JP2007504280A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007504280A5 JP2007504280A5 JP2006532897A JP2006532897A JP2007504280A5 JP 2007504280 A5 JP2007504280 A5 JP 2007504280A5 JP 2006532897 A JP2006532897 A JP 2006532897A JP 2006532897 A JP2006532897 A JP 2006532897A JP 2007504280 A5 JP2007504280 A5 JP 2007504280A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- ovr110
- cells
- cancer
- pta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004965 antibodies Human genes 0.000 claims 22
- 108090001123 antibodies Proteins 0.000 claims 22
- 210000004027 cells Anatomy 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 7
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 210000004408 Hybridomas Anatomy 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012216 imaging agent Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 210000004962 mammalian cells Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000005614 monoclonal antibodies Human genes 0.000 claims 2
- 108010045030 monoclonal antibodies Proteins 0.000 claims 2
- 229940064005 Antibiotic throat preparations Drugs 0.000 claims 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 claims 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 claims 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 claims 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 claims 1
- 231100000765 Toxin Toxicity 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000003115 biocidal Effects 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 108091006028 chimera Proteins 0.000 claims 1
- 239000003966 growth inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229940079866 intestinal antibiotics Drugs 0.000 claims 1
- 230000001293 nucleolytic Effects 0.000 claims 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 108020003112 toxins Proteins 0.000 claims 1
Claims (17)
- インビボで哺乳動物細胞上のＯｖｒ１１０に結合することができる、単離されたＯｖｒ１１０抗体。
- インビボで哺乳動物細胞上のＯｖｒ１１０に結合すると内部移行する、請求項１に記載の抗体。
- アメリカンタイプカルチャーコレクション受託番号PTA-5180、PTA-5855、PTA-5856およびPTA-5884から選択されるハイブリドーマにより産生されるか、または、アメリカンタイプカルチャーコレクション受託番号PTA-5180、PTA-5855、PTA-5856およびPTA-5884から選択されるハイブリドーマにより産生されるモノクローナル抗体が結合するエピトープと同一のエピトープへの結合に競合する抗体。
- インビボでＯｖｒ１１０発現癌細胞の増殖を阻害することができる、抗Ｏｖｒ１１０モノクローナル抗体。
- キメラ抗体、ヒト化抗体、またはヒト抗体である、請求項１〜４のいずれかに記載の抗体。
- 増殖阻害剤または細胞毒性剤に結合している、請求項１〜５のいずれかに記載の抗体。
- 細胞毒性剤が、毒素、抗生物質、放射性同位体および核酸分解酵素から選択される、請求項６に記載の抗体。
- 請求項１〜４のいずれかに記載の抗体を産生する細胞。
- 請求項１〜７のいずれかに記載の抗体と担体とを含む組成物。
- Ｏｖｒ１１０発現癌細胞を死滅させるインビトロの方法であって、該方法が、該癌細胞を、請求項１〜７のいずれかに記載の抗体または請求項９に記載の組成物と接触させ、これにより該癌細胞を死滅させることを含む、前記方法。
- 癌細胞が、卵巣癌細胞、膵臓癌細胞、肺癌細胞および乳癌細胞から選択される、請求項１０に記載の方法。
- 抗体を、少なくとも１種の化学療法剤と組み合わせて投与する、請求項１０または１１に記載の方法。
- 試料中の細胞がＯｖｒ１１０を発現するか否かを決定するためのインビトロの方法であって、該方法が：
（ａ）細胞の試料と、請求項１〜７のいずれかに記載のＯｖｒ１１０抗体とを、Ｏｖｒ１１０抗体のＯｖｒ１１０への特異的結合に適する条件の下で接触させること；および
（ｂ）該抗体の試料中の細胞への結合のレベル、または前記試料中の細胞によるＯｖｒ１１０抗体の内部移行のレベルを決定すること
を含み、
ここで、試料中の細胞へのＯｖｒ１１０抗体の結合、または該試料中の細胞によるＯｖｒ１１０抗体の内部移行が、該試料中の細胞がＯｖｒ１１０を発現することを示す、前記方法。 - 請求項１〜７のいずれかに記載の抗体の、癌を処置するための医薬の製造における使用。
- 医薬が、卵巣癌、膵臓癌、肺癌または乳癌を処置するためのものである、請求項１４に記載の使用。
- 請求項１〜７のいずれかに記載の抗体の、癌を検出するためのイメージング剤の製造における使用。
- イメージング剤が、卵巣癌、膵臓癌、肺癌または乳癌を検出するためのものである、請求項１６に記載の使用。
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46955503P | 2003-05-09 | 2003-05-09 | |
| US60/469,555 | 2003-05-09 | ||
| US55295904P | 2004-03-12 | 2004-03-12 | |
| US60/552,959 | 2004-03-12 | ||
| US55646404P | 2004-03-25 | 2004-03-25 | |
| US60/556,464 | 2004-03-25 | ||
| PCT/US2004/014490 WO2004101756A2 (en) | 2003-05-09 | 2004-05-10 | Ovr110 antibody compositions and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007504280A JP2007504280A (ja) | 2007-03-01 |
| JP2007504280A5 true JP2007504280A5 (ja) | 2007-11-22 |
| JP4884224B2 JP4884224B2 (ja) | 2012-02-29 |
Family
ID=33458763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006532897A Expired - Fee Related JP4884224B2 (ja) | 2003-05-09 | 2004-05-10 | Ｏｖｒ１１０抗体組成物および使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7619068B2 (ja) |
| EP (1) | EP1633784B1 (ja) |
| JP (1) | JP4884224B2 (ja) |
| AT (1) | ATE516047T1 (ja) |
| AU (1) | AU2004239301B2 (ja) |
| CA (1) | CA2525899C (ja) |
| DK (1) | DK1633784T3 (ja) |
| IL (1) | IL171797A (ja) |
| WO (1) | WO2004101756A2 (ja) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002523760A (ja) * | 1998-09-02 | 2002-07-30 | ダイアデクスアス・インコーポレーテッド | 様々な癌を診断、監視、段階づけ、造影及び治療する新規な方法 |
| WO2004000221A2 (en) * | 2002-06-20 | 2003-12-31 | The Regents Of The University Of California | Compositions and methods for modulating lymphocyte activity |
| US7153950B2 (en) | 2002-10-25 | 2006-12-26 | Genentech, Inc. | Nucleic acids encoding an immune related polypeptide |
| JP4884224B2 (ja) * | 2003-05-09 | 2012-02-29 | ディアデクサス インコーポレーテッド | Ｏｖｒ１１０抗体組成物および使用方法 |
| EP1817055B1 (en) * | 2004-11-10 | 2012-12-26 | Diadexus, Inc. | Ovr110 antibody compositions and methods of use |
| WO2006054961A2 (en) * | 2004-11-12 | 2006-05-26 | Genentech, Inc. | Novel composition and methods for the treatment of immune related diseases |
| DE602006013275D1 (de) | 2005-01-07 | 2010-05-12 | Diadexus Inc | Ovr110-antikörperzusammensetzungen und verwendungsverfahren dafür |
| US8759490B2 (en) | 2005-03-24 | 2014-06-24 | Millennium Pharamaceuticals, Inc. | Antibodies that bind OV064 and methods of use therefor |
| WO2006104677A2 (en) | 2005-03-24 | 2006-10-05 | Millennium Pharmaceuticals, Inc. | Antibodies that bind ov064 and methods of use therefor |
| EP1963371A2 (en) * | 2005-12-08 | 2008-09-03 | Medarex Inc. | Human monoclonal antibodies to o8e |
| WO2007081767A2 (en) * | 2006-01-04 | 2007-07-19 | Fujirebio America, Inc. | Use of he4 and other biochemical markers for assessment of endometrial and uterine cancers |
| CA2670696A1 (en) | 2006-11-27 | 2008-06-05 | Diadexus, Inc. | Ovr110 antibody compositions and methods of use |
| WO2012019061A2 (en) | 2010-08-05 | 2012-02-09 | Stem Centrx, Inc. | Novel effectors and methods of use |
| SG187965A1 (en) | 2010-08-27 | 2013-04-30 | Stem Centrx Inc | Notum protein modulators and methods of use |
| CA2810016A1 (en) | 2010-09-03 | 2012-03-08 | Stem Centrx, Inc. | Novel modulators and methods of use |
| RU2016123839A (ru) | 2010-12-08 | 2018-11-30 | АббВай Стемсентркс ЭлЭлСи | Новые модуляторы и способы их применения |
| SA112330278B1 (ar) | 2011-02-18 | 2015-10-09 | ستيم سينتركس، انك. | مواد ضابطة جديدة وطرق للاستخدام |
| JP6120848B2 (ja) | 2011-08-15 | 2017-04-26 | メディミューン，エルエルシー | 抗ｂ７−ｈ４抗体およびその使用 |
| US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
| JP6401060B2 (ja) | 2012-02-24 | 2018-10-03 | アッヴィ・ステムセントルクス・エル・エル・シー | 抗ｓｅｚ６抗体及び使用方法 |
| PE20190658A1 (es) | 2012-02-24 | 2019-05-08 | Abbvie Stemcentrx Llc | Moduladores y metodos de empleo novedosos |
| KR20150029017A (ko) | 2012-07-10 | 2015-03-17 | 박스터 헬쓰케어 에스에이 | 항-mif 면역조직화학 |
| CA2894879A1 (en) | 2012-12-19 | 2014-06-26 | Amplimmune, Inc. | B7-h4 specific antibodies, and compositions and methods of use thereof |
| JP6462591B2 (ja) | 2013-02-22 | 2019-01-30 | アッヴィ・ステムセントルクス・エル・エル・シー | 新規抗体コンジュゲートおよびその使用 |
| US9562099B2 (en) | 2013-03-14 | 2017-02-07 | Genentech, Inc. | Anti-B7-H4 antibodies and immunoconjugates |
| BR112015022019A2 (pt) * | 2013-03-14 | 2017-08-29 | Genentech Inc | Anticorpos isolados, ácido nucleico, célula hospedeira, método de produção de anticorpos, imunoconjugado, formulação farmacêutica, métodos de tratamento de indivíduos, de inibição da proliferação de células, de detecção de b7-h4 humano e de detecção de câncer |
| JP2016538318A (ja) | 2013-08-28 | 2016-12-08 | ステムセントリックス， インコーポレイテッド | 新規ｓｅｚ６モジュレーターおよび使用方法 |
| BR112016004242A8 (pt) | 2013-08-28 | 2018-06-12 | Stemcentrx Inc | Métodos para conjugação sítio-específica de anticorpos e composições |
| KR20160070191A (ko) | 2013-11-06 | 2016-06-17 | 스템센트알엑스 인코포레이티드 | 신규한 항-클라우딘 항체 및 사용 방법 |
| US10308721B2 (en) | 2014-02-21 | 2019-06-04 | Abbvie Stemcentrx Llc | Anti-DLL3 antibodies and drug conjugates for use in melanoma |
| AU2015253422B2 (en) | 2014-04-30 | 2020-09-03 | Abbvie Stemcentrx Llc | Anti-PTK7 antibody-drug conjugates |
| TW201617368A (zh) | 2014-09-05 | 2016-05-16 | 史坦森特瑞斯公司 | 新穎抗ｍｆｉ２抗體及使用方法 |
| CN113698488A (zh) | 2014-09-12 | 2021-11-26 | 基因泰克公司 | 抗-b7-h4抗体及免疫缀合物 |
| US10934359B2 (en) | 2016-04-21 | 2021-03-02 | Abbvie Stemcentrx Llc | Anti-BMPR1B antibodies and methods of use |
| CA3045466A1 (en) | 2016-12-01 | 2018-06-07 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging |
| BR112020003533A2 (pt) | 2017-08-25 | 2020-11-17 | Five Prime Therapeutics, Inc. | anticorpos b7-h4 e métodos de uso dos mesmos |
| EP3743447B1 (en) | 2018-01-23 | 2024-03-27 | Nextcure, Inc. | B7-h4 antibodies and methods of use thereof |
| CA3091801A1 (en) | 2018-03-02 | 2019-09-06 | Five Prime Therapeutics, Inc. | B7-h4 antibodies and methods of use thereof |
| CN116172059A (zh) * | 2021-11-29 | 2023-05-30 | 内蒙古伊利实业集团股份有限公司 | 青苹果微胶囊、包含其的发酵乳及发酵乳饮料和制备方法 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
| US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
| US4137230A (en) | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
| US4265814A (en) | 1978-03-24 | 1981-05-05 | Takeda Chemical Industries | Matansinol 3-n-hexadecanoate |
| US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
| JPS5562090A (en) | 1978-10-27 | 1980-05-10 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164687A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
| JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
| JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS55164685A (en) | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164686A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US4309428A (en) | 1979-07-30 | 1982-01-05 | Takeda Chemical Industries, Ltd. | Maytansinoids |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| EP0028683A1 (en) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PHO and production thereof |
| JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
| WO1982001188A1 (en) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | 4,5-deoxymaytansinoide compounds and process for preparing same |
| US4450254A (en) | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
| US4313946A (en) | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
| US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
| JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| EP0861893A3 (en) | 1991-09-19 | 1999-11-10 | Genentech, Inc. | High level expression of immunoglobulin polypeptides |
| WO1993025673A1 (en) | 1992-06-04 | 1993-12-23 | The Regents Of The University Of California | In vivo gene therapy with intron-free sequence of interest |
| DE69329503T2 (de) | 1992-11-13 | 2001-05-03 | Idec Pharma Corp | Therapeutische Verwendung von chimerischen und markierten Antikörpern, die gegen ein Differenzierung-Antigen gerichtet sind, dessen Expression auf menschliche B Lymphozyt beschränkt ist, für die Behandlung von B-Zell-Lymphoma |
| DE69326937T2 (de) | 1993-03-24 | 2000-12-28 | Berlex Biosciences Richmond | Kombination von Antihormonale und bindende Moleküle zur Krebsbehandlung |
| US5910486A (en) | 1994-09-06 | 1999-06-08 | Uab Research Foundation | Methods for modulating protein function in cells using, intracellular antibody homologues |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| TW589189B (en) | 1997-08-04 | 2004-06-01 | Scras | Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| CA2328895A1 (en) * | 1998-06-02 | 1999-12-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| GB9827152D0 (en) | 1998-07-03 | 1999-02-03 | Devgen Nv | Characterisation of gene function using double stranded rna inhibition |
| JP2002523760A (ja) * | 1998-09-02 | 2002-07-30 | ダイアデクスアス・インコーポレーテッド | 様々な癌を診断、監視、段階づけ、造影及び治療する新規な方法 |
| US6468546B1 (en) * | 1998-12-17 | 2002-10-22 | Corixa Corporation | Compositions and methods for therapy and diagnosis of ovarian cancer |
| US20020119158A1 (en) * | 1998-12-17 | 2002-08-29 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| CA2361201A1 (en) | 1999-01-28 | 2000-08-03 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
| CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| WO2001049844A1 (en) | 1999-12-30 | 2001-07-12 | Rutgers, The State University Of New Jersey | Compositions and methods for gene silencing |
| JP2003526367A (ja) | 2000-03-16 | 2003-09-09 | ジェネティカ インコーポレイテッド | Ｒｎａ干渉の方法とｒｎａ干渉組成物 |
| EP2345742B1 (en) | 2000-03-30 | 2014-06-11 | The Whitehead Institute for Biomedical Research | RNA sequence-specific mediators of RNA interference |
| DK2857516T3 (en) * | 2000-04-11 | 2017-08-07 | Genentech Inc | Multivalent antibodies and uses thereof |
| MXPA02012749A (es) * | 2000-06-30 | 2003-10-06 | Amgen Inc | Moleculas semejantes a b7 y sus usos. |
| ES2728168T3 (es) | 2000-12-01 | 2019-10-22 | Max Planck Gesellschaft | Moléculas pequeñas de ARN que median en la interferencia de ARN |
| US20030087250A1 (en) * | 2001-03-14 | 2003-05-08 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer |
| JP4884224B2 (ja) * | 2003-05-09 | 2012-02-29 | ディアデクサス インコーポレーテッド | Ｏｖｒ１１０抗体組成物および使用方法 |
| CA2670696A1 (en) * | 2006-11-27 | 2008-06-05 | Diadexus, Inc. | Ovr110 antibody compositions and methods of use |
-
2004
- 2004-05-10 JP JP2006532897A patent/JP4884224B2/ja not_active Expired - Fee Related
- 2004-05-10 AT AT04760956T patent/ATE516047T1/de active
- 2004-05-10 CA CA2525899A patent/CA2525899C/en not_active Expired - Lifetime
- 2004-05-10 AU AU2004239301A patent/AU2004239301B2/en not_active Ceased
- 2004-05-10 DK DK04760956.5T patent/DK1633784T3/da active
- 2004-05-10 EP EP04760956A patent/EP1633784B1/en not_active Expired - Lifetime
- 2004-05-10 WO PCT/US2004/014490 patent/WO2004101756A2/en active Application Filing
- 2004-05-10 US US10/557,331 patent/US7619068B2/en not_active Expired - Lifetime
-
2005
- 2005-11-06 IL IL171797A patent/IL171797A/en active IP Right Grant
-
2009
- 2009-10-09 US US12/576,313 patent/US20100209438A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007504280A5 (ja) | ||
| Sun et al. | CD44+/CD24− breast cancer cells isolated from MCF-7 cultures exhibit enhanced angiogenic properties | |
| RU2627176C2 (ru) | Новые модуляторы и способы их применения | |
| JP2021151263A (ja) | シアリル−Ｌｅｗｉｓ ａに対するヒト抗体をコードする核酸 | |
| CN109422811A (zh) | 抗cd47抗体及其用途 | |
| JP2022106840A (ja) | Ｂ細胞成熟抗原結合タンパク質 | |
| AU2011293127B2 (en) | Notum protein modulators and methods of use | |
| JP2010510809A5 (ja) | ||
| US9101674B2 (en) | Targeting and in vivo imaging of tumor-associated macrophages | |
| JP2018008949A (ja) | 新規モジュレーターと使用の方法 | |
| RU2007133108A (ru) | АНТИТЕЛА, СВЯЗЫВАЮЩИЕСЯ С EphA2, И МЕТОДЫ ИХ ИСПОЛЬЗОВАНИЯ | |
| JP2005538701A5 (ja) | ||
| JP2008546780A5 (ja) | ||
| JP2012100677A5 (ja) | ||
| CN111183156A (zh) | 用于用抗cd19/cd20免疫治疗来治疗癌症的组合物和方法 | |
| Jiang et al. | Selective targeting of glioblastoma with EGFRvIII/EGFR bitargeted chimeric antigen receptor T cell | |
| JP2017500028A (ja) | 新規の抗ｄｐｅｐ３抗体および使用方法 | |
| JP2008537673A5 (ja) | ||
| RU2015108348A (ru) | Антитела, связывающиеся с лизилоксидазоподобным ферментом-2 (loxl2), и способы их применения | |
| NZ283366A (en) | Monoclonal antibodies recognizing tie receptors (receptor tyrosine kinase) and their use | |
| JP2005533493A5 (ja) | ||
| DK2623594T5 (en) | Antibody against human prostaglandin E2 receptor EP4 | |
| JP2009539380A5 (ja) | ||
| JP2010537671A5 (ja) | ||
| CN109970856A (zh) | 抗lag-3抗体及其用途 |