JP2007314517A5 - - Google Patents

Info

Publication number

JP2007314517A5

JP2007314517A5 JP2007108055A JP2007108055A JP2007314517A5 JP 2007314517 A5 JP2007314517 A5 JP 2007314517A5 JP 2007108055 A JP2007108055 A JP 2007108055A JP 2007108055 A JP2007108055 A JP 2007108055A JP 2007314517 A5 JP2007314517 A5 JP 2007314517A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

caffeine

ephedrine

loxoprofen

Prior art date

2007-04-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 15
• 239000008194 pharmaceutical composition Substances 0.000 claims 15
• KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 claims 12
• OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 10
• 229960001948 caffeine Drugs 0.000 claims 8
• LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 7
• VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 7
• YMBXTVYHTMGZDW-UHFFFAOYSA-N loxoprofen Chemical compound C1=CC(C(C(O)=O)C)=CC=C1CC1C(=O)CCC1 YMBXTVYHTMGZDW-UHFFFAOYSA-N 0.000 claims 7
• 229960002373 loxoprofen Drugs 0.000 claims 7
• KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims 6
• 229960002179 ephedrine Drugs 0.000 claims 6
• 229960004126 codeine Drugs 0.000 claims 5
• OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 5
• 230000001154 acute effect Effects 0.000 claims 2
• 206010006451 bronchitis Diseases 0.000 claims 2
• 229940124579 cold medicine Drugs 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• DKSZLDSPXIWGFO-BLOJGBSASA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 claims 1
• 206010006458 Bronchitis chronic Diseases 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• 206010014561 Emphysema Diseases 0.000 claims 1
• BALXUFOVQVENIU-GNAZCLTHSA-N Ephedrine hydrochloride Chemical group Cl.CN[C@@H](C)[C@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-GNAZCLTHSA-N 0.000 claims 1
• 206010057190 Respiratory tract infections Diseases 0.000 claims 1
• NTCYWJCEOILKNG-ROLPUNSJSA-N [(1r,2s)-1-hydroxy-1-phenylpropan-2-yl]-dimethylazanium;chloride Chemical compound Cl.CN(C)[C@@H](C)[C@H](O)C1=CC=CC=C1 NTCYWJCEOILKNG-ROLPUNSJSA-N 0.000 claims 1
• 230000000954 anitussive effect Effects 0.000 claims 1
• 229940124584 antitussives Drugs 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 201000009267 bronchiectasis Diseases 0.000 claims 1
• 208000007451 chronic bronchitis Diseases 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 229960004415 codeine phosphate Drugs 0.000 claims 1
• 229940000425 combination drug Drugs 0.000 claims 1
• 229960000920 dihydrocodeine Drugs 0.000 claims 1
• RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 claims 1
• ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims 1
• 229960002534 ephedrine hydrochloride Drugs 0.000 claims 1
• 239000003172 expectorant agent Substances 0.000 claims 1
• 230000003419 expectorant effect Effects 0.000 claims 1
• 210000002175 goblet cell Anatomy 0.000 claims 1
• 206010020718 hyperplasia Diseases 0.000 claims 1
• 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
• 229940051020 methylephedrine hydrochloride Drugs 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 206010035653 pneumoconiosis Diseases 0.000 claims 1
• 208000008128 pulmonary tuberculosis Diseases 0.000 claims 1
• 210000002345 respiratory system Anatomy 0.000 claims 1
• 208000023504 respiratory system disease Diseases 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1