DE102004015723A1 - Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel - Google Patents

Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel Download PDF

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Publication number
DE102004015723A1
DE102004015723A1 DE102004015723A DE102004015723A DE102004015723A1 DE 102004015723 A1 DE102004015723 A1 DE 102004015723A1 DE 102004015723 A DE102004015723 A DE 102004015723A DE 102004015723 A DE102004015723 A DE 102004015723A DE 102004015723 A1 DE102004015723 A1 DE 102004015723A1
Authority
DE
Germany
Prior art keywords
preparation
pharmaceuticals
cgrp antagonists
salts
selected cgrp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102004015723A
Other languages
German (de)
English (en)
Inventor
Philipp Lustenberger
Stephan Georg Mueller
Klaus Rudolf
Alexander Dreyer
Dirk Stenkamp
Marco Santagostino
Fabio Paleari
Kirsten Arndt
Henri Doods
Gerhard Schaenzle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to DE102004015723A priority Critical patent/DE102004015723A1/de
Priority to ES05741783T priority patent/ES2330865T3/es
Priority to BRPI0509368-6A priority patent/BRPI0509368A/pt
Priority to PT05741783T priority patent/PT1732917E/pt
Priority to RSP-2009/0374A priority patent/RS51150B/sr
Priority to NZ550774A priority patent/NZ550774A/en
Priority to EP05741783A priority patent/EP1732917B8/de
Priority to CA002558889A priority patent/CA2558889A1/en
Priority to CNA2005800175452A priority patent/CN1976916A/zh
Priority to KR1020067022593A priority patent/KR20070007867A/ko
Priority to EP09160781A priority patent/EP2108648A1/de
Priority to EA200601621A priority patent/EA012111B1/ru
Priority to UAA200611256A priority patent/UA88163C2/ru
Priority to PL05741783T priority patent/PL1732917T3/pl
Priority to DE502005007786T priority patent/DE502005007786D1/de
Priority to SI200530817T priority patent/SI1732917T1/sl
Priority to AT05741783T priority patent/ATE437868T1/de
Priority to PE2005000336A priority patent/PE20060150A1/es
Priority to HR20090457T priority patent/HRP20090457T1/hr
Priority to AU2005225539A priority patent/AU2005225539A1/en
Priority to PE2009001130A priority patent/PE20091884A1/es
Priority to ARP050101139A priority patent/AR049625A1/es
Priority to DK05741783T priority patent/DK1732917T3/da
Priority to PCT/EP2005/003094 priority patent/WO2005092880A1/de
Priority to JP2007505453A priority patent/JP4796567B2/ja
Priority to MYPI20051328A priority patent/MY141754A/en
Priority to TW094109570A priority patent/TW200602338A/zh
Priority to US11/093,834 priority patent/US7479488B2/en
Publication of DE102004015723A1 publication Critical patent/DE102004015723A1/de
Priority to NZ562537A priority patent/NZ562537A/en
Priority to BRPI0608929-1A priority patent/BRPI0608929A2/pt
Priority to MX2007011526A priority patent/MX2007011526A/es
Priority to AT06723571T priority patent/ATE414074T1/de
Priority to ARP060101117A priority patent/AR053344A1/es
Priority to UY29437A priority patent/UY29437A1/es
Priority to ZA200606056A priority patent/ZA200606056B/xx
Priority to NO20064166A priority patent/NO20064166L/no
Priority to IL178334A priority patent/IL178334A0/en
Priority to EC2006006898A priority patent/ECSP066898A/es
Priority to ZA200705879A priority patent/ZA200705879B/xx
Priority to IL186089A priority patent/IL186089A0/en
Priority to JP2008099425A priority patent/JP2008189689A/ja
Priority to US12/246,067 priority patent/US7700598B2/en
Priority to CY20091100128T priority patent/CY1108744T1/el
Priority to CY20091101109T priority patent/CY1109510T1/el
Priority to US12/712,801 priority patent/US20100249114A1/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
DE102004015723A 2004-03-29 2004-03-29 Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel Withdrawn DE102004015723A1 (de)

Priority Applications (45)

Application Number Priority Date Filing Date Title
DE102004015723A DE102004015723A1 (de) 2004-03-29 2004-03-29 Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
JP2007505453A JP4796567B2 (ja) 2004-03-29 2005-03-23 選択されたｃｇｒｐアンタゴニスト、その製造方法及びその薬物としての使用
PCT/EP2005/003094 WO2005092880A1 (de) 2004-03-29 2005-03-23 Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
PT05741783T PT1732917E (pt) 2004-03-29 2005-03-23 Antagonistas de cgrp seleccionados, processos para a sua preparação bem como sua utilização como medicamentos
RSP-2009/0374A RS51150B (sr) 2004-03-29 2005-03-23 Izabrani cgrp - antagonisti, postupci za njihovo dobijanje, kao i njihova primena kao medikamenata
NZ550774A NZ550774A (en) 2004-03-29 2005-03-23 Selected CGRP antagonists, method for the production thereof and their use as medicaments
EP05741783A EP1732917B8 (de) 2004-03-29 2005-03-23 Ausgewahlte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
CA002558889A CA2558889A1 (en) 2004-03-29 2005-03-23 Selected cgrp antagonists, methods for the production thereof and their use as medicaments
CNA2005800175452A CN1976916A (zh) 2004-03-29 2005-03-23 选择的cgrp－拮抗剂，其制备方法以及它们作为药物的用途
KR1020067022593A KR20070007867A (ko) 2004-03-29 2005-03-23 선택된 ｃｇｒｐ 길항제, 이의 제조방법 및 약제로서의이의 용도
EP09160781A EP2108648A1 (de) 2004-03-29 2005-03-23 Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
EA200601621A EA012111B1 (ru) 2004-03-29 2005-03-23 Выбранные cgrp-антагонисты, способ их получения, а также их применение в качестве лекарственных средств
UAA200611256A UA88163C2 (ru) 2004-03-29 2005-03-23 Cgrp-антагонисты, способ их получения, а также их применение как лекарственных средств
PL05741783T PL1732917T3 (pl) 2004-03-29 2005-03-23 Wybrani antagoniści CGRP, sposoby ich produkcji i ich zastosowanie jako leki
DE502005007786T DE502005007786D1 (de) 2004-03-29 2005-03-23 Ausgewahlte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
SI200530817T SI1732917T1 (sl) 2004-03-29 2005-03-23 Izbrani CGRP-antagonisti, postopki za njihovo pripravo in tudi njihova uporaba kot zdravila
BRPI0509368-6A BRPI0509368A (pt) 2004-03-29 2005-03-23 antagonistas cgrp selecionados, processo para a sua fabricação bem como seu uso como medicamento
PE2005000336A PE20060150A1 (es) 2004-03-29 2005-03-23 Antagonistas de cgrp seleccionados, composiciones farmaceuticas y procedimiento para su preparacion
HR20090457T HRP20090457T1 (hr) 2004-03-29 2005-03-23 Odabrani cgrp-antagonisti, postupci njihove priprave i njihova uporaba kao lijekova
AU2005225539A AU2005225539A1 (en) 2004-03-29 2005-03-23 Selected CGRP antagonists, methods for the production thereof and their use as medicaments
PE2009001130A PE20091884A1 (es) 2004-03-29 2005-03-23 Antagonistas de cgrp seleccionados, procedimiento para su preparacion, asi como su uso como medicamento
ARP050101139A AR049625A1 (es) 2004-03-29 2005-03-23 Antagonistas de cgrp, procedimiento para su preparacion asi como su uso como medicamento
DK05741783T DK1732917T3 (da) 2004-03-29 2005-03-23 Udvalgte CGRP-antagonister, fremgangsmåde til fremstilling deraf, samt anvendelse deraf som lægemiddel
ES05741783T ES2330865T3 (es) 2004-03-29 2005-03-23 Antagonistas de cgrp seleccionados, procedimiento para su preparacion, asi como su uso como medicamentos.
AT05741783T ATE437868T1 (de) 2004-03-29 2005-03-23 Ausgewahlte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
MYPI20051328A MY141754A (en) 2004-03-29 2005-03-25 Selected cgrp-antagonists, process for preparing them and their use as pharmaceutical compositions
TW094109570A TW200602338A (en) 2004-03-29 2005-03-28 Selected CGRP antagonists, process for preparing them and their use as pharmaceutical compositions
US11/093,834 US7479488B2 (en) 2004-03-29 2005-03-29 Selected CGRP—antagonists, process for preparing them and their use as pharmaceutical compositions
BRPI0608929-1A BRPI0608929A2 (pt) 2004-03-29 2006-03-21 compostos antagonistas de cgrp, seus sais e seus usos, bem como composições farmacêuticas que os contêm e processo para preparação das mesmas
MX2007011526A MX2007011526A (es) 2004-03-29 2006-03-21 2-oxo-1,2,4,5-tetrahidro-1,3-benzodiazepin-3-il-piperidinas utilizadas como antagonistas de cgrp.
AT06723571T ATE414074T1 (de) 2004-03-29 2006-03-21 2-oxo-1,2,4,5-tetrahydro-1,3-benzdiazepin-3-yl- piperidine als cgrp-antagonisten
NZ562537A NZ562537A (en) 2004-03-29 2006-03-21 2-Oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl-piperidines used as CGRP antagonists
ARP060101117A AR053344A1 (es) 2004-03-29 2006-03-22 Antagonistas del cgrp,procedimiento para su preparacion,composiciones farmaceuticas que los contienen y usos para el tratamiento de la migrana y otras enfermedades
UY29437A UY29437A1 (es) 2004-03-29 2006-03-22 Nuevos antagonistas de cgrp
ZA200606056A ZA200606056B (en) 2004-03-29 2006-07-21 Selected CGRP antagonists, methods for the production thereof and their use as medicaments
NO20064166A NO20064166L (no) 2004-03-29 2006-09-14 Utvalgte CGRP-antagonister, deres fremstilling og deres anvendelse som medikanmenter
IL178334A IL178334A0 (en) 2004-03-29 2006-09-27 Selected cgrp antagonists, methods for the production thereof and their use as medicaments
EC2006006898A ECSP066898A (es) 2004-03-29 2006-09-29 Antagonistas de cgrp seleccionados, procedimiento para su preparación así como su uso como medicamento
ZA200705879A ZA200705879B (en) 2004-03-29 2007-07-18 CGRP antagonists, method for production thereof, and their use as medicaments
IL186089A IL186089A0 (en) 2004-03-29 2007-09-20 2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl-piperidines used as cgrp antagonists
JP2008099425A JP2008189689A (ja) 2004-03-29 2008-04-07 Ｃｇｒｐアンタゴニストとして使用される２−オキソ−１，２，４，５−テトラヒドロ−１，３−ベンゾジアゼピン−３−イル−ピペリジン
US12/246,067 US7700598B2 (en) 2004-03-29 2008-10-06 Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
CY20091100128T CY1108744T1 (el) 2004-03-29 2009-02-04 2-οξο-1,2,4,5-τετραϋδρo-1,3-βενζοδιαζεπιν-3-υλ-πιπεριδινες ως ανταγωνιστες της cgrp
CY20091101109T CY1109510T1 (el) 2004-03-29 2009-10-26 Επιλεγμενοι ανταγωνιστες toy cgrp, μεθοδος για την παραγωγη τους και για τη χρηση τους ως φαρμακων
US12/712,801 US20100249114A1 (en) 2004-03-29 2010-02-25 Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions

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