JP2007505916A5 - - Google Patents
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- Publication number
- JP2007505916A5 JP2007505916A5 JP2006527026A JP2006527026A JP2007505916A5 JP 2007505916 A5 JP2007505916 A5 JP 2007505916A5 JP 2006527026 A JP2006527026 A JP 2006527026A JP 2006527026 A JP2006527026 A JP 2006527026A JP 2007505916 A5 JP2007505916 A5 JP 2007505916A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- alkyl
- halo
- cycloalkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50414603P | 2003-09-19 | 2003-09-19 | |
| US60/504,146 | 2003-09-19 | ||
| PCT/US2004/030375 WO2005042478A2 (en) | 2003-09-19 | 2004-09-16 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007505916A JP2007505916A (ja) | 2007-03-15 |
| JP2007505916A5 true JP2007505916A5 (https=) | 2007-11-08 |
| JP4928941B2 JP4928941B2 (ja) | 2012-05-09 |
Family
ID=34549183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006527026A Expired - Lifetime JP4928941B2 (ja) | 2003-09-19 | 2004-09-16 | ４−（（フェノキシアルキル）チオ）−フェノキシ酢酸および類似化合物 |
Country Status (29)
| Country | Link |
|---|---|
| US (9) | US7301050B2 (https=) |
| EP (2) | EP1667964B1 (https=) |
| JP (1) | JP4928941B2 (https=) |
| KR (1) | KR101111475B1 (https=) |
| CN (1) | CN1882533B (https=) |
| AR (1) | AR045773A1 (https=) |
| AT (1) | ATE542793T1 (https=) |
| AU (1) | AU2004285849B2 (https=) |
| BR (1) | BRPI0414268B8 (https=) |
| CA (1) | CA2539446C (https=) |
| CO (1) | CO5680476A2 (https=) |
| CR (1) | CR8301A (https=) |
| CY (1) | CY1110555T1 (https=) |
| DE (1) | DE602004022179D1 (https=) |
| DK (1) | DK1667964T3 (https=) |
| EA (1) | EA012241B1 (https=) |
| EC (1) | ECSP066434A (https=) |
| ES (2) | ES2378435T3 (https=) |
| IL (1) | IL174398A (https=) |
| NO (2) | NO338511B1 (https=) |
| NZ (1) | NZ545943A (https=) |
| PL (1) | PL1667964T3 (https=) |
| PT (1) | PT1667964E (https=) |
| SG (1) | SG145752A1 (https=) |
| SI (1) | SI1667964T1 (https=) |
| TW (1) | TWI336238B (https=) |
| UA (1) | UA87467C2 (https=) |
| WO (1) | WO2005042478A2 (https=) |
| ZA (1) | ZA200603085B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5016922B2 (ja) * | 2003-09-19 | 2012-09-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ４−（（フェノキシアルキル）チオ）−フェノキシ酢酸および類似化合物 |
| EP1667964B1 (en) | 2003-09-19 | 2009-07-22 | Janssen Pharmaceutica N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| MY145712A (en) * | 2004-09-15 | 2012-03-30 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| UY30288A1 (es) * | 2006-04-18 | 2007-08-31 | Janssen Pharmaceutica Nv | Derivados del ácido benzoazepin-oxi-acético como agonistas de ppar-delta usados para aumentar hdl-c. reducir ldl-c y reducir colesterol |
| JP5694941B2 (ja) | 2008-10-17 | 2015-04-01 | シーマベイ セラピューティクス，インコーポレイティド | 小型高密度ｌｄｌ粒子を減少させる方法 |
| US20150203756A1 (en) * | 2012-07-06 | 2015-07-23 | Merck Patent Gmbh | Bimesogenic compounds and mesogenic media |
| HK1224186A1 (zh) | 2013-11-20 | 2017-08-18 | Cymabay Therapeutics, Inc. | 纯阖家族型高胆固醇血症的治疗 |
| US10272058B2 (en) | 2014-03-20 | 2019-04-30 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| PT3119384T (pt) | 2014-03-20 | 2018-12-12 | Cymabay Therapeutics Inc | Tratamento de doenças colestáticas intra-hepáticas |
| BR112016023269A8 (pt) | 2014-04-11 | 2021-06-29 | Cymabay Therapeutics Inc | uso de ácido (r)-2-(4-((2-etóxi-3-(4-(trifluormetil)fenóxi)propil)-tio)-2-metilfenóxi)-acético ou sal do mesmo na fabricação de um medicamento para tratar doença hepática gordurosa não alcoólica ou esteato-hepatite não alcoólica |
| EA201790091A1 (ru) | 2014-06-26 | 2017-07-31 | Саймабэй Терапьютикс, Инк. | Лечение тяжелой гипертриглицеридемии |
| US10512622B2 (en) | 2017-07-14 | 2019-12-24 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| US20200276178A1 (en) | 2017-09-13 | 2020-09-03 | Novartis Ag | Combinations comprising fxr agonists |
| SMT202200171T1 (it) | 2017-09-26 | 2022-05-12 | Cymabay Therapeutics Inc | Trattamento del prurito colestatico con seladelpar |
| US11497723B1 (en) * | 2017-12-19 | 2022-11-15 | Tony Antakly | PPAR-gamma activators, HDAC inhibitors and their therapeutical usages |
| US10702488B2 (en) * | 2017-12-19 | 2020-07-07 | Theriac Biomedical Inc. | PPAR-γ activators, HDAC inhibitors and their therapeutical usages |
| CA3118965A1 (en) | 2018-11-16 | 2020-05-22 | Cymabay Therapeutics, Inc. | Treatment of obesity and its complications |
| WO2020102337A1 (en) | 2018-11-16 | 2020-05-22 | Cymabay Therapeutics, Inc. | Combination treatment of nafld and nash |
| US20210145774A1 (en) | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Treatment of alcoholic liver disease |
| US20210145775A1 (en) | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Treatment of intestinal barrier dysfunction and associated diseases |
| CN112824380B (zh) * | 2019-11-21 | 2024-11-29 | 杭州百诚医药科技股份有限公司 | α-氟代查耳酮类衍生物及其应用 |
| FI4225291T3 (fi) | 2021-02-01 | 2024-06-03 | Cymabay Therapeutics Inc | Kolangiopatioiden hoito seladelpaarilla |
| CN120500333A (zh) | 2023-01-29 | 2025-08-15 | 西玛贝医药公司 | 尿毒症瘙痒的治疗 |
| KR20250139304A (ko) | 2023-01-29 | 2025-09-23 | 사이머베이 쎄라퓨틱스, 인코퍼레이티드 | 만성 소양증 피부병의 치료 |
| WO2026030533A1 (en) | 2024-07-31 | 2026-02-05 | Cymabay Therapeutics, Inc. | Seladelpar for use in treating liver disease |
| US20260055055A1 (en) * | 2024-07-31 | 2026-02-26 | Cymabay Therapeutics, Inc. | Process for making seladelpar |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3517051A (en) * | 1964-03-20 | 1970-06-23 | Merck & Co Inc | Phenoxy substituted phenylacetic acids |
| US4144351A (en) * | 1974-12-20 | 1979-03-13 | Klinge Pharma Gmbh & Co. | Substituted propanol-(2) derivatives and their preparation and use as hypolipemic drugs |
| DE2460689C3 (de) * | 1974-12-20 | 1980-06-26 | Klinge Pharma Gmbh & Co, 8000 Muenchen | 13-disubstituierte Propanol-(2)-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US4125732A (en) | 1977-05-06 | 1978-11-14 | American Cyanamid Company | 2-Aryloxy-2-(phenoxyalkoxy)phenyl acetic acid and esters |
| DE3026924A1 (de) | 1980-07-16 | 1982-02-18 | Klinge Pharma GmbH & Co, 8000 München | 1,3-diphenoxypropan-2-ol-derivate sowie verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| DE3028776A1 (de) | 1980-07-29 | 1982-02-25 | Klinge Pharma GmbH & Co, 8000 München | Neue 1,3-diphenoxypropan-2-on-derivate sowie verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| EP0056172B1 (en) * | 1981-01-09 | 1985-04-03 | FISONS plc | Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them |
| JPS58177934A (ja) * | 1982-04-13 | 1983-10-18 | Takeda Chem Ind Ltd | ベンゾキノン誘導体 |
| EP0106565B1 (en) | 1982-09-30 | 1986-09-10 | Merck Frosst Canada Inc. | Leukotriene antagonists, their production, and compositions containing them |
| US4820867A (en) * | 1983-04-21 | 1989-04-11 | Merck Frosst Canada, Inc. | Phenoxypropoxy halophenylacetic acids as leukotriene antagonists |
| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| JPS61268651A (ja) * | 1985-05-23 | 1986-11-28 | Takeda Chem Ind Ltd | フエニル酢酸誘導体およびその製造法 |
| EP0204349A3 (de) | 1985-06-01 | 1990-01-03 | Dr. Karl Thomae GmbH | Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| JPH0714910B2 (ja) | 1988-12-13 | 1995-02-22 | 塩野義製薬株式会社 | 安定な結晶性の塩およびそれを含有するトロンボキサン受容体拮抗剤 |
| US5487008A (en) | 1990-04-20 | 1996-01-23 | The Regents Of The University Of Michigan | Method and system for detecting the misfire of a reciprocating internal combustion engine in frequency domain |
| CA2092152A1 (en) | 1992-03-23 | 1993-09-24 | Azuma Igarashi | Phenoxyacetic acid compounds and medical preparations containing them |
| US5726165A (en) * | 1994-07-29 | 1998-03-10 | Smithkline Beecham P.L.C. | Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic acid and pharmaceutical and veterinary uses therefor |
| EP1011651B1 (en) * | 1996-02-02 | 2005-04-27 | Merck & Co., Inc. | Method of treating diabetes and related disease states |
| EP0888278B1 (en) | 1996-02-02 | 2003-07-23 | Merck & Co., Inc. | Antidiabetic agents |
| JP3268242B2 (ja) | 1996-11-14 | 2002-03-25 | 三共株式会社 | 縮合複素環化合物を含有する医薬 |
| AU8355998A (en) | 1997-07-24 | 1999-02-16 | Yamanouchi Pharmaceutical Co., Ltd. | Medicinal compositions with cholesterol-lowering effect |
| CA2315397C (en) * | 1997-12-19 | 2007-08-07 | Merck & Co., Inc. | Arylthiazolidinedione derivatives |
| KR20020005703A (ko) | 1999-04-20 | 2002-01-17 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 신규한 화합물, 그의 제법 및 용도 |
| DE60029446T2 (de) * | 1999-06-18 | 2007-02-08 | Merck & Co., Inc. | Arylthiazolidindione und aryloxazolidindion-derivate |
| GB9914977D0 (en) | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| GB0003310D0 (en) * | 2000-02-15 | 2000-04-05 | Univ Sheffield | Bone formation |
| GB0031107D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| MXPA03011201A (es) | 2001-06-07 | 2004-02-26 | Lilly Co Eli | Moduladores de receptores activados por proliferadores de persoxisomas. |
| BR0211414A (pt) | 2001-07-30 | 2004-08-17 | Novo Nordisk As | Composto, uso do mesmo, composição farmacêutica, e, métodos para o tratamento e/ou prevenção de condições mediadas pelos receptores nucleares e de diabetes tipo i, diabetes tipo ii, tolerância à glicose, resistência à insulina ou obesidade prejudicadas |
| AU2002323776B2 (en) | 2001-08-10 | 2008-07-31 | Nippon Chemiphar Co., Ltd. | Activator for peroxisome proliferator-responsive receptor Delta |
| MXPA04003398A (es) | 2001-10-12 | 2004-11-22 | Nippon Chemiphar Co | Activador para el receptor o activado con el proliferador de peroxisoma. |
| ITRM20020014A1 (it) | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del |
| US7319104B2 (en) * | 2002-03-01 | 2008-01-15 | Smithkline Beecham Corporation | hPPARs activators |
| US6875780B2 (en) | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| GB0214149D0 (en) | 2002-06-19 | 2002-07-31 | Glaxo Group Ltd | Chemical compounds |
| CA2499380A1 (en) | 2002-09-05 | 2004-03-18 | Novo Nordisk A/S | Novel vinyl carboxylic acid derivatives and their therapeutical use |
| AU2003273783C1 (en) | 2002-10-28 | 2010-08-12 | Vtv Therapeutics Llc | Novel compounds and their use as PPAR-modulators |
| JP4584714B2 (ja) | 2002-10-28 | 2010-11-24 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 新規化合物、その調製および使用 |
| JP2006517802A (ja) | 2003-02-14 | 2006-08-03 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 外来性分子の一過性の発現もしくは安定な発現のための発現カセットおよび発現ベクター |
| JP2007502815A (ja) * | 2003-08-20 | 2007-02-15 | イーライ リリー アンド カンパニー | Ｐｐａｒ調節因子 |
| EP1667964B1 (en) * | 2003-09-19 | 2009-07-22 | Janssen Pharmaceutica N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| JP5016922B2 (ja) * | 2003-09-19 | 2012-09-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ４−（（フェノキシアルキル）チオ）−フェノキシ酢酸および類似化合物 |
| CN1897939A (zh) | 2003-10-31 | 2007-01-17 | 詹森药业有限公司 | 适用作过氧化物酶体增生物激活受体（ppar）双重激动剂的苯氧基乙酸衍生物 |
| EP1745047B1 (en) | 2004-04-21 | 2010-03-24 | Schering Corporation | Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine adenosine-a2a- receptor antagonists |
| JP4568329B2 (ja) | 2004-07-01 | 2010-10-27 | エフ．ホフマン−ラ ロシュ アーゲー | アセチレン基を含むフェニル誘導体 |
| MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| MY145712A (en) * | 2004-09-15 | 2012-03-30 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| PE20060664A1 (es) | 2004-09-15 | 2006-08-04 | Novartis Ag | Amidas biciclicas como inhibidores de cinasa |
| JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| GB0618963D0 (en) | 2006-09-26 | 2006-11-08 | Ucl Business Plc | Formulations and composites with reactive fillers |
-
2004
- 2004-09-16 EP EP04816875A patent/EP1667964B1/en not_active Expired - Lifetime
- 2004-09-16 NZ NZ545943A patent/NZ545943A/en not_active IP Right Cessation
- 2004-09-16 PT PT04816875T patent/PT1667964E/pt unknown
- 2004-09-16 ES ES09075188T patent/ES2378435T3/es not_active Expired - Lifetime
- 2004-09-16 DK DK04816875T patent/DK1667964T3/da active
- 2004-09-16 SI SI200431248T patent/SI1667964T1/sl unknown
- 2004-09-16 UA UAA200603107A patent/UA87467C2/ru unknown
- 2004-09-16 DE DE602004022179T patent/DE602004022179D1/de not_active Expired - Lifetime
- 2004-09-16 AT AT09075188T patent/ATE542793T1/de active
- 2004-09-16 WO PCT/US2004/030375 patent/WO2005042478A2/en not_active Ceased
- 2004-09-16 EA EA200600440A patent/EA012241B1/ru unknown
- 2004-09-16 ES ES04816875T patent/ES2328581T3/es not_active Expired - Lifetime
- 2004-09-16 EP EP09075188A patent/EP2100877B1/en not_active Expired - Lifetime
- 2004-09-16 SG SG200806114-5A patent/SG145752A1/en unknown
- 2004-09-16 KR KR1020067007358A patent/KR101111475B1/ko not_active Expired - Lifetime
- 2004-09-16 BR BRPI0414268A patent/BRPI0414268B8/pt active IP Right Grant
- 2004-09-16 JP JP2006527026A patent/JP4928941B2/ja not_active Expired - Lifetime
- 2004-09-16 AU AU2004285849A patent/AU2004285849B2/en not_active Expired
- 2004-09-16 PL PL04816875T patent/PL1667964T3/pl unknown
- 2004-09-16 CN CN2004800335902A patent/CN1882533B/zh not_active Expired - Lifetime
- 2004-09-16 CA CA2539446A patent/CA2539446C/en not_active Expired - Lifetime
- 2004-09-16 US US10/942,478 patent/US7301050B2/en not_active Expired - Lifetime
- 2004-09-17 TW TW093128361A patent/TWI336238B/zh not_active IP Right Cessation
- 2004-09-20 AR ARP040103376A patent/AR045773A1/es active IP Right Grant
-
2006
- 2006-03-17 EC EC2006006434A patent/ECSP066434A/es unknown
- 2006-03-17 CR CR8301A patent/CR8301A/es not_active Application Discontinuation
- 2006-03-19 IL IL174398A patent/IL174398A/en active IP Right Grant
- 2006-03-30 CO CO06031466A patent/CO5680476A2/es active IP Right Grant
- 2006-04-18 ZA ZA200603085A patent/ZA200603085B/en unknown
- 2006-04-19 NO NO20061728A patent/NO338511B1/no unknown
-
2007
- 2007-10-15 US US11/872,417 patent/US7635718B2/en not_active Expired - Lifetime
-
2009
- 2009-10-20 CY CY20091101087T patent/CY1110555T1/el unknown
- 2009-11-23 US US12/623,824 patent/US8106095B2/en not_active Expired - Lifetime
-
2011
- 2011-12-21 US US13/332,453 patent/US8518997B2/en not_active Expired - Fee Related
-
2013
- 2013-08-14 US US13/966,493 patent/US20130331453A1/en not_active Abandoned
-
2015
- 2015-04-15 NO NO20150447A patent/NO341448B1/no unknown
-
2016
- 2016-03-18 US US15/074,125 patent/US9724322B2/en not_active Expired - Fee Related
-
2017
- 2017-07-10 US US15/644,993 patent/US20170304254A1/en not_active Abandoned
-
2019
- 2019-03-05 US US16/292,406 patent/US20190192475A1/en not_active Abandoned
-
2023
- 2023-03-13 US US18/120,484 patent/US20230210808A1/en active Pending