYZQBPJO-JGCGQSQUSA-N 0.000 description 2
• MQNWGIVYNZOTGV-SSEXGKCCSA-N [(2r)-3-(6-amino-5-methylpyridin-3-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(C)C(N)=NC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 MQNWGIVYNZOTGV-SSEXGKCCSA-N 0.000 description 2
• QEBDWZVGDWKPDX-WJOKGBTCSA-N [(2r)-3-(6-amino-5-methylpyridin-3-yl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(N)=NC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 QEBDWZVGDWKPDX-WJOKGBTCSA-N 0.000 description 2
• WDRMGWXYWWMTCL-WJOKGBTCSA-N [(2r)-3-(6-amino-5-methylpyridin-3-yl)-1-[4-(4-methyl-1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(N)=NC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 WDRMGWXYWWMTCL-WJOKGBTCSA-N 0.000 description 2
• FQIVLQPMIICIGC-SSEXGKCCSA-N [(2r)-3-(6-amino-5-methylpyridin-3-yl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(N)=NC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 FQIVLQPMIICIGC-SSEXGKCCSA-N 0.000 description 2
• WOTLVAWJFXLEEX-SSEXGKCCSA-N [(2r)-3-[3,5-bis(trifluoromethyl)phenyl]-1-(4-morpholin-4-ylpiperidin-1-yl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCOCC2)=C1 WOTLVAWJFXLEEX-SSEXGKCCSA-N 0.000 description 2
• KPMNDLSRIKTYHC-JGCGQSQUSA-N [(2r)-3-[3,5-bis(trifluoromethyl)phenyl]-1-[4-(4,4-dimethylpiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(C)(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 KPMNDLSRIKTYHC-JGCGQSQUSA-N 0.000 description 2
• XKYLFTKTBIHIJC-WJOKGBTCSA-N [(2r)-3-[3,5-bis(trifluoromethyl)phenyl]-1-[4-(4-hydroxy-4-methylpiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(C)(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 XKYLFTKTBIHIJC-WJOKGBTCSA-N 0.000 description 2
• JPHGRFOTHOBKRM-JGCGQSQUSA-N [(2r)-3-[3,5-bis(trifluoromethyl)phenyl]-1-[4-(4-methyl-1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 JPHGRFOTHOBKRM-JGCGQSQUSA-N 0.000 description 2
• FJQVBPFLPXIWEX-WJOKGBTCSA-N [(2r)-3-[3,5-bis(trifluoromethyl)phenyl]-1-[4-[4-hydroxy-4-(hydroxymethyl)piperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(CO)(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 FJQVBPFLPXIWEX-WJOKGBTCSA-N 0.000 description 2
• AUWDVMIQDCBRAJ-SSEXGKCCSA-N [(2r)-3-[3,5-bis(trifluoromethyl)phenyl]-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCN(CC2)C2CCNCC2)=C1 AUWDVMIQDCBRAJ-SSEXGKCCSA-N 0.000 description 2
• DGZKQKIULGBGRJ-JGCGQSQUSA-N [(2r)-3-[3-bromo-4-(trifluoromethyl)phenyl]-1-[4-(4-methyl-1,4-diazepan-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(=CC=2)C(F)(F)F)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 DGZKQKIULGBGRJ-JGCGQSQUSA-N 0.000 description 2
• LDACOKYGEZBFMK-WJOKGBTCSA-N [(2r)-3-[3-bromo-4-(trifluoromethyl)phenyl]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(=CC=2)C(F)(F)F)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 LDACOKYGEZBFMK-WJOKGBTCSA-N 0.000 description 2
• MGMIMOPWEYCJFB-MUUNZHRXSA-N [(2r)-3-[3-bromo-4-(trifluoromethyl)phenyl]-1-[4-(dimethylamino)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(N(C)C)CCN1C(=O)[C@H](OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)CC1=CC=C(C(F)(F)F)C(Br)=C1 MGMIMOPWEYCJFB-MUUNZHRXSA-N 0.000 description 2
• UPRQUSMFHPRUBM-SSEXGKCCSA-N [(2r)-3-[3-bromo-4-(trifluoromethyl)phenyl]-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(C(F)(F)F)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 UPRQUSMFHPRUBM-SSEXGKCCSA-N 0.000 description 2
• DCWPGDYKWSUBRO-WJOKGBTCSA-N [(2r)-3-[3-bromo-4-(trifluoromethyl)phenyl]-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(C(F)(F)F)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 DCWPGDYKWSUBRO-WJOKGBTCSA-N 0.000 description 2
• HECCPFZYSKLZKK-JGCGQSQUSA-N [(2r)-3-[3-chloro-4-(trifluoromethyl)phenyl]-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(=CC=2)C(F)(F)F)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 HECCPFZYSKLZKK-JGCGQSQUSA-N 0.000 description 2
• DRTLHXICUCETJB-MUUNZHRXSA-N [(2r)-3-[3-chloro-4-(trifluoromethyl)phenyl]-1-[4-(dimethylamino)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(N(C)C)CCN1C(=O)[C@H](OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)CC1=CC=C(C(F)(F)F)C(Cl)=C1 DRTLHXICUCETJB-MUUNZHRXSA-N 0.000 description 2
• MOMKLWDARKTBIC-SSEXGKCCSA-N [(2r)-3-[3-chloro-4-(trifluoromethyl)phenyl]-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(C(F)(F)F)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 MOMKLWDARKTBIC-SSEXGKCCSA-N 0.000 description 2
• WXTUTDMSCVMZEO-SSEXGKCCSA-N [(2r)-3-[3-chloro-4-(trifluoromethyl)phenyl]-1-oxo-1-(4-piperidin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(C(F)(F)F)=CC=C1C[C@H](C(=O)N1CCN(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 WXTUTDMSCVMZEO-SSEXGKCCSA-N 0.000 description 2
• CVZKYNHTRNOZDV-WJOKGBTCSA-N [(2r)-3-[3-chloro-4-(trifluoromethyl)phenyl]-1-oxo-1-(4-piperidin-4-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(C(F)(F)F)=CC=C1C[C@H](C(=O)N1CCC(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 CVZKYNHTRNOZDV-WJOKGBTCSA-N 0.000 description 2
• 230000003213 activating effect Effects 0.000 description 2
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• 230000001476 alcoholic effect Effects 0.000 description 2
• 229910000288 alkali metal carbonate Inorganic materials 0.000 description 2
• 150000008041 alkali metal carbonates Chemical class 0.000 description 2
• 229910000272 alkali metal oxide Inorganic materials 0.000 description 2
• 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 2
• 239000002333 angiotensin II receptor antagonist Substances 0.000 description 2
• 239000012300 argon atmosphere Substances 0.000 description 2
• 125000005605 benzo group Chemical group 0.000 description 2
• 230000015572 biosynthetic process Effects 0.000 description 2
• QARVLSVVCXYDNA-UHFFFAOYSA-N bromobenzene Chemical compound BrC1=CC=CC=C1 QARVLSVVCXYDNA-UHFFFAOYSA-N 0.000 description 2
• FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 description 2
• 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 description 2
• BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
• DNKYDHSONDSTNJ-XJVRLEFXSA-N chembl1910953 Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CN=CN1 DNKYDHSONDSTNJ-XJVRLEFXSA-N 0.000 description 2
• PSEHHVRCDVOTID-VMAIWCPRSA-N chloro-bis[(1r,3r,4s,5r)-4,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl]borane Chemical compound C([C@H]([C@@H]1C)B(Cl)[C@H]2[C@H](C)[C@]3(C[C@@](C2)(C3(C)C)[H])[H])[C@@]2([H])C(C)(C)[C@]1([H])C2 PSEHHVRCDVOTID-VMAIWCPRSA-N 0.000 description 2
• 238000011097 chromatography purification Methods 0.000 description 2
• 239000013078 crystal Substances 0.000 description 2
• PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 description 2
• BGRWYRAHAFMIBJ-UHFFFAOYSA-N diisopropylcarbodiimide Natural products CC(C)NC(=O)NC(C)C BGRWYRAHAFMIBJ-UHFFFAOYSA-N 0.000 description 2
• SQNZJJAZBFDUTD-UHFFFAOYSA-N durene Chemical compound CC1=CC(C)=C(C)C=C1C SQNZJJAZBFDUTD-UHFFFAOYSA-N 0.000 description 2
• 230000008030 elimination Effects 0.000 description 2
• 238000003379 elimination reaction Methods 0.000 description 2
• 238000002474 experimental method Methods 0.000 description 2
• 150000004675 formic acid derivatives Chemical class 0.000 description 2
• 125000002541 furyl group Chemical group 0.000 description 2
• NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 2
• 125000002883 imidazolyl group Chemical group 0.000 description 2
• 239000003112 inhibitor Substances 0.000 description 2
• 239000000543 intermediate Substances 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
• 238000002844 melting Methods 0.000 description 2
• 230000008018 melting Effects 0.000 description 2
• LWDXNEDWGSJWKT-FIRIVFDPSA-N methyl (2r)-1-[1-[(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-2-[4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carbonyl]oxypropanoyl]piperidin-4-yl]piperidine-2-carboxylate Chemical compound COC(=O)[C@H]1CCCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 LWDXNEDWGSJWKT-FIRIVFDPSA-N 0.000 description 2
• KVXCALANLDFFNF-XLJNKUFUSA-N methyl (2r)-1-[1-[(2r)-3-(3-bromo-4-hydroxyphenyl)-2-[4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carbonyl]oxypropanoyl]piperidin-4-yl]piperidine-2-carboxylate Chemical compound COC(=O)[C@H]1CCCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 KVXCALANLDFFNF-XLJNKUFUSA-N 0.000 description 2
• RCRJRCREKJMINP-CZNDPXEESA-N methyl (2r)-1-[1-[(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-2-[4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carbonyl]oxypropanoyl]piperidin-4-yl]piperidine-2-carboxylate Chemical compound COC(=O)[C@H]1CCCCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 RCRJRCREKJMINP-CZNDPXEESA-N 0.000 description 2
• LWDXNEDWGSJWKT-IOWSJCHKSA-N methyl (2s)-1-[1-[(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-2-[4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carbonyl]oxypropanoyl]piperidin-4-yl]piperidine-2-carboxylate Chemical compound COC(=O)[C@@H]1CCCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 LWDXNEDWGSJWKT-IOWSJCHKSA-N 0.000 description 2
• KVXCALANLDFFNF-XDFJSJKPSA-N methyl (2s)-1-[1-[(2r)-3-(3-bromo-4-hydroxyphenyl)-2-[4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carbonyl]oxypropanoyl]piperidin-4-yl]piperidine-2-carboxylate Chemical compound COC(=O)[C@@H]1CCCCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 KVXCALANLDFFNF-XDFJSJKPSA-N 0.000 description 2
• RCRJRCREKJMINP-JHOUSYSJSA-N methyl (2s)-1-[1-[(2r)-3-(4-hydroxy-3,5-dimethylphenyl)-2-[4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carbonyl]oxypropanoyl]piperidin-4-yl]piperidine-2-carboxylate Chemical compound COC(=O)[C@@H]1CCCCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C(O)=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 RCRJRCREKJMINP-JHOUSYSJSA-N 0.000 description 2
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• DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 description 2
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• 239000002243 precursor Substances 0.000 description 2
• AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
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• KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 description 2
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• INQAQYGOGFJJGJ-GDLZYMKVSA-N [(2r)-3-(3,4-dibromophenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-3h-benzimidazol-1-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(Br)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C32)=O)CC1 INQAQYGOGFJJGJ-GDLZYMKVSA-N 0.000 description 1
• PHWDRTFIWQGKIF-JGCGQSQUSA-N [(2r)-3-(3,4-dibromophenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(7-methoxy-2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C([C@@H](OC(=O)N1CCC(CC1)N1C(=O)NC2=CC=C(C=C2CC1)OC)C(=O)N1CCC(CC1)N1CCN(C)CC1)C1=CC=C(Br)C(Br)=C1 PHWDRTFIWQGKIF-JGCGQSQUSA-N 0.000 description 1
• GCRGHADNPHRFII-JGCGQSQUSA-N [(2r)-3-(3,4-dibromophenyl)-1-[4-[4-(2-methoxy-2-oxoethyl)piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)OC)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(Br)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 GCRGHADNPHRFII-JGCGQSQUSA-N 0.000 description 1
• BVLVCWHHNMWYPW-HSZRJFAPSA-N [(2r)-3-(3,4-dibromophenyl)-1-ethoxy-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C([C@H](C(=O)OCC)OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)C1=CC=C(Br)C(Br)=C1 BVLVCWHHNMWYPW-HSZRJFAPSA-N 0.000 description 1
• JQJNBXVCVWAAIU-SSEXGKCCSA-N [(2r)-3-(3,4-dibromophenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(Br)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 JQJNBXVCVWAAIU-SSEXGKCCSA-N 0.000 description 1
• UMLKVBNTTNZSEO-SSEXGKCCSA-N [(2r)-3-(3,4-dibromophenyl)-1-oxo-1-(4-pyridin-4-ylpiperazin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(Br)=CC=C1C[C@H](C(=O)N1CCN(CC1)C=1C=CN=CC=1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 UMLKVBNTTNZSEO-SSEXGKCCSA-N 0.000 description 1
• ZKUXRZXAZDFVOR-SSEXGKCCSA-N [(2r)-3-(3,4-dibromophenyl)-1-oxo-1-(4-pyrrolidin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(Br)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 ZKUXRZXAZDFVOR-SSEXGKCCSA-N 0.000 description 1
• MIGUCJSHOCDDQO-GDLZYMKVSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-3h-benzimidazol-1-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C32)=O)CC1 MIGUCJSHOCDDQO-GDLZYMKVSA-N 0.000 description 1
• MBXYCCQUAHZMAX-GDLZYMKVSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(3-oxo-5-phenyl-1h-1,2,4-triazol-2-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC(=N2)C=2C=CC=CC=2)=O)CC1 MBXYCCQUAHZMAX-GDLZYMKVSA-N 0.000 description 1
• WXRVOWLOXAYMHV-JGCGQSQUSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-1h-imidazo[4,5-c]quinolin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=C4C=CC=CC4=NC=C32)=O)CC1 WXRVOWLOXAYMHV-JGCGQSQUSA-N 0.000 description 1
• AQNYVHUWWDJYIE-SSEXGKCCSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-3h-benzimidazol-1-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C32)=O)CC1 AQNYVHUWWDJYIE-SSEXGKCCSA-N 0.000 description 1
• BZPQYLJGRKJQRU-JGCGQSQUSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 BZPQYLJGRKJQRU-JGCGQSQUSA-N 0.000 description 1
• IQCODCXTAZXKBI-JGCGQSQUSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(4-fluorophenyl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=CC(F)=CC=C1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 IQCODCXTAZXKBI-JGCGQSQUSA-N 0.000 description 1
• PPKUSMOJVICEIA-GDLZYMKVSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-3h-benzimidazol-1-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C32)=O)CC1 PPKUSMOJVICEIA-GDLZYMKVSA-N 0.000 description 1
• RWSZOOFRDGHYHT-GDLZYMKVSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(3-oxo-5-phenyl-1h-1,2,4-triazol-2-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(Cl)=CC=2)OC(=O)N2CCC(CC2)N2C(NC(=N2)C=2C=CC=CC=2)=O)CC1 RWSZOOFRDGHYHT-GDLZYMKVSA-N 0.000 description 1
• OIORCKBDSSNMRS-HHHXNRCGSA-N [(2r)-3-(3,4-dichlorophenyl)-1-[4-(methylamino)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(NC)CCN1C(=O)[C@H](OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)CC1=CC=C(Cl)C(Cl)=C1 OIORCKBDSSNMRS-HHHXNRCGSA-N 0.000 description 1
• LUBZXQLLKSYNHC-VAVYLYDRSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[(3r)-3-hydroxypyrrolidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1[C@H](O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 LUBZXQLLKSYNHC-VAVYLYDRSA-N 0.000 description 1
• LROXYZUEQDLOHT-WJOKGBTCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[1-(2-hydroxyethyl)piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CCO)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 LROXYZUEQDLOHT-WJOKGBTCSA-N 0.000 description 1
• DOQHCTRSJYNOIP-SSEXGKCCSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[1-[2-(hydroxyamino)-2-oxoethyl]piperidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)NO)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 DOQHCTRSJYNOIP-SSEXGKCCSA-N 0.000 description 1
• HGVICPUGKPQWCP-JGCGQSQUSA-N [(2r)-3-(3,5-dibromo-4-hydroxyphenyl)-1-[4-[1-[2-[hydroxy(methyl)amino]-2-oxoethyl]piperidin-4-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)N(O)C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 HGVICPUGKPQWCP-JGCGQSQUSA-N 0.000 description 1
• BBCVOWOICJQSRM-JGCGQSQUSA-N [(2r)-3-(3,5-dibromo-4-methoxyphenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(OC)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)C1CCN(C)CC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 BBCVOWOICJQSRM-JGCGQSQUSA-N 0.000 description 1
• PKXSIFXMKRCSBK-MUUNZHRXSA-N [(2r)-3-(3,5-dibromo-4-methoxyphenyl)-1-[4-(dimethylamino)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(OC)=C(Br)C=C1C[C@H](C(=O)N1CCC(CC1)N(C)C)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 PKXSIFXMKRCSBK-MUUNZHRXSA-N 0.000 description 1
• FFGRFJIBFWUUHL-JGCGQSQUSA-N [(2r)-3-(3,5-dibromo-4-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(C)=C(Br)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 FFGRFJIBFWUUHL-JGCGQSQUSA-N 0.000 description 1
• GHPZFNLBDSDCPH-GDLZYMKVSA-N [(2r)-3-(3,5-dibromo-4-methylphenyl)-1-[4-(dimethylamino)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(N(C)C)CCN1C(=O)[C@H](OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)CC1=CC(Br)=C(C)C(Br)=C1 GHPZFNLBDSDCPH-GDLZYMKVSA-N 0.000 description 1
• SCQQNMLXYDIEDT-JOCHJYFZSA-N [(2r)-3-(3,5-dibromophenyl)-1-methoxy-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C([C@H](C(=O)OC)OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)C1=CC(Br)=CC(Br)=C1 SCQQNMLXYDIEDT-JOCHJYFZSA-N 0.000 description 1
• CIWUTCCALACGRJ-SSEXGKCCSA-N [(2r)-3-(3,5-dichloro-4-hydroxyphenyl)-1-[4-[4-hydroxy-4-(hydroxymethyl)piperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(CO)(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(O)=C(Cl)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 CIWUTCCALACGRJ-SSEXGKCCSA-N 0.000 description 1
• AINKLJGNLADCQU-MGBGTMOVSA-N [(2r)-3-(3,5-dichloro-4-methylphenyl)-1-[4-(1-methylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Cl)C(C)=C(Cl)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 AINKLJGNLADCQU-MGBGTMOVSA-N 0.000 description 1
• HGDPAEIKXOEFJX-JGCGQSQUSA-N [(2r)-3-(3,5-dichloro-4-methylphenyl)-1-oxo-1-(4-piperidin-4-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Cl)C(C)=C(Cl)C=C1C[C@H](C(=O)N1CCC(CC1)C1CCNCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 HGDPAEIKXOEFJX-JGCGQSQUSA-N 0.000 description 1
• XHPGDYLMXWFVNF-WJOKGBTCSA-N [(2r)-3-(3,5-dichlorophenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Cl)C=C(Cl)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 XHPGDYLMXWFVNF-WJOKGBTCSA-N 0.000 description 1
• UYOKDSSJWVGZNY-SSEXGKCCSA-N [(2r)-3-(3,5-dichlorophenyl)-1-oxo-1-(4-piperazin-1-ylpiperidin-1-yl)propan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound ClC1=CC(Cl)=CC(C[C@@H](OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)C(=O)N2CCC(CC2)N2CCNCC2)=C1 UYOKDSSJWVGZNY-SSEXGKCCSA-N 0.000 description 1
• KKMKLEKDGTUOMI-SSEXGKCCSA-N [(2r)-3-(3,5-dimethyl-4-phenylmethoxyphenyl)-1-methoxy-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C([C@H](C(=O)OC)OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)C(C=C1C)=CC(C)=C1OCC1=CC=CC=C1 KKMKLEKDGTUOMI-SSEXGKCCSA-N 0.000 description 1
• LVAMSOMMRIDCHM-MGBGTMOVSA-N [(2r)-3-(3,5-dimethylphenyl)-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(C)C=C(C)C=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 LVAMSOMMRIDCHM-MGBGTMOVSA-N 0.000 description 1
• VJGAIGLHTMZAQZ-SSEXGKCCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-(4-morpholin-4-ylpiperidin-1-yl)-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1=C(Br)C(O)=CC=C1C[C@H](C(=O)N1CCC(CC1)N1CCOCC1)OC(=O)N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1 VJGAIGLHTMZAQZ-SSEXGKCCSA-N 0.000 description 1
• NWNPNIHKHJYURO-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C)CCC1N1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 NWNPNIHKHJYURO-WJOKGBTCSA-N 0.000 description 1
• XZRJCWRXCJIILP-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(1-methylsulfonylpiperidin-4-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)C)CCC1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 XZRJCWRXCJIILP-JGCGQSQUSA-N 0.000 description 1
• HTTPCBBSKNIUQR-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-(4-hydroxy-4-methylpiperidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(C)(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 HTTPCBBSKNIUQR-WJOKGBTCSA-N 0.000 description 1
• FWNNDIFMCDEFSQ-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[4-(methylsulfamoyl)piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(S(=O)(=O)NC)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 FWNNDIFMCDEFSQ-WJOKGBTCSA-N 0.000 description 1
• RKLVZSODSKKXHF-JGCGQSQUSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[4-[2-(methoxyamino)-2-oxoethyl]piperazin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CN(CC(=O)NOC)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 RKLVZSODSKKXHF-JGCGQSQUSA-N 0.000 description 1
• YOQUINPHDJJZEZ-WJOKGBTCSA-N [(2r)-3-(3-bromo-4-hydroxyphenyl)-1-[4-[4-hydroxy-4-(hydroxymethyl)piperidin-1-yl]piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C1CC(CO)(O)CCN1C1CCN(C(=O)[C@@H](CC=2C=C(Br)C(O)=CC=2)OC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3CC2)=O)CC1 YOQUINPHDJJZEZ-WJOKGBTCSA-N 0.000 description 1
• KSTAVULORXQGMK-HSZRJFAPSA-N [(2r)-3-(3-bromo-4-methylphenyl)-1-methoxy-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1h-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate Chemical compound C([C@H](C(=O)OC)OC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2CC1)=O)C1=CC=C(C)C(Br)=C1 KSTAVULORXQGMK-HSZRJFAPSA-N 0.000 description 1
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