JP2006527178A5 - - Google Patents
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- Publication number
- JP2006527178A5 JP2006527178A5 JP2006508271A JP2006508271A JP2006527178A5 JP 2006527178 A5 JP2006527178 A5 JP 2006527178A5 JP 2006508271 A JP2006508271 A JP 2006508271A JP 2006508271 A JP2006508271 A JP 2006508271A JP 2006527178 A5 JP2006527178 A5 JP 2006527178A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- dimethylamine
- methoxy
- dimethylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10326097.8 | 2003-06-06 | ||
| DE10326097A DE10326097A1 (de) | 2003-06-06 | 2003-06-06 | Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen |
| PCT/EP2004/006027 WO2004108658A1 (de) | 2003-06-06 | 2004-06-04 | Verfahren zur herstellung substituierter 3-aryl-butyl-aminverbindungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006527178A JP2006527178A (ja) | 2006-11-30 |
| JP2006527178A5 true JP2006527178A5 (enExample) | 2011-09-08 |
| JP4848268B2 JP4848268B2 (ja) | 2011-12-28 |
Family
ID=33494923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006508271A Expired - Lifetime JP4848268B2 (ja) | 2003-06-06 | 2004-06-04 | 置換された３−アリールブチル−アミン−化合物の製造方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7417170B2 (enExample) |
| EP (1) | EP1633697B1 (enExample) |
| JP (1) | JP4848268B2 (enExample) |
| KR (1) | KR101146205B1 (enExample) |
| CN (1) | CN1829681B (enExample) |
| AT (1) | ATE425136T1 (enExample) |
| AU (1) | AU2004245223C1 (enExample) |
| BR (1) | BRPI0411268C8 (enExample) |
| CA (1) | CA2528087C (enExample) |
| CY (1) | CY1109088T1 (enExample) |
| DE (2) | DE10326097A1 (enExample) |
| DK (1) | DK1633697T3 (enExample) |
| EC (1) | ECSP056218A (enExample) |
| ES (1) | ES2323870T3 (enExample) |
| HR (1) | HRP20090333T1 (enExample) |
| IL (1) | IL172357A (enExample) |
| MX (1) | MXPA05013193A (enExample) |
| NO (1) | NO335587B1 (enExample) |
| NZ (1) | NZ544231A (enExample) |
| PL (1) | PL1633697T3 (enExample) |
| PT (1) | PT1633697E (enExample) |
| RU (1) | RU2380355C2 (enExample) |
| SI (1) | SI1633697T1 (enExample) |
| WO (1) | WO2004108658A1 (enExample) |
| ZA (1) | ZA200600109B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10328316A1 (de) | 2003-06-23 | 2005-01-20 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| DE102005052588A1 (de) | 2005-11-02 | 2007-05-10 | Grünenthal GmbH | Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse |
| MX2009000911A (es) * | 2006-07-24 | 2009-02-04 | Janssen Pharmaceutica Nv | Preparacion de (2r,3r)-3-(3-metoxifenil)-n,n,2-trimetilpentanamina . |
| TWI496762B (zh) * | 2006-07-24 | 2015-08-21 | 歌林達股份有限公司 | 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法 |
| TWI401237B (zh) | 2006-07-24 | 2013-07-11 | ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備 | |
| CN101939287B (zh) * | 2007-12-07 | 2014-10-22 | 格吕伦塔尔有限公司 | (1r,2r)-3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚的结晶变体 |
| US20100227921A1 (en) * | 2009-03-03 | 2010-09-09 | Shire Llc | Amino acid and peptide carbamate prodrugs of tapentadol and uses thereof |
| CN102002065B (zh) * | 2009-09-02 | 2014-09-10 | 上海特化医药科技有限公司 | 他喷他多的制备方法及其中间体 |
| US8288592B2 (en) | 2009-09-22 | 2012-10-16 | Actavis Group Ptc Ehf | Solid state forms of tapentadol salts |
| IT1397189B1 (it) * | 2009-12-01 | 2013-01-04 | Archimica Srl | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
| WO2011080736A1 (en) | 2009-12-29 | 2011-07-07 | Mapi Pharma Hk Limited | Intermediate compounds and processes for the preparation of tapentadol and related compounds |
| WO2011092719A2 (en) * | 2010-02-01 | 2011-08-04 | Ind-Swift Laboratories Limited | Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives |
| US20130096346A1 (en) | 2010-03-05 | 2013-04-18 | Actavis Group Ptc Ehf | Resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol |
| WO2011128784A2 (en) | 2010-04-05 | 2011-10-20 | Actavis Group Ptc Ehf | Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof |
| ITMI20100924A1 (it) * | 2010-05-21 | 2011-11-22 | Fidia Farmaceutici | Nuovo metodo di sintesi delle due forme enantiomeriche del tapentadol |
| CN103168025B (zh) * | 2010-06-15 | 2015-02-25 | 格吕伦塔尔有限公司 | 用于制备取代的3-(1-氨基-2-甲基戊烷-3-基)苯基化合物的方法 |
| IT1401109B1 (it) | 2010-07-02 | 2013-07-12 | Archimica Srl | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
| ES2860676T3 (es) * | 2010-07-23 | 2021-10-05 | Gruenenthal Gmbh | Sales o cocristales de 3- (3-dimetilamino-1-etil-2-metil-propil) -fenol |
| EP2606030B1 (en) | 2010-08-16 | 2016-05-18 | Indoco Remedies Limited | Process for the preparation of tapentadol |
| US8552219B2 (en) | 2010-09-20 | 2013-10-08 | Ind-Swift Laboratories Limited | Process for preparing L-phenyl-3-dimethylaminopropane derivative |
| CN102477016B (zh) * | 2010-11-26 | 2014-12-17 | 中国医学科学院药物研究所 | 他喷他多的中间体的合成与应用 |
| HUP1300623A2 (en) * | 2010-12-30 | 2014-03-28 | Zentiva Ks | O-substituted (2r,3r)-3-(3-hidroxiphenil)-2-metyil-4-pentenoic acids and a method of obtaining the same |
| CZ2010998A3 (cs) * | 2010-12-30 | 2012-02-08 | Zentiva, K.S. | Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu) |
| CZ2010997A3 (cs) * | 2010-12-30 | 2012-02-08 | Zentiva, K.S. | Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu) |
| WO2012146978A2 (en) | 2011-04-28 | 2012-11-01 | Actavis Group Ptc Ehf | A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof |
| EP2530072A1 (en) | 2011-06-03 | 2012-12-05 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
| WO2013016840A1 (zh) | 2011-07-29 | 2013-02-07 | 安徽省新星药物开发有限责任公司 | 用于合成他喷他多或其类似物的新中间体 |
| WO2013105109A1 (en) | 2011-11-09 | 2013-07-18 | Indoco Remedies Limited | Process for the preparation of tapentadol |
| US20130150622A1 (en) | 2011-12-12 | 2013-06-13 | Boehringer Ingelheim International Gmbh | Stereoselective synthesis of tapentadol and its salts |
| WO2013120466A1 (en) | 2012-02-17 | 2013-08-22 | Zentiva, K.S. | A new solid form of tapentadol and a method of its preparation |
| EP2674414A1 (en) | 2012-06-15 | 2013-12-18 | Siegfried AG | Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds |
| CN103159633B (zh) * | 2012-07-06 | 2015-08-12 | 江苏恩华药业股份有限公司 | 他喷他多的制备方法及用于制备他喷他多的化合物 |
| IN2013MU03670A (enExample) | 2013-11-21 | 2015-07-31 | Unimark Remedies Ltd | |
| SI3083551T1 (en) | 2013-12-16 | 2018-04-30 | Farma Grs, D.O.O. | CRYSTAL FORM INTERMEDIATE TAPENTADOL |
| CZ307492B6 (cs) | 2014-02-04 | 2018-10-17 | Zentiva, K.S. | Pevná forma maleátu tapentadolu a způsob její přípravy |
| CA2991421C (en) | 2015-07-10 | 2019-04-30 | Mallinckrodt Llc | A two-step process for preparing 3-substituted phenylalkylamines |
| EP4269384A1 (en) | 2022-04-26 | 2023-11-01 | KRKA, d.d., Novo mesto | Method for crystallizing tapentadol intermediate, tapentadol intermediate of high purity, method of making tapentadol and tapentadol of high purity |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3978129A (en) * | 1972-01-28 | 1976-08-31 | A. H. Robins Company, Incorporated | Alkenyl- and alkanylamines |
| DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| DE19857475A1 (de) * | 1998-12-14 | 2000-06-15 | Gruenenthal Gmbh | Substituierte Cycloheptene, deren Herstellung und Verwendung |
| DE19933421A1 (de) | 1999-07-16 | 2001-01-25 | Gruenenthal Gmbh | 2-Benzyl-3-dimethylamino-1-phenyl-propanderi- vate |
| DE10000311A1 (de) * | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Aminomethyl-Phonyl-Cyclohexanonderivate |
-
2003
- 2003-06-06 DE DE10326097A patent/DE10326097A1/de not_active Withdrawn
-
2004
- 2004-06-04 CN CN2004800218627A patent/CN1829681B/zh not_active Expired - Lifetime
- 2004-06-04 JP JP2006508271A patent/JP4848268B2/ja not_active Expired - Lifetime
- 2004-06-04 KR KR1020057023464A patent/KR101146205B1/ko not_active Expired - Lifetime
- 2004-06-04 HR HR20090333T patent/HRP20090333T1/xx unknown
- 2004-06-04 DK DK04739583T patent/DK1633697T3/da active
- 2004-06-04 PL PL04739583T patent/PL1633697T3/pl unknown
- 2004-06-04 MX MXPA05013193A patent/MXPA05013193A/es active IP Right Grant
- 2004-06-04 WO PCT/EP2004/006027 patent/WO2004108658A1/de not_active Ceased
- 2004-06-04 AU AU2004245223A patent/AU2004245223C1/en not_active Expired
- 2004-06-04 BR BRPI0411268A patent/BRPI0411268C8/pt not_active IP Right Cessation
- 2004-06-04 SI SI200431114T patent/SI1633697T1/sl unknown
- 2004-06-04 EP EP04739583A patent/EP1633697B1/de not_active Expired - Lifetime
- 2004-06-04 NZ NZ544231A patent/NZ544231A/en not_active IP Right Cessation
- 2004-06-04 CA CA2528087A patent/CA2528087C/en not_active Expired - Lifetime
- 2004-06-04 DE DE502004009142T patent/DE502004009142D1/de not_active Expired - Lifetime
- 2004-06-04 PT PT04739583T patent/PT1633697E/pt unknown
- 2004-06-04 AT AT04739583T patent/ATE425136T1/de active
- 2004-06-04 RU RU2005141518/04A patent/RU2380355C2/ru active
- 2004-06-04 ES ES04739583T patent/ES2323870T3/es not_active Expired - Lifetime
-
2005
- 2005-12-05 IL IL172357A patent/IL172357A/en not_active IP Right Cessation
- 2005-12-06 US US11/294,449 patent/US7417170B2/en not_active Expired - Lifetime
- 2005-12-13 EC EC2005006218A patent/ECSP056218A/es unknown
-
2006
- 2006-01-04 NO NO20060044A patent/NO335587B1/no unknown
- 2006-01-05 ZA ZA200600109A patent/ZA200600109B/en unknown
-
2009
- 2009-05-21 CY CY20091100536T patent/CY1109088T1/el unknown
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