PE28497A1 - Compuestos de naftilo, intermedios, composiciones y procedimientos - Google Patents
Compuestos de naftilo, intermedios, composiciones y procedimientosInfo
- Publication number
- PE28497A1 PE28497A1 PE1996000130A PE00013096A PE28497A1 PE 28497 A1 PE28497 A1 PE 28497A1 PE 1996000130 A PE1996000130 A PE 1996000130A PE 00013096 A PE00013096 A PE 00013096A PE 28497 A1 PE28497 A1 PE 28497A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- formula
- naftile
- compounds
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/257—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
- C07C43/295—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE REFIERE A COMPUESTOS NAFTILO DE FORMULA (I), DONDE:R1 ES R1a, OH, O-ALQUILO(C1-C4), OCOC6H5, OCO-ALQUILO(C1-C6) o SO2-ALQUILO(C2-C6); R2 ES R2a, OH, -O-ALQUILO(C1-C4), ENTRE OTROS; R1a ES H o -0R5; R2a ES H, HALOGENO o -0R6; R3 ES 1-PIPERIDINILO o 1-PIRROLIDINILO, ENTRE OTROS; n ES 2 o 3; R4 ES -O-(CH2)n-R3, OH, CHO; R5 Y R6 SON GRUPOS PROTECTORES DE HIDROXI. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE OBTENCION, QUE COMPRENDE: (A) HACER REACCIONAR UN COMPUESTO DE FORMULA (I) EN EL QUE R1 ES R1a, R2 ES R2a, R4 ES OH, CON UN COMPUESTO DE FORMULA: 1) R3-(CH2)n-Q o 2) Q-(CH2)n-Q`, EN DONDE Q Y Q' SON UN GRUPO SALIENTE; EN EL CASO DE REACCIONAR CON (2) EL PRODUCTO RESULTANTE SE HACE REACCIONAR CON R3; (B) OPCIONAL RETIRO DE LOS GRUPOS PROTECTORES; Y (C) OPCIONAL FORMACION DE LA SAL FARMACEUTICAMENTE ACTIVA. SE USAN EN EL TRATAMIENTO DEL SINDROME POSTMENOPAUSICO Y OTROS TRANSTORNOS PATOLOGICOS RELACIONADOS CON LOS ESTROGENOS TALES COMO FIBROSIS UTERINA, ENDOMETROSIS, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/395,950 US5998401A (en) | 1995-02-28 | 1995-02-28 | Naphthyl compounds, intermediates, compositions, and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
PE28497A1 true PE28497A1 (es) | 1997-08-27 |
Family
ID=23565221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1996000130A PE28497A1 (es) | 1995-02-28 | 1996-02-26 | Compuestos de naftilo, intermedios, composiciones y procedimientos |
Country Status (32)
Country | Link |
---|---|
US (5) | US5998401A (es) |
EP (1) | EP0729951B1 (es) |
JP (1) | JPH08268881A (es) |
KR (1) | KR960030938A (es) |
CN (2) | CN1053886C (es) |
AR (2) | AR001036A1 (es) |
AT (1) | ATE180776T1 (es) |
AU (1) | AU694837B2 (es) |
BR (1) | BR9600821A (es) |
CA (1) | CA2170337A1 (es) |
CO (1) | CO4700421A1 (es) |
CY (1) | CY2178B1 (es) |
CZ (1) | CZ288213B6 (es) |
DE (1) | DE69602638T2 (es) |
DK (1) | DK0729951T3 (es) |
ES (1) | ES2132841T3 (es) |
FI (1) | FI115524B (es) |
GR (1) | GR3030407T3 (es) |
IL (1) | IL117168A (es) |
IN (1) | IN182138B (es) |
MX (1) | MX9600743A (es) |
MY (1) | MY113232A (es) |
NO (1) | NO305833B1 (es) |
NZ (1) | NZ286072A (es) |
PE (1) | PE28497A1 (es) |
PL (1) | PL183578B1 (es) |
RU (1) | RU2167849C2 (es) |
SG (1) | SG55098A1 (es) |
TR (1) | TR199600126A1 (es) |
TW (1) | TW349946B (es) |
YU (1) | YU11496A (es) |
ZA (1) | ZA961291B (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5856340A (en) * | 1995-02-28 | 1999-01-05 | Eli Lilly And Company | Method of treating estrogen dependent cancers |
US5510357A (en) * | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
US5919800A (en) * | 1995-02-28 | 1999-07-06 | Eli Lilly And Company | Benzothiophene compounds, intermediates, compositions, and methods |
US5998401A (en) * | 1995-02-28 | 1999-12-07 | Eli Lilly And Company | Naphthyl compounds, intermediates, compositions, and methods |
US5856339A (en) * | 1995-02-28 | 1999-01-05 | Eli Lilly And Company | Benzothiophene compounds, intermediates, compositions, and methods |
CA2213814A1 (en) * | 1996-08-29 | 1998-02-28 | Henry Uhlman Bryant | Naphthalene compounds, intermediates, formulations, and methods |
ID19392A (id) * | 1996-08-29 | 1998-07-09 | Lilly Co Eli | Senyawa naftil dan bahan pertengahan serta komposisi dan metode penggunaan |
EP1142862A3 (en) * | 1996-08-29 | 2002-10-02 | Eli Lilly And Company | Naphthyl and tetralone derivatives as intermediates |
CA2214931A1 (en) * | 1996-09-26 | 1998-03-26 | Henry Uhlman Bryant | Tetrahydrobenzo-a-fluorene compounds and method of use |
CA2214929A1 (en) * | 1996-09-26 | 1998-03-26 | Charles Willis Lugar, Iii | Naphthofluorene compounds, intermediates, compositions and methods |
CA2214935A1 (en) * | 1996-09-26 | 1998-03-26 | Henry Uhlman Bryant | Benzofluorene compounds, intermediates, compositions, and methods |
CA2217810A1 (en) * | 1996-10-10 | 1998-04-10 | Eli Lilly And Company | 2-aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods |
US5916916A (en) * | 1996-10-10 | 1999-06-29 | Eli Lilly And Company | 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods |
PA8444901A1 (es) * | 1997-01-28 | 2000-05-24 | Hoffmann La Roche | Derivados de 5-aroilnaftaleno como agentes anti-inflamatorios |
ZA982877B (en) * | 1997-04-09 | 1999-10-04 | Lilly Co Eli | Treatment of central nervous system disorders with selective estrogen receptor modulators. |
JP2001513501A (ja) | 1997-08-07 | 2001-09-04 | イーライ・リリー・アンド・カンパニー | エストロゲン阻害活性を有する1−[4−(置換アルコキシ)ベンジル]ナフタレン化合物 |
US6107346A (en) * | 1997-08-11 | 2000-08-22 | Eli Lilly And Company | Methods for treating hyperlipidemia |
US5929090A (en) * | 1997-09-12 | 1999-07-27 | Eli Lilly And Company | 2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods |
EP1173164A2 (en) * | 1999-04-16 | 2002-01-23 | AstraZeneca AB | Estrogen receptor-beta ligands |
US6312474B1 (en) * | 1999-09-15 | 2001-11-06 | Bio-Vascular, Inc. | Resorbable implant materials |
KR100370597B1 (ko) * | 2000-06-22 | 2003-02-05 | 박정일 | 산형매립초로부터 분리한 신규한 나프탈렌계 화합물 및이를 유효성분으로 하는 약학적 조성물 |
WO2002044119A2 (en) * | 2000-11-28 | 2002-06-06 | Eli Lilly And Company | Synthesis of 2-aryl-1-naphthol derivatives via a tandem palladium catalyzed arylation and dehydrogenation |
JP2004531559A (ja) * | 2001-05-22 | 2004-10-14 | イーライ・リリー・アンド・カンパニー | エストロゲン欠乏または内因性エストロゲンに対する異常な生理反応に関連する疾患を抑制するためのテトラヒドロキノリン誘導体 |
WO2002094788A1 (en) | 2001-05-22 | 2002-11-28 | Eli Lilly And Company | 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods |
US6914074B2 (en) | 2001-12-13 | 2005-07-05 | Wyeth | Substituted phenyl naphthalenes as estrogenic agents |
DE60327931D1 (de) | 2002-07-22 | 2009-07-23 | Lilly Co Eli | Selektive östrogenrezeptor modulatoren, die eine phenylsulfonyl-gruppe enthalten |
US9315539B2 (en) * | 2002-10-01 | 2016-04-19 | Yale University | 11 beta-short chain substituted estradiol analogs and their use in the treatment of menopausal symptoms and estrogen sensitive cancer |
CN100348192C (zh) * | 2003-02-25 | 2007-11-14 | 伊莱利利公司 | 晶状的非溶剂化1-(4-(2-哌啶基乙氧基)苯氧基)-2-(4-甲磺酰基苯基)-6-羟基萘盐酸化物 |
EP1601356A1 (en) | 2003-02-25 | 2005-12-07 | Eli Lilly and Company | Crystalline non-solvated 1-(4-(2-piperidinylethoxy)phenoxy)-2-(4-methanesulfonylphenyl)-6-hydroxynaphthalene hydrochloride |
US20040253319A1 (en) * | 2003-06-11 | 2004-12-16 | Shrirang Netke | Pharmaceutical compositions and method for alleviating side-effects of estrogen replacement therapy |
CA2544501A1 (en) * | 2003-11-20 | 2005-06-09 | Eli Lilly And Company | Vitamin d receptor modulators |
CA2544517A1 (en) * | 2003-11-20 | 2005-06-09 | Eli Lilly And Company | Vitamin d receptor modulators |
WO2005073204A1 (en) * | 2004-01-22 | 2005-08-11 | Eli Lilly And Company | Selective estrogen receptor modulators for the treatment of vasomotor symptoms |
CN1910167B (zh) * | 2004-01-22 | 2011-08-10 | 伊莱利利公司 | 用于治疗血管舒缩症状的选择性雌激素受体调节剂 |
US20070066595A1 (en) | 2004-01-22 | 2007-03-22 | Dodge Jeffrey A | Selective estrogen receptor modulators |
AU2005258085A1 (en) * | 2004-06-22 | 2006-01-05 | Smithkline Beecham Corporation | Chemical compounds |
JP5548205B2 (ja) * | 2008-09-29 | 2014-07-16 | イーライ リリー アンド カンパニー | 選択的エストロゲン受容体調節因子 |
KR20160088947A (ko) | 2010-06-16 | 2016-07-26 | 앙도르쉐르슈 인코포레이티드 | 에스트로겐-관련 질병의 치료 또는 예방 방법 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3274213A (en) * | 1961-09-05 | 1966-09-20 | Upjohn Co | Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes |
US3396169A (en) * | 1966-10-26 | 1968-08-06 | Upjohn Co | Substituted 2-phenyl-1-(tertiary-aminoalkoxy) phenyl-3, 4-dihydronaphthalenes |
US3862232A (en) * | 1963-07-03 | 1975-01-21 | Upjohn Co | 1-(p-hydroxyphenyl)-2-phenyl-6-(2-diethylaminoethoxy)-3,4-dihydronaphthalene and the salts thereof |
US3313853A (en) * | 1963-10-16 | 1967-04-11 | Upjohn Co | 2-(tertiaryaminoalkoxyphenyl)-3, 4-dihydronaphthalenes and 2-(tertiaryaminoalkoxyphenyl) -3, 4- dihydro -1(2h)-naphthalenones |
US3293263A (en) * | 1963-12-09 | 1966-12-20 | Upjohn Co | Diphenylbenzocycloalkenes |
US3320271A (en) * | 1964-06-01 | 1967-05-16 | Upjohn Co | 1, 2-diphenyl-3, 4-dihydronaphthalenes and 2, 3-diphenylindenes |
GB1138163A (en) * | 1965-05-21 | 1968-12-27 | Bristol Myers Co | Benzothiophene derivatives having anti-fertility properties |
US3394125A (en) * | 1965-10-23 | 1968-07-23 | Bristol Myers Co | 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group |
US3483293A (en) * | 1967-12-15 | 1969-12-09 | Upjohn Co | Method for controlling birds and rodents |
US3567737A (en) * | 1968-01-02 | 1971-03-02 | Upjohn Co | Derivatives of (2-cycloalkyl-1-phenyl-3,4-dihydronaphthalenes and) 2 - cycloalkyl - 1 - phenyl - 1,2,3,4 - tetrahydro-naphthalenes |
US3862323A (en) | 1971-09-20 | 1975-01-21 | Betz Laboratories | Dioxide slime control composition and its use |
US4400543A (en) * | 1975-10-28 | 1983-08-23 | Eli Lilly And Company | 3-Phenyl-4-benzoyl-1,2-dihydronaphthalenes |
US4230862A (en) * | 1975-10-28 | 1980-10-28 | Eli Lilly And Company | Antifertility compounds |
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
DE3121175A1 (de) * | 1981-05-27 | 1982-12-16 | Klinge Pharma GmbH, 8000 München | Erythro-1,2,3-triphenyl-1-pentanon-derivate sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
GB8311678D0 (en) * | 1983-04-28 | 1983-06-02 | Ici Plc | Phenol derivatives |
GB8705174D0 (en) * | 1987-03-05 | 1987-04-08 | Ici Plc | Heterocyclic compounds |
US5013761A (en) * | 1988-06-03 | 1991-05-07 | Eli Lilly And Company | Serotonin antagonists |
FR2665444B1 (fr) | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
US5254568A (en) * | 1990-08-09 | 1993-10-19 | Council Of Scientific & Industrial Research | Benzopyrans as antiestrogenic agents |
DE4117512A1 (de) | 1991-05-25 | 1992-11-26 | Schering Ag | 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
US5147880A (en) * | 1991-07-22 | 1992-09-15 | Eli Lilly And Company | Benzo[a]fluorene compounds |
WO1993010742A2 (en) * | 1991-11-27 | 1993-06-10 | Novo Nordisk A/S | Chemical compounds, their preparation and use |
US5424334A (en) | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
US7501441B1 (en) * | 1994-09-20 | 2009-03-10 | Eli Lilly And Company | Naphthyl compounds, intermediates, processes, compositions, and methods |
US5998401A (en) * | 1995-02-28 | 1999-12-07 | Eli Lilly And Company | Naphthyl compounds, intermediates, compositions, and methods |
US5510357A (en) | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
-
1995
- 1995-02-28 US US08/395,950 patent/US5998401A/en not_active Expired - Fee Related
- 1995-06-06 US US08/469,971 patent/US5567712A/en not_active Expired - Fee Related
- 1995-06-06 US US08/466,954 patent/US6268361B1/en not_active Expired - Fee Related
- 1995-06-06 US US08/465,844 patent/US5574190A/en not_active Expired - Fee Related
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1996
- 1996-02-09 ES ES96300877T patent/ES2132841T3/es not_active Expired - Lifetime
- 1996-02-09 EP EP96300877A patent/EP0729951B1/en not_active Expired - Lifetime
- 1996-02-09 DK DK96300877T patent/DK0729951T3/da active
- 1996-02-09 AT AT96300877T patent/ATE180776T1/de not_active IP Right Cessation
- 1996-02-09 DE DE69602638T patent/DE69602638T2/de not_active Expired - Fee Related
- 1996-02-15 PL PL96312829A patent/PL183578B1/pl unknown
- 1996-02-15 TW TW085101903A patent/TW349946B/zh active
- 1996-02-16 TR TR96/00126A patent/TR199600126A1/xx unknown
- 1996-02-19 ZA ZA9601291A patent/ZA961291B/xx unknown
- 1996-02-19 IL IL11716896A patent/IL117168A/en not_active IP Right Cessation
- 1996-02-22 IN IN321CA1996 patent/IN182138B/en unknown
- 1996-02-26 CZ CZ1996581A patent/CZ288213B6/cs not_active IP Right Cessation
- 1996-02-26 AU AU45732/96A patent/AU694837B2/en not_active Ceased
- 1996-02-26 KR KR1019960004619A patent/KR960030938A/ko not_active Application Discontinuation
- 1996-02-26 PE PE1996000130A patent/PE28497A1/es not_active Application Discontinuation
- 1996-02-26 BR BR9600821A patent/BR9600821A/pt not_active Application Discontinuation
- 1996-02-26 AR ARP960101524A patent/AR001036A1/es active IP Right Grant
- 1996-02-26 MX MX9600743A patent/MX9600743A/es not_active IP Right Cessation
- 1996-02-26 NO NO960772A patent/NO305833B1/no not_active IP Right Cessation
- 1996-02-26 CO CO96008862A patent/CO4700421A1/es unknown
- 1996-02-26 CN CN96105727A patent/CN1053886C/zh not_active Expired - Fee Related
- 1996-02-26 AR ARP960101525A patent/AR002964A1/es unknown
- 1996-02-26 FI FI960889A patent/FI115524B/fi active IP Right Grant
- 1996-02-26 CA CA002170337A patent/CA2170337A1/en not_active Abandoned
- 1996-02-26 RU RU96103632/04A patent/RU2167849C2/ru active
- 1996-02-26 YU YU11496A patent/YU11496A/sh unknown
- 1996-02-26 NZ NZ286072A patent/NZ286072A/en unknown
- 1996-02-26 JP JP8037970A patent/JPH08268881A/ja active Pending
- 1996-02-27 MY MYPI96000686A patent/MY113232A/en unknown
- 1996-02-27 SG SG1996006121A patent/SG55098A1/en unknown
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1999
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- 1999-11-05 CN CNB99123572XA patent/CN1152683C/zh not_active Expired - Fee Related
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2000
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