JP2007512027A5 - - Google Patents
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- Publication number
- JP2007512027A5 JP2007512027A5 JP2006541617A JP2006541617A JP2007512027A5 JP 2007512027 A5 JP2007512027 A5 JP 2007512027A5 JP 2006541617 A JP2006541617 A JP 2006541617A JP 2006541617 A JP2006541617 A JP 2006541617A JP 2007512027 A5 JP2007512027 A5 JP 2007512027A5
- Authority
- JP
- Japan
- Prior art keywords
- irna
- irna molecule
- cell
- molecule
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 13
- 108020004999 messenger RNA Proteins 0.000 claims 12
- 108020004414 DNA Proteins 0.000 claims 11
- 239000002773 nucleotide Substances 0.000 claims 11
- 125000003729 nucleotide group Chemical group 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 230000000295 complement effect Effects 0.000 claims 9
- 230000014509 gene expression Effects 0.000 claims 9
- 241000881705 Porcine endogenous retrovirus Species 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 238000003780 insertion Methods 0.000 claims 4
- 230000037431 insertion Effects 0.000 claims 4
- 230000009261 transgenic effect Effects 0.000 claims 4
- 230000006801 homologous recombination Effects 0.000 claims 2
- 238000002744 homologous recombination Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 108020004635 Complementary DNA Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000003252 repetitive effect Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52393803P | 2003-11-21 | 2003-11-21 | |
| PCT/US2004/039191 WO2005081714A2 (en) | 2003-11-21 | 2004-11-22 | Use of interfering rna in the production of transgenic animals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007512027A JP2007512027A (ja) | 2007-05-17 |
| JP2007512027A5 true JP2007512027A5 (enExample) | 2008-01-10 |
Family
ID=34910676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006541617A Pending JP2007512027A (ja) | 2003-11-21 | 2004-11-22 | トランスジェニック動物の産生における干渉rnaの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10793873B2 (enExample) |
| EP (2) | EP2514826A3 (enExample) |
| JP (1) | JP2007512027A (enExample) |
| CN (2) | CN103397019A (enExample) |
| AU (1) | AU2004316293A1 (enExample) |
| CA (1) | CA2546853C (enExample) |
| WO (1) | WO2005081714A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4948163B2 (ja) * | 2003-05-23 | 2012-06-06 | サーナ・セラピューティクス・インコーポレイテッド | 化学修飾した低分子干渉核酸(siNA)を使用する遺伝子発現のRNA干渉仲介抑制 |
| CA2533259C (en) | 2003-07-21 | 2014-01-28 | Lifecell Corporation | Acellular tissue matrices made from galactose .alpha.-1,3-galactose-deficient tissue |
| EP1582591A3 (en) * | 2004-02-27 | 2005-12-21 | Bundesrepublik Deutschland vertreten durch das Bundesminsterium für Gesundheit, dieses vertr. durch das Robert-Koch-Institut | Sirna and their use for knock down expression of porcine endogenous retrovirus |
| DK1895835T3 (da) * | 2005-06-24 | 2014-05-05 | Recombinetics Inc | Anvendelse af cytosindeaminaser til reducering af retroelementoverførsel fra grise til mennesker |
| JP2007104969A (ja) * | 2005-10-13 | 2007-04-26 | Bio Think Tank Co Ltd | ショートヘアピン型RNA(shRNA)前駆体を産生するための核酸及びその利用 |
| CA2680589A1 (en) * | 2007-03-14 | 2008-09-18 | Universita' Degli Studi Di Milano - Bicocca | Modulator compounds of the drug resistance in epithelial tumour cells |
| CA2691617C (en) | 2007-05-31 | 2020-07-21 | University Of Iowa Research Foundation | Reduction of off-target rna interference toxicity |
| WO2008151364A1 (en) * | 2007-06-13 | 2008-12-18 | Commonwealth Scientific And Industrial Research Organisation | Modulating production traits in avians |
| WO2010008562A2 (en) | 2008-07-16 | 2010-01-21 | Recombinetics | Methods and materials for producing transgenic animals |
| EP2425015B1 (en) * | 2009-04-29 | 2018-01-10 | Ralph Wirtz | A method to assess prognosis and to predict therapeutic success in cancer by determining hormone receptor expression levels |
| WO2011019929A1 (en) * | 2009-08-14 | 2011-02-17 | The Regents Of The University Of California | Methods of diagnosing and treating autism |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| CA2802738A1 (en) * | 2010-06-24 | 2011-12-29 | The Ohio State University | Chronic lymphocytic leukemia modeled in mouse by targeted mir-29 expression |
| EP2673286B1 (en) | 2011-02-12 | 2019-07-03 | University of Iowa Research Foundation | Therapeutic compounds |
| CN102675438B (zh) * | 2011-03-18 | 2015-04-22 | 中国科学院上海生命科学研究院 | 基于RNAi技术的抗虫制剂及方法 |
| WO2013188358A1 (en) * | 2012-06-12 | 2013-12-19 | The General Hospital Corporation | Miniature swine transgenic for one or more coagulation factors |
| EP3799893A1 (en) | 2013-11-04 | 2021-04-07 | LifeCell Corporation | Methods of removing alpha-galactose |
| CN104677866A (zh) * | 2014-03-25 | 2015-06-03 | 中国科学院大连化学物理研究所 | 测定CP装载siRNA体系中siRNA释放的方法 |
| RU2711147C2 (ru) | 2014-05-20 | 2020-01-15 | Юниверсити Оф Айова Рисерч Фаундейшн | Терапевтические соединения для лечения болезни хантингтона |
| CN104232670A (zh) * | 2014-08-25 | 2014-12-24 | 中国水产科学研究院黑龙江水产研究所 | 一种采用鱼类转基因方法构建的基于鲤鱼mstn干涉载体及其构建方法 |
| EP3314258B1 (en) | 2015-06-26 | 2023-11-15 | The Regents of the University of California | Antigenic peptides and uses thereof for diagnosing and treating autism |
| MX2018004263A (es) | 2015-10-08 | 2019-08-16 | Harvard College | Edición genómica multiplexada. |
| CN106918697B (zh) * | 2017-02-15 | 2018-07-31 | 中国医学科学院北京协和医院 | 一种预测ra药物疗效的诊断标志物及其应用 |
| KR102746223B1 (ko) * | 2017-04-20 | 2024-12-27 | 이제네시스, 인크. | 유전자 변형 동물의 생성 방법 |
| CN107760682B (zh) * | 2017-10-18 | 2020-12-18 | 云南大学 | 一种可用于分子防治害虫的核酸序列及其应用 |
| CN110628807B (zh) * | 2018-05-30 | 2021-06-18 | 中国科学院植物研究所 | 盐角草SePSS蛋白及其编码基因与应用 |
| WO2020033456A1 (en) * | 2018-08-06 | 2020-02-13 | Nemametrix Inc | Homologous recombination reporter construct and uses thereof |
| US10883084B2 (en) | 2018-10-05 | 2021-01-05 | Xenotherapeutics, Inc. | Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same |
| WO2020072982A1 (en) | 2018-10-05 | 2020-04-09 | Xenotherapeutics, Inc. | Xenotransplantation products and methods |
| US20210395738A1 (en) | 2018-11-08 | 2021-12-23 | Greenlight Biosciences, Inc. | Control of insect infestation |
| CN110055253A (zh) * | 2019-04-28 | 2019-07-26 | 复旦大学附属金山医院 | 一种针对人半胱氨酸蛋白酶抑制剂B的siRNA分子及其应用 |
| US20220012673A1 (en) * | 2020-07-13 | 2022-01-13 | ZenDesk, Inc. | Maintaining status information for customer-support agents across multiple channels |
| AU2021392972A1 (en) * | 2020-12-01 | 2023-06-08 | ETH Zürich | Dna constructs comprising alternative promoters |
| US20240240178A1 (en) * | 2021-05-06 | 2024-07-18 | Systems Oncology, Llc | Sirna constructs for inhibiting gene expression in targeted cancer cells |
| US20240271112A1 (en) * | 2021-06-01 | 2024-08-15 | University Of Massachusetts | Cas9 nickase-mediated gene editing |
| WO2023004365A1 (en) * | 2021-07-20 | 2023-01-26 | Sio Gene Therapies Inc. | Vector constructs for delivery of nucleic acids encoding therapeutic proteasome activator complex subunits and methods of using the same |
| CN115011601B (zh) * | 2022-06-27 | 2023-07-21 | 山东大学齐鲁医院 | 一种干扰JUND表达的shRNA、重组腺相关病毒载体及其应用 |
| CN118581151B (zh) * | 2024-05-29 | 2024-12-06 | 中国农业科学院兰州兽医研究所(中国动物卫生与流行病学中心兰州分中心) | 一种猪becn1基因敲除细胞的构建方法及其应用 |
| CN120608104B (zh) * | 2025-08-12 | 2025-11-25 | 中国科学院水生生物研究所 | lasp1基因在鱼类抗病毒免疫调控中的功能和应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4517338A (en) | 1983-06-20 | 1985-05-14 | Chiron Corporation | Multiple reactor system and method for polynucleotide synthesis |
| US4888274A (en) | 1985-09-18 | 1989-12-19 | Yale University | RecA nucleoprotein filament and methods |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| AU3276599A (en) * | 1998-03-12 | 1999-09-27 | Japan As Represented By Director General Of Agency Of Industrial Science And Technology | Nucleic acid enzyme showing allosteric rna-cleaving activity on target rna |
| AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| CZ295108B6 (cs) | 1998-03-20 | 2005-05-18 | Benitec Australia Ltd | Syntetický gen obsahující dispergovanou nebo cizorodou deoxyribonukleovou molekulu a genový konstrukt obsahující tento syntetický gen |
| WO2000011187A1 (en) | 1998-08-18 | 2000-03-02 | Bio-Transplant, Inc. | Molecular sequence of swine retrovirus and methods of use |
| US20030084471A1 (en) * | 2000-03-16 | 2003-05-01 | David Beach | Methods and compositions for RNA interference |
| AU2001245793A1 (en) * | 2000-03-16 | 2001-09-24 | Cold Spring Harbor Laboratory | Methods and compositions for rna interference |
| EP1309726B2 (en) | 2000-03-30 | 2018-10-03 | Whitehead Institute For Biomedical Research | Rna sequence-specific mediators of rna interference |
| US20030143597A1 (en) * | 2000-12-28 | 2003-07-31 | Finney Robert E. | Methods for making polynucleotide libraries, polynucleotide arrays, and cell libraries for high-throughput genomics analysis |
| EP1386004A4 (en) | 2001-04-05 | 2005-02-16 | Ribozyme Pharm Inc | MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID |
| CN1522300A (zh) * | 2001-05-01 | 2004-08-18 | 独立行政法人产业技术综合研究所 | 新型大酶 |
| JP4210737B2 (ja) * | 2001-07-12 | 2009-01-21 | ユニバーシティー オブ マサチューセッツ | 遺伝子サイレンシングを仲介する低分子干渉リボ核酸のインビボにおける製造方法 |
| WO2003012052A2 (en) | 2001-07-30 | 2003-02-13 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Specific inhibition of gene expression by small double stranded rnas |
| US7732193B2 (en) | 2001-09-13 | 2010-06-08 | California Institute Of Technology | Method for expression of small RNA molecules within a cell |
| US20030148519A1 (en) | 2001-11-14 | 2003-08-07 | Engelke David R. | Intracellular expression and delivery of siRNAs in mammalian cells |
| JP2005538685A (ja) | 2001-12-21 | 2005-12-22 | トランザイム, インコーポレイテッド | レンチウイルスベクターを使用して遺伝的に改変された動物を生成するための方法および組成物 |
| EP1458879A2 (en) | 2001-12-21 | 2004-09-22 | Oxford Biomedica (UK) Limited | Method for producing a transgenic organism using a lentiviral expression vector such as eiav |
| GB0130955D0 (en) | 2001-12-24 | 2002-02-13 | Cancer Res Ventures | Expression system |
| EP1572902B1 (en) | 2002-02-01 | 2014-06-11 | Life Technologies Corporation | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
| US20030203868A1 (en) * | 2002-02-06 | 2003-10-30 | Bushman Frederic D. | Inhibition of pathogen replication by RNA interference |
| US20040045043A1 (en) | 2002-05-20 | 2004-03-04 | Finney Robert E. | Compositions and methods for generating conditional knockouts |
| NZ562736A (en) | 2002-08-21 | 2009-07-31 | Revivicor Inc | Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase |
| US20040072769A1 (en) * | 2002-09-16 | 2004-04-15 | Yin James Qinwei | Methods for design and selection of short double-stranded oligonucleotides, and compounds of gene drugs |
| CN1276976C (zh) * | 2003-10-30 | 2006-09-27 | 封江南 | 单一载体编码多个发夹结构小干扰性rna表达系统及其构建方法 |
| EP1582591A3 (en) * | 2004-02-27 | 2005-12-21 | Bundesrepublik Deutschland vertreten durch das Bundesminsterium für Gesundheit, dieses vertr. durch das Robert-Koch-Institut | Sirna and their use for knock down expression of porcine endogenous retrovirus |
-
2004
- 2004-11-22 CN CN2013103209599A patent/CN103397019A/zh active Pending
- 2004-11-22 WO PCT/US2004/039191 patent/WO2005081714A2/en not_active Ceased
- 2004-11-22 EP EP12153484A patent/EP2514826A3/en not_active Ceased
- 2004-11-22 US US10/996,217 patent/US10793873B2/en not_active Expired - Fee Related
- 2004-11-22 CA CA2546853A patent/CA2546853C/en not_active Expired - Lifetime
- 2004-11-22 AU AU2004316293A patent/AU2004316293A1/en not_active Abandoned
- 2004-11-22 EP EP04821501A patent/EP1734811A4/en not_active Ceased
- 2004-11-22 CN CNA200480040601XA patent/CN1972593A/zh active Pending
- 2004-11-22 JP JP2006541617A patent/JP2007512027A/ja active Pending
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