PE44597A1 - Compuestos de benzotiofeno, productos intermedios, composiciones y procedimientos - Google Patents
Compuestos de benzotiofeno, productos intermedios, composiciones y procedimientosInfo
- Publication number
- PE44597A1 PE44597A1 PE1996000133A PE00013396A PE44597A1 PE 44597 A1 PE44597 A1 PE 44597A1 PE 1996000133 A PE1996000133 A PE 1996000133A PE 00013396 A PE00013396 A PE 00013396A PE 44597 A1 PE44597 A1 PE 44597A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- alkyl
- formula
- group
- benzotiofen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A COMPUESTOS TIOFENO DE FORMULA (I), EN DONDE: R1 ES R1a, OH, -O-ALQUILO(C1-C4), -OCOC6H5, -OCO-ALQUILO(C1-C6) o SO2-ALQUILO(C2-C6); R2 ES R2a, R1; R1a ES H, OR7; R2a ES H, HALO, OR8; R6,R7 Y R8 SON GRUPOS PROTECTORES HIDROXI; R9 ES GRUPO SALIENTE, Z-pFENILO-O(CH2)n-R3, Z-pFENILO-OR6; Z ES O o S; R11 NO EXISTE O ES =O. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE OBTENCION, QUE COMPRENDE: (A) OXIDACION DEL ATOMO DE AZUFRE DE UN COMPUESTO DE FORMULA (I), EN EL QUE R1 ES R1a, R2 ES R2a, R11 NO EXISTE Y R9 ES UN GRUPO SALIENTE; (B) POSTERIOR REACCION CON UN GRUPO NUCLEOFILICO R12-pFENILO-O(CH2)n-R3 DONDE R12 ES OH o SH; (C) REDUCCION DEL PRODUCTO DEL PASO (B) PARA DAR UN COMPUESTO DE FORMULA (I), DONDE R9 ES Z-pFENILO-O(CH2)nR3; Y (D) OPCIONAL ELIMINACION DE LOS GRUPOS PROTECTORES HIDROXI, Y FORMACION DE LA SAL. ESTOS COMPUESTOS SON USADOS PARA EL TRATAMIENTO DEL SINDROME POST MENOPAUSICO Y OTROS TRANSTORNOS PATOLOGICOS RELACIONADOS CON LOS ESTROGENOS TALES COMO FIBROSIS UTERINA, ENDOMETROSIS, ENTRE OTROS
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/396,401 US5510357A (en) | 1995-02-28 | 1995-02-28 | Benzothiophene compounds as anti-estrogenic agents |
US55276095A | 1995-11-03 | 1995-11-03 | |
US08/552,890 US5919800A (en) | 1995-02-28 | 1995-11-03 | Benzothiophene compounds, intermediates, compositions, and methods |
US08/552,564 US5998441A (en) | 1995-02-28 | 1995-11-03 | Benzothiophene compounds, intermediates, compositions, and methods |
US08/552,679 US5856339A (en) | 1995-02-28 | 1995-11-03 | Benzothiophene compounds, intermediates, compositions, and methods |
US08/552,565 US5977093A (en) | 1995-02-28 | 1995-11-03 | Benzothiophene compounds, intermediates, compositions, and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
PE44597A1 true PE44597A1 (es) | 1997-10-13 |
Family
ID=27559919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1996000133A PE44597A1 (es) | 1995-02-28 | 1996-02-27 | Compuestos de benzotiofeno, productos intermedios, composiciones y procedimientos |
Country Status (16)
Country | Link |
---|---|
EP (2) | EP0729956B1 (es) |
JP (2) | JP3989569B2 (es) |
AR (1) | AR003930A1 (es) |
AT (1) | ATE207913T1 (es) |
DE (1) | DE69616396T2 (es) |
DK (1) | DK0729956T3 (es) |
ES (1) | ES2163587T3 (es) |
FI (1) | FI20095804A (es) |
HK (1) | HK1013991A1 (es) |
IL (7) | IL117276A (es) |
PE (1) | PE44597A1 (es) |
PL (1) | PL182493B1 (es) |
PT (1) | PT729956E (es) |
SG (2) | SG90193A1 (es) |
SI (1) | SI0729956T1 (es) |
UA (1) | UA44710C2 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL182493B1 (pl) * | 1995-02-28 | 2002-01-31 | Lilly Co Eli | Nowe pochodne benzotiofenu, nowe związki pośrednie i sposób wytwarzania nowych pochodnych benzotiofenu oraz środek farmaceutyczny |
CA2214072C (en) * | 1996-08-29 | 2006-11-14 | Eli Lilly And Company | Benzo [b] thiophene compounds, intermediates, processes, compositions, and methods |
CA2216592C (en) * | 1996-10-24 | 2006-07-18 | Brian Stephen Muehl | Benzothiophene compounds, intermediates, compositions, and methods |
ZA982877B (en) * | 1997-04-09 | 1999-10-04 | Lilly Co Eli | Treatment of central nervous system disorders with selective estrogen receptor modulators. |
ZA982818B (en) * | 1997-04-09 | 1999-10-04 | Lilly Co Eli | Prevention of breast cancer using selective estrogen receptor modulators. |
ZA982819B (en) * | 1997-04-09 | 1999-10-04 | Lilly Co Eli | Treatment or prophylaxis of prostatic cancer and benign prostatic hyperplasia with selective estrogn receptor modulators. |
WO1998055454A2 (en) * | 1997-06-05 | 1998-12-10 | Takeda Chemical Industries, Ltd. | Benzofurans and benzothophenes as suppressors of neurodegeneration |
US6653297B1 (en) * | 1997-07-03 | 2003-11-25 | Medical College Of Hampton Roads | Control of selective estrogen receptor modulators |
US6090843A (en) * | 1997-08-11 | 2000-07-18 | Eli Lilly And Company | Benzothiophenes compounds which have useful pharmaceutical activity |
ID24978A (id) * | 1997-11-14 | 2000-08-31 | Lilly Co Eli | 2-ARYL-3-AROYLBENZO (b) THIOPHENES BERGUNA UNTUK PENGOBATAN SINDROM DEPRIVASI ESTROGEN |
US6096781A (en) * | 1997-11-14 | 2000-08-01 | Eli Lilly And Company | 2-arylbenzo[B]thiophenes useful for the treatment of estrogen deprivation syndrome |
US6288108B1 (en) | 1998-06-16 | 2001-09-11 | Eli Lilly And Company | Methods for increasing levels of acetylcholine |
HUP0103834A2 (hu) * | 1998-06-16 | 2002-05-29 | Eli Lilly And Co. | Eljárás az acetil-kolin-szint növelésére |
CN1305377A (zh) | 1998-06-16 | 2001-07-25 | 伊莱利利公司 | 提高乙酰胆碱水平的方法 |
US6087378A (en) * | 1998-10-13 | 2000-07-11 | Eli Lilly And Company | Pharmaceutical formulations and applications thereof for the treatment of estrogen deprivation syndrome |
PT1140888E (pt) * | 1998-12-14 | 2003-09-30 | Vertex Pharma San Diego Llc | Sensores opticos moleculares para a actividade do citocromo p450 |
AU3964400A (en) * | 1999-04-06 | 2000-10-23 | Akzo Nobel N.V. | Selective estrogenic compounds |
DE60005693T2 (de) * | 1999-07-29 | 2004-07-29 | Eli Lilly And Co., Indianapolis | Eine kristalline form von 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophen-hydrochlorid |
EP1204656A2 (en) * | 1999-07-29 | 2002-05-15 | Eli Lilly And Company | A crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl) ethoxy] phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene hydrochloride |
ATE368046T1 (de) * | 2000-03-10 | 2007-08-15 | Univ Baylor | Tubulin bindende liganden |
EP1757291A3 (en) * | 2000-05-08 | 2009-07-15 | Eli Lilly & Company | Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-YL)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene and salts thereof |
WO2001085147A2 (en) * | 2000-05-08 | 2001-11-15 | Eli Lilly And Company | STABILIZED FORMULATIONS OF 6-HYDROXY-3-(4-[2-(PIPERIDIN-1-YL) ETHOXY]PHENOXY)-2-(4-METHOXYPHENYL) BENZO[b]THIOPHENE AND SALTS THEREOF |
AR029538A1 (es) | 2000-07-06 | 2003-07-02 | Wyeth Corp | Composiciones farmaceuticas de agentes estrogenicos |
KR20030037690A (ko) * | 2000-10-20 | 2003-05-14 | 일라이 릴리 앤드 캄파니 | 6-히드록시-3-(4-[2-(피페리딘-1-일)에톡시]페녹시)-2-(4-메톡시페닐)벤조[b]티오펜 히드로클로라이드의 신규 결정형 |
JP4656939B2 (ja) | 2002-07-22 | 2011-03-23 | イーライ リリー アンド カンパニー | フェニルスルホニル基を含む選択的エストロゲン受容体モジュレーター |
CN1548434B (zh) * | 2003-05-16 | 2010-07-28 | 中国科学院上海药物研究所 | 一类苯并噻吩类化合物、及制备和它的医药用途 |
EP1709022A1 (en) * | 2004-01-22 | 2006-10-11 | Eli Lilly And Company | Selective estrogen receptor modulators |
WO2006088648A1 (en) * | 2005-02-11 | 2006-08-24 | Eli Lilly And Company | Compositions and methods for treating dyslipidemia |
FR2913017A1 (fr) * | 2007-02-23 | 2008-08-29 | Cerep Sa | Derives de piperidine et piperazine comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire |
US8124776B2 (en) | 2007-03-16 | 2012-02-28 | Eli Lilly And Company | Process and intermediates for preparing arzoxifene |
SG11201505697VA (en) | 2013-02-19 | 2015-09-29 | Novartis Ag | Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders |
HUE056957T2 (hu) * | 2014-08-29 | 2022-04-28 | Chdi Foundation Inc | Próbák huntingtin fehérjét megjelenítõ képalkotásra |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1300575B (de) * | 1965-05-21 | 1969-08-07 | Bristol Myers Co | Benzo[b]thiophene |
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
FR2447914A1 (fr) * | 1979-02-05 | 1980-08-29 | Sanofi Sa | Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
IL65379A0 (en) * | 1981-04-03 | 1982-05-31 | Lilly Co Eli | Process for preparing acylated benzothiophenes |
DE4117512A1 (de) * | 1991-05-25 | 1992-11-26 | Schering Ag | 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
CA2145614A1 (en) * | 1994-03-31 | 1995-10-01 | Jeffrey A. Dodge | Intermediates and processes for preparing benzothiophene compounds |
US5484798A (en) * | 1994-09-20 | 1996-01-16 | Eli Lilly And Company | Benzothiopene compounds, compositions, and method of inhibiting restenosis |
PL182493B1 (pl) * | 1995-02-28 | 2002-01-31 | Lilly Co Eli | Nowe pochodne benzotiofenu, nowe związki pośrednie i sposób wytwarzania nowych pochodnych benzotiofenu oraz środek farmaceutyczny |
-
1996
- 1996-02-27 PL PL96312955A patent/PL182493B1/pl not_active IP Right Cessation
- 1996-02-27 ES ES96301304T patent/ES2163587T3/es not_active Expired - Lifetime
- 1996-02-27 EP EP96301304A patent/EP0729956B1/en not_active Expired - Lifetime
- 1996-02-27 IL IL11727696A patent/IL117276A/en not_active IP Right Cessation
- 1996-02-27 IL IL13295396A patent/IL132953A/en not_active IP Right Cessation
- 1996-02-27 IL IL13295296A patent/IL132952A/en not_active IP Right Cessation
- 1996-02-27 SI SI9630423T patent/SI0729956T1/xx unknown
- 1996-02-27 DE DE69616396T patent/DE69616396T2/de not_active Expired - Lifetime
- 1996-02-27 PT PT96301304T patent/PT729956E/pt unknown
- 1996-02-27 AR ARP960101537A patent/AR003930A1/es active IP Right Grant
- 1996-02-27 PE PE1996000133A patent/PE44597A1/es not_active Application Discontinuation
- 1996-02-27 AT AT96301304T patent/ATE207913T1/de not_active IP Right Cessation
- 1996-02-27 EP EP01107356A patent/EP1113013A1/en not_active Withdrawn
- 1996-02-27 IL IL13295496A patent/IL132954A/en not_active IP Right Cessation
- 1996-02-27 DK DK96301304T patent/DK0729956T3/da active
- 1996-02-27 SG SG200006389A patent/SG90193A1/en unknown
- 1996-02-27 UA UA96020759A patent/UA44710C2/uk unknown
- 1996-02-27 JP JP03962096A patent/JP3989569B2/ja not_active Expired - Fee Related
- 1996-02-27 SG SG1996006160A patent/SG64896A1/en unknown
-
1998
- 1998-12-23 HK HK98115195A patent/HK1013991A1/xx not_active IP Right Cessation
-
1999
- 1999-11-15 IL IL13295399A patent/IL132953A0/xx active IP Right Grant
- 1999-11-15 IL IL13295299A patent/IL132952A0/xx active IP Right Grant
- 1999-11-15 IL IL13295499A patent/IL132954A0/xx active IP Right Grant
-
2007
- 2007-05-10 JP JP2007125626A patent/JP2007238626A/ja not_active Withdrawn
-
2009
- 2009-07-23 FI FI20095804A patent/FI20095804A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE69616396T2 (de) | 2002-07-11 |
IL132954A0 (en) | 2001-03-19 |
UA44710C2 (uk) | 2002-03-15 |
JPH09183776A (ja) | 1997-07-15 |
ATE207913T1 (de) | 2001-11-15 |
ES2163587T3 (es) | 2002-02-01 |
EP0729956B1 (en) | 2001-10-31 |
IL132953A (en) | 2002-02-10 |
IL117276A (en) | 2001-10-31 |
DE69616396D1 (de) | 2001-12-06 |
HK1013991A1 (en) | 1999-09-17 |
DK0729956T3 (da) | 2001-11-26 |
IL132954A (en) | 2002-02-10 |
IL117276A0 (en) | 1996-06-18 |
JP2007238626A (ja) | 2007-09-20 |
PT729956E (pt) | 2002-03-28 |
FI20095804A (fi) | 2009-07-23 |
PL182493B1 (pl) | 2002-01-31 |
SI0729956T1 (en) | 2002-04-30 |
AR003930A1 (es) | 1998-09-30 |
SG90193A1 (en) | 2002-07-23 |
PL312955A1 (en) | 1996-09-02 |
JP3989569B2 (ja) | 2007-10-10 |
SG64896A1 (en) | 1999-05-25 |
EP0729956A1 (en) | 1996-09-04 |
IL132952A0 (en) | 2001-03-19 |
EP1113013A1 (en) | 2001-07-04 |
IL132952A (en) | 2002-02-10 |
IL132953A0 (en) | 2001-03-19 |
Similar Documents
Publication | Publication Date | Title |
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