JP2007508011A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007508011A5 JP2007508011A5 JP2006534031A JP2006534031A JP2007508011A5 JP 2007508011 A5 JP2007508011 A5 JP 2007508011A5 JP 2006534031 A JP2006534031 A JP 2006534031A JP 2006534031 A JP2006534031 A JP 2006534031A JP 2007508011 A5 JP2007508011 A5 JP 2007508011A5
- Authority
- JP
- Japan
- Prior art keywords
- core mimetibody
- polypeptide
- hinge core
- nucleic acid
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 25
- 229920001184 polypeptide Polymers 0.000 claims 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims 22
- 239000003814 drug Substances 0.000 claims 18
- 229940079593 drug Drugs 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 12
- 108060003951 Immunoglobulin Proteins 0.000 claims 9
- 102000018358 immunoglobulin Human genes 0.000 claims 9
- 210000003403 autonomic nervous system Anatomy 0.000 claims 4
- 210000003169 central nervous system Anatomy 0.000 claims 4
- 230000002526 effect on cardiovascular system Effects 0.000 claims 4
- 102000004127 Cytokines Human genes 0.000 claims 3
- 108090000695 Cytokines Proteins 0.000 claims 3
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 3
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 3
- 239000005557 antagonist Substances 0.000 claims 3
- 230000000975 bioactive effect Effects 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 238000007918 intramuscular administration Methods 0.000 claims 3
- 238000007912 intraperitoneal administration Methods 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 3
- 238000007914 intraventricular administration Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 238000007920 subcutaneous administration Methods 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229940041181 antineoplastic drug Drugs 0.000 claims 2
- 239000010836 blood and blood product Substances 0.000 claims 2
- 229940125691 blood product Drugs 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 210000001124 body fluid Anatomy 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003221 ear drop Substances 0.000 claims 2
- 229940047652 ear drops Drugs 0.000 claims 2
- 239000003792 electrolyte Substances 0.000 claims 2
- 239000003889 eye drop Substances 0.000 claims 2
- 229940012356 eye drops Drugs 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 229940121354 immunomodulator Drugs 0.000 claims 2
- 238000007919 intrasynovial administration Methods 0.000 claims 2
- 229940100662 nasal drops Drugs 0.000 claims 2
- 235000016709 nutrition Nutrition 0.000 claims 2
- 210000002345 respiratory system Anatomy 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 230000009261 transgenic effect Effects 0.000 claims 2
- 101100007328 Cocos nucifera COS-1 gene Proteins 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 230000002924 anti-infective effect Effects 0.000 claims 1
- 229960005475 antiinfective agent Drugs 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000000084 colloidal system Substances 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 239000000409 cytokine receptor agonist Substances 0.000 claims 1
- 239000000430 cytokine receptor antagonist Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- -1 hormonal drugs Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 239000007923 nasal drop Substances 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000037317 transdermal delivery Effects 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50723603P | 2003-09-30 | 2003-09-30 | |
| PCT/US2004/031855 WO2005044807A2 (en) | 2003-09-30 | 2004-09-29 | Benzoimidazole compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007508011A JP2007508011A (ja) | 2007-04-05 |
| JP2007508011A5 true JP2007508011A5 (https=) | 2007-11-22 |
Family
ID=38952593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006534031A Pending JP2007508011A (ja) | 2003-09-30 | 2004-09-29 | ヒトヒンジコアミメティボディ、組成物、方法および用途 |
Country Status (21)
| Country | Link |
|---|---|
| US (10) | US7432378B2 (https=) |
| EP (1) | EP1673348B1 (https=) |
| JP (1) | JP2007508011A (https=) |
| KR (1) | KR20060097024A (https=) |
| CN (1) | CN1886380B (https=) |
| AR (1) | AR045955A1 (https=) |
| AT (1) | ATE427303T1 (https=) |
| AU (1) | AU2004286933B2 (https=) |
| BR (1) | BRPI0414918A (https=) |
| CA (1) | CA2540704A1 (https=) |
| DE (1) | DE602004020364D1 (https=) |
| ES (1) | ES2323178T3 (https=) |
| HR (1) | HRP20060126A2 (https=) |
| IL (1) | IL174677A0 (https=) |
| NO (1) | NO20061950L (https=) |
| NZ (1) | NZ546259A (https=) |
| PT (1) | PT1673348E (https=) |
| RU (1) | RU2006110561A (https=) |
| TW (1) | TW200526637A (https=) |
| WO (1) | WO2005044807A2 (https=) |
| ZA (1) | ZA200603411B (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2006110561A (ru) * | 2003-09-30 | 2007-10-10 | Янссен Фармацевтика Н.В. (Be) | Соединения бензоимидазола |
| AU2005226729B2 (en) | 2004-03-25 | 2010-01-28 | Janssen Pharmaceutica N.V. | Imidazole compounds |
| ES2362102T3 (es) | 2004-06-30 | 2011-06-28 | Janssen Pharmaceutica Nv | Eteres de bencimidazol e imidazopiridina sustituidos con arilo como agentes anticáncer. |
| MX2007014881A (es) * | 2005-05-26 | 2008-02-15 | Tibotec Pharm Ltd | Procedimiento para preparar 4-(1,6-dihidro-6-oxo-2-pirimidinil) amino benzonitrilo. |
| MX2007016508A (es) * | 2005-06-30 | 2008-03-04 | Prosidion Ltd | Agonistas del receptor acoplado a la proteina g. |
| JP5301999B2 (ja) * | 2005-10-31 | 2013-09-25 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｃｅｔｐ阻害薬 |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| WO2007069565A1 (ja) * | 2005-12-12 | 2007-06-21 | Ono Pharmaceutical Co., Ltd. | 二環式複素環化合物 |
| PL2007752T3 (pl) * | 2006-03-31 | 2011-02-28 | Janssen Pharmaceutica Nv | Benzoimidazol-2-ilopirymidyny i pirazyny jako modulatory receptora histaminowego H4 |
| DE602007008859D1 (de) * | 2006-03-31 | 2010-10-14 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyridine als modulatoren des histamin-h4-rezeptors |
| WO2007120690A2 (en) * | 2006-04-10 | 2007-10-25 | Janssen Pharmaceutica N.V. | Combination histamine h1r and h4r antagonist therapy for treating pruritus |
| FR2903311B1 (fr) * | 2006-07-10 | 2012-06-15 | Centre Nat Rech Scient | Utilisation de ligands du recepteur h4 de l'histamine pour proteger les progeniteurs hematopoietiques contre la toxicite hematologique des agents chimiotherapeutiques |
| US7985745B2 (en) | 2006-10-02 | 2011-07-26 | Abbott Laboratories | Method for pain treatment |
| WO2009079001A1 (en) | 2007-12-18 | 2009-06-25 | Janssen Pharmaceutica N.V. | Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine h4 receptor |
| EP2077263A1 (en) | 2008-01-02 | 2009-07-08 | Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg | Quinazolines and related heterocyclic compounds and their therapeutic use |
| MX2010013727A (es) * | 2008-06-12 | 2011-01-14 | Janssen Pharmaceutica Nv | Uso de un antagonista h4 de histamina para el tratamiento de adherencias postoperatorias. |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| US20100029942A1 (en) | 2008-06-30 | 2010-02-04 | Sergio Cesco-Cancian | Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives |
| US8354400B2 (en) | 2008-09-26 | 2013-01-15 | Eisai R&D Co., Ltd. | Benzoxazole compounds and methods of use |
| BRPI0919816A2 (pt) * | 2008-09-26 | 2019-09-24 | Eisai R&D Man Co Ltd | uso compostos benzoxazólicos no tratamento de malária |
| EP2201982A1 (en) | 2008-12-24 | 2010-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Histamine H4 receptor antagonists for the treatment of vestibular disorders |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| IT1395137B1 (it) * | 2009-08-05 | 2012-09-05 | Spider Biotech S R L | Nuovi peptidi antipatogeni |
| TW201111378A (en) | 2009-09-11 | 2011-04-01 | Bayer Schering Pharma Ag | Substituted (heteroarylmethyl) thiohydantoins |
| JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体 |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| JP5748777B2 (ja) | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
| EP2447263A1 (en) | 2010-09-27 | 2012-05-02 | Bioprojet | Benzazole derivatives as histamine H4 receptor ligands |
| UY34094A (es) | 2011-05-27 | 2013-01-03 | Novartis Ag | Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina |
| DE102011122420B4 (de) | 2011-12-24 | 2016-07-28 | Volkswagen Aktiengesellschaft | Verfahren zur Feststellung der Spannungsfreiheit in einem elektrischen Hochvolt-System und ein elektrisches Hochvolt-System |
| CA2867043A1 (en) | 2012-05-03 | 2013-11-07 | Novartis Ag | L-malate salt of 2,7-diaza-spiro[4.5]dec-7-yle derivatives and crystalline forms thereof as ghrelin receptor agonists |
| EP2671870A1 (en) * | 2012-06-05 | 2013-12-11 | Bioprojet | Novel (aza)benzhydryl ether derivatives, their process of preparation and their use as H4-receptor ligands for therapeutical applications |
| HUE039713T2 (hu) | 2012-06-08 | 2019-02-28 | Sensorion | H4 receptor inhibitorok tinnitus kezelésére |
| SMT202000084T1 (it) | 2013-03-06 | 2020-03-13 | Janssen Pharmaceutica Nv | Modulatori benzoimidazol-2-il pirimidinici del recettore h4 dell'istamina |
| EP3798212A4 (en) * | 2018-05-22 | 2022-03-23 | Nihon Nohyaku Co., Ltd. | BENZIMIDAZOLE COMPOUND OR SALT THEREOF, INSECTICIDE AND ACARICIDE FOR AGRICULTURE AND HORTICULTURE WITH THIS COMPOUND AND METHODS OF USE |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2587029B1 (fr) * | 1985-09-11 | 1987-10-30 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| WO1998006703A1 (en) * | 1996-08-14 | 1998-02-19 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as mcp-1 antagonists |
| IL142917A0 (en) * | 1998-11-03 | 2002-04-21 | Basf Ag | Substituted 2-phenylbenzimidazoles, the production thereof and their use |
| DE19920936A1 (de) * | 1999-05-07 | 2000-11-09 | Basf Ag | Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung |
| EP1373204B1 (en) * | 2001-03-09 | 2016-10-26 | Janssen Pharmaceuticals, Inc. | Heterocyclic compounds |
| RU2006110561A (ru) * | 2003-09-30 | 2007-10-10 | Янссен Фармацевтика Н.В. (Be) | Соединения бензоимидазола |
-
2004
- 2004-09-29 RU RU2006110561/04A patent/RU2006110561A/ru not_active Application Discontinuation
- 2004-09-29 AU AU2004286933A patent/AU2004286933B2/en not_active Ceased
- 2004-09-29 JP JP2006534031A patent/JP2007508011A/ja active Pending
- 2004-09-29 AT AT04816894T patent/ATE427303T1/de not_active IP Right Cessation
- 2004-09-29 BR BRPI0414918-1A patent/BRPI0414918A/pt not_active IP Right Cessation
- 2004-09-29 CA CA002540704A patent/CA2540704A1/en not_active Abandoned
- 2004-09-29 WO PCT/US2004/031855 patent/WO2005044807A2/en not_active Ceased
- 2004-09-29 PT PT04816894T patent/PT1673348E/pt unknown
- 2004-09-29 TW TW093129453A patent/TW200526637A/zh unknown
- 2004-09-29 NZ NZ546259A patent/NZ546259A/en unknown
- 2004-09-29 US US10/952,989 patent/US7432378B2/en not_active Expired - Lifetime
- 2004-09-29 ES ES04816894T patent/ES2323178T3/es not_active Expired - Lifetime
- 2004-09-29 AR ARP040103534A patent/AR045955A1/es not_active Application Discontinuation
- 2004-09-29 DE DE602004020364T patent/DE602004020364D1/de not_active Expired - Lifetime
- 2004-09-29 HR HR20060126A patent/HRP20060126A2/xx not_active Application Discontinuation
- 2004-09-29 EP EP04816894A patent/EP1673348B1/en not_active Expired - Lifetime
- 2004-09-29 KR KR1020067008435A patent/KR20060097024A/ko not_active Withdrawn
- 2004-09-29 CN CN2004800354157A patent/CN1886380B/zh not_active Expired - Fee Related
-
2006
- 2006-03-30 IL IL174677A patent/IL174677A0/en unknown
- 2006-04-28 ZA ZA200603411A patent/ZA200603411B/en unknown
- 2006-05-02 NO NO20061950A patent/NO20061950L/no not_active Application Discontinuation
-
2008
- 2008-08-26 US US12/229,882 patent/US7705149B2/en not_active Expired - Lifetime
- 2008-08-26 US US12/229,888 patent/US7705143B2/en not_active Expired - Lifetime
- 2008-08-26 US US12/229,779 patent/US20090270611A1/en not_active Abandoned
- 2008-08-26 US US12/229,886 patent/US7723527B2/en not_active Expired - Lifetime
- 2008-08-26 US US12/229,890 patent/US7723359B2/en not_active Expired - Lifetime
- 2008-08-26 US US12/229,891 patent/US20090281307A1/en not_active Abandoned
- 2008-08-26 US US12/229,781 patent/US7723526B2/en not_active Expired - Lifetime
- 2008-08-26 US US12/229,892 patent/US7662966B2/en not_active Expired - Lifetime
- 2008-10-23 US US12/257,362 patent/US20090247508A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007508011A5 (https=) | ||
| JP2005512522A5 (https=) | ||
| JP2024161402A (ja) | 抗ｔｌ１ａモノクローナル抗体の中和 | |
| ES2384110T3 (es) | Anticuerpo anti-PLGF novedoso | |
| ES2401536T3 (es) | Anticuerpos monoclonales que se unen a HGM-CSF y composiciones medicinales que los comprenden | |
| EP2291659B1 (en) | Chimeric small molecules for the recruitment of antibodies to cancer cells | |
| KR101309948B1 (ko) | 혈관 신생 억제 화합물 | |
| BR112020000766A2 (pt) | anticorpos anti-cd166 e seus usos | |
| ES2872964T3 (es) | Inmunoconjugado de IL-12 | |
| RU2714933C2 (ru) | Конъюгаты var2csa-лекарственное средство | |
| HRP20140982T1 (hr) | Ljudska anti-il-23 antitijela, pripravci, postupci i upotrebe | |
| JPWO2019044946A1 (ja) | 抗体−薬物コンジュゲートの新規製造方法 | |
| ES2759530T3 (es) | Composición farmacéutica que contiene derivados de glutarimida, y la aplicación de la misma para el tratamiento de enfermedades eosinofílicas | |
| ME02185B (me) | Anti-il-6 antitela, preparati, postupci pripreme i upotrebe | |
| CA2609349A1 (en) | Anti-mcp-1 antibodies, compositions, methods and uses | |
| JP2019059730A (ja) | デュシェンヌ筋ジストロフィーの治療におけるフォリスタチン | |
| JP2008525477A5 (https=) | ||
| JP2005533001A5 (https=) | ||
| CN111529717A (zh) | 抗体药物偶联物 | |
| KR20210100145A (ko) | 거세-저항성 및 거세-민감성 전립선암의 치료 방법 | |
| JP2012524030A (ja) | Ａｎｇｉｏｐｅｐ−２アナログにコンジュゲート化した抗癌剤を用いた卵巣癌の治療 | |
| WO2021082573A1 (zh) | 抗il-4r单域抗体及其应用 | |
| JP2011517548A5 (https=) | ||
| JP2010534664A5 (https=) | ||
| WO2025040047A1 (zh) | 抗体偶联药物、其制备方法及应用 |