DE60003435D1 - Neue 2-decarboxy-2-phosphinico prostaglandin f analoge - Google Patents

Neue 2-decarboxy-2-phosphinico prostaglandin f analoge

Info

Publication number
DE60003435D1
DE60003435D1 DE60003435T DE60003435T DE60003435D1 DE 60003435 D1 DE60003435 D1 DE 60003435D1 DE 60003435 T DE60003435 T DE 60003435T DE 60003435 T DE60003435 T DE 60003435T DE 60003435 D1 DE60003435 D1 DE 60003435D1
Authority
DE
Germany
Prior art keywords
compounds
decarboxy
analog
new
glaucoma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60003435T
Other languages
English (en)
Other versions
DE60003435T2 (de
Inventor
Anthony Delong
August Wos
Biswanath De
Hallock Ebetino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of DE60003435D1 publication Critical patent/DE60003435D1/de
Publication of DE60003435T2 publication Critical patent/DE60003435T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/303—Cycloaliphatic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE60003435T 1999-08-04 2000-08-01 Neue 2-decarboxy-2-phosphinico prostaglandin f analoge Expired - Lifetime DE60003435T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14713299P 1999-08-04 1999-08-04
US147132P 1999-08-04
PCT/US2000/020851 WO2001010873A1 (en) 1999-08-04 2000-08-01 Novel 2-decarboxy-2-phosphinico prostaglandin f analogs

Publications (2)

Publication Number Publication Date
DE60003435D1 true DE60003435D1 (de) 2003-07-24
DE60003435T2 DE60003435T2 (de) 2004-05-19

Family

ID=22520396

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60003435T Expired - Lifetime DE60003435T2 (de) 1999-08-04 2000-08-01 Neue 2-decarboxy-2-phosphinico prostaglandin f analoge

Country Status (12)

Country Link
US (1) US6372730B1 (de)
EP (1) EP1202999B1 (de)
JP (1) JP4846150B2 (de)
AT (1) ATE243215T1 (de)
AU (1) AU776375B2 (de)
CA (1) CA2380326C (de)
CO (1) CO5180630A1 (de)
DE (1) DE60003435T2 (de)
ES (1) ES2202156T3 (de)
IL (1) IL147771A0 (de)
NO (1) NO20020523L (de)
WO (1) WO2001010873A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4834224B2 (ja) 1999-03-05 2011-12-14 デューク ユニバーシティ Ｃ１６不飽和ｆｐ−選択的プロスタグランジン類縁体
US6884858B2 (en) 1999-10-19 2005-04-26 Texas Petrochemicals Lp Process for preparing polyolefin products
US20020146439A1 (en) * 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
US20020172693A1 (en) * 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) * 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
EP1812017A2 (de) 2004-10-21 2007-08-01 Duke University Ophthalmologische arzneimittel
JP5131971B2 (ja) 2005-12-26 2013-01-30 株式会社Ｌｔｔバイオファーマ 水溶性非ペプチド性低分子薬物含有ナノ粒子
US20070254920A1 (en) * 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
EP2156848A4 (de) * 2007-05-14 2012-11-28 Ltt Bio Pharma Co Ltd Niedermolekulares arzneimittelhaltiges nanoteilchen mit negativ geladener gruppe mit verzögerter freisetzung
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
WO2010058669A1 (ja) * 2008-11-18 2010-05-27 株式会社Ｌｔｔバイオファーマ 新規プロスタグランジンｅ１誘導体及びそれを封入するナノ粒子
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
CN105319283A (zh) * 2014-07-17 2016-02-10 上海市农药研究所 检测三联吡啶含量的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4171331A (en) 1978-06-05 1979-10-16 Miles Laboratories, Inc. 1 And 2-substituted analogues of certain prostaglandins
US5312832A (en) 1991-05-17 1994-05-17 Allergan, Inc. Ocular hypotensive 2-decarboxyl-2-acylthioalkyl prostaglandin derivatives
US5409911A (en) * 1992-09-11 1995-04-25 Merck & Co., Inc. Prostaglandin analog for treating osteoporosis
US5658897A (en) * 1996-04-08 1997-08-19 Allergan Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid, 2-hydrocarbyl phosphinyloxyalkyl or phosphonamidoalkyl as therapeutic agents
PL339212A1 (en) * 1997-09-09 2000-12-04 Procter & Gamble Aromatic c16-c20-substituted tetrahydroprostaglandines useful as fp agonists
SK3382000A3 (en) * 1997-09-09 2000-10-09 Procter & Gamble A compound having structure of aromatic substituted prostaglandins and its use for the treatment of bone disorders
EP1021402B1 (de) * 1997-09-09 2005-11-23 Duke University Aromatische c16-c20-substituierte tetrahydro-prostaglandinen verwendbar wie fp agoniste
US6121253A (en) * 1998-11-20 2000-09-19 Merck Frosst Canada & Co. Prostaglandin conjugates for treating or preventing bone disease

Also Published As

Publication number Publication date
ATE243215T1 (de) 2003-07-15
DE60003435T2 (de) 2004-05-19
US6372730B1 (en) 2002-04-16
NO20020523L (no) 2002-04-02
JP4846150B2 (ja) 2011-12-28
AU6393300A (en) 2001-03-05
WO2001010873A1 (en) 2001-02-15
EP1202999A1 (de) 2002-05-08
AU776375B2 (en) 2004-09-09
EP1202999B1 (de) 2003-06-18
CA2380326C (en) 2008-03-18
CO5180630A1 (es) 2002-07-30
IL147771A0 (en) 2002-08-14
NO20020523D0 (no) 2002-02-01
CA2380326A1 (en) 2001-02-15
JP2003506454A (ja) 2003-02-18
ES2202156T3 (es) 2004-04-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DUKE UNIVERSITY, DURHAM, N.C., US

8328 Change in the person/name/address of the agent

Representative=s name: GRUENECKER, KINKELDEY, STOCKMAIR & SCHWANHAEUSSER