JP2007506442A5 - - Google Patents
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- JP2007506442A5 JP2007506442A5 JP2006533538A JP2006533538A JP2007506442A5 JP 2007506442 A5 JP2007506442 A5 JP 2007506442A5 JP 2006533538 A JP2006533538 A JP 2006533538A JP 2006533538 A JP2006533538 A JP 2006533538A JP 2007506442 A5 JP2007506442 A5 JP 2007506442A5
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- 238000000034 method Methods 0.000 claims 29
- 230000014509 gene expression Effects 0.000 claims 26
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 102100028629 Cytoskeleton-associated protein 4 Human genes 0.000 claims 10
- 101000766853 Homo sapiens Cytoskeleton-associated protein 4 Proteins 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 10
- 239000002157 polynucleotide Substances 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 7
- 229940121647 egfr inhibitor Drugs 0.000 claims 7
- 102100024746 Dihydrofolate reductase Human genes 0.000 claims 6
- 102100037859 G1/S-specific cyclin-D3 Human genes 0.000 claims 6
- 102100033044 Glutathione peroxidase 2 Human genes 0.000 claims 6
- 102100027893 Homeobox protein Nkx-2.1 Human genes 0.000 claims 6
- 101000738559 Homo sapiens G1/S-specific cyclin-D3 Proteins 0.000 claims 6
- 101000871129 Homo sapiens Glutathione peroxidase 2 Proteins 0.000 claims 6
- 108010057966 Thyroid Nuclear Factor 1 Proteins 0.000 claims 6
- 108020001096 dihydrofolate reductase Proteins 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims 5
- 102000004161 Claudin-4 Human genes 0.000 claims 5
- 108090000601 Claudin-4 Proteins 0.000 claims 5
- 102100022334 Dihydropyrimidine dehydrogenase [NADP(+)] Human genes 0.000 claims 5
- 102100037024 E3 ubiquitin-protein ligase XIAP Human genes 0.000 claims 5
- 102100033183 Epithelial membrane protein 1 Human genes 0.000 claims 5
- 102000004961 Furin Human genes 0.000 claims 5
- 108090001126 Furin Proteins 0.000 claims 5
- 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 claims 5
- 101000902632 Homo sapiens Dihydropyrimidine dehydrogenase [NADP(+)] Proteins 0.000 claims 5
- 101000850989 Homo sapiens Epithelial membrane protein 1 Proteins 0.000 claims 5
- 101000645296 Homo sapiens Metalloproteinase inhibitor 2 Proteins 0.000 claims 5
- 101001027925 Homo sapiens Metastasis-associated protein MTA1 Proteins 0.000 claims 5
- 101000585703 Homo sapiens Protein L-Myc Proteins 0.000 claims 5
- 101000712958 Homo sapiens Ras association domain-containing protein 1 Proteins 0.000 claims 5
- 101000652736 Homo sapiens Transgelin Proteins 0.000 claims 5
- 101000851018 Homo sapiens Vascular endothelial growth factor receptor 1 Proteins 0.000 claims 5
- 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 claims 5
- 102100037517 Metastasis-associated protein MTA1 Human genes 0.000 claims 5
- 102100030128 Protein L-Myc Human genes 0.000 claims 5
- 102100033243 Ras association domain-containing protein 1 Human genes 0.000 claims 5
- 101150063267 STAT5B gene Proteins 0.000 claims 5
- 102100024474 Signal transducer and activator of transcription 5B Human genes 0.000 claims 5
- 102100031013 Transgelin Human genes 0.000 claims 5
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims 5
- 108700031544 X-Linked Inhibitor of Apoptosis Proteins 0.000 claims 5
- 238000003752 polymerase chain reaction Methods 0.000 claims 5
- 238000011282 treatment Methods 0.000 claims 5
- 102100031173 CCN family member 4 Human genes 0.000 claims 4
- 102100035139 Folate receptor alpha Human genes 0.000 claims 4
- 101000777560 Homo sapiens CCN family member 4 Proteins 0.000 claims 4
- 101001023230 Homo sapiens Folate receptor alpha Proteins 0.000 claims 4
- 101001044927 Homo sapiens Insulin-like growth factor-binding protein 3 Proteins 0.000 claims 4
- 101000840582 Homo sapiens Insulin-like growth factor-binding protein 6 Proteins 0.000 claims 4
- 101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 claims 4
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 4
- 101000579123 Homo sapiens Phosphoglycerate kinase 1 Proteins 0.000 claims 4
- 102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 claims 4
- 102100029180 Insulin-like growth factor-binding protein 6 Human genes 0.000 claims 4
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 4
- 102100034256 Mucin-1 Human genes 0.000 claims 4
- 101150038994 PDGFRA gene Proteins 0.000 claims 4
- KJWZYMMLVHIVSU-IYCNHOCDSA-N PGK1 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](CCCCCCC(O)=O)C(=O)CC1=O KJWZYMMLVHIVSU-IYCNHOCDSA-N 0.000 claims 4
- 102100028251 Phosphoglycerate kinase 1 Human genes 0.000 claims 4
- 102100021206 60S ribosomal protein L19 Human genes 0.000 claims 3
- 102100025403 Epoxide hydrolase 1 Human genes 0.000 claims 3
- 102100029283 Hepatocyte nuclear factor 3-alpha Human genes 0.000 claims 3
- 101001105789 Homo sapiens 60S ribosomal protein L19 Proteins 0.000 claims 3
- 101001077852 Homo sapiens Epoxide hydrolase 1 Proteins 0.000 claims 3
- 101001062353 Homo sapiens Hepatocyte nuclear factor 3-alpha Proteins 0.000 claims 3
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims 3
- 101000998027 Homo sapiens Keratin, type I cytoskeletal 17 Proteins 0.000 claims 3
- 101001023271 Homo sapiens Laminin subunit gamma-2 Proteins 0.000 claims 3
- 101001116520 Homo sapiens Myotubularin-related protein 11 Proteins 0.000 claims 3
- 101000933173 Homo sapiens Pro-cathepsin H Proteins 0.000 claims 3
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 3
- 101000577877 Homo sapiens Stromelysin-3 Proteins 0.000 claims 3
- 101000904152 Homo sapiens Transcription factor E2F1 Proteins 0.000 claims 3
- 101000742596 Homo sapiens Vascular endothelial growth factor C Proteins 0.000 claims 3
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 3
- 102100033511 Keratin, type I cytoskeletal 17 Human genes 0.000 claims 3
- 102100035159 Laminin subunit gamma-2 Human genes 0.000 claims 3
- 102100024963 Myotubularin-related protein 11 Human genes 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 102000018967 Platelet-Derived Growth Factor beta Receptor Human genes 0.000 claims 3
- 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 claims 3
- 102100025974 Pro-cathepsin H Human genes 0.000 claims 3
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 3
- 102100028847 Stromelysin-3 Human genes 0.000 claims 3
- 102100024026 Transcription factor E2F1 Human genes 0.000 claims 3
- 102100038232 Vascular endothelial growth factor C Human genes 0.000 claims 3
- 238000001574 biopsy Methods 0.000 claims 3
- 102100033824 A-kinase anchor protein 12 Human genes 0.000 claims 2
- 108091093088 Amplicon Proteins 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 101000779382 Homo sapiens A-kinase anchor protein 12 Proteins 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 2
- 238000010195 expression analysis Methods 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
- 238000013188 needle biopsy Methods 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 1
- 102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
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- 201000010536 head and neck cancer Diseases 0.000 claims 1
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- 238000004393 prognosis Methods 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 150000003384 small molecules Chemical group 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000011277 treatment modality Methods 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47490803P | 2003-05-30 | 2003-05-30 | |
| PCT/US2004/017215 WO2004111273A2 (en) | 2003-05-30 | 2004-05-28 | Gene expression markers for response to egfr inhibitor drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007506442A JP2007506442A (ja) | 2007-03-22 |
| JP2007506442A5 true JP2007506442A5 (enExample) | 2007-07-05 |
Family
ID=33551513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533538A Pending JP2007506442A (ja) | 2003-05-30 | 2004-05-28 | Ｅｇｆｒ阻害薬への応答に関する遺伝子発現マーカー |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20050164218A1 (enExample) |
| EP (2) | EP1636380A2 (enExample) |
| JP (1) | JP2007506442A (enExample) |
| AU (2) | AU2004248140A1 (enExample) |
| CA (1) | CA2527321A1 (enExample) |
| WO (1) | WO2004111273A2 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050059012A1 (en) * | 2002-07-31 | 2005-03-17 | Daniel Afar | Diagnosis of ZD1839 resistant tumors |
| US20050267689A1 (en) * | 2003-07-07 | 2005-12-01 | Maxim Tsypin | Method to automatically identify peak and monoisotopic peaks in mass spectral data for biomolecular applications |
| JP4708342B2 (ja) | 2003-07-25 | 2011-06-22 | デックスコム・インコーポレーテッド | 埋設可能な装置に用いる酸素増大膜システム |
| WO2005070020A2 (en) | 2004-01-23 | 2005-08-04 | The Regents Of The University Of Colorado | Gefitinib sensitivity-related gene expression and products and methods related thereto |
| EP2527460B1 (en) * | 2004-05-27 | 2014-12-24 | The Regents of The University of Colorado | Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients |
| EP3042964A1 (en) | 2004-06-04 | 2016-07-13 | Genentech, Inc. | Egfr mutations |
| US8383357B2 (en) | 2005-03-16 | 2013-02-26 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors |
| ATE477495T1 (de) | 2005-03-16 | 2010-08-15 | Osi Pharm Inc | Biologische marker prediktiv für das ansprechen von krebs auf inhibitoren der kinase des rezeptors für epidermalen wachstumsfaktor |
| KR20080014745A (ko) | 2005-04-01 | 2008-02-14 | 암젠 인코포레이티드 | 상피세포 성장인자 수용체 유전자 복제 수 |
| EP2083088A3 (en) * | 2005-04-07 | 2009-10-14 | Novartis Vaccines and Diagnostics, Inc. | Cancer-related genes |
| KR20080003422A (ko) * | 2005-04-14 | 2008-01-07 | 메르크 파텐트 게엠베하 | 종양 조직 내의 ｅｇｆｒ 유전자의 증가된 복제수에 기초한항-ｅｇｆｒ 항체 치료 |
| KR20080026093A (ko) * | 2005-05-04 | 2008-03-24 | 유니버시티 오브 사우스 플로리다 | 암 환자의 치료 반응을 예측하는 방법 |
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| CA2623125A1 (en) | 2005-09-20 | 2007-03-29 | Osi Pharmaceuticals, Inc. | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
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| US20070207467A1 (en) * | 2006-03-01 | 2007-09-06 | Ming Xu | Detection of lymph node metastasis from gastric carcinoma |
| JP2007252312A (ja) * | 2006-03-24 | 2007-10-04 | Japan Health Science Foundation | 上皮成長因子受容体−チロシンキナーゼ阻害剤に対する肺ガンの感度測定方法および肺ガン治療剤のスクリーニング方法 |
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| US8024282B2 (en) * | 2006-03-31 | 2011-09-20 | Biodesix, Inc. | Method for reliable classification of samples in clinical diagnostics using an improved method of classification |
| US7736905B2 (en) | 2006-03-31 | 2010-06-15 | Biodesix, Inc. | Method and system for determining whether a drug will be effective on a patient with a disease |
| US7858390B2 (en) * | 2006-03-31 | 2010-12-28 | Biodesix, Inc. | Selection of colorectal cancer patients for treatment with drugs targeting EGFR pathway |
| US7858389B2 (en) * | 2006-03-31 | 2010-12-28 | Biodesix, Inc. | Selection of non-small-cell lung cancer patients for treatment with monoclonal antibody drugs targeting EGFR pathway |
| US7906342B2 (en) | 2006-03-31 | 2011-03-15 | Biodesix, Inc. | Monitoring treatment of cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples |
| US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| WO2007137187A2 (en) | 2006-05-18 | 2007-11-29 | Molecular Profiling Institute, Inc. | System and method for determining individualized medical intervention for a disease state |
| US20070281305A1 (en) * | 2006-06-05 | 2007-12-06 | Sean Wuxiong Cao | Detection of lymph node metastasis from gastric carcinoma |
| ES2372217T3 (es) * | 2006-09-12 | 2012-01-17 | Genentech, Inc. | Procedimientos y composiciones para el diagnóstico y tratamiento del cáncer de pulmón utilizando el gen de pdgfra, kit o kdr como marcador genético. |
| DK2465950T3 (en) | 2007-03-13 | 2017-10-09 | Amgen Inc | K-RAS MUTATIONS AND ANTI-EGFR ANTIBODY TREATMENT |
| JP5240739B2 (ja) | 2007-04-13 | 2013-07-17 | オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー | キナーゼ阻害剤に対する抗癌応答を予測する生物学的マーカー |
| WO2009023172A2 (en) * | 2007-08-09 | 2009-02-19 | The Johns Hopkins University | Predictions of responsiveness to egfr inhibitors |
| BRPI0815372A2 (pt) * | 2007-08-14 | 2019-09-24 | Hoffmann La Roche | marcador preditivo para o tratamento com inibidor do egfr |
| JP5416107B2 (ja) * | 2007-08-14 | 2014-02-12 | エフ．ホフマン−ラ ロシュ アーゲー | Ｅｇｆｒ阻害剤治療のための予測マーカー |
| EP2179058A2 (en) * | 2007-08-14 | 2010-04-28 | F. Hoffmann-Roche AG | Predictive marker for egfr inhibitor treatment |
| KR20100037638A (ko) * | 2007-08-14 | 2010-04-09 | 에프. 호프만-라 로슈 아게 | Ｅｇｆｒ 억제제를 이용한 치료에 대한 예측 마커 |
| KR101169247B1 (ko) * | 2007-08-14 | 2012-08-03 | 에프. 호프만-라 로슈 아게 | Ｅｇｆｒ 저해제 처리 마커 |
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| WO2010015538A2 (en) * | 2008-08-05 | 2010-02-11 | F. Hoffmann-La Roche Ag | Predictive marker for egfr inhibitor treatment |
| CN106153918A (zh) * | 2008-10-14 | 2016-11-23 | 卡里斯Mpi公司 | 描绘肿瘤类型生物标志模式和特征集的基因靶和基因表达的蛋白靶 |
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| JP2014519813A (ja) | 2011-04-25 | 2014-08-21 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 癌薬剤発見、診断、および治療におけるｅｍｔ遺伝子シグネチャーの使用 |
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- 2004-05-28 US US10/857,715 patent/US20050164218A1/en not_active Abandoned
- 2004-05-28 WO PCT/US2004/017215 patent/WO2004111273A2/en not_active Ceased
- 2004-05-28 AU AU2004248140A patent/AU2004248140A1/en not_active Abandoned
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- 2004-05-28 JP JP2006533538A patent/JP2007506442A/ja active Pending
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2007
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