JP2007511212A5 - - Google Patents

Info

Publication number

JP2007511212A5

JP2007511212A5 JP2006538818A JP2006538818A JP2007511212A5 JP 2007511212 A5 JP2007511212 A5 JP 2007511212A5 JP 2006538818 A JP2006538818 A JP 2006538818A JP 2006538818 A JP2006538818 A JP 2006538818A JP 2007511212 A5 JP2007511212 A5 JP 2007511212A5

Authority

JP

Japan

Prior art keywords

adenovirus

protein

promoter

nucleic acid

tumor

Prior art date

2004-11-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 241000701161 unidentified adenovirus Species 0.000 claims 101
• 108090000623 proteins and genes Proteins 0.000 claims 68
• 102000004169 proteins and genes Human genes 0.000 claims 65
• 150000007523 nucleic acids Chemical class 0.000 claims 41
• 108020004707 nucleic acids Proteins 0.000 claims 35
• 102000039446 nucleic acids Human genes 0.000 claims 35
• 210000004027 cell Anatomy 0.000 claims 29
• 206010028980 Neoplasm Diseases 0.000 claims 20
• 230000010076 replication Effects 0.000 claims 19
• 239000003814 drug Substances 0.000 claims 14
• 101710199711 Early E1A protein Proteins 0.000 claims 13
• 229940079593 drug Drugs 0.000 claims 12
• 239000013598 vector Substances 0.000 claims 12
• 241000700605 Viruses Species 0.000 claims 11
• 239000003795 chemical substances by application Substances 0.000 claims 11
• 201000010099 disease Diseases 0.000 claims 9
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
• 230000001613 neoplastic effect Effects 0.000 claims 7
• 210000000056 organ Anatomy 0.000 claims 7
• 210000001519 tissue Anatomy 0.000 claims 7
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
• 239000000824 cytostatic agent Substances 0.000 claims 5
• 239000003112 inhibitor Substances 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 4
• RTKIYFITIVXBLE-UHFFFAOYSA-N Trichostatin A Natural products ONC(=O)C=CC(C)=CC(C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-UHFFFAOYSA-N 0.000 claims 3
• 239000013543 active substance Substances 0.000 claims 3
• 230000022131 cell cycle Effects 0.000 claims 3
• 230000006037 cell lysis Effects 0.000 claims 3
• 230000001085 cytostatic effect Effects 0.000 claims 3
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• 230000001404 mediated effect Effects 0.000 claims 3
• 230000005855 radiation Effects 0.000 claims 3
• 230000003362 replicative effect Effects 0.000 claims 3
• RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 claims 3
• 230000003612 virological effect Effects 0.000 claims 3
• JWOGUUIOCYMBPV-GMFLJSBRSA-N (3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone Chemical compound N1C(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]1CC1=CN(OC)C2=CC=CC=C12 JWOGUUIOCYMBPV-GMFLJSBRSA-N 0.000 claims 2
• BWDQBBCUWLSASG-MDZDMXLPSA-N (e)-n-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1h-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide Chemical compound C=1NC2=CC=CC=C2C=1CCN(CCO)CC1=CC=C(\C=C\C(=O)NO)C=C1 BWDQBBCUWLSASG-MDZDMXLPSA-N 0.000 claims 2
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• JWOGUUIOCYMBPV-UHFFFAOYSA-N OT-Key 11219 Natural products N1C(=O)C(CCCCCC(=O)CC)NC(=O)C2CCCCN2C(=O)C(C(C)CC)NC(=O)C1CC1=CN(OC)C2=CC=CC=C12 JWOGUUIOCYMBPV-UHFFFAOYSA-N 0.000 claims 2
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• NCNRHFGMJRPRSK-MDZDMXLPSA-N belinostat Chemical compound ONC(=O)\C=C\C1=CC=CC(S(=O)(=O)NC=2C=CC=CC=2)=C1 NCNRHFGMJRPRSK-MDZDMXLPSA-N 0.000 claims 2
• 229960003094 belinostat Drugs 0.000 claims 2
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• INVTYAOGFAGBOE-UHFFFAOYSA-N entinostat Chemical compound NC1=CC=CC=C1NC(=O)C(C=C1)=CC=C1CNC(=O)OCC1=CC=CN=C1 INVTYAOGFAGBOE-UHFFFAOYSA-N 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 229960004768 irinotecan Drugs 0.000 claims 2
• UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 2
• 210000004962 mammalian cell Anatomy 0.000 claims 2
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• OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 claims 2
• 229940044693 topoisomerase inhibitor Drugs 0.000 claims 2
• 108700026220 vif Genes Proteins 0.000 claims 2
• VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
• STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
• FUXVKZWTXQUGMW-FQEVSTJZSA-N 9-Aminocamptothecin Chemical compound C1=CC(N)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 FUXVKZWTXQUGMW-FQEVSTJZSA-N 0.000 claims 1
• 108010057856 Adenovirus E2 Proteins Proteins 0.000 claims 1
• 108091023037 Aptamer Proteins 0.000 claims 1
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• KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
• 102000053642 Catalytic RNA Human genes 0.000 claims 1
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• 229940123587 Cell cycle inhibitor Drugs 0.000 claims 1
• 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
• 206010061968 Gastric neoplasm Diseases 0.000 claims 1
• 206010019695 Hepatic neoplasm Diseases 0.000 claims 1
• 241000282412 Homo Species 0.000 claims 1
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• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 208000005016 Intestinal Neoplasms Diseases 0.000 claims 1
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 206010029098 Neoplasm skin Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
• 102000001253 Protein Kinase Human genes 0.000 claims 1
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• 108020004459 Small interfering RNA Proteins 0.000 claims 1
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• 102000044209 Tumor Suppressor Genes Human genes 0.000 claims 1
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• 108010067390 Viral Proteins Proteins 0.000 claims 1
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• 229940127093 camptothecin Drugs 0.000 claims 1
• VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
• STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
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• VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
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• VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
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• VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 claims 1
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