HUP0002109A2 - (E)-4,6-diklór-3-(2-oxo-1-fenilpirrolidin-3-ilidén-metil)-1H-indol-2-karbonsav kristályos hidratált nátriumsója, eljárás előállítására és az ilyen vegyületet tartalmazó gyógyszerkészítmény - Google Patents

(E)-4,6-diklór-3-(2-oxo-1-fenilpirrolidin-3-ilidén-metil)-1H-indol-2-karbonsav kristályos hidratált nátriumsója, eljárás előállítására és az ilyen vegyületet tartalmazó gyógyszerkészítmény

Info

Publication number
HUP0002109A2
HUP0002109A2 HU0002109A HUP0002109A HUP0002109A2 HU P0002109 A2 HUP0002109 A2 HU P0002109A2 HU 0002109 A HU0002109 A HU 0002109A HU P0002109 A HUP0002109 A HU P0002109A HU P0002109 A2 HUP0002109 A2 HU P0002109A2
Authority
HU
Hungary
Prior art keywords
indole
dichloro
oxo
carboxylic acid
sodium salt
Prior art date
Application number
HU0002109A
Other languages
English (en)
Inventor
Zadeo Cimarosti
Paolo Maragni
Original Assignee
Glaxo Wellcome S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome S.P.A. filed Critical Glaxo Wellcome S.P.A.
Publication of HUP0002109A2 publication Critical patent/HUP0002109A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány az (I) képletű (E)-4,6-diklór-3-(2-oxo-1-fenil-pirrolidin-3-ilidén-metil)-1H-indol-2-karbonsav nátriumsójának kristályoshidratált formájára, ennek előállítására és az ezt tartalmazófájdalomcsillapító hatású gyógyszerkészítményre vonatkozik. Ó
HU0002109A 1997-03-05 1998-03-03 (E)-4,6-diklór-3-(2-oxo-1-fenilpirrolidin-3-ilidén-metil)-1H-indol-2-karbonsav kristályos hidratált nátriumsója, eljárás előállítására és az ilyen vegyületet tartalmazó gyógyszerkészítmény HUP0002109A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9704498.6A GB9704498D0 (en) 1997-03-05 1997-03-05 Chemical compound
PCT/EP1998/001146 WO1998039327A1 (en) 1997-03-05 1998-03-03 Crystalline hydrated sodium salt of (e)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1h-indole-2-carboxylic acid

Publications (1)

Publication Number Publication Date
HUP0002109A2 true HUP0002109A2 (hu) 2001-04-28

Family

ID=10808697

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002109A HUP0002109A2 (hu) 1997-03-05 1998-03-03 (E)-4,6-diklór-3-(2-oxo-1-fenilpirrolidin-3-ilidén-metil)-1H-indol-2-karbonsav kristályos hidratált nátriumsója, eljárás előállítására és az ilyen vegyületet tartalmazó gyógyszerkészítmény

Country Status (29)

Country Link
EP (1) EP0966463A1 (hu)
JP (1) JP2001513796A (hu)
KR (1) KR20000075907A (hu)
CN (1) CN1249750A (hu)
AP (1) AP9901637A0 (hu)
AR (1) AR011178A1 (hu)
AU (1) AU6825198A (hu)
BG (1) BG103779A (hu)
BR (1) BR9808305A (hu)
CA (1) CA2282851A1 (hu)
CO (1) CO4940415A1 (hu)
EA (1) EA199900710A1 (hu)
EE (1) EE9900387A (hu)
GB (1) GB9704498D0 (hu)
HR (1) HRP980114A2 (hu)
HU (1) HUP0002109A2 (hu)
ID (1) ID24207A (hu)
IL (1) IL131489A0 (hu)
IS (1) IS5166A (hu)
NO (1) NO994303L (hu)
NZ (1) NZ337315A (hu)
OA (1) OA11154A (hu)
PE (1) PE51399A1 (hu)
PL (1) PL335652A1 (hu)
SK (1) SK119699A3 (hu)
TR (1) TR199902117T2 (hu)
WO (1) WO1998039327A1 (hu)
YU (1) YU43499A (hu)
ZA (1) ZA981791B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9704499D0 (en) * 1997-03-05 1997-04-23 Glaxo Wellcome Spa Method of manufacture
GB9825988D0 (en) 1998-11-27 1999-01-20 Pfizer Ltd Indole derivatives
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
KR102609676B1 (ko) 2017-06-12 2023-12-05 글리테크 엘엘씨. Nmda 길항제 및 d2/5ht2a 또는 선택적 5ht2a 길항제를 이용한 우울증의 치료

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds

Also Published As

Publication number Publication date
AU6825198A (en) 1998-09-22
CA2282851A1 (en) 1998-09-11
IL131489A0 (en) 2001-01-28
IS5166A (is) 1999-08-27
SK119699A3 (en) 2000-05-16
CO4940415A1 (es) 2000-07-24
KR20000075907A (ko) 2000-12-26
OA11154A (en) 2003-04-16
NO994303L (no) 1999-11-03
BR9808305A (pt) 2000-05-16
HRP980114A2 (en) 1998-12-31
EP0966463A1 (en) 1999-12-29
NZ337315A (en) 2001-02-23
EA199900710A1 (ru) 2000-04-24
GB9704498D0 (en) 1997-04-23
EE9900387A (et) 2000-04-17
AP9901637A0 (en) 1999-09-30
JP2001513796A (ja) 2001-09-04
ZA981791B (en) 1999-09-03
YU43499A (sh) 2000-12-28
ID24207A (id) 2000-07-13
CN1249750A (zh) 2000-04-05
NO994303D0 (no) 1999-09-03
PE51399A1 (es) 1999-06-07
AR011178A1 (es) 2000-08-02
WO1998039327A1 (en) 1998-09-11
BG103779A (en) 2000-06-30
TR199902117T2 (xx) 2000-03-21
PL335652A1 (en) 2000-05-08

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