JP2007518777A - アミノアルコール誘導体およびレニン阻害剤としてのその使用 - Google Patents

アミノアルコール誘導体およびレニン阻害剤としてのその使用 Download PDF

Info

Publication number
JP2007518777A
JP2007518777A JP2006550177A JP2006550177A JP2007518777A JP 2007518777 A JP2007518777 A JP 2007518777A JP 2006550177 A JP2006550177 A JP 2006550177A JP 2006550177 A JP2006550177 A JP 2006550177A JP 2007518777 A JP2007518777 A JP 2007518777A
Authority
JP
Japan
Prior art keywords
alkyl
alkoxy
aryl
alkanoyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2006550177A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007518777A5 (https=
Inventor
ヘーロルト，ペーター
シュトゥッツ，シュテファン
ストヤノビッチ，アレクサンダー
チンケ，ヴィンチェンツォ
マルツィ，クリスティアーネ
クヴィルムバハ，ミヒャエル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Speedel Experimenta AG
Original Assignee
Speedel Experimenta AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speedel Experimenta AG filed Critical Speedel Experimenta AG
Publication of JP2007518777A publication Critical patent/JP2007518777A/ja
Publication of JP2007518777A5 publication Critical patent/JP2007518777A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
JP2006550177A 2004-01-23 2005-01-21 アミノアルコール誘導体およびレニン阻害剤としてのその使用 Ceased JP2007518777A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH952004 2004-01-23
PCT/EP2005/050273 WO2005070870A2 (en) 2004-01-23 2005-01-21 Amino alcohol derivatives and their use as renin inhibitors

Publications (2)

Publication Number Publication Date
JP2007518777A true JP2007518777A (ja) 2007-07-12
JP2007518777A5 JP2007518777A5 (https=) 2008-03-21

Family

ID=34800315

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006550177A Ceased JP2007518777A (ja) 2004-01-23 2005-01-21 アミノアルコール誘導体およびレニン阻害剤としてのその使用

Country Status (10)

Country Link
US (1) US7767690B2 (https=)
EP (1) EP1711456A2 (https=)
JP (1) JP2007518777A (https=)
CN (1) CN1910136A (https=)
AR (1) AR047445A1 (https=)
BR (1) BRPI0506490A (https=)
CA (1) CA2553836A1 (https=)
IL (1) IL176901A0 (https=)
TW (1) TW200530214A (https=)
WO (1) WO2005070870A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0505969D0 (en) 2005-03-23 2005-04-27 Novartis Ag Organic compounds
EP1745776A1 (en) 2005-07-20 2007-01-24 Speedel Experimenta AG Aminoalcohols as therapeutic compounds
JP5306821B2 (ja) 2005-12-30 2013-10-02 ノバルティス アーゲー レニン阻害剤としての３，５−置換ピペリジン化合物
AU2007262004B2 (en) 2006-06-23 2011-07-07 Daiichi Sankyo Company, Limited Cyclic amine compound
NZ582098A (en) 2007-06-25 2012-03-30 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
WO2009106599A2 (en) * 2008-02-29 2009-09-03 Novartis Ag Substituted piperidines as therapeutic compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05186461A (ja) * 1991-06-21 1993-07-27 Hoechst Ag レニン阻害特性を有する化合物及びそれらの製造法
JPH08176087A (ja) * 1994-09-15 1996-07-09 Ciba Geigy Ag ２，９−ジアミノ−及び２−アミノ−８−カルバモイル−４−ヒドロキシ−アルカノン酸アミド誘導体
WO2002040007A1 (en) * 2000-11-17 2002-05-23 Novartis Ag Synergistic combinations comprising a renin inhibitor for cardiovascular diseases
JP2007520487A (ja) * 2004-01-23 2007-07-26 シュペーデル・エクスペリメンタ・アーゲー アミノアルコール誘導体およびレニン阻害剤としてのその活性

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05186461A (ja) * 1991-06-21 1993-07-27 Hoechst Ag レニン阻害特性を有する化合物及びそれらの製造法
JPH08176087A (ja) * 1994-09-15 1996-07-09 Ciba Geigy Ag ２，９−ジアミノ−及び２−アミノ−８−カルバモイル−４−ヒドロキシ−アルカノン酸アミド誘導体
WO2002040007A1 (en) * 2000-11-17 2002-05-23 Novartis Ag Synergistic combinations comprising a renin inhibitor for cardiovascular diseases
JP2007520487A (ja) * 2004-01-23 2007-07-26 シュペーデル・エクスペリメンタ・アーゲー アミノアルコール誘導体およびレニン阻害剤としてのその活性

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6011004161, ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ, 1992, ｖｏｌ． ３５， ｎｏ． １９, ｐａｇｅｓ ３５２５−３５３６ *
JPN6011004163, ＣＵＲＲＥＮＴ ＯＰＩＮＩＯＮ ＩＮ ＩＮＶＥＳＴＩＧＡＴＩＯＮＡＬ ＤＲＵＧＳ, 2002, ｖｏｌ． ３， ｎｏ． １０, ｐａｇｅｓ １４７９−１４８２ *
JPN6011004165, ＢＩＯＣＨＥＭＩＣＡＬ ＡＮＤ ＢＩＯＰＨＹＳＩＣＡＬ ＲＥＳＥＡＲＣＨ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ, 2003, ｖｏｌ． ３０８， ｎｏ． ４, ｐａｇｅｓ ６９８−７０５ *

Also Published As

Publication number Publication date
US7767690B2 (en) 2010-08-03
IL176901A0 (en) 2006-12-10
BRPI0506490A (pt) 2007-02-13
US20090118281A1 (en) 2009-05-07
CN1910136A (zh) 2007-02-07
CA2553836A1 (en) 2005-08-04
EP1711456A2 (en) 2006-10-18
AR047445A1 (es) 2006-01-18
WO2005070870A2 (en) 2005-08-04
TW200530214A (en) 2005-09-16
WO2005070870A3 (en) 2005-09-22

Similar Documents

Publication Publication Date Title
RU2468011C2 (ru) Замещенные циклоалкиламином производные изохинолина и изохинолинона
KR102533094B1 (ko) 옥사디아졸 일시적 수용체 전위 채널 억제제
US8071651B2 (en) 5-amino-4-hydroxy-7-(imidazo [1,2-A] pyridin-6-ylmethyl)-8-methyl-nonamide derivatives and related compounds as renin inhibitors for the treatment of hypertension
BRPI0718460A2 (pt) Inibidores da renina
KR20190135027A (ko) 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물
JP2006504621A (ja) Ｈｉｖプロテアーゼ阻害剤としてのカルバミン酸エステル
CZ236595A3 (en) Amide derivatives of 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxyalkanoic acids
JP4927704B2 (ja) 有機化合物
EP1863803A2 (en) Substituted piperidines
JP4764833B2 (ja) ジアミノアルコールおよびレニン阻害剤としてのその使用
JP2007518777A (ja) アミノアルコール誘導体およびレニン阻害剤としてのその使用
JP2008532983A (ja) レニン阻害剤として有用な複素環置換アルカンアミド
JP2009532443A (ja) レニンインヒビターとして用いるための置換４−フェニルピペリジン
ES2357585T3 (es) Derivados de aminoalcoholes y su actividad como inhibidores de la renina.
CA2702745A1 (en) Trisubstituted piperidines
ES2346081T3 (es) Amidas de acido alcanoico sustituidas por o-heterociclos sustituidos.
ES2355580T3 (es) Derivados de 2-oxoimidazol sustituidos con n-dihidroxialquilo.
US20080167381A1 (en) 5-Amino-4-Hydroxy-2-Isopropyl-7-[4-Methoxy-3-(3-Methoxypropoxy)Benzyl]-8-Methylnonamides
EP1897879A2 (en) 2,4,5 substituted piperidines as renin inhibitors
HK1116163A (en) 2,4,5 substituted piperidines as renin inhibitors
JP2011511038A (ja) レニン阻害剤としての置換ピペリジン

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080118

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20080129

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20110126

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110201

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110427

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110510

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110530

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110606

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110701

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110802

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111202

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20111202

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20111202

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20111222

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120124

A045 Written measure of dismissal of application [lapsed due to lack of payment]

Free format text: JAPANESE INTERMEDIATE CODE: A045

Effective date: 20120529