PE28497A1 - Compuestos de naftilo, intermedios, composiciones y procedimientos - Google Patents

Compuestos de naftilo, intermedios, composiciones y procedimientos

Info

Publication number
PE28497A1
PE28497A1 PE1996000130A PE00013096A PE28497A1 PE 28497 A1 PE28497 A1 PE 28497A1 PE 1996000130 A PE1996000130 A PE 1996000130A PE 00013096 A PE00013096 A PE 00013096A PE 28497 A1 PE28497 A1 PE 28497A1
Authority
PE
Peru
Prior art keywords
alkyl
formula
naftile
compounds
intermediates
Prior art date
Application number
PE1996000130A
Other languages
English (en)
Inventor
Alan David Palkowitz
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE28497A1 publication Critical patent/PE28497A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/257—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
    • C07C43/295—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A COMPUESTOS NAFTILO DE FORMULA (I), DONDE:R1 ES R1a, OH, O-ALQUILO(C1-C4), OCOC6H5, OCO-ALQUILO(C1-C6) o SO2-ALQUILO(C2-C6); R2 ES R2a, OH, -O-ALQUILO(C1-C4), ENTRE OTROS; R1a ES H o -0R5; R2a ES H, HALOGENO o -0R6; R3 ES 1-PIPERIDINILO o 1-PIRROLIDINILO, ENTRE OTROS; n ES 2 o 3; R4 ES -O-(CH2)n-R3, OH, CHO; R5 Y R6 SON GRUPOS PROTECTORES DE HIDROXI. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE OBTENCION, QUE COMPRENDE: (A) HACER REACCIONAR UN COMPUESTO DE FORMULA (I) EN EL QUE R1 ES R1a, R2 ES R2a, R4 ES OH, CON UN COMPUESTO DE FORMULA: 1) R3-(CH2)n-Q o 2) Q-(CH2)n-Q`, EN DONDE Q Y Q' SON UN GRUPO SALIENTE; EN EL CASO DE REACCIONAR CON (2) EL PRODUCTO RESULTANTE SE HACE REACCIONAR CON R3; (B) OPCIONAL RETIRO DE LOS GRUPOS PROTECTORES; Y (C) OPCIONAL FORMACION DE LA SAL FARMACEUTICAMENTE ACTIVA. SE USAN EN EL TRATAMIENTO DEL SINDROME POSTMENOPAUSICO Y OTROS TRANSTORNOS PATOLOGICOS RELACIONADOS CON LOS ESTROGENOS TALES COMO FIBROSIS UTERINA, ENDOMETROSIS, ENTRE OTROS
PE1996000130A 1995-02-28 1996-02-26 Compuestos de naftilo, intermedios, composiciones y procedimientos PE28497A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/395,950 US5998401A (en) 1995-02-28 1995-02-28 Naphthyl compounds, intermediates, compositions, and methods

Publications (1)

Publication Number Publication Date
PE28497A1 true PE28497A1 (es) 1997-08-27

Family

ID=23565221

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000130A PE28497A1 (es) 1995-02-28 1996-02-26 Compuestos de naftilo, intermedios, composiciones y procedimientos

Country Status (32)

Country Link
US (5) US5998401A (es)
EP (1) EP0729951B1 (es)
JP (1) JPH08268881A (es)
KR (1) KR960030938A (es)
CN (2) CN1053886C (es)
AR (2) AR002964A1 (es)
AT (1) ATE180776T1 (es)
AU (1) AU694837B2 (es)
BR (1) BR9600821A (es)
CA (1) CA2170337A1 (es)
CO (1) CO4700421A1 (es)
CY (1) CY2178B1 (es)
CZ (1) CZ288213B6 (es)
DE (1) DE69602638T2 (es)
DK (1) DK0729951T3 (es)
ES (1) ES2132841T3 (es)
FI (1) FI115524B (es)
GR (1) GR3030407T3 (es)
IL (1) IL117168A (es)
IN (1) IN182138B (es)
MX (1) MX9600743A (es)
MY (1) MY113232A (es)
NO (1) NO305833B1 (es)
NZ (1) NZ286072A (es)
PE (1) PE28497A1 (es)
PL (1) PL183578B1 (es)
RU (1) RU2167849C2 (es)
SG (1) SG55098A1 (es)
TR (1) TR199600126A1 (es)
TW (1) TW349946B (es)
YU (1) YU11496A (es)
ZA (1) ZA961291B (es)

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JP2007537991A (ja) * 2003-02-25 2007-12-27 イーライ リリー アンド カンパニー 溶媒和していない結晶性１−（４−（２−ピペリジニルエトキシ）フェノキシ）−２−（４−メタンスルホニルフェニル）−６−ヒドロキシナフタレン塩酸塩
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Also Published As

Publication number Publication date
GR3030407T3 (en) 1999-09-30
AU4573296A (en) 1996-09-05
US6355632B1 (en) 2002-03-12
SG55098A1 (en) 1998-12-21
US5567712A (en) 1996-10-22
US5998401A (en) 1999-12-07
ES2132841T3 (es) 1999-08-16
IL117168A (en) 2001-11-25
BR9600821A (pt) 1997-12-23
CN1053886C (zh) 2000-06-28
PL312829A1 (en) 1996-09-02
NO305833B1 (no) 1999-08-02
FI960889A0 (fi) 1996-02-26
FI115524B (fi) 2005-05-31
KR960030938A (ko) 1996-09-17
ATE180776T1 (de) 1999-06-15
IL117168A0 (en) 1996-06-18
US5574190A (en) 1996-11-12
JPH08268881A (ja) 1996-10-15
FI960889A (fi) 1996-08-29
CZ58196A3 (en) 1996-09-11
RU2167849C2 (ru) 2001-05-27
AU694837B2 (en) 1998-07-30
IN182138B (es) 1999-01-09
ZA961291B (en) 1997-08-19
YU11496A (sh) 1999-03-04
CN1261534A (zh) 2000-08-02
CN1137525A (zh) 1996-12-11
CN1152683C (zh) 2004-06-09
TW349946B (en) 1999-01-11
CZ288213B6 (en) 2001-05-16
DE69602638D1 (de) 1999-07-08
NO960772D0 (no) 1996-02-26
NZ286072A (en) 1996-10-28
US6268361B1 (en) 2001-07-31
DK0729951T3 (da) 1999-06-23
EP0729951B1 (en) 1999-06-02
MY113232A (en) 2001-12-31
EP0729951A1 (en) 1996-09-04
DE69602638T2 (de) 1999-10-21
AR002964A1 (es) 1998-05-27
TR199600126A1 (tr) 1996-10-21
CA2170337A1 (en) 1996-08-29
CO4700421A1 (es) 1998-12-29
PL183578B1 (pl) 2002-06-28
NO960772L (no) 1996-08-29
MX9600743A (es) 1997-02-28
CY2178B1 (en) 2002-08-23
AR001036A1 (es) 1997-08-27

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