JP2006525315A - 活性薬剤構成要素および活性薬剤層の遠位に逆作用薬剤構成要素を含んでなる不正使用防止機能付き経皮的剤形 - Google Patents

活性薬剤構成要素および活性薬剤層の遠位に逆作用薬剤構成要素を含んでなる不正使用防止機能付き経皮的剤形 Download PDF

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Publication number
JP2006525315A
JP2006525315A JP2006507485A JP2006507485A JP2006525315A JP 2006525315 A JP2006525315 A JP 2006525315A JP 2006507485 A JP2006507485 A JP 2006507485A JP 2006507485 A JP2006507485 A JP 2006507485A JP 2006525315 A JP2006525315 A JP 2006525315A
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Prior art keywords
dosage form
active agent
agent component
barrier
transdermal dosage
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JP2006507485A
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Japanese (ja)
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JP2006525315A5 (enExample
Inventor
アール． ハート，ジョン
シー． アンダーソン，スティーブン
エー． バンブラリコム，メリッサ
アール． ボスル，エレン
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3M Innovative Properties Co
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3M Innovative Properties Co
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Publication of JP2006525315A publication Critical patent/JP2006525315A/ja
Publication of JP2006525315A5 publication Critical patent/JP2006525315A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2006507485A 2003-04-30 2004-03-23 活性薬剤構成要素および活性薬剤層の遠位に逆作用薬剤構成要素を含んでなる不正使用防止機能付き経皮的剤形 Pending JP2006525315A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46724303P 2003-04-30 2003-04-30
US10/744,966 US20040219195A1 (en) 2003-04-30 2003-12-23 Abuse-resistant transdermal dosage form
PCT/US2004/008856 WO2004098568A2 (en) 2003-04-30 2004-03-23 Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012064165A Division JP2012140453A (ja) 2003-04-30 2012-03-21 活性薬剤構成要素および活性薬剤層の遠位に逆作用薬剤構成要素を含んでなる不正使用防止機能付き経皮的剤形

Publications (2)

Publication Number Publication Date
JP2006525315A true JP2006525315A (ja) 2006-11-09
JP2006525315A5 JP2006525315A5 (enExample) 2007-05-10

Family

ID=33313652

Family Applications (2)

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JP2006507485A Pending JP2006525315A (ja) 2003-04-30 2004-03-23 活性薬剤構成要素および活性薬剤層の遠位に逆作用薬剤構成要素を含んでなる不正使用防止機能付き経皮的剤形
JP2012064165A Pending JP2012140453A (ja) 2003-04-30 2012-03-21 活性薬剤構成要素および活性薬剤層の遠位に逆作用薬剤構成要素を含んでなる不正使用防止機能付き経皮的剤形

Family Applications After (1)

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JP2012064165A Pending JP2012140453A (ja) 2003-04-30 2012-03-21 活性薬剤構成要素および活性薬剤層の遠位に逆作用薬剤構成要素を含んでなる不正使用防止機能付き経皮的剤形

Country Status (9)

Country Link
US (2) US20040219195A1 (enExample)
EP (1) EP1651196B1 (enExample)
JP (2) JP2006525315A (enExample)
AT (1) ATE423551T1 (enExample)
AU (2) AU2004237579A1 (enExample)
CA (1) CA2523709A1 (enExample)
DE (1) DE602004019653D1 (enExample)
ES (1) ES2322154T3 (enExample)
WO (1) WO2004098568A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006525370A (ja) * 2003-04-30 2006-11-09 パーデュー、ファーマ、リミテッド、パートナーシップ 耐タンパー性経皮剤形
JP2010222269A (ja) * 2009-03-19 2010-10-07 Lintec Corp 経皮吸収型貼付剤
JP2013524275A (ja) * 2010-04-03 2013-06-17 ドシ，プラフル 薬剤を含む医療機器、その製造方法とその使用方法
JP2017505312A (ja) * 2014-01-22 2017-02-16 ４ピー セラピューティクス 乱用および誤用抑止経皮システム
JP2018059117A (ja) * 2012-03-30 2018-04-12 スリーエム イノベイティブ プロパティズ カンパニー 尿素系及びウレタン系の感圧性接着剤ブレンド

Families Citing this family (16)

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US8790689B2 (en) * 2003-04-30 2014-07-29 Purdue Pharma L.P. Tamper resistant transdermal dosage form
US8608889B2 (en) * 2005-06-10 2013-12-17 3M Innovative Properties Company Method for handling adhesive laminate sections
CN101330903B (zh) * 2005-12-13 2015-07-08 生物递送科学国际公司 防滥用的经黏膜给药装置
US7740879B2 (en) * 2006-01-17 2010-06-22 Harrogate Holdings Abuse resistant transdermal drug delivery patch
DE102006025282A1 (de) 2006-05-31 2007-12-20 Lts Lohmann Therapie-Systeme Ag Selbstzerstörendes transdermales therapeutisches System
CN103550136B (zh) 2006-07-21 2016-04-13 生物递送科学国际公司 吸收增强的经粘膜递送装置
US20080140024A1 (en) * 2006-12-08 2008-06-12 Yoseph Yaacobi Drug delivery device
EP2259780A2 (en) * 2008-02-28 2010-12-15 Syntropharma Limited Pharmaceutical composition comprising naltrexone
ES2660116T3 (es) 2011-08-18 2018-03-20 Biodelivery Sciences International, Inc. Dispositivos mucoadhesivos resistentes al uso inadecuado para la administración de buprenorfina
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
US9950106B2 (en) 2012-12-05 2018-04-24 Cook Medical Technologies Llc Antimicrobial barrier device
CN107107598B (zh) 2014-12-18 2019-11-22 3M创新有限公司 处理粘合层合物贴剂的方法
US10010543B1 (en) 2014-12-23 2018-07-03 Barr Laboratories, Inc. Transdermal dosage form
AU2016209190A1 (en) 2015-01-23 2017-08-10 Marcio Marc Abreu Apparatus and method for skin treatment
CN110470607B (zh) * 2018-05-09 2021-12-07 江苏集萃智能液晶科技有限公司 一种检测混合溶液中亲水性有机溶剂含量的方法
WO2020008370A1 (en) * 2018-07-02 2020-01-09 Clexio Biosciences Ltd. Transdermal patch

Citations (5)

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Publication number Priority date Publication date Assignee Title
JPS63145828U (enExample) * 1987-03-17 1988-09-27
US5149538A (en) * 1991-06-14 1992-09-22 Warner-Lambert Company Misuse-resistive transdermal opioid dosage form
US5840327A (en) * 1995-08-21 1998-11-24 Alza Corporation Transdermal drug delivery device having enhanced adhesion
WO2002087482A1 (en) * 2001-05-01 2002-11-07 Euro-Celtique Abuse resistant opioid containing transdermal systems
JP2005526839A (ja) * 2002-04-23 2005-09-08 アルザ・コーポレーシヨン 不正使用の可能性が低い経皮鎮痛薬システム

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US1602344A (en) * 1924-01-09 1926-10-05 Eagle Peter Medicating compress
US2807262A (en) * 1952-12-10 1957-09-24 Robert B Lew Perforated plastic adhesive tape bandage
US3773955A (en) * 1970-08-03 1973-11-20 Bristol Myers Co Analgetic compositions
US4457933A (en) * 1980-01-24 1984-07-03 Bristol-Myers Company Prevention of analgesic abuse
US4539256A (en) * 1982-09-09 1985-09-03 Minnesota Mining And Manufacturing Co. Microporous sheet material, method of making and articles made therewith
US4693776A (en) * 1985-05-16 1987-09-15 Minnesota Mining And Manufacturing Company Macromer reinforced pressure sensitive skin adhesive
US4666441A (en) * 1985-12-17 1987-05-19 Ciba-Geigy Corporation Multicompartmentalized transdermal patches
US4743249A (en) * 1986-02-14 1988-05-10 Ciba-Geigy Corp. Dermal and transdermal patches having a discontinuous pattern adhesive layer
DE3634016A1 (de) * 1986-04-17 1987-10-29 Lohmann Gmbh & Co Kg Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung
US4917688A (en) * 1987-01-14 1990-04-17 Nelson Research & Development Co. Bandage for transdermal delivery of systemically-active drug
DE3722775A1 (de) * 1987-07-09 1989-01-19 Lohmann Therapie Syst Lts Transdermales therapeutisches system
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5236714A (en) * 1988-11-01 1993-08-17 Alza Corporation Abusable substance dosage form having reduced abuse potential
US5176917A (en) * 1989-03-15 1993-01-05 Lts Lohmann Transdermal system exhibiting graduated drug release and its use for the local or systemic administration of active substances
US5756117A (en) * 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
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NZ528148A (en) * 2001-03-16 2006-02-24 Alza Corp Transdermal patch for administering fentanyl
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US20040109886A1 (en) * 2002-08-27 2004-06-10 Larry Rigby Methods and apparatus for transdermal delivery of abusable drugs with a deterrent agent
US20040191301A1 (en) * 2003-03-27 2004-09-30 Van Duren Albert Philip Transdermal device having a phase change material
US7182955B2 (en) * 2003-04-30 2007-02-27 3M Innovative Properties Company Abuse-resistant transdermal dosage form
NZ542969A (en) * 2003-04-30 2009-09-25 Purdue Pharma Lp Tamper resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer
DE102004038179A1 (de) * 2004-08-06 2006-03-16 Daimlerchrysler Ag Verfahren zur Herstellung einer thermisch beschichteten Zylinderlauffläche mit einer Einfuhrfase

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63145828U (enExample) * 1987-03-17 1988-09-27
US5149538A (en) * 1991-06-14 1992-09-22 Warner-Lambert Company Misuse-resistive transdermal opioid dosage form
US5840327A (en) * 1995-08-21 1998-11-24 Alza Corporation Transdermal drug delivery device having enhanced adhesion
WO2002087482A1 (en) * 2001-05-01 2002-11-07 Euro-Celtique Abuse resistant opioid containing transdermal systems
JP2005526839A (ja) * 2002-04-23 2005-09-08 アルザ・コーポレーシヨン 不正使用の可能性が低い経皮鎮痛薬システム

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006525370A (ja) * 2003-04-30 2006-11-09 パーデュー、ファーマ、リミテッド、パートナーシップ 耐タンパー性経皮剤形
US8778382B2 (en) 2003-04-30 2014-07-15 Purdue Pharma L.P. Tamper resistant transdermal dosage form
JP2010222269A (ja) * 2009-03-19 2010-10-07 Lintec Corp 経皮吸収型貼付剤
JP2013524275A (ja) * 2010-04-03 2013-06-17 ドシ，プラフル 薬剤を含む医療機器、その製造方法とその使用方法
JP2018059117A (ja) * 2012-03-30 2018-04-12 スリーエム イノベイティブ プロパティズ カンパニー 尿素系及びウレタン系の感圧性接着剤ブレンド
JP2017505312A (ja) * 2014-01-22 2017-02-16 ４ピー セラピューティクス 乱用および誤用抑止経皮システム

Also Published As

Publication number Publication date
US20100068249A1 (en) 2010-03-18
ATE423551T1 (de) 2009-03-15
WO2004098568A2 (en) 2004-11-18
AU2010257440B2 (en) 2011-11-24
US20040219195A1 (en) 2004-11-04
CA2523709A1 (en) 2004-11-18
ES2322154T3 (es) 2009-06-17
AU2004237579A1 (en) 2004-11-18
DE602004019653D1 (de) 2009-04-09
EP1651196B1 (en) 2009-02-25
JP2012140453A (ja) 2012-07-26
WO2004098568A3 (en) 2005-02-03
AU2010257440A1 (en) 2011-01-20
EP1651196A2 (en) 2006-05-03

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