JP2007501857A5 - - Google Patents
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- Publication number
- JP2007501857A5 JP2007501857A5 JP2006532301A JP2006532301A JP2007501857A5 JP 2007501857 A5 JP2007501857 A5 JP 2007501857A5 JP 2006532301 A JP2006532301 A JP 2006532301A JP 2006532301 A JP2006532301 A JP 2006532301A JP 2007501857 A5 JP2007501857 A5 JP 2007501857A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- compound
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 146
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 88
- 150000003839 salts Chemical class 0.000 claims 86
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 77
- 239000003814 drug Substances 0.000 claims 56
- 238000004519 manufacturing process Methods 0.000 claims 56
- 125000000217 alkyl group Chemical group 0.000 claims 48
- 125000001475 halogen functional group Chemical group 0.000 claims 41
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 32
- 125000003277 amino group Chemical group 0.000 claims 22
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 208000002249 Diabetes Complications Diseases 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 15
- 206010012655 Diabetic complications Diseases 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 8
- -1 bicyclic heterocyclic amines Chemical class 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 208000020832 chronic kidney disease Diseases 0.000 claims 8
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims 8
- 238000010276 construction Methods 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 239000003937 drug carrier Substances 0.000 claims 8
- 208000027866 inflammatory disease Diseases 0.000 claims 8
- 230000000302 ischemic effect Effects 0.000 claims 8
- 125000004076 pyridyl group Chemical group 0.000 claims 8
- 230000010410 reperfusion Effects 0.000 claims 8
- 125000003107 substituted aryl group Chemical group 0.000 claims 8
- 208000019553 vascular disease Diseases 0.000 claims 8
- 239000003981 vehicle Substances 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45092503P | 2003-02-28 | 2003-02-28 | |
| PCT/US2004/005737 WO2005009398A2 (en) | 2003-02-28 | 2004-02-26 | Tetracyclic benzamide derivatives and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007501857A JP2007501857A (ja) | 2007-02-01 |
| JP2007501857A5 true JP2007501857A5 (https=) | 2007-04-05 |
Family
ID=34102592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006532301A Pending JP2007501857A (ja) | 2003-02-28 | 2004-02-26 | 四環系ベンズアミド誘導体およびその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7217709B2 (https=) |
| EP (1) | EP1603567A4 (https=) |
| JP (1) | JP2007501857A (https=) |
| KR (1) | KR20050118169A (https=) |
| CN (1) | CN100398519C (https=) |
| AU (1) | AU2004258801A1 (https=) |
| BR (1) | BRPI0407757A (https=) |
| CA (1) | CA2517260A1 (https=) |
| PL (1) | PL378331A1 (https=) |
| RU (1) | RU2005130169A (https=) |
| WO (1) | WO2005009398A2 (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6956035B2 (en) * | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| JP2007501857A (ja) * | 2003-02-28 | 2007-02-01 | イノテック ファーマシューティカルズ コーポレーション | 四環系ベンズアミド誘導体およびその使用方法 |
| EA200601558A1 (ru) * | 2004-02-26 | 2007-08-31 | Инотек Фармасьютикалз Корпорейшн | Производные изохинолинов и способы их использования |
| US20050261288A1 (en) * | 2004-02-26 | 2005-11-24 | Prakash Jagtap | Tetracyclic lactam derivatives and uses thereof |
| CA2571001A1 (en) * | 2004-06-16 | 2006-01-26 | Inotek Pharmaceuticals Corporation | Methods for treating or preventing erectile dysfunction or urinary incontinence |
| WO2006093677A1 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Tetracyclic sulfonamide compounds and methods of use thereof |
| RU2007135362A (ru) * | 2005-02-25 | 2009-03-27 | Инотек Фармасьютикалз Корпорейшн (Us) | Тетрациклические амино- и карбоксамидосоединения и способ их применения |
| JP2008531561A (ja) * | 2005-02-25 | 2008-08-14 | イノテック ファーマシューティカルズ コーポレイション | イソキノリン化合物およびその使用方法 |
| CA2617101A1 (en) * | 2005-08-08 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Method for the protection against the risk of cardiac disorders comprising administration of tiotropium salts |
| CN101316592A (zh) * | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
| CA2629530C (en) | 2005-11-14 | 2014-07-08 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | N-substituted indenoisoquinolines and syntheses thereof |
| US9399660B2 (en) | 2005-11-14 | 2016-07-26 | Purdue Research Foundation | N-substituted indenoisoquinolines and syntheses thereof |
| WO2007117289A2 (en) * | 2005-12-14 | 2007-10-18 | Inotek Pharmaceuticals Corporation | Methods for treating or preventing erectile dysfunction or urinary incontinence |
| MX2009009183A (es) * | 2007-02-28 | 2009-09-07 | Inotek Pharmaceuticals Corp | Analogos de indenoisoquinolinona y metodos de utilizacion de los mismos. |
| WO2008114114A2 (en) * | 2007-03-16 | 2008-09-25 | Pfizer Products Inc. | Poly(adp-ribose) polymerases inhibitor for treating ophthalmic condition |
| JP2009196973A (ja) * | 2007-09-26 | 2009-09-03 | Santen Pharmaceut Co Ltd | キナゾリノン誘導体又はキノキサリン誘導体を有効成分として含有する後眼部疾患の予防又は治療剤 |
| JP2009096804A (ja) * | 2007-09-26 | 2009-05-07 | Santen Pharmaceut Co Ltd | キナゾリノン誘導体又はキノキサリン誘導体を有効成分として含む角結膜障害の予防又は治療剤 |
| US20100137976A1 (en) * | 2008-12-02 | 2010-06-03 | Medtronic Vascular, Inc. | Systems and Methods for Treating Heart Tissue Via Localized Delivery of Parp Inhibitors |
| WO2010077663A2 (en) * | 2008-12-08 | 2010-07-08 | Inotek Pharmaceuticals Corporation | Substituted tetracyclic 1h-indeno (1,2-b) pyridine-2 (5h)-one analogs thereof and uses thereof |
| ITFI20090005A1 (it) * | 2009-01-19 | 2010-07-20 | Alberto Chiarugi | Formulazioni farmaceutiche per indurre immunosoppressione attraverso l'inibizione del fenomeno dell'epitope spreading e loro uso. |
| EP3613729A1 (en) * | 2009-06-10 | 2020-02-26 | Chugai Seiyaku Kabushiki Kaisha | Tetracyclic compounds |
| KR101034051B1 (ko) * | 2009-07-13 | 2011-05-11 | (재)광주테크노파크 | 신규한 이소인돌로[2,1-ｂ]이소퀴놀린온 유도체 및 이를 함유하는 항암제 조성물 |
| EP2280011A1 (en) * | 2009-07-28 | 2011-02-02 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Condensed pyridine derivatives useful as potent inhibitors of the protein kinase CK2 |
| WO2011058367A2 (en) | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor |
| WO2011094416A1 (en) | 2010-01-27 | 2011-08-04 | Purdue Research Foundation | Substituted norindenoisoquinolines, syntheses thereof, and methods of use |
| HUP1000243A2 (en) | 2010-05-06 | 2012-01-30 | Avidin Kft | 8-hidroxy-quinoline derivatives |
| CN102250000A (zh) * | 2010-05-17 | 2011-11-23 | 中国人民解放军第二军医大学 | 茚并喹啉酮类化合物及其制备方法和用途 |
| EP2578587B1 (en) * | 2010-05-24 | 2016-09-07 | Hande Starlake Bioscience Co., Ltd. | Pyrazole derivatives |
| US9073920B2 (en) | 2010-08-17 | 2015-07-07 | Purdue Research Foundation | Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor |
| CA2808210C (en) | 2010-08-20 | 2019-10-01 | Chugai Seiyaku Kabushiki Kaisha | Tetracyclic compounds having alk inhibitory activity and compositions thereof |
| TW201307347A (zh) | 2010-11-01 | 2013-02-16 | Arqule Inc | 經取代苯並－咪唑並－吡啶並－二氮呯化合物 |
| US9682990B2 (en) | 2011-05-25 | 2017-06-20 | Purdue Research Foundation | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors |
| US9328073B2 (en) | 2011-05-25 | 2016-05-03 | Purdue Research Foundation | Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors |
| US8912213B2 (en) | 2012-04-13 | 2014-12-16 | Purdue Research Foundation | Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors |
| US8686146B2 (en) | 2012-07-13 | 2014-04-01 | Purdue Research Foundation | Azaindenoisoquinoline topoisomerase I inhibitors |
| US9034870B2 (en) | 2012-07-13 | 2015-05-19 | Purdue Research Foundation | Azaindenoisoquinoline topoisomerase I inhibitors |
| SI2902029T1 (sl) | 2012-09-25 | 2018-11-30 | Chugai Seiyaku Kabushiki Kaisha | Inhibitor ret |
| WO2014063189A1 (en) * | 2012-10-23 | 2014-05-01 | Adelaide Research & Innovation Pty Ltd | Methods and products for preventing and/or treating a stress induced cardiomyopathy |
| EP3010055B1 (en) * | 2013-06-11 | 2021-10-20 | Idemitsu Kosan Co., Ltd | Material for organic electroluminescent elements, organic electroluminescent element using same, and electronic device |
| WO2015163448A1 (ja) | 2014-04-25 | 2015-10-29 | 中外製薬株式会社 | ４環性化合物を高用量含有する製剤 |
| WO2015163447A1 (ja) | 2014-04-25 | 2015-10-29 | 中外製薬株式会社 | ４環性化合物の新規結晶 |
| TWI831347B (zh) | 2014-08-08 | 2024-02-01 | 日商中外製藥股份有限公司 | 包含４環性化合物的非晶質體之固體分散體及製劑 |
| CA2973857C (en) | 2015-01-16 | 2023-11-07 | Chugai Seiyaku Kabushiki Kaisha | Combination drug |
| DE102016214092A1 (de) | 2016-07-29 | 2018-02-01 | Alligator Ventilfabrik Gmbh | Befestigungsvorrichtung zum Befestigen eines Messsensors, insbesondere Reifendrucksensors, und Verfahren zum Montieren eines Messsensors |
| WO2018197461A1 (en) | 2017-04-28 | 2018-11-01 | Akribes Biomedical Gmbh | A parp inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing |
| EP4316598B1 (en) | 2018-06-29 | 2025-06-18 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition comprising a poorly soluble basic agent |
| BR112021001145A2 (pt) | 2018-09-04 | 2021-04-20 | Chugai Seiyaku Kabushiki Kaisha | método para a produção de composto tetracíclico |
| EP3870572A1 (en) * | 2018-10-23 | 2021-09-01 | Myelopro Diagnostics and Research GmbH | Compounds targeting mutant calreticulin |
| CN118146221B (zh) * | 2024-05-13 | 2024-10-25 | 南京市鸿舜医药科技有限公司 | 一种吡咯并[3,2-b]吡啶类拓扑异构酶抑制剂、制法及其药物组合物和应用 |
| CN118221674B (zh) * | 2024-05-27 | 2025-01-28 | 南京市鸿舜医药科技有限公司 | 一种吡咯并[3,2-b]吡啶类Top/HDAC双靶点抑制剂、制法及其药物组合物和应用 |
Family Cites Families (52)
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| US3710795A (en) * | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| IT1054655B (it) * | 1975-08-27 | 1981-11-30 | Lepetit Spa | Derivati condensati del l isochinolina |
| US4263304A (en) * | 1978-06-05 | 1981-04-21 | Sumitomo Chemical Company, Limited | 7 H-indolo[2,3-c]isoquinolines |
| GB2025932B (en) * | 1978-06-13 | 1982-10-27 | Sumitomo Chemical Co | Indoloisoquinolines and processes for producing them |
| US4623304A (en) * | 1981-12-08 | 1986-11-18 | Sanyo Electric Co., Ltd. | Hermetically sealed rotary compressor |
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| SK278794B6 (sk) * | 1991-08-29 | 1998-03-04 | V�Fb | 2-hydroxyetylaminosubstituované deriváty 5,11-diox |
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| JP3643916B2 (ja) * | 1995-11-17 | 2005-04-27 | 大鵬薬品工業株式会社 | 新規な縮合インデン誘導体又はその塩 |
| AU8784698A (en) | 1997-08-15 | 1999-03-08 | Johns Hopkins University, The | Method of using selective parp inhibitors to prevent or treat neurotoxicity |
| US6250301B1 (en) | 1997-08-28 | 2001-06-26 | Hortal Harm B.V. | Vaporizer for inhalation and method for extraction of active ingredients from a crude natural product or other matrix |
| US6197785B1 (en) | 1997-09-03 | 2001-03-06 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity |
| US6635642B1 (en) | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
| US6346536B1 (en) * | 1997-09-03 | 2002-02-12 | Guilford Pharmaceuticals Inc. | Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same |
| US6514983B1 (en) | 1997-09-03 | 2003-02-04 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage |
| WO1999011644A1 (en) | 1997-09-03 | 1999-03-11 | Guilford Pharmaceuticals Inc. | Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity |
| US20020028813A1 (en) | 1997-09-03 | 2002-03-07 | Paul F. Jackson | Thioalkyl compounds, methods, and compositions for inhibiting parp activity |
| CA2332239A1 (en) | 1998-05-15 | 1999-11-25 | Guilford Pharmaceuticals Inc. | Fused tricyclic compounds which inhibit parp activity |
| JP2002515488A (ja) | 1998-05-15 | 2002-05-28 | ギルフォード ファーマシューティカルズ インコーポレイテッド | カルボキサミド化合物、組成物、及びｐａｒｐ活性の抑制方法 |
| WO2000010600A2 (en) * | 1998-08-24 | 2000-03-02 | Maxim Pharmaceuticals, Inc. | Activation and protection of t-cells (cd4+ and cd8+) using an h¿2? receptor agonist and other t-cell activating agents |
| CA2347100C (en) | 1998-10-14 | 2010-12-14 | Purdue Research Foundation | Novel indenoisoquinolines as antineoplastic agents |
| DE59911249D1 (de) | 1998-11-03 | 2005-01-13 | Abbott Gmbh & Co Kg | Substituierte 2-phenylbenzimidazole, deren herstellung und anwendung |
| US6387902B1 (en) | 1998-12-31 | 2002-05-14 | Guilford Pharmaceuticals, Inc. | Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP |
| US6201020B1 (en) | 1998-12-31 | 2001-03-13 | Guilford Pharmaceuticals, Inc. | Ortho-diphenol compounds, methods and pharmaceutical compositions for inhibiting parp |
| OA11749A (en) | 1999-01-11 | 2005-07-19 | Agouron Pharma | Tricyclic inhibitors of poly(adp-ribose)polymerases. |
| US6346535B1 (en) * | 1999-01-29 | 2002-02-12 | American Cyanamid Company | Fungicidal mixtures |
| AU779215B2 (en) * | 1999-07-16 | 2005-01-13 | Maxim Pharmaceuticals, Inc. | Activation and protection of cytotoxic lymphocytes using a reactive oxygen metabolite inhibitor |
| US6465448B1 (en) | 1999-08-13 | 2002-10-15 | Case Western Reserve University | Methoxyamine potentiation of temozolomide anti-cancer activity |
| US6277990B1 (en) * | 1999-12-07 | 2001-08-21 | Inotek Corporation | Substituted phenanthridinones and methods of use thereof |
| US6723733B2 (en) * | 2000-05-19 | 2004-04-20 | Guilford Pharmaceuticals, Inc. | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses |
| GB0017508D0 (en) | 2000-07-17 | 2000-08-30 | Novartis Ag | Antimicrobials |
| AUPR201600A0 (en) * | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| US6956035B2 (en) * | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| JP2003267888A (ja) | 2002-03-15 | 2003-09-25 | Seishi Yoneda | 心停止液 |
| US6992088B2 (en) | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
| JPWO2004043959A1 (ja) | 2002-11-12 | 2006-03-09 | 持田製薬株式会社 | 新規ｐａｒｐ阻害剤 |
| JP2007501857A (ja) * | 2003-02-28 | 2007-02-01 | イノテック ファーマシューティカルズ コーポレーション | 四環系ベンズアミド誘導体およびその使用方法 |
| GB0317466D0 (en) | 2003-07-25 | 2003-08-27 | Univ Sheffield | Use |
| KR20060123403A (ko) | 2003-12-01 | 2006-12-01 | 쿠도스 파마슈티칼스 리미티드 | 암 치료를 위한 ｄｎａ 손상 수복 억제제 |
| EA200601558A1 (ru) * | 2004-02-26 | 2007-08-31 | Инотек Фармасьютикалз Корпорейшн | Производные изохинолинов и способы их использования |
| US20050261288A1 (en) * | 2004-02-26 | 2005-11-24 | Prakash Jagtap | Tetracyclic lactam derivatives and uses thereof |
| CA2571001A1 (en) * | 2004-06-16 | 2006-01-26 | Inotek Pharmaceuticals Corporation | Methods for treating or preventing erectile dysfunction or urinary incontinence |
| US20060079510A1 (en) * | 2004-09-30 | 2006-04-13 | Kristoffer Hellstrand | Use of PARP-1 inhibitors for protecting tumorcidal lymphocytes from apoptosis |
| WO2006093677A1 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Tetracyclic sulfonamide compounds and methods of use thereof |
| JP2008531561A (ja) * | 2005-02-25 | 2008-08-14 | イノテック ファーマシューティカルズ コーポレイション | イソキノリン化合物およびその使用方法 |
| RU2007135362A (ru) * | 2005-02-25 | 2009-03-27 | Инотек Фармасьютикалз Корпорейшн (Us) | Тетрациклические амино- и карбоксамидосоединения и способ их применения |
| CN101316592A (zh) * | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
-
2004
- 2004-02-26 JP JP2006532301A patent/JP2007501857A/ja active Pending
- 2004-02-26 US US10/788,228 patent/US7217709B2/en not_active Expired - Fee Related
- 2004-02-26 CN CNB2004800114280A patent/CN100398519C/zh not_active Expired - Fee Related
- 2004-02-26 PL PL378331A patent/PL378331A1/pl unknown
- 2004-02-26 CA CA002517260A patent/CA2517260A1/en not_active Abandoned
- 2004-02-26 AU AU2004258801A patent/AU2004258801A1/en not_active Abandoned
- 2004-02-26 RU RU2005130169/04A patent/RU2005130169A/ru not_active Application Discontinuation
- 2004-02-26 WO PCT/US2004/005737 patent/WO2005009398A2/en not_active Ceased
- 2004-02-26 KR KR1020057016126A patent/KR20050118169A/ko not_active Withdrawn
- 2004-02-26 EP EP04775806A patent/EP1603567A4/en not_active Withdrawn
- 2004-02-26 BR BRPI0407757-1A patent/BRPI0407757A/pt not_active IP Right Cessation
-
2007
- 2007-04-12 US US11/786,627 patent/US20070249653A1/en not_active Abandoned
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