JP2005538089A5 - - Google Patents
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- Publication number
- JP2005538089A5 JP2005538089A5 JP2004522648A JP2004522648A JP2005538089A5 JP 2005538089 A5 JP2005538089 A5 JP 2005538089A5 JP 2004522648 A JP2004522648 A JP 2004522648A JP 2004522648 A JP2004522648 A JP 2004522648A JP 2005538089 A5 JP2005538089 A5 JP 2005538089A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- methyl
- acid addition
- addition salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 239000002253 acid Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- -1 chloro, methyl Chemical group 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39786902P | 2002-07-22 | 2002-07-22 | |
| US45023303P | 2003-02-25 | 2003-02-25 | |
| PCT/IB2003/003349 WO2004009086A1 (en) | 2002-07-22 | 2003-07-16 | Selective estrogen receptor modulators containing a phenylsulfonyl group |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010109009A Division JP5220800B2 (ja) | 2002-07-22 | 2010-05-11 | フェニルスルホニル基を含む選択的エストロゲン受容体モジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005538089A JP2005538089A (ja) | 2005-12-15 |
| JP2005538089A5 true JP2005538089A5 (https=) | 2007-08-16 |
| JP4656939B2 JP4656939B2 (ja) | 2011-03-23 |
Family
ID=30773044
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004522648A Expired - Fee Related JP4656939B2 (ja) | 2002-07-22 | 2003-07-16 | フェニルスルホニル基を含む選択的エストロゲン受容体モジュレーター |
| JP2010109009A Expired - Fee Related JP5220800B2 (ja) | 2002-07-22 | 2010-05-11 | フェニルスルホニル基を含む選択的エストロゲン受容体モジュレーター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010109009A Expired - Fee Related JP5220800B2 (ja) | 2002-07-22 | 2010-05-11 | フェニルスルホニル基を含む選択的エストロゲン受容体モジュレーター |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7399867B2 (https=) |
| EP (1) | EP1530470B9 (https=) |
| JP (2) | JP4656939B2 (https=) |
| CN (1) | CN1668303B (https=) |
| AT (1) | ATE433322T1 (https=) |
| AU (1) | AU2003253129B2 (https=) |
| BR (1) | BR0312675A (https=) |
| CA (1) | CA2490580C (https=) |
| CO (1) | CO5680445A2 (https=) |
| CR (1) | CR7657A (https=) |
| DE (1) | DE60327931D1 (https=) |
| EA (1) | EA008024B1 (https=) |
| EC (1) | ECSP055549A (https=) |
| ES (1) | ES2326593T3 (https=) |
| HR (1) | HRP20041233A2 (https=) |
| IL (1) | IL165745A0 (https=) |
| MX (1) | MXPA05000898A (https=) |
| MY (1) | MY141879A (https=) |
| NO (1) | NO20050832L (https=) |
| NZ (1) | NZ537138A (https=) |
| PE (1) | PE20040678A1 (https=) |
| PL (1) | PL374845A1 (https=) |
| TW (1) | TWI314860B (https=) |
| WO (1) | WO2004009086A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE433322T1 (de) * | 2002-07-22 | 2009-06-15 | Lilly Co Eli | Selektive östrogenrezeptor modulatoren, die eine phenylsulfonyl-gruppe enthalten |
| HRP20050675A2 (en) * | 2003-02-25 | 2005-10-31 | Eli Lilly And Company | Crystalline non-solavated 1-(4-(2-piperidinylethoxy)phenoxy)-2-(4-methanesulfonylphenyl)-6-hydroxynaphthalene hydrochloride |
| CN100348192C (zh) * | 2003-02-25 | 2007-11-14 | 伊莱利利公司 | 晶状的非溶剂化1－(4－(2－哌啶基乙氧基)苯氧基)－2－(4－甲磺酰基苯基)－6－羟基萘盐酸化物 |
| EP1709021B1 (en) * | 2004-01-22 | 2010-08-04 | Eli Lilly And Company | Selective estrogen receptor modulators for the treatment of vasomotor symptoms |
| ATE448215T1 (de) * | 2004-01-22 | 2009-11-15 | Lilly Co Eli | Selektive östrogen-rezeptor-modulatoren |
| CN1910167B (zh) * | 2004-01-22 | 2011-08-10 | 伊莱利利公司 | 用于治疗血管舒缩症状的选择性雌激素受体调节剂 |
| EP1713770A1 (en) * | 2004-01-29 | 2006-10-25 | Eli Lilly And Company | Selective estrogen receptor modulators |
| CA2571309A1 (en) * | 2004-06-22 | 2006-01-05 | Smithkline Beecham Corporation | Chemical compounds |
| CA2617146A1 (en) * | 2005-07-29 | 2007-02-08 | Eli Lilly And Company | Crystalline non-solvated methanesulfonic acid salt of 1-(4-(2-piperidinylethoxy)phenoxy)-2-(3-hydroxyphenyl)-6-hydroxynaphthalene |
| EA020742B1 (ru) * | 2008-09-29 | 2015-01-30 | Эли Лилли Энд Компани | Селективный модулятор рецепторов эстрогена |
| DE102008057230A1 (de) * | 2008-11-11 | 2010-05-12 | Bayer Schering Pharma Aktiengesellschaft | Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin |
| US20110319379A1 (en) | 2009-03-11 | 2011-12-29 | Corbett Jeffrey W | Substituted Indazole Amides And Their Use As Glucokinase Activators |
| KR20200144591A (ko) | 2010-06-16 | 2020-12-29 | 앙도르쉐르슈 인코포레이티드 | 에스트로겐-관련 질병의 치료 또는 예방 방법 |
| JP6292744B2 (ja) * | 2012-09-19 | 2018-03-14 | 富士カプセル株式会社 | 医薬品組成物 |
| BR112015018882B1 (pt) | 2013-02-19 | 2021-09-14 | Novartis Ag | Derivados de benzotiofeno e composições dos mesmos como degradadores de receptor de estrogênio seletivo |
| WO2020182649A1 (en) | 2019-03-08 | 2020-09-17 | Syngenta Crop Protection Ag | Pesticidally active azole-amide compounds |
| BR112021018501A2 (pt) | 2019-03-20 | 2021-11-30 | Syngenta Crop Protection Ag | Compostos de azolamida ativos em termos pesticidas |
| CN113597426A (zh) | 2019-03-22 | 2021-11-02 | 先正达农作物保护股份公司 | N-[1-(5-溴-2-嘧啶-2-基-1,2,4-三唑-3-基)乙基]-2-环丙基-6-(三氟甲基)吡啶-4-甲酰胺衍生物及相关的化合物作为杀昆虫剂 |
| TWI853009B (zh) | 2019-03-29 | 2024-08-21 | 瑞士商先正達農作物保護公司 | 殺有害生物活性之二-醯胺化合物 |
| JP7611848B2 (ja) | 2019-04-05 | 2025-01-10 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物的に活性なジアジン－アミド化合物 |
| BR112022003375A2 (pt) | 2019-08-23 | 2022-05-17 | Syngenta Crop Protection Ag | Compostos de pirazina-amida pesticidamente ativos |
| CN110526881B (zh) * | 2019-08-27 | 2020-09-22 | 河南省锐达医药科技有限公司 | 一种萘胺类化合物及其生物学可接受的盐，其制备方法和应用 |
| JP2023515979A (ja) | 2020-02-27 | 2023-04-17 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物的に活性なジアジン－ビスアミド化合物 |
| WO2022237904A1 (zh) * | 2021-05-14 | 2022-11-17 | 江苏亚虹医药科技股份有限公司 | 一种含萘环的化合物、含其的药物组合物及其应用 |
| JP2024524883A (ja) | 2021-06-09 | 2024-07-09 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物的に活性なジアジン－アミド化合物 |
| US20240208950A1 (en) * | 2021-07-07 | 2024-06-27 | South Dakota Board Of Regents | Compositions and methods for treatment of cervical and ovarian cancer |
| CN119768396A (zh) | 2022-08-25 | 2025-04-04 | 赛诺菲 | 新颖的取代的苯并噻吩-6-羧酸衍生物、其制备方法及其治疗用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| CA2135160A1 (en) | 1992-05-08 | 1993-11-25 | Otsuka Pharmaceutical Factory, Inc. | Indole derivative |
| US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US6399634B1 (en) * | 1994-09-20 | 2002-06-04 | Eli Lilly And Company | Benzothiophene compounds, compositions, and methods |
| US7501441B1 (en) * | 1994-09-20 | 2009-03-10 | Eli Lilly And Company | Naphthyl compounds, intermediates, processes, compositions, and methods |
| US5552412A (en) | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| US5998401A (en) * | 1995-02-28 | 1999-12-07 | Eli Lilly And Company | Naphthyl compounds, intermediates, compositions, and methods |
| UA44710C2 (uk) | 1995-02-28 | 2002-03-15 | Елі Ліллі Енд Компані | Похідні бензотіофену, спосіб їх одержання (варіанти), проміжні сполуки, фармацевтична композиція |
| US5599822A (en) | 1995-06-06 | 1997-02-04 | Eli Lilly And Company | Methods for minimizing bone loss |
| CA2236007A1 (en) * | 1995-10-31 | 1997-07-17 | Gerald Floyd Smith | Antithrombotic diamines |
| PT791591E (pt) * | 1996-02-22 | 2001-12-28 | Lilly Co Eli | Benzotiofenos, formulacoes que os contem e metodos |
| DE69707189T2 (de) | 1996-04-19 | 2002-06-20 | American Home Products Corp., Madison | Östrogene Verbindungen |
| CA2213810C (en) | 1996-08-29 | 2006-06-06 | Lewis Dale Pennington | Benzo¬b|thiophene compounds, intermediates, processes, compositions and methods |
| ID19392A (id) | 1996-08-29 | 1998-07-09 | Lilly Co Eli | Senyawa naftil dan bahan pertengahan serta komposisi dan metode penggunaan |
| CA2214070C (en) | 1996-08-29 | 2006-03-14 | Eli Lilly And Company | Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods |
| CA2213814A1 (en) | 1996-08-29 | 1998-02-28 | Henry Uhlman Bryant | Naphthalene compounds, intermediates, formulations, and methods |
| CA2217810A1 (en) | 1996-10-10 | 1998-04-10 | Eli Lilly And Company | 2-aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods |
| CA2218756A1 (en) | 1996-10-25 | 1998-04-25 | Kristin Sue Marron | Substituted benzo¢b!thiophene compounds having activity as selective estrogen receptor modulators |
| ATE433322T1 (de) * | 2002-07-22 | 2009-06-15 | Lilly Co Eli | Selektive östrogenrezeptor modulatoren, die eine phenylsulfonyl-gruppe enthalten |
-
2003
- 2003-07-16 AT AT03765254T patent/ATE433322T1/de not_active IP Right Cessation
- 2003-07-16 JP JP2004522648A patent/JP4656939B2/ja not_active Expired - Fee Related
- 2003-07-16 ES ES03765254T patent/ES2326593T3/es not_active Expired - Lifetime
- 2003-07-16 HR HR20041233A patent/HRP20041233A2/hr not_active Application Discontinuation
- 2003-07-16 WO PCT/IB2003/003349 patent/WO2004009086A1/en not_active Ceased
- 2003-07-16 US US10/521,896 patent/US7399867B2/en not_active Expired - Fee Related
- 2003-07-16 PL PL03374845A patent/PL374845A1/xx unknown
- 2003-07-16 CN CN038172011A patent/CN1668303B/zh not_active Expired - Fee Related
- 2003-07-16 NZ NZ537138A patent/NZ537138A/en not_active IP Right Cessation
- 2003-07-16 EA EA200500248A patent/EA008024B1/ru not_active IP Right Cessation
- 2003-07-16 BR BR0312675-7A patent/BR0312675A/pt not_active IP Right Cessation
- 2003-07-16 EP EP03765254A patent/EP1530470B9/en not_active Expired - Lifetime
- 2003-07-16 AU AU2003253129A patent/AU2003253129B2/en not_active Ceased
- 2003-07-16 MX MXPA05000898A patent/MXPA05000898A/es active IP Right Grant
- 2003-07-16 DE DE60327931T patent/DE60327931D1/de not_active Expired - Lifetime
- 2003-07-16 CA CA2490580A patent/CA2490580C/en not_active Expired - Fee Related
- 2003-07-18 TW TW092119725A patent/TWI314860B/zh not_active IP Right Cessation
- 2003-07-18 PE PE2003000717A patent/PE20040678A1/es not_active Application Discontinuation
- 2003-07-18 MY MYPI20032711A patent/MY141879A/en unknown
-
2004
- 2004-12-13 IL IL16574504A patent/IL165745A0/xx unknown
-
2005
- 2005-01-18 CR CR7657A patent/CR7657A/es unknown
- 2005-01-19 EC EC2005005549A patent/ECSP055549A/es unknown
- 2005-01-20 CO CO05004232A patent/CO5680445A2/es not_active Application Discontinuation
- 2005-02-16 NO NO20050832A patent/NO20050832L/no not_active Application Discontinuation
-
2008
- 2008-04-09 US US12/100,093 patent/US7585977B2/en not_active Expired - Fee Related
-
2010
- 2010-05-11 JP JP2010109009A patent/JP5220800B2/ja not_active Expired - Fee Related