JP2007514782A5 - - Google Patents
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- JP2007514782A5 JP2007514782A5 JP2006545691A JP2006545691A JP2007514782A5 JP 2007514782 A5 JP2007514782 A5 JP 2007514782A5 JP 2006545691 A JP2006545691 A JP 2006545691A JP 2006545691 A JP2006545691 A JP 2006545691A JP 2007514782 A5 JP2007514782 A5 JP 2007514782A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- pharmaceutically acceptable
- compound according
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 58
- 125000000217 alkyl group Chemical group 0.000 claims 37
- 150000003839 salts Chemical class 0.000 claims 29
- 150000002148 esters Chemical class 0.000 claims 19
- 239000000651 prodrug Substances 0.000 claims 19
- 229940002612 prodrug Drugs 0.000 claims 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 12
- 229920006395 saturated elastomer Polymers 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- 241000124008 Mammalia Species 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 239000001301 oxygen Substances 0.000 claims 6
- 239000011593 sulfur Substances 0.000 claims 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 238000010276 construction Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- 206010056519 Abdominal infection Diseases 0.000 claims 1
- 206010060968 Arthritis infective Diseases 0.000 claims 1
- 208000031729 Bacteremia Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 208000017228 Gastrointestinal motility disease Diseases 0.000 claims 1
- 208000008745 Healthcare-Associated Pneumonia Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 208000037942 Methicillin-resistant Staphylococcus aureus infection Diseases 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 206010035737 Pneumonia viral Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010058028 Shunt infection Diseases 0.000 claims 1
- 206010041925 Staphylococcal infections Diseases 0.000 claims 1
- 108010059993 Vancomycin Proteins 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 206010014665 endocarditis Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 claims 1
- 229960003907 linezolid Drugs 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 206010034674 peritonitis Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 206010040872 skin infection Diseases 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
- 229960003165 vancomycin Drugs 0.000 claims 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 230000002861 ventricular Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 208000009421 viral pneumonia Diseases 0.000 claims 1
- 0 *C[C@](CN1c2ccc(*(*)*N)cc2)OC1=O Chemical compound *C[C@](CN1c2ccc(*(*)*N)cc2)OC1=O 0.000 description 4
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53037103P | 2003-12-17 | 2003-12-17 | |
| US57626704P | 2004-06-02 | 2004-06-02 | |
| PCT/US2004/039988 WO2005061468A1 (en) | 2003-12-17 | 2004-12-01 | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007514782A JP2007514782A (ja) | 2007-06-07 |
| JP2007514782A5 true JP2007514782A5 (https=) | 2008-02-07 |
Family
ID=34713773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006545691A Pending JP2007514782A (ja) | 2003-12-17 | 2004-12-01 | ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7129259B2 (https=) |
| EP (1) | EP1713785A1 (https=) |
| JP (1) | JP2007514782A (https=) |
| AR (1) | AR046782A1 (https=) |
| TW (1) | TW200526649A (https=) |
| WO (1) | WO2005061468A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR043050A1 (es) * | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
| JP5043428B2 (ja) | 2003-06-03 | 2012-10-10 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | ビアリール複素環式化合物ならびにその製造および使用方法 |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| US8428884B1 (en) | 2003-07-14 | 2013-04-23 | Rib-X Pharmaceuticals, Inc. | Protein synthesis modulators |
| CN1902158B (zh) * | 2003-08-18 | 2011-04-06 | 诺华科尔制药公司 | N,n-二卤代氨基酸及其衍生物 |
| AR046782A1 (es) * | 2003-12-17 | 2005-12-21 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos. |
| KR100854211B1 (ko) * | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| JP2008500318A (ja) * | 2004-05-25 | 2008-01-10 | アストラゼネカ アクチボラグ | 抗菌剤としての３−｛４−（ピリジン−３−イル）フェニル｝−５−（１ｈ−１，２，３−トリアゾール−１−イルメチル）−１，３−オキサゾリジン−２−オン |
| TWI386201B (zh) * | 2005-01-25 | 2013-02-21 | Novabay Pharmaceuticals Inc | Ｎ-鹵化胺基酸、ｎ，ｎ-二鹵化胺基酸與其衍生物；以及使用其之組合物與方法 |
| DE602006019870D1 (de) * | 2005-06-08 | 2011-03-10 | Rib X Pharmaceuticals Inc | Verfahren zur synthese von triazolen |
| TW200740779A (en) * | 2005-07-22 | 2007-11-01 | Mitsubishi Pharma Corp | Intermediate compound for synthesizing pharmaceutical agent and production method thereof |
| WO2007133803A2 (en) * | 2006-05-15 | 2007-11-22 | Rib-X Pharmaceuticals, Inc. | Treatment of mycobacterial infections |
| TW200843787A (en) * | 2006-12-29 | 2008-11-16 | Novabay Pharmaceuticals Inc | N-halogenated amino compounds and derivatives; compositions and methods of using them |
| US20090132514A1 (en) * | 2007-11-16 | 2009-05-21 | Iac Search & Media, Inc. | method and system for building text descriptions in a search database |
| CA2712613C (en) * | 2008-03-26 | 2017-02-28 | Global Alliance For Tb Drug Development | Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones |
| CA2723262A1 (en) * | 2008-04-15 | 2009-10-22 | Waldemar Gottardi | Compositions and devices for antisepsis and anticoagulation |
| WO2010042887A2 (en) * | 2008-10-10 | 2010-04-15 | Trius Therapeutics | Methods for preparing oxazolidinones and compositions containing them |
| KR101918678B1 (ko) | 2009-02-03 | 2018-11-14 | 머크 샤프 앤드 돔 코포레이션 | Ｒ)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형 |
| EP2230231A1 (de) * | 2009-03-16 | 2010-09-22 | Bayer CropScience AG | Verfahren zur Herstellung von 2,2-Difluorethylamin-Derivaten durch Imin-Hydrierung |
| US8580767B2 (en) * | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
| SG10201406571YA (en) | 2009-10-13 | 2014-11-27 | Melinta Therapeutics Inc | Pharmaceutical compositions |
| AU2011332031B2 (en) | 2010-11-24 | 2017-01-12 | Melinta Subsidiary Corp. | Pharmaceutical compositions |
| CA2904387C (en) | 2013-03-15 | 2021-12-07 | Melinta Therapeutics, Inc. | Methods of treating infections in overweight and obese patients using antibiotics |
| HK1244211A1 (zh) | 2014-11-14 | 2018-08-03 | Melinta Therapeutics, Inc. | 治疗、预防或降低皮肤感染风险的方法 |
| WO2017066964A1 (en) * | 2015-10-22 | 2017-04-27 | Merck Sharp & Dohme Corp. | Oxazolidinone compounds and methods of use thereof as antibacterial agents |
| EP3914587A4 (en) * | 2019-01-18 | 2022-11-23 | Merck Sharp & Dohme LLC | OXAZOLIDINONE COMPOUNDS AND USES THEREOF AS ANTIBACTERIAL AGENTS |
| CN113045477B (zh) * | 2019-12-26 | 2022-11-01 | 中蓝晨光化工研究设计院有限公司 | 一种含氟伯胺中间体的制备方法 |
| CN120794967A (zh) * | 2024-04-10 | 2025-10-17 | 沈阳药科大学 | 联芳基噁唑烷酮类化合物及其应用 |
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| KR20010015910A (ko) | 1998-01-23 | 2001-02-26 | 로렌스 티. 마이젠헬더 | 옥사졸리디논 조합 라이브러리, 조성물 및 제조 방법 |
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| AR043050A1 (es) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
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| GB0229526D0 (en) | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| GB0229518D0 (en) | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| GB0229521D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| TW200500360A (en) | 2003-03-01 | 2005-01-01 | Astrazeneca Ab | Hydroxymethyl compounds |
| BRPI0409217A (pt) | 2003-04-09 | 2006-03-28 | Pharmacia & Upjohn Co Llc | derivados e análogos antimicrobianos da [3.1.0]bicicloexilfeniloxazolidinona |
| JP5043428B2 (ja) | 2003-06-03 | 2012-10-10 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | ビアリール複素環式化合物ならびにその製造および使用方法 |
| CN101429170B (zh) | 2003-06-03 | 2015-05-13 | 梅林塔医疗有限公司 | 联芳基杂环化合物的制备和用途 |
| WO2005003087A2 (en) | 2003-07-01 | 2005-01-13 | Orchid Chemicals And Pharmaceuticals Ltd. | Oxazole derivatives as antibacterial agents |
| DE602004027811D1 (de) * | 2003-07-02 | 2010-08-05 | Kyorin Seiyaku Kk | Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon |
| WO2005012270A2 (en) | 2003-07-29 | 2005-02-10 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same |
| EP1660465B1 (en) | 2003-07-29 | 2014-12-17 | Melinta Therapeutics, Inc. | Process for the synthesis of biaryl oxazolidinones |
| AR046782A1 (es) * | 2003-12-17 | 2005-12-21 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos. |
| KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
-
2004
- 2004-12-01 AR ARP040104472A patent/AR046782A1/es unknown
- 2004-12-01 JP JP2006545691A patent/JP2007514782A/ja active Pending
- 2004-12-01 EP EP04812498A patent/EP1713785A1/en not_active Withdrawn
- 2004-12-01 WO PCT/US2004/039988 patent/WO2005061468A1/en not_active Ceased
- 2004-12-01 US US11/001,446 patent/US7129259B2/en not_active Expired - Lifetime
- 2004-12-01 TW TW093136988A patent/TW200526649A/zh unknown
-
2006
- 2006-02-23 US US11/362,133 patent/US20060148869A1/en not_active Abandoned
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