JP2007314517A5 - - Google Patents

Info

Publication number

JP2007314517A5

JP2007314517A5 JP2007108055A JP2007108055A JP2007314517A5 JP 2007314517 A5 JP2007314517 A5 JP 2007314517A5 JP 2007108055 A JP2007108055 A JP 2007108055A JP 2007108055 A JP2007108055 A JP 2007108055A JP 2007314517 A5 JP2007314517 A5 JP 2007314517A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

caffeine

ephedrine

loxoprofen

Prior art date

2007-04-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 15
• 239000008194 pharmaceutical composition Substances 0.000 claims 15
• OROGSEYTTFOCAN-DNJOTXNNSA-N Codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 12
• KWGRBVOPPLSCSI-WPRPVWTQSA-N Ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 claims 12
• 229960001948 caffeine Drugs 0.000 claims 8
• YMBXTVYHTMGZDW-UHFFFAOYSA-N Loxoprofen Chemical compound C1=CC(C(C(O)=O)C)=CC=C1CC1C(=O)CCC1 YMBXTVYHTMGZDW-UHFFFAOYSA-N 0.000 claims 7
• 229960002373 loxoprofen Drugs 0.000 claims 7
• 229960002179 ephedrine Drugs 0.000 claims 6
• 229960004126 codeine Drugs 0.000 claims 5
• 206010006451 Bronchitis Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• DKSZLDSPXIWGFO-BLOJGBSASA-N (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 claims 1
• 208000006673 Asthma Diseases 0.000 claims 1
• 206010006458 Bronchitis chronic Diseases 0.000 claims 1
• 208000007451 Chronic Bronchitis Diseases 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• 229960004415 Codeine Phosphate Drugs 0.000 claims 1
• RBOXVHNMENFORY-DNJOTXNNSA-N Dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 claims 1
• 206010014561 Emphysema Diseases 0.000 claims 1
• 229960002534 Ephedrine hydrochloride Drugs 0.000 claims 1
• 210000002175 Goblet Cells Anatomy 0.000 claims 1
• 206010020718 Hyperplasia Diseases 0.000 claims 1
• 229940051020 Methylephedrine hydrochloride Drugs 0.000 claims 1
• 206010035653 Pneumoconiosis Diseases 0.000 claims 1
• 208000008128 Pulmonary Tuberculosis Diseases 0.000 claims 1
• 206010057190 Respiratory tract infection Diseases 0.000 claims 1
• NTCYWJCEOILKNG-ROLPUNSJSA-N [(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-dimethylazanium;chloride Chemical compound Cl.CN(C)[C@@H](C)[C@H](O)C1=CC=CC=C1 NTCYWJCEOILKNG-ROLPUNSJSA-N 0.000 claims 1
• 230000001154 acute Effects 0.000 claims 1
• 230000000954 anitussive Effects 0.000 claims 1
• 201000009267 bronchiectasis Diseases 0.000 claims 1
• 230000001684 chronic Effects 0.000 claims 1
• 229940000425 combination drugs Drugs 0.000 claims 1
• 229960000920 dihydrocodeine Drugs 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 230000003419 expectorant Effects 0.000 claims 1
• 239000003172 expectorant agent Substances 0.000 claims 1
• BALXUFOVQVENIU-UHFFFAOYSA-N hydron;2-(methylamino)-1-phenylpropan-1-ol;chloride Chemical group Cl.CNC(C)C(O)C1=CC=CC=C1 BALXUFOVQVENIU-UHFFFAOYSA-N 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 210000002345 respiratory system Anatomy 0.000 claims 1
• 230000001629 suppression Effects 0.000 claims 1