JP2007511212A - 新規アデノウイルス、それをコードする核酸及びその使用 - Google Patents

新規アデノウイルス、それをコードする核酸及びその使用 Download PDF

Info

Publication number
JP2007511212A
JP2007511212A JP2006538818A JP2006538818A JP2007511212A JP 2007511212 A JP2007511212 A JP 2007511212A JP 2006538818 A JP2006538818 A JP 2006538818A JP 2006538818 A JP2006538818 A JP 2006538818A JP 2007511212 A JP2007511212 A JP 2007511212A
Authority
JP
Japan
Prior art keywords
adenovirus
protein
promoter
nucleic acid
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006538818A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007511212A5 (enExample
Inventor
ホルム,ペル・ゾンネ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2007511212A publication Critical patent/JP2007511212A/ja
Publication of JP2007511212A5 publication Critical patent/JP2007511212A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/20Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/20Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C12N2840/206Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES having multiple IRES

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2006538818A 2003-11-14 2004-11-15 新規アデノウイルス、それをコードする核酸及びその使用 Pending JP2007511212A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10353152 2003-11-14
DE102004018117 2004-04-14
PCT/EP2004/012931 WO2005052143A2 (de) 2003-11-14 2004-11-15 Neue adenoviren, dafür codierende nukleinsäuren und deren verwendung

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011098213A Division JP5618896B2 (ja) 2003-11-14 2011-04-26 新規アデノウイルス、それをコードする核酸及びその使用

Publications (2)

Publication Number Publication Date
JP2007511212A true JP2007511212A (ja) 2007-05-10
JP2007511212A5 JP2007511212A5 (enExample) 2008-01-10

Family

ID=34635104

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006538818A Pending JP2007511212A (ja) 2003-11-14 2004-11-15 新規アデノウイルス、それをコードする核酸及びその使用
JP2011098213A Expired - Fee Related JP5618896B2 (ja) 2003-11-14 2011-04-26 新規アデノウイルス、それをコードする核酸及びその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011098213A Expired - Fee Related JP5618896B2 (ja) 2003-11-14 2011-04-26 新規アデノウイルス、それをコードする核酸及びその使用

Country Status (5)

Country Link
US (2) US20060270016A1 (enExample)
EP (1) EP1689446B1 (enExample)
JP (2) JP2007511212A (enExample)
CA (1) CA2590257A1 (enExample)
WO (1) WO2005052143A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008526189A (ja) * 2004-12-31 2008-07-24 ホルム,ペル・ゾンネ E1−マイナスアデノウイルス及びその使用
JP2008526188A (ja) * 2004-12-31 2008-07-24 ホルム,ペル・ゾンネ 動物細胞における多剤耐性を逆転させる方法
US10155930B2 (en) 2002-05-27 2018-12-18 Per Sonne Holm Use of adenovirus and nucleic acids coding therefor
US10300096B2 (en) 2003-11-14 2019-05-28 Per Sonne Holm Use of adenoviruses and nucleic acids that code for said viruses
JP2021517119A (ja) * 2018-03-05 2021-07-15 クリニクム レヒツ デア イザール デア テクニシェン ウニフェルジテート ミュンヘン 腫瘍溶解性アデノウイルスとcdk4/6阻害剤との組み合わせによる腫瘍の処置

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ589276A (en) 2005-02-03 2012-06-29 Topotarget Uk Ltd Combination therapies using hdac inhibitors and erlotinib (tarceva)
ES2380887T3 (es) 2005-05-13 2012-05-21 Topotarget Uk Limited Formulaciones farmacéuticas de inhibidores de la HDAC
EP2361619A1 (en) 2005-11-10 2011-08-31 TopoTarget UK Limited Histone deacetylase (hdac) inhibitors (pxd-101) alone for the treatment of hematological cancer
AU2006318652A1 (en) * 2005-11-18 2007-05-31 Gloucester Pharmaceuticals, Inc. Metabolite derivatives of the HDAC inhibitor FK228
EP2012801A4 (en) 2006-04-24 2009-08-05 Gloucester Pharmaceuticals Inc GEMCITABINE COMBINATION THERAPY
WO2007146730A2 (en) 2006-06-08 2007-12-21 Gloucester Pharmaceuticals Deacetylase inhibitor therapy
MX2009006969A (es) * 2006-12-29 2010-04-07 Gloucester Pharmaceuticals Purificacion de romidepsina.
CN101687010A (zh) * 2006-12-29 2010-03-31 格洛斯特制药公司 制备Romidepsin
WO2008136213A1 (ja) * 2007-04-27 2008-11-13 Oncolys Biopharma Inc. 放射線増感増強剤
MX2010003230A (es) * 2007-09-25 2010-04-07 Topotarget Uk Ltd Metodos para la sintesis de ciertos compuestos de acido hidroxamico.
CA2717207A1 (en) * 2008-03-07 2009-09-11 Topotarget A/S Methods of treatment employing prolonged continuous infusion of belinostat
GB0900555D0 (en) * 2009-01-14 2009-02-11 Topotarget As New methods
SI2403951T1 (sl) 2009-03-02 2016-04-29 The Regents Of The University Of California Tumorsko selektivni mutanti adenovirusa e1a in e1b
UA114074C2 (xx) 2010-07-12 2017-04-25 Кристалічна форма с ромідепсину та її застосування для лікування шкірної т-клітинної лімфоми або периферичної т-клітинної лімфоми
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
AU2013202507B9 (en) 2012-11-14 2015-08-13 Celgene Corporation Inhibition of drug resistant cancer cells
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
CN109576231B (zh) * 2017-09-28 2022-03-25 北京康万达医药科技有限公司 分离的重组溶瘤腺病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途
AU2019294294A1 (en) * 2018-06-25 2021-02-11 Fondazione Telethon Ets Gene therapy
CN114269344A (zh) * 2019-06-25 2022-04-01 微生物公司 用费洛西洛韦治疗或预防眼部感染的组合物和方法
CN116179604B (zh) * 2022-08-31 2025-08-26 上海锦斯生物技术有限公司 一种降低回复突变频率的重组5型腺病毒载体及其构建方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002053711A2 (de) * 2000-12-28 2002-07-11 Per Sonne Holm Verwendung des transkriptionsfaktors yb-1 in adenoviralen systemen
JP2006512284A (ja) * 2002-05-27 2006-04-13 ホルム,ペル・ゾンネ アデノウイルスおよびそれをコードしている核酸の新たな使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0784690B1 (en) * 1994-06-10 2006-08-16 Genvec, Inc. Complementary adenoviral vector systems and cell lines
US5998205A (en) * 1994-11-28 1999-12-07 Genetic Therapy, Inc. Vectors for tissue-specific replication
DE19929569A1 (de) * 1999-06-21 2000-12-28 Holm Per Sonne Mittel zur Behandlung maligner Erkrankungen unter Verwendung des Proteins YB-1
US20030095989A1 (en) * 2000-12-18 2003-05-22 Irving John M. Chimeric cytolytic viruses for cancer treatment
DE10150945A1 (de) * 2001-10-16 2003-04-17 Holm Per Sonne Adenovirale Systeme und deren Anwendungen
KR101123510B1 (ko) * 2002-10-15 2012-04-12 페르 손네 홀름 신규한 아데노바이러스, 이를 암호화하는 핵산 및 이들의 조성물

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002053711A2 (de) * 2000-12-28 2002-07-11 Per Sonne Holm Verwendung des transkriptionsfaktors yb-1 in adenoviralen systemen
JP2006512284A (ja) * 2002-05-27 2006-04-13 ホルム,ペル・ゾンネ アデノウイルスおよびそれをコードしている核酸の新たな使用

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10155930B2 (en) 2002-05-27 2018-12-18 Per Sonne Holm Use of adenovirus and nucleic acids coding therefor
US10538744B2 (en) 2002-05-27 2020-01-21 Per Sonne Holm Use of adenovirus and nucleic acids coding therefor
US10731136B2 (en) 2002-05-27 2020-08-04 Per Sonne Holm Use of adenovirus and nucleic acids coding therefor
US11268073B2 (en) 2002-05-27 2022-03-08 Per Sonne Holm Use of adenovirus and nucleic acids coding therefor
US10300096B2 (en) 2003-11-14 2019-05-28 Per Sonne Holm Use of adenoviruses and nucleic acids that code for said viruses
JP2008526189A (ja) * 2004-12-31 2008-07-24 ホルム,ペル・ゾンネ E1−マイナスアデノウイルス及びその使用
JP2008526188A (ja) * 2004-12-31 2008-07-24 ホルム,ペル・ゾンネ 動物細胞における多剤耐性を逆転させる方法
JP2021517119A (ja) * 2018-03-05 2021-07-15 クリニクム レヒツ デア イザール デア テクニシェン ウニフェルジテート ミュンヘン 腫瘍溶解性アデノウイルスとcdk4/6阻害剤との組み合わせによる腫瘍の処置
JP2025013934A (ja) * 2018-03-05 2025-01-28 クリニクム レヒツ デア イザール デア テクニシェン ウニフェルジテート ミュンヘン 腫瘍溶解性アデノウイルスとcdk4/6阻害剤との組み合わせによる腫瘍の処置

Also Published As

Publication number Publication date
WO2005052143A2 (de) 2005-06-09
CA2590257A1 (en) 2005-06-09
JP5618896B2 (ja) 2014-11-05
JP2011200234A (ja) 2011-10-13
EP1689446A2 (de) 2006-08-16
EP1689446B1 (de) 2015-01-07
US20100297731A1 (en) 2010-11-25
US20060270016A1 (en) 2006-11-30
WO2005052143A3 (de) 2005-09-22
US8586354B2 (en) 2013-11-19

Similar Documents

Publication Publication Date Title
JP5618896B2 (ja) 新規アデノウイルス、それをコードする核酸及びその使用
US20220339219A1 (en) Method for reversing multiple resistance in animal cells
JP5873893B2 (ja) アデノウイルスおよびそれをコードしている核酸の新たな使用
AU2010257327B2 (en) Adenovirus expressing genes in reverse order and use thereof
JP5435871B2 (ja) E1−マイナスアデノウイルス及びその使用
JP4988199B2 (ja) 新規アデノウイルス、それをコードする核酸及びその使用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071113

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071113

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101026

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20101220

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20101228

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110927