IL165745A0 - Selective estrogen receptor modulators containing a phenylsulfonyl group - Google Patents
Selective estrogen receptor modulators containing a phenylsulfonyl groupInfo
- Publication number
- IL165745A0 IL165745A0 IL16574504A IL16574504A IL165745A0 IL 165745 A0 IL165745 A0 IL 165745A0 IL 16574504 A IL16574504 A IL 16574504A IL 16574504 A IL16574504 A IL 16574504A IL 165745 A0 IL165745 A0 IL 165745A0
- Authority
- IL
- Israel
- Prior art keywords
- estrogen receptor
- selective estrogen
- receptor modulators
- phenylsulfonyl group
- modulators containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39786902P | 2002-07-22 | 2002-07-22 | |
| US45023303P | 2003-02-25 | 2003-02-25 | |
| PCT/IB2003/003349 WO2004009086A1 (en) | 2002-07-22 | 2003-07-16 | Selective estrogen receptor modulators containing a phenylsulfonyl group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL165745A0 true IL165745A0 (en) | 2006-01-15 |
Family
ID=30773044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16574504A IL165745A0 (en) | 2002-07-22 | 2004-12-13 | Selective estrogen receptor modulators containing a phenylsulfonyl group |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7399867B2 (xx) |
| EP (1) | EP1530470B9 (xx) |
| JP (2) | JP4656939B2 (xx) |
| CN (1) | CN1668303B (xx) |
| AT (1) | ATE433322T1 (xx) |
| AU (1) | AU2003253129B2 (xx) |
| BR (1) | BR0312675A (xx) |
| CA (1) | CA2490580C (xx) |
| CO (1) | CO5680445A2 (xx) |
| CR (1) | CR7657A (xx) |
| DE (1) | DE60327931D1 (xx) |
| EA (1) | EA008024B1 (xx) |
| EC (1) | ECSP055549A (xx) |
| ES (1) | ES2326593T3 (xx) |
| HK (1) | HK1078003A1 (xx) |
| HR (1) | HRP20041233A2 (xx) |
| IL (1) | IL165745A0 (xx) |
| MX (1) | MXPA05000898A (xx) |
| MY (1) | MY141879A (xx) |
| NO (1) | NO20050832L (xx) |
| NZ (1) | NZ537138A (xx) |
| PE (1) | PE20040678A1 (xx) |
| PL (1) | PL374845A1 (xx) |
| TW (1) | TWI314860B (xx) |
| WO (1) | WO2004009086A1 (xx) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4656939B2 (ja) * | 2002-07-22 | 2011-03-23 | イーライ リリー アンド カンパニー | フェニルスルホニル基を含む選択的エストロゲン受容体モジュレーター |
| CA2512663A1 (en) * | 2003-02-25 | 2004-09-10 | Eli Lilly And Company | Crystalline non-solvated 1-(4-(2-piperidinylethoxy)phenoxy)-2-(4-methanesulfonylphenyl)-6-hydroxynaphthalene hydrochloride |
| KR100693242B1 (ko) * | 2003-02-25 | 2007-03-12 | 일라이 릴리 앤드 캄파니 | 결정성 비-용매화1-(4-(2-피페리디닐에톡시)페녹시)-2-(4-메탄술포닐페닐)-6-하이드록시나프탈렌 하이드로클로라이드 |
| DE602005022673D1 (de) * | 2004-01-22 | 2010-09-16 | Lilly Co Eli | Selektive modulatoren des östrogenrezeptors zur behandlung von vasomotorischen symptomen |
| CN1910167B (zh) * | 2004-01-22 | 2011-08-10 | 伊莱利利公司 | 用于治疗血管舒缩症状的选择性雌激素受体调节剂 |
| EP1709023B1 (en) * | 2004-01-22 | 2009-11-11 | Eli Lilly And Company | Selective estrogen receptor modulators |
| WO2005073190A1 (en) * | 2004-01-29 | 2005-08-11 | Eli Lilly And Company | Selective estrogen receptor modulators |
| CN101006042A (zh) * | 2004-06-22 | 2007-07-25 | 史密丝克莱恩比彻姆公司 | 化合物 |
| CA2617146A1 (en) * | 2005-07-29 | 2007-02-08 | Eli Lilly And Company | Crystalline non-solvated methanesulfonic acid salt of 1-(4-(2-piperidinylethoxy)phenoxy)-2-(3-hydroxyphenyl)-6-hydroxynaphthalene |
| KR101319675B1 (ko) * | 2008-09-29 | 2013-10-22 | 일라이 릴리 앤드 캄파니 | 골관절염의 치료를 위한 선택적 에스트로겐 수용체 조절자 |
| DE102008057230A1 (de) * | 2008-11-11 | 2010-05-12 | Bayer Schering Pharma Aktiengesellschaft | Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin |
| WO2010103438A1 (en) | 2009-03-11 | 2010-09-16 | Pfizer Inc. | Substituted indazole amides and their use as glucokinase activators |
| KR20220061258A (ko) | 2010-06-16 | 2022-05-12 | 앙도르쉐르슈 인코포레이티드 | 에스트로겐-관련 질병의 치료 또는 예방 방법 |
| JP6292744B2 (ja) * | 2012-09-19 | 2018-03-14 | 富士カプセル株式会社 | 医薬品組成物 |
| BR112015018882B1 (pt) | 2013-02-19 | 2021-09-14 | Novartis Ag | Derivados de benzotiofeno e composições dos mesmos como degradadores de receptor de estrogênio seletivo |
| JP2022523434A (ja) | 2019-03-08 | 2022-04-22 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物的に活性なアゾール－アミド化合物 |
| WO2020188027A1 (en) | 2019-03-20 | 2020-09-24 | Syngenta Crop Protection Ag | Pesticidally active azole amide compounds |
| JP2022525809A (ja) | 2019-03-22 | 2022-05-19 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺虫剤としてのｎ－［１－（５－ブロモ－２－ピリミジン－２－イル－１，２，４－トリアゾール－３－イル）エチル］－２－シクロプロピル－６－（トリフルオロメチル）ピリジン－４－カルボキサミド誘導体及び関連化合物 |
| TW202102489A (zh) | 2019-03-29 | 2021-01-16 | 瑞士商先正達農作物保護公司 | 殺有害生物活性之二𠯤-醯胺化合物 |
| CN113661165A (zh) | 2019-04-05 | 2021-11-16 | 先正达农作物保护股份公司 | 杀有害生物活性的二嗪-酰胺化合物 |
| WO2021037614A1 (en) | 2019-08-23 | 2021-03-04 | Syngenta Crop Protection Ag | Pesticidally active pyrazine-amide compounds |
| CN110526881B (zh) * | 2019-08-27 | 2020-09-22 | 河南省锐达医药科技有限公司 | 一种萘胺类化合物及其生物学可接受的盐，其制备方法和应用 |
| BR112022017093A2 (pt) | 2020-02-27 | 2023-02-14 | Syngenta Crop Protection Ag | Compostos de diazina-bisamida ativos em termos pesticidas |
| CN117279884A (zh) * | 2021-05-14 | 2023-12-22 | 江苏亚虹医药科技股份有限公司 | 一种含萘环的化合物、含其的药物组合物及其应用 |
| WO2022258481A1 (en) | 2021-06-09 | 2022-12-15 | Syngenta Crop Protection Ag | Pesticidally active diazine-amide compounds |
| WO2023283315A1 (en) * | 2021-07-07 | 2023-01-12 | South Dakota Board Of Regents | Compositions and methods for treatment of cervical and ovarian cancer |
| WO2024042187A1 (en) | 2022-08-25 | 2024-02-29 | Sanofi | Novel substituted benzothiophene-6-carboxylic acid derivatives, processes for their preparation and therapeutic uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| WO1993023374A1 (en) | 1992-05-08 | 1993-11-25 | Otsuka Pharmaceutical Factory, Inc. | Indole derivative |
| US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US6399634B1 (en) * | 1994-09-20 | 2002-06-04 | Eli Lilly And Company | Benzothiophene compounds, compositions, and methods |
| US7501441B1 (en) * | 1994-09-20 | 2009-03-10 | Eli Lilly And Company | Naphthyl compounds, intermediates, processes, compositions, and methods |
| US5552412A (en) | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| US5998401A (en) * | 1995-02-28 | 1999-12-07 | Eli Lilly And Company | Naphthyl compounds, intermediates, compositions, and methods |
| PE44597A1 (es) | 1995-02-28 | 1997-10-13 | Lilly Co Eli | Compuestos de benzotiofeno, productos intermedios, composiciones y procedimientos |
| US5599822A (en) | 1995-06-06 | 1997-02-04 | Eli Lilly And Company | Methods for minimizing bone loss |
| DE69634045T2 (de) * | 1995-10-31 | 2005-05-19 | Eli Lilly And Co., Indianapolis | Antithrombotische diamine |
| IL125863A (en) * | 1996-02-22 | 2000-10-31 | Lilly Co Eli | Benzothiophenes and formulations containing same |
| ATE206701T1 (de) | 1996-04-19 | 2001-10-15 | American Home Prod | Östrogene verbindungen |
| CA2214070C (en) | 1996-08-29 | 2006-03-14 | Eli Lilly And Company | Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods |
| CA2213814A1 (en) | 1996-08-29 | 1998-02-28 | Henry Uhlman Bryant | Naphthalene compounds, intermediates, formulations, and methods |
| CA2213810C (en) | 1996-08-29 | 2006-06-06 | Lewis Dale Pennington | Benzo¬b|thiophene compounds, intermediates, processes, compositions and methods |
| ID19392A (id) | 1996-08-29 | 1998-07-09 | Lilly Co Eli | Senyawa naftil dan bahan pertengahan serta komposisi dan metode penggunaan |
| CA2217810A1 (en) | 1996-10-10 | 1998-04-10 | Eli Lilly And Company | 2-aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods |
| CA2218756A1 (en) | 1996-10-25 | 1998-04-25 | Kristin Sue Marron | Substituted benzo¢b!thiophene compounds having activity as selective estrogen receptor modulators |
| JP4656939B2 (ja) * | 2002-07-22 | 2011-03-23 | イーライ リリー アンド カンパニー | フェニルスルホニル基を含む選択的エストロゲン受容体モジュレーター |
-
2003
- 2003-07-16 JP JP2004522648A patent/JP4656939B2/ja not_active Expired - Fee Related
- 2003-07-16 DE DE60327931T patent/DE60327931D1/de not_active Expired - Lifetime
- 2003-07-16 EP EP03765254A patent/EP1530470B9/en not_active Expired - Lifetime
- 2003-07-16 AT AT03765254T patent/ATE433322T1/de not_active IP Right Cessation
- 2003-07-16 ES ES03765254T patent/ES2326593T3/es not_active Expired - Lifetime
- 2003-07-16 US US10/521,896 patent/US7399867B2/en not_active Expired - Fee Related
- 2003-07-16 NZ NZ537138A patent/NZ537138A/en not_active IP Right Cessation
- 2003-07-16 MX MXPA05000898A patent/MXPA05000898A/es active IP Right Grant
- 2003-07-16 WO PCT/IB2003/003349 patent/WO2004009086A1/en active Application Filing
- 2003-07-16 CN CN038172011A patent/CN1668303B/zh not_active Expired - Fee Related
- 2003-07-16 AU AU2003253129A patent/AU2003253129B2/en not_active Ceased
- 2003-07-16 EA EA200500248A patent/EA008024B1/ru not_active IP Right Cessation
- 2003-07-16 CA CA2490580A patent/CA2490580C/en not_active Expired - Fee Related
- 2003-07-16 PL PL03374845A patent/PL374845A1/xx unknown
- 2003-07-16 BR BR0312675-7A patent/BR0312675A/pt not_active IP Right Cessation
- 2003-07-18 TW TW092119725A patent/TWI314860B/zh not_active IP Right Cessation
- 2003-07-18 PE PE2003000717A patent/PE20040678A1/es not_active Application Discontinuation
- 2003-07-18 MY MYPI20032711A patent/MY141879A/en unknown
-
2004
- 2004-12-13 IL IL16574504A patent/IL165745A0/xx unknown
- 2004-12-30 HR HR20041233A patent/HRP20041233A2/hr not_active Application Discontinuation
-
2005
- 2005-01-18 CR CR7657A patent/CR7657A/es unknown
- 2005-01-19 EC EC2005005549A patent/ECSP055549A/es unknown
- 2005-01-20 CO CO05004232A patent/CO5680445A2/es not_active Application Discontinuation
- 2005-02-16 NO NO20050832A patent/NO20050832L/no not_active Application Discontinuation
- 2005-10-28 HK HK05109638.4A patent/HK1078003A1/xx not_active IP Right Cessation
-
2008
- 2008-04-09 US US12/100,093 patent/US7585977B2/en not_active Expired - Fee Related
-
2010
- 2010-05-11 JP JP2010109009A patent/JP5220800B2/ja not_active Expired - Fee Related
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