PE23198A1 - Nuevos derivados de fenilamidina, procedimiento para su preparacion y su utilizacion como medicamentos - Google Patents

Nuevos derivados de fenilamidina, procedimiento para su preparacion y su utilizacion como medicamentos

Info

Publication number
PE23198A1
PE23198A1 PE1996000847A PE00084796A PE23198A1 PE 23198 A1 PE23198 A1 PE 23198A1 PE 1996000847 A PE1996000847 A PE 1996000847A PE 00084796 A PE00084796 A PE 00084796A PE 23198 A1 PE23198 A1 PE 23198A1
Authority
PE
Peru
Prior art keywords
preparation
alkyl
hydrogen
formula
phenylamidine
Prior art date
Application number
PE1996000847A
Other languages
English (en)
Inventor
Kurt Schromm
Ernst-Otto Renth
Franz Birke
Christopher John Montague Meade
Andreas Ding
Ralf Anderskewitz
Hans Michael Jennewein
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of PE23198A1 publication Critical patent/PE23198A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: "A" ES EL COMPUESTO DE FORMULA X1-CmH2m-X2, EN DONDE m ES 2; 3; 4; 5 o 6; X1 PREFERENTEMENTE ES OXIGENO; X2 PREFERENTEMENTE ES -X1-C6H4- O EL COMPUESTO DE FORMULA (II), EN DONDE: X3 ES -X1-CnH2n; X4 ES -CnH2n-X1; n ES 1 o 2; R7 Y R8 SON HIDROGENO O HALOGENO, ENTRE OTROS; R1 ES CICLOALQUILO C5-C7, Ar1, O-Ar1, CH2-Ar2, CR4R5Ar3 o C(CH3)2R6, EN DONDE: Ar1, Ar2 Y Ar3 SON ARILO OPCIONALMENTE SUSTITUIDO CON HIDROXILO o CON HIDROXILO Y ALQUILO DE C1-C6; R4 Y R5 SON CH3 O CH2OH o PUEDEN FORMAR UN ALQUILENO DE C4-C6; R6 ES CH20H o COOH, ENTRE OTROS; R2 ES HIDROGENO, HIDROXILO o O-ALQUILO DE C1-C6, ENTRE OTROS; R3 ES HIDROGENO o ALQUILO DE C1-C6. TAMBIEN SE REFIEREN A LOS PROCEDIMIENTOS PARA LA PREPARACION DE (I), QUE COMPRENDEN: HACER REACCIONAR AMONIACO CON EL IMIDOESTER o EL IMIDOCLORURO DE (I), o REDUCIR LA IMIDOOXIMA DE (I), ENTRE OTROS. ACTUAN COMO ANTAGONISTAS DE LOS RECEPTORES LTB4, SIENDO UTILES EN EL TRATAMIENTO DEL ASMA, DE LAS ENFERMEDADES OBSTRUCTIVAS DE LOS PULMONES, ENTRE OTROS
PE1996000847A 1995-12-13 1996-11-27 Nuevos derivados de fenilamidina, procedimiento para su preparacion y su utilizacion como medicamentos PE23198A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19546452A DE19546452A1 (de) 1995-12-13 1995-12-13 Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
PE23198A1 true PE23198A1 (es) 1998-05-13

Family

ID=7779950

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000847A PE23198A1 (es) 1995-12-13 1996-11-27 Nuevos derivados de fenilamidina, procedimiento para su preparacion y su utilizacion como medicamentos

Country Status (36)

Country Link
US (1) US6127423A (es)
EP (1) EP1015421B1 (es)
JP (1) JP4334016B2 (es)
KR (1) KR100475207B1 (es)
CN (1) CN100366606C (es)
AR (1) AR005034A1 (es)
AT (1) ATE263144T1 (es)
AU (1) AU716473B2 (es)
BG (1) BG64020B1 (es)
BR (1) BR9611949A (es)
CO (1) CO4750814A1 (es)
CZ (1) CZ291860B6 (es)
DE (2) DE19546452A1 (es)
DK (1) DK1015421T3 (es)
EE (1) EE04371B1 (es)
ES (1) ES2218609T3 (es)
HK (1) HK1016575A1 (es)
HR (1) HRP960583B1 (es)
HU (1) HUP9903733A3 (es)
IL (2) IL123900A0 (es)
MX (1) MX9803672A (es)
MY (1) MY120683A (es)
NO (1) NO311353B1 (es)
NZ (1) NZ325235A (es)
PE (1) PE23198A1 (es)
PL (1) PL186720B1 (es)
PT (1) PT1015421E (es)
RS (1) RS49503B (es)
RU (1) RU2184726C2 (es)
SI (1) SI1015421T1 (es)
SK (1) SK282212B6 (es)
TR (1) TR199801039T2 (es)
TW (1) TW438746B (es)
UA (1) UA57013C2 (es)
WO (1) WO1997021670A1 (es)
ZA (1) ZA9610460B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636689A1 (de) * 1996-09-10 1998-03-12 Boehringer Ingelheim Kg Neue Benzamidinderivate
DE19637123A1 (de) * 1996-09-12 1998-03-19 Boehringer Ingelheim Kg Neue Pyranosidderivate
ID24720A (id) 1997-12-12 2000-08-03 Novartis Ag Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis
US6635668B1 (en) * 1998-07-22 2003-10-21 The University Of North Carolina At Chapel Hill Imidazoline receptor binding compounds
TR200101744T2 (tr) 1998-12-14 2001-12-21 F. Hoffmann-La Roche Ag Fenilglisin türevleri.
US6528491B2 (en) 2000-10-24 2003-03-04 Boehringer Ingelheim Pharma Kg Pyranoside derivatives
US6489359B2 (en) 2000-10-24 2002-12-03 Boehringer Ingelheim Pharma Kg Sulphoxybenzamides
DE10052333A1 (de) * 2000-10-24 2002-05-02 Boehringer Ingelheim Pharma Neue Sulfooxybenzamide
WO2002055065A2 (en) * 2001-01-16 2002-07-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of an ltb4 antagonist for the treatment and/or prevention of diseases caused by increased expression of mucin genes
IL159493A0 (en) * 2001-07-14 2004-06-01 Boehringer Ingeiheim Pharma Gm Pharmaceutical formulation containing an ltb4 antagonist
US20030119901A1 (en) * 2001-07-14 2003-06-26 Boehringer Ingelheim Pharma Kg Pharmaceutical formulation containing an LTB4 antagonist
WO2003017994A1 (en) * 2001-08-31 2003-03-06 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
RS20050390A (en) * 2002-11-26 2008-04-04 Boehringer Ingelheim Pharma Gmbh. & Co.Kg., Pharmaceutical composition comprising a ltb4 antagonist and a cox-2 inhibitor or a combined cox 1/2 inhibitor
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
US20200199168A1 (en) * 2017-05-12 2020-06-25 Riken Class a gpcr-binding compound modifier

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246965A (en) * 1991-06-11 1993-09-21 Ciba-Geigy Arylethers, their manufacture and methods of treatment
DE59309630D1 (de) * 1992-02-05 1999-07-08 Boehringer Ingelheim Pharma Neue amidinderivate, ihre herstellung und verwendung als arzneimittel mit ltb4-antagonistischer wirkung
DE4309285A1 (de) * 1993-03-23 1994-09-29 Boehringer Ingelheim Kg Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung
DE4424714A1 (de) * 1994-07-13 1996-01-18 Boehringer Ingelheim Kg Neue chemische Verbindung, ihre Herstellung und ihre Verwendung als Arnzneistoff

Also Published As

Publication number Publication date
CN100366606C (zh) 2008-02-06
EE9800145A (et) 1998-10-15
KR100475207B1 (ko) 2005-09-02
TW438746B (en) 2001-06-07
EP1015421A1 (de) 2000-07-05
EE04371B1 (et) 2004-10-15
WO1997021670A1 (de) 1997-06-19
IL123900A0 (en) 1998-10-30
NO311353B1 (no) 2001-11-19
IL123900A (en) 2006-07-05
US6127423A (en) 2000-10-03
HRP960583A2 (en) 1998-02-28
YU63696A (sh) 1999-07-28
PL186720B1 (pl) 2004-02-27
BG64020B1 (bg) 2003-10-31
AU716473B2 (en) 2000-02-24
HRP960583B1 (en) 2002-02-28
HUP9903733A2 (hu) 2000-03-28
HUP9903733A3 (en) 2000-07-28
AR005034A1 (es) 1999-04-07
SI1015421T1 (en) 2004-06-30
RS49503B (sr) 2006-10-27
JP4334016B2 (ja) 2009-09-16
DE19546452A1 (de) 1997-06-19
BG102395A (en) 1999-01-29
KR19990072100A (ko) 1999-09-27
RU2184726C2 (ru) 2002-07-10
NZ325235A (en) 2000-01-28
ES2218609T3 (es) 2004-11-16
JP2000502333A (ja) 2000-02-29
BR9611949A (pt) 1999-03-30
MY120683A (en) 2005-11-30
UA57013C2 (uk) 2003-06-16
SK77098A3 (en) 1998-11-04
DE59610963D1 (de) 2004-05-06
NO982708L (no) 1998-06-12
CN1204315A (zh) 1999-01-06
SK282212B6 (sk) 2001-12-03
DK1015421T3 (da) 2004-07-05
CZ183698A3 (cs) 1998-11-11
NO982708D0 (no) 1998-06-12
CO4750814A1 (es) 1999-03-31
MX9803672A (es) 1998-09-30
ZA9610460B (en) 1998-06-10
TR199801039T2 (xx) 1998-08-21
CZ291860B6 (cs) 2003-06-18
PL327171A1 (en) 1998-11-23
PT1015421E (pt) 2004-08-31
AU1369997A (en) 1997-07-03
ATE263144T1 (de) 2004-04-15
HK1016575A1 (en) 1999-11-05
EP1015421B1 (de) 2004-03-31

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