JP2007506732A5 - - Google Patents
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- Publication number
- JP2007506732A5 JP2007506732A5 JP2006527571A JP2006527571A JP2007506732A5 JP 2007506732 A5 JP2007506732 A5 JP 2007506732A5 JP 2006527571 A JP2006527571 A JP 2006527571A JP 2006527571 A JP2006527571 A JP 2006527571A JP 2007506732 A5 JP2007506732 A5 JP 2007506732A5
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- JP
- Japan
- Prior art keywords
- red
- group
- carbon
- phenol
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 18
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 18
- 229910052760 oxygen Inorganic materials 0.000 claims description 18
- 239000001301 oxygen Substances 0.000 claims description 18
- 229910052717 sulfur Inorganic materials 0.000 claims description 18
- 239000011593 sulfur Substances 0.000 claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 13
- 125000003118 aryl group Chemical group 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
- 150000002431 hydrogen Chemical class 0.000 claims description 8
- 229940002612 prodrug Drugs 0.000 claims description 6
- 239000000651 prodrug Substances 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- -1 carboxyphenyl Chemical group 0.000 claims 24
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 20
- 229910052799 carbon Inorganic materials 0.000 claims 20
- 125000005036 alkoxyphenyl group Chemical group 0.000 claims 12
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims 12
- QSZCGGBDNYTQHH-UHFFFAOYSA-N 2,3-dimethoxyphenol Chemical compound COC1=CC=CC(O)=C1OC QSZCGGBDNYTQHH-UHFFFAOYSA-N 0.000 claims 8
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000004104 aryloxy group Chemical group 0.000 claims 8
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000004043 oxo group Chemical group O=* 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000005309 thioalkoxy group Chemical group 0.000 claims 8
- 125000005296 thioaryloxy group Chemical group 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- LSFYCRUFNRBZNC-UHFFFAOYSA-N (2-hydroxyphenyl) acetate Chemical compound CC(=O)OC1=CC=CC=C1O LSFYCRUFNRBZNC-UHFFFAOYSA-N 0.000 claims 4
- HGPSVOAVAYJEIJ-XDHOZWIPSA-N 2-[(e)-(3,4-dihydroxyphenyl)-(3-hydroxy-4-oxoniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzenesulfonate Chemical compound C1=CC(=O)C(O)=C\C1=C(C=1C(=CC=CC=1)S(O)(=O)=O)/C1=CC=C(O)C(O)=C1 HGPSVOAVAYJEIJ-XDHOZWIPSA-N 0.000 claims 4
- OYCLSQDXZMROJK-UHFFFAOYSA-N 2-bromo-4-[3-(3-bromo-4-hydroxyphenyl)-1,1-dioxo-2,1$l^{6}-benzoxathiol-3-yl]phenol Chemical compound C1=C(Br)C(O)=CC=C1C1(C=2C=C(Br)C(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 OYCLSQDXZMROJK-UHFFFAOYSA-N 0.000 claims 4
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 claims 4
- 125000002723 alicyclic group Chemical group 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- PGAZAORSURCSOS-UHFFFAOYSA-N benzene-1,2-diol;phenol Chemical compound OC1=CC=CC=C1.OC1=CC=CC=C1O PGAZAORSURCSOS-UHFFFAOYSA-N 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims 4
- 229960003531 phenolsulfonphthalein Drugs 0.000 claims 4
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 4
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 4
- 125000005300 thiocarboxy group Chemical group C(=S)(O)* 0.000 claims 4
- 125000005190 thiohydroxy group Chemical group 0.000 claims 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229960001295 tocopherol Drugs 0.000 claims 3
- 229930003799 tocopherol Natural products 0.000 claims 3
- 235000010384 tocopherol Nutrition 0.000 claims 3
- 239000011732 tocopherol Substances 0.000 claims 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 3
- 230000000368 destabilizing effect Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000005022 packaging material Substances 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50542503P | 2003-09-25 | 2003-09-25 | |
| US60/505,425 | 2003-09-25 | ||
| US55395304P | 2004-03-18 | 2004-03-18 | |
| US60/553,953 | 2004-03-18 | ||
| US58836204P | 2004-07-16 | 2004-07-16 | |
| US60/588,362 | 2004-07-16 | ||
| PCT/IL2004/000890 WO2005027901A1 (en) | 2003-09-25 | 2004-09-23 | Compositions and methods using same for treating amyloid-associated diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007506732A JP2007506732A (ja) | 2007-03-22 |
| JP2007506732A5 true JP2007506732A5 (cg-RX-API-DMAC7.html) | 2007-08-09 |
| JP4917889B2 JP4917889B2 (ja) | 2012-04-18 |
Family
ID=34381987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006527571A Expired - Fee Related JP4917889B2 (ja) | 2003-09-25 | 2004-09-23 | アミロイド関連疾患を処置するための組成物及びその使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8372880B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1663199B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4917889B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2540407A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005027901A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7781396B2 (en) * | 2002-01-31 | 2010-08-24 | Tel Aviv University Future Technology Development L.P. | Peptides directed for diagnosis and treatment of amyloid-associated disease |
| US20040052928A1 (en) * | 2002-09-06 | 2004-03-18 | Ehud Gazit | Peptides and methods using same for diagnosing and treating amyloid-associated diseases |
| US7491699B2 (en) | 2002-12-09 | 2009-02-17 | Ramot At Tel Aviv University Ltd. | Peptide nanostructures and methods of generating and using the same |
| DE602004020179D1 (de) | 2003-01-07 | 2009-05-07 | Univ Ramot | Peptidenanostrukturen die fremdmaterial enthalten, und verfahren zur herstellung derselben |
| US7625707B2 (en) | 2003-10-02 | 2009-12-01 | Ramot At Tel Aviv University Ltd. | Antibacterial agents and methods of identifying and utilizing same |
| WO2006006172A2 (en) * | 2004-07-15 | 2006-01-19 | Ramot At Tel Aviv University Ltd. | Use of anti-amyloid agents for treating and typing pathogen infections |
| US8568637B2 (en) | 2004-08-02 | 2013-10-29 | Ramot At Tel-Aviv University Ltd. | Method of forming a fiber made of peptide nanostructures |
| WO2006018850A2 (en) | 2004-08-19 | 2006-02-23 | Tel Aviv University Future Technology Development L.P. | Compositions for treating amyloid associated diseases |
| WO2006027780A2 (en) | 2004-09-08 | 2006-03-16 | Ramot At Tel Aviv University Ltd. | Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same |
| ATE452632T1 (de) * | 2005-04-07 | 2010-01-15 | Astrum Therapeutics Pty Ltd | Verbindungen zur behandlung von amyloidose und verhinderung des tods von beta-zellen bei diabetes mellitus typ 2 |
| US10004828B2 (en) | 2005-10-11 | 2018-06-26 | Romat at Tel-Aviv University Ltd. | Self-assembled Fmoc-ff hydrogels |
| US7879212B2 (en) * | 2005-11-03 | 2011-02-01 | Ramot At Tel-Aviv University Ltd. | Peptide nanostructure-coated electrodes |
| KR20080036902A (ko) * | 2006-10-24 | 2008-04-29 | 재단법인서울대학교산학협력재단 | 아밀로이드 형성 펩타이드 또는 단백질의 가용성 회합체에선택적으로 작용하는 절단제 |
| JP5918264B2 (ja) | 2010-12-22 | 2016-05-18 | アッヴィ・インコーポレイテッド | Ｃ型肝炎阻害剤およびその使用 |
| US9061006B2 (en) | 2011-03-08 | 2015-06-23 | Ramot At Tel-Aviv University Ltd. | Compositions and methods for diagnosing and treating phenylketonuria (PKU) |
| CN102940712B (zh) * | 2012-12-07 | 2014-03-19 | 辽宁大学 | 枳实在制备抗朊病毒药物中的应用 |
| WO2017075145A1 (en) * | 2015-10-28 | 2017-05-04 | Yale University | Quinoline amides and methods of using same |
| WO2017096049A1 (en) | 2015-12-03 | 2017-06-08 | The University Of North Carolina At Pembroke | Materials for cathepsin b enhancement and methods of use |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| US20230148589A1 (en) * | 2020-03-31 | 2023-05-18 | Lg Chem, Ltd. | Composition for protecting islet transplantation |
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-
2004
- 2004-09-23 WO PCT/IL2004/000890 patent/WO2005027901A1/en not_active Ceased
- 2004-09-23 CA CA002540407A patent/CA2540407A1/en not_active Abandoned
- 2004-09-23 EP EP04770561A patent/EP1663199B1/en not_active Expired - Lifetime
- 2004-09-23 JP JP2006527571A patent/JP4917889B2/ja not_active Expired - Fee Related
-
2006
- 2006-03-23 US US11/386,880 patent/US8372880B2/en not_active Expired - Fee Related
-
2012
- 2012-11-27 US US13/685,919 patent/US20130078233A1/en not_active Abandoned
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