JP2013508299A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013508299A5 JP2013508299A5 JP2012534413A JP2012534413A JP2013508299A5 JP 2013508299 A5 JP2013508299 A5 JP 2013508299A5 JP 2012534413 A JP2012534413 A JP 2012534413A JP 2012534413 A JP2012534413 A JP 2012534413A JP 2013508299 A5 JP2013508299 A5 JP 2013508299A5
- Authority
- JP
- Japan
- Prior art keywords
- unsaturated
- group
- membered saturated
- alkyl
- aromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920006395 saturated elastomer Polymers 0.000 claims description 126
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 89
- 229910052757 nitrogen Inorganic materials 0.000 claims description 68
- 229910052760 oxygen Inorganic materials 0.000 claims description 68
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 66
- 125000005842 heteroatom Chemical group 0.000 claims description 66
- 239000001301 oxygen Substances 0.000 claims description 66
- 229910052717 sulfur Chemical group 0.000 claims description 64
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 63
- 239000011593 sulfur Chemical group 0.000 claims description 63
- 125000003118 aryl group Chemical group 0.000 claims description 60
- 125000000217 alkyl group Chemical group 0.000 claims description 58
- 229910052739 hydrogen Inorganic materials 0.000 claims description 54
- 150000002148 esters Chemical class 0.000 claims description 47
- 239000000651 prodrug Substances 0.000 claims description 47
- 229940002612 prodrug Drugs 0.000 claims description 47
- 150000003839 salts Chemical class 0.000 claims description 47
- 150000001875 compounds Chemical class 0.000 claims description 45
- 239000001257 hydrogen Substances 0.000 claims description 44
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 43
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 32
- 208000015181 infectious disease Diseases 0.000 claims description 30
- 125000000304 alkynyl group Chemical group 0.000 claims description 26
- 125000003342 alkenyl group Chemical group 0.000 claims description 24
- 229910052799 carbon Inorganic materials 0.000 claims description 23
- 125000004432 carbon atom Chemical group C* 0.000 claims description 15
- 241001465754 Metazoa Species 0.000 claims description 13
- 230000000813 microbial effect Effects 0.000 claims description 10
- 206010040872 skin infection Diseases 0.000 claims description 9
- 206010035664 Pneumonia Diseases 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 206010062255 Soft tissue infection Diseases 0.000 claims description 7
- 150000002431 hydrogen Chemical class 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 208000008745 Healthcare-Associated Pneumonia Diseases 0.000 claims description 4
- 241000282412 Homo Species 0.000 claims description 4
- 125000003725 azepanyl group Chemical group 0.000 claims description 4
- 125000002393 azetidinyl group Chemical group 0.000 claims description 4
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 4
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 4
- 125000003678 cyclohexadienyl group Chemical group C1(=CC=CCC1)* 0.000 claims description 4
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 4
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 4
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 125000002541 furyl group Chemical group 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000003386 piperidinyl group Chemical group 0.000 claims description 4
- 125000004076 pyridyl group Chemical group 0.000 claims description 4
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 4
- 125000005942 tetrahydropyridyl group Chemical group 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 230000002194 synthesizing effect Effects 0.000 claims description 3
- HCUOEKSZWPGJIM-IYNMRSRQSA-N (e,2z)-2-hydroxyimino-6-methoxy-4-methyl-5-nitrohex-3-enamide Chemical compound COCC([N+]([O-])=O)\C(C)=C\C(=N\O)\C(N)=O HCUOEKSZWPGJIM-IYNMRSRQSA-N 0.000 claims description 2
- 206010060968 Arthritis infective Diseases 0.000 claims description 2
- 208000031729 Bacteremia Diseases 0.000 claims description 2
- 206010018612 Gonorrhoea Diseases 0.000 claims description 2
- 201000009906 Meningitis Diseases 0.000 claims description 2
- 206010031252 Osteomyelitis Diseases 0.000 claims description 2
- 206010058674 Pelvic Infection Diseases 0.000 claims description 2
- 206010035148 Plague Diseases 0.000 claims description 2
- 206010035737 Pneumonia viral Diseases 0.000 claims description 2
- 206010057190 Respiratory tract infections Diseases 0.000 claims description 2
- 206010040047 Sepsis Diseases 0.000 claims description 2
- 206010058028 Shunt infection Diseases 0.000 claims description 2
- 206010041925 Staphylococcal infections Diseases 0.000 claims description 2
- 108010059993 Vancomycin Proteins 0.000 claims description 2
- 208000009470 Ventilator-Associated Pneumonia Diseases 0.000 claims description 2
- 241000607479 Yersinia pestis Species 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- 208000022338 anthrax infection Diseases 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 206010014665 endocarditis Diseases 0.000 claims description 2
- 208000001786 gonorrhea Diseases 0.000 claims description 2
- TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 claims description 2
- 229960003907 linezolid Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 206010034674 peritonitis Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 238000011321 prophylaxis Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 201000008827 tuberculosis Diseases 0.000 claims description 2
- 229960003165 vancomycin Drugs 0.000 claims description 2
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims description 2
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims description 2
- 208000009421 viral pneumonia Diseases 0.000 claims description 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
- 150000001721 carbon Chemical group 0.000 claims 3
- 206010056519 Abdominal infection Diseases 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 1
- 206010062910 Vascular infections Diseases 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229960003085 meticillin Drugs 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 claims 1
- 208000015339 staphylococcus aureus infection Diseases 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 description 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 208000036209 Intraabdominal Infections Diseases 0.000 description 1
- 208000037942 Methicillin-resistant Staphylococcus aureus infection Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25247809P | 2009-10-16 | 2009-10-16 | |
| US61/252,478 | 2009-10-16 | ||
| US31428710P | 2010-03-16 | 2010-03-16 | |
| US61/314,287 | 2010-03-16 | ||
| US35820110P | 2010-06-24 | 2010-06-24 | |
| US61/358,201 | 2010-06-24 | ||
| PCT/US2010/052928 WO2011047323A2 (en) | 2009-10-16 | 2010-10-15 | Antimicrobial compounds and methods of making and using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016015912A Division JP2016121171A (ja) | 2009-10-16 | 2016-01-29 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013508299A JP2013508299A (ja) | 2013-03-07 |
| JP2013508299A5 true JP2013508299A5 (https=) | 2013-11-07 |
Family
ID=44343890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534413A Pending JP2013508299A (ja) | 2009-10-16 | 2010-10-15 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9216979B2 (https=) |
| EP (1) | EP2488502A4 (https=) |
| JP (1) | JP2013508299A (https=) |
| KR (1) | KR20180069098A (https=) |
| CN (1) | CN102725274A (https=) |
| AU (3) | AU2010306650B2 (https=) |
| BR (1) | BR112012008795A2 (https=) |
| CA (1) | CA2777741A1 (https=) |
| EA (1) | EA023350B1 (https=) |
| IL (1) | IL219135A0 (https=) |
| MX (2) | MX339000B (https=) |
| MY (1) | MY176900A (https=) |
| NZ (1) | NZ599290A (https=) |
| WO (1) | WO2011047323A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011047320A2 (en) | 2009-10-16 | 2011-04-21 | Rib-X Pharmaceuticals, Inc. | Antimicrobial compounds and methods of making and using the same |
| US9216979B2 (en) * | 2009-10-16 | 2015-12-22 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| RU2609259C2 (ru) | 2011-01-14 | 2017-01-31 | Сперо Тринем, Инк. | Пиримидиновые ингибиторы гиразы и топоизомеразы iv |
| BR112013017977A2 (pt) | 2011-01-14 | 2019-09-24 | Vertex Pharma | formas sólidas de inibidor de girase (r) 1-etil-3-[5-[2-{1-hidroxi-1-metil-etil}pirimidin-5-il]-7-(tetrai-drofuran-2-il)-1h-benzimidazol-2-il]ureia |
| US8476281B2 (en) | 2011-01-14 | 2013-07-02 | Vertex Pharmaceuticals Incorporated | Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea |
| KR101882172B1 (ko) | 2011-01-14 | 2018-07-26 | 스페로 트리넴, 인코포레이티드 | 자이라제 및 토포이소머라제 ⅳ 억제제의 제조방법 |
| CN103702994B (zh) | 2011-06-20 | 2016-03-23 | 沃泰克斯药物股份有限公司 | 旋转酶和拓扑异构酶抑制剂的磷酸酯 |
| US9018216B2 (en) | 2012-07-18 | 2015-04-28 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof |
| WO2014014845A1 (en) | 2012-07-18 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases |
| KR20160070066A (ko) | 2013-09-09 | 2016-06-17 | 멜린타 테라퓨틱스, 인크. | 항균 화합물, 및 이의 제조 방법 및 이용 방법 |
| EP3038623A4 (en) | 2013-09-09 | 2017-04-19 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| US11633487B2 (en) * | 2014-08-06 | 2023-04-25 | Ascendis Pharma A/S | Prodrugs comprising an aminoalkyl glycine linker |
| CA2979342A1 (en) | 2015-03-11 | 2016-09-15 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| US10774051B2 (en) | 2015-04-24 | 2020-09-15 | Shionogi & Co., Ltd. | 6-membered heterocyclic derivatives and pharmaceutical composition comprising the same |
| WO2017193016A1 (en) * | 2016-05-06 | 2017-11-09 | Melinta Therapeutics, Inc. | Antimicrobials and methods of making and using same |
| WO2018074390A1 (ja) | 2016-10-17 | 2018-04-26 | 塩野義製薬株式会社 | 二環性含窒素複素環誘導体およびそれらを含有する医薬組成物 |
| WO2019013789A1 (en) | 2017-07-12 | 2019-01-17 | Curza Global, Llc | ANTIMICROBIAL COMPOUNDS |
| WO2019013790A1 (en) | 2017-07-12 | 2019-01-17 | Curza Global, Llc | ANTIMICROBIAL COMPOUNDS AND USES THEREOF |
| AU2020209167B2 (en) * | 2019-01-16 | 2025-09-04 | Curza Global, Llc | Antimicrobial compounds and methods |
| AU2020209170B2 (en) * | 2019-01-16 | 2025-09-04 | Curza Global, Llc | Antimicrobial compounds and methods |
| EP4085910A1 (en) * | 2021-05-05 | 2022-11-09 | 4Living Biotech | Use of a compound such as plerixafor for treating a viral pulmonary disease |
| TW202313065A (zh) | 2021-05-28 | 2023-04-01 | 美商季卡尼醫療公司 | 用於治療遺傳疾病之化合物 |
| WO2023250513A1 (en) | 2022-06-24 | 2023-12-28 | Zikani Therapeutics, Inc. | 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation |
| KR20250048331A (ko) | 2022-08-11 | 2025-04-08 | 지카니 테라퓨틱스, 인크. | 치료용 아자케톨라이드 제조용 합성 공정 및 중간체 |
| CN120152721A (zh) | 2022-09-01 | 2025-06-13 | 齐卡尼治疗股份有限公司 | 使用13元大环内酯治疗家族性腺瘤性息肉病 |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2624731A (en) * | 1953-01-06 | S-phenylpyrimidkn e x derivativesx | ||
| US3980781A (en) * | 1966-03-31 | 1976-09-14 | Imperial Chemical Industries Limited | Fungicidal composition and method containing 2-amino-pyrimidines |
| US4361557A (en) | 1980-01-28 | 1982-11-30 | Schering Corporation | 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor |
| EP0067610A1 (en) | 1981-06-16 | 1982-12-22 | Beecham Group Plc | Penicillins, a process for their preparation and compositions containing them |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5332835A (en) | 1984-02-03 | 1994-07-26 | Zambon S.P.A. | Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process |
| JPS6191184A (ja) * | 1984-10-08 | 1986-05-09 | Morishita Seiyaku Kk | ２−アニリノ−５−（１ｈ−テトラゾ−ル−５−イル）ピリミジン−４（３ｈ）−オン誘導体 |
| JP2873340B2 (ja) | 1988-04-29 | 1999-03-24 | 武田薬品工業株式会社 | 抗生物質ｔａｎ―１０５７，その製造法および用途 |
| JP2991382B2 (ja) | 1990-07-18 | 1999-12-20 | 大日本製薬株式会社 | 縮合三環式化合物およびその塩 |
| US5208141A (en) | 1990-10-09 | 1993-05-04 | Konica Corporation | Silver halide color photographic light-sensitive material |
| US5958930A (en) | 1991-04-08 | 1999-09-28 | Duquesne University Of The Holy Ghost | Pyrrolo pyrimidine and furo pyrimidine derivatives |
| US6451968B1 (en) | 1991-05-24 | 2002-09-17 | Isis Pharmaceuticals, Inc. | Peptide nucleic acids |
| US5434257A (en) | 1992-06-01 | 1995-07-18 | Gilead Sciences, Inc. | Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages |
| US5646163A (en) | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
| WO1994026722A1 (en) | 1993-05-12 | 1994-11-24 | E.I. Du Pont De Nemours And Company | Fungicidal fused bicyclic pyrimidinones |
| US5502177A (en) | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| US5668127A (en) | 1995-06-26 | 1997-09-16 | Pathogenesis Corporation | Nitroimidazole antibacterial compounds and methods of use thereof |
| TW424090B (en) * | 1995-08-18 | 2001-03-01 | Nat Science Council | Pyrimidines as folate antimetabolites with selective activity against human brain cancer |
| US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| US7282327B2 (en) * | 1996-01-23 | 2007-10-16 | Affymetrix, Inc. | Nucleic acid labeling compounds |
| GB9708611D0 (en) | 1997-04-28 | 1997-06-18 | Univ Cardiff | Chemical compounds |
| WO1999007685A1 (en) | 1997-08-07 | 1999-02-18 | Research Corporation Technologies, Inc. | Antibiotic for methicillin resistant bacteria |
| EP1027364B1 (en) | 1997-11-07 | 2004-12-08 | Isis Pharmaceuticals, Inc. | Pyrimidine derivatives for labeled binding partners |
| US6028183A (en) | 1997-11-07 | 2000-02-22 | Gilead Sciences, Inc. | Pyrimidine derivatives and oligonucleotides containing same |
| DE19838998A1 (de) * | 1998-08-27 | 2000-03-09 | Bayer Ag | Neue Naturstoffderivate |
| WO2001007027A2 (en) * | 1999-07-22 | 2001-02-01 | Vertex Pharmaceuticals Incorporated | Pyrimidine derivatives for the treatment of viral diseases |
| SE9903894D0 (sv) * | 1999-10-28 | 1999-10-28 | New Pharma Research Ab | Novel compounds |
| EP1113008A1 (en) | 1999-12-29 | 2001-07-04 | Pfizer Products Inc. | 4-oxo-2-ureido-1,4,5,6-tetrahydro-pyrimidine derivatives useful as antibacterial and antiprotozoal agents |
| KR100358083B1 (ko) | 2000-02-17 | 2002-10-25 | 에스케이케미칼주식회사 | 피롤로피리미디논 유도체와 이의 제조방법, 그리고 이의용도 |
| WO2002032920A2 (en) | 2000-10-18 | 2002-04-25 | Pharmasset Limited | Modified nucleosides for treatment of viral infections and abnormal cellular proliferation |
| DE10061538A1 (de) * | 2000-12-11 | 2002-06-20 | Bayer Ag | Ureido-Dihydropyrimidinone |
| DE10061542A1 (de) * | 2000-12-11 | 2002-06-13 | Bayer Ag | Alkanoylamino-pyrimidine |
| DE10061537A1 (de) | 2000-12-11 | 2002-06-20 | Bayer Ag | beta-Alanin-Derivate |
| DE10061541A1 (de) | 2000-12-11 | 2002-06-20 | Bayer Ag | Arylamino-Dihydropyrimidinone |
| ATE304539T1 (de) | 2000-12-14 | 2005-09-15 | Procter & Gamble | Antimikrobielle chinolone |
| US6900215B2 (en) | 2000-12-15 | 2005-05-31 | Merck Sharp & Dohme Ltd. | Imidazo-pyrimidine derivatives as ligands for gaba receptors |
| AU2002230058B2 (en) | 2001-01-29 | 2005-11-17 | Bio-Rad Laboratories, Inc. | Nucleic acid derivatives |
| TWI248936B (en) | 2001-03-21 | 2006-02-11 | Merck Sharp & Dohme | Imidazo-pyrimidine derivatives as ligands for GABA receptors |
| US20030207804A1 (en) | 2001-05-25 | 2003-11-06 | Muthiah Manoharan | Modified peptide nucleic acids |
| US20030158403A1 (en) | 2001-07-03 | 2003-08-21 | Isis Pharmaceuticals, Inc. | Nuclease resistant chimeric oligonucleotides |
| CA2452458A1 (en) | 2001-07-03 | 2003-01-16 | Isis Pharmaceuticals, Inc. | Nuclease resistant chimeric oligonucleotides |
| DE10133277A1 (de) | 2001-07-09 | 2003-01-23 | Bayer Ag | ß-Alanin-Derivate |
| DE10141271A1 (de) | 2001-08-23 | 2003-03-06 | Bayer Ag | Neue Tetrahydro-1,3,5-triazin-2-on-Derivate und ihre Verwendung |
| DE10208256A1 (de) | 2002-02-26 | 2003-09-04 | Bayer Ag | Piperidinouracile |
| WO2003077828A2 (en) | 2002-03-08 | 2003-09-25 | Schering-Plough, Ltd. | Novel florfenicol-type antibiotics |
| WO2004080466A1 (en) | 2003-03-07 | 2004-09-23 | Ribapharm Inc. | Cytidine analogs and methods of use |
| KR20060069836A (ko) | 2003-08-12 | 2006-06-22 | 아칠리온 파르마세우티칼스 인코포레이티드 | 항-감염제로서의 이소티아졸로퀴놀론 및 관련 화합물 |
| RU2358975C2 (ru) | 2003-08-26 | 2009-06-20 | Тейдзин Фарма Лимитед | Пирролопиримидиноновые производные |
| TW200524880A (en) * | 2003-10-21 | 2005-08-01 | Sankyo Co | Pyrimidine compounds |
| AU2006272571B2 (en) | 2005-07-27 | 2012-03-08 | Achillion Pharmaceuticals, Inc. | 8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents |
| EP1951680A4 (en) | 2005-11-15 | 2011-08-10 | Astrazeneca Ab | NOVEL 2-AMINOPYRIMIDINONE DERIVATIVES AND THEIR USE |
| NZ544187A (en) | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| JP2007270087A (ja) * | 2006-03-31 | 2007-10-18 | Fujifilm Corp | 硬化性組成物、インク組成物、インクジェット記録方法、印刷物、平版印刷版の製造方法、及び平版印刷版 |
| EP1829684B1 (en) | 2006-03-03 | 2011-01-26 | FUJIFILM Corporation | Curable composition, ink composition, inkjet-recording method, and planographic printing plate |
| KR20080003599A (ko) | 2006-07-03 | 2008-01-08 | 에스케이케미칼주식회사 | 피롤로피리미디논 유도체의 겐티세이트 염 및 이의제조방법 |
| US20100069632A1 (en) | 2006-07-03 | 2010-03-18 | Sk Chemicals Co., Ltd | Salts of pyrrolopyrimidinone derivatives and process for preparing the same |
| WO2008082440A2 (en) | 2006-08-25 | 2008-07-10 | Emory University | Fluorescent nucleoside analogues |
| NZ575365A (en) | 2006-09-07 | 2012-02-24 | Ind Res Ltd | Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases |
| EP1964841A1 (en) | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]azine and their use as pharmaceuticals |
| WO2008106204A1 (en) | 2007-02-28 | 2008-09-04 | Rib-X-Pharmaceuticals, Inc. | Macrolide compounds and methods of making and using the same |
| JP2010520293A (ja) * | 2007-03-07 | 2010-06-10 | アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド | 複素環式部分を含有するメタロプロテアーゼ阻害剤 |
| JP2008222557A (ja) | 2007-03-08 | 2008-09-25 | Kotobuki Seiyaku Kk | ピロロ［３，２−ｄ］ピリミジン誘導体及びこれを有効成分とする医薬組成物 |
| RU2009148864A (ru) | 2007-05-30 | 2011-07-10 | Шеринг-Плоу Лтд. (CH) | Способ получения защищенных оксазолином соединений аминодиола, применяемых в качестве промежуточных соединений для флорфеникола |
| TWI519508B (zh) | 2007-06-12 | 2016-02-01 | Achaogen Inc | 抗菌劑 |
| GB0724342D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Anitbacterial compositions |
| KR20090098710A (ko) | 2008-03-14 | 2009-09-17 | 주식회사 씨티아이바이오 | 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체 |
| US20100190747A1 (en) | 2009-01-27 | 2010-07-29 | Hideo Suzuki | Fused ring compound and use thereof |
| US20120263646A1 (en) | 2009-10-15 | 2012-10-18 | Guerbet | Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
| WO2011047320A2 (en) | 2009-10-16 | 2011-04-21 | Rib-X Pharmaceuticals, Inc. | Antimicrobial compounds and methods of making and using the same |
| KR101972992B1 (ko) | 2009-10-16 | 2019-04-29 | 멜린타 서브시디어리 코프. | 항미생물성 화합물 및 이의 제조 방법 및 사용 방법 |
| TW201726630A (zh) | 2009-10-16 | 2017-08-01 | 梅林塔療法公司 | 抗微生物性化合物及其製造與使用方法 |
| US9216979B2 (en) * | 2009-10-16 | 2015-12-22 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| CA2829993A1 (en) | 2011-03-15 | 2012-09-20 | Rib-X Pharmaceuticals, Inc. | Antimicrobial agents |
| KR20140065378A (ko) | 2011-04-15 | 2014-05-29 | 멜린타 테라퓨틱스, 인크. | 항미생물 화합물 및 그의 제조 방법과 사용 방법 |
| KR20160070066A (ko) | 2013-09-09 | 2016-06-17 | 멜린타 테라퓨틱스, 인크. | 항균 화합물, 및 이의 제조 방법 및 이용 방법 |
| EP3038623A4 (en) | 2013-09-09 | 2017-04-19 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
-
2010
- 2010-10-15 US US13/501,834 patent/US9216979B2/en not_active Expired - Fee Related
- 2010-10-15 MY MYPI2012001649A patent/MY176900A/en unknown
- 2010-10-15 MX MX2012004342A patent/MX339000B/es active IP Right Grant
- 2010-10-15 CN CN2010800573060A patent/CN102725274A/zh active Pending
- 2010-10-15 CA CA2777741A patent/CA2777741A1/en not_active Abandoned
- 2010-10-15 WO PCT/US2010/052928 patent/WO2011047323A2/en not_active Ceased
- 2010-10-15 AU AU2010306650A patent/AU2010306650B2/en not_active Ceased
- 2010-10-15 BR BR112012008795-9A patent/BR112012008795A2/pt active Search and Examination
- 2010-10-15 EA EA201270567A patent/EA023350B1/ru not_active IP Right Cessation
- 2010-10-15 NZ NZ599290A patent/NZ599290A/en not_active IP Right Cessation
- 2010-10-15 KR KR1020187016578A patent/KR20180069098A/ko not_active Ceased
- 2010-10-15 JP JP2012534413A patent/JP2013508299A/ja active Pending
- 2010-10-15 EP EP10824207.4A patent/EP2488502A4/en not_active Withdrawn
- 2010-10-15 MX MX2014010301A patent/MX358697B/es unknown
-
2012
- 2012-04-15 IL IL219135A patent/IL219135A0/en unknown
-
2015
- 2015-10-16 US US14/884,985 patent/US9845297B2/en not_active Expired - Fee Related
-
2016
- 2016-09-22 AU AU2016231568A patent/AU2016231568A1/en not_active Abandoned
-
2017
- 2017-12-18 US US15/844,817 patent/US20180334439A1/en not_active Abandoned
-
2018
- 2018-03-23 AU AU2018202065A patent/AU2018202065A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013508299A5 (https=) | ||
| JP2013508297A5 (https=) | ||
| JP2013508298A5 (https=) | ||
| JP2016121171A5 (https=) | ||
| JP2014510788A5 (https=) | ||
| JP2007514782A5 (https=) | ||
| US8324264B1 (en) | Inhibitors of bacterial biofilms and related methods | |
| RU2005100516A (ru) | Производные 2-уреидо-6-гетероарил-3н-бензимидазол-6-карбоновой кислоты и родственные соединения в качестве ингибиторов гиразы и/или топоизомеразы iv для лечения бактериальных инфекций | |
| JP2019532928A5 (https=) | ||
| US20210322409A1 (en) | Metalloenzyme inhibitor compounds | |
| JP2011526283A5 (https=) | ||
| JP2010518067A (ja) | 抗寄生虫剤 | |
| JP2007500707A5 (https=) | ||
| JP2004507521A (ja) | 抗炎症活性および抗生物質活性を有する５−ａｓａ誘導体およびこれを用いて疾患を治療する方法 | |
| TW201028161A (en) | Novel antibacterial agents for the treatment of gram positive infections | |
| WO2015134171A1 (en) | Heteroarylamide inhibitors of tbk1 | |
| KR20170118106A (ko) | 아미노아실-tRNA 합성효소 저해제로서 신규한 N-아실-아릴술폰아미드 유도체 | |
| US9994547B2 (en) | Heteroarylamide inhibitors of TBK1 | |
| JP2025509846A5 (https=) | ||
| US10023602B2 (en) | Hamamelitannin analogues and uses thereof | |
| WO2020117755A1 (en) | Compositions and methods for treating biofilms | |
| JP2024009968A5 (https=) | ||
| CA3059192A1 (en) | Compounds and methods for hematopoietic regeneration | |
| TW200530255A (en) | 3-pyridiniummethylcefem compound | |
| JP2017507162A (ja) | 抗菌薬を含む医薬組成物 |