JP2006523192A

JP2006523192A - ビフェニル−カルボキサミド誘導体およびそれらのｐ３８キナーゼ阻害剤としての使用

ビフェニル−カルボキサミド誘導体およびそれらのｐ３８キナーゼ阻害剤としての使用 Download PDF

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Publication number: JP2006523192A
Authority: JP; Japan
Prior art keywords: alkyl; compound; hydrogen; substituted; formula
Prior art date: 2003-04-09
Legal status : Pending

Application number

JP2006505066A

Other languages

English (en)

Japanese (ja)

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JP2006523192A5 (enExample

Inventor

アストン，ニコラ，マリー

Original Assignee

スミスクラインビーチャムコーポレーション

Priority date

2003-04-09

Filing date

2004-04-07

Publication date

2006-10-12

2004-04-07 Application filed by スミスクラインビーチャムコーポレーション filed Critical スミスクラインビーチャムコーポレーション

2006-10-12 Publication of JP2006523192A publication Critical patent/JP2006523192A/ja

2007-05-24 Publication of JP2006523192A5 publication Critical patent/JP2006523192A5/ja

Status Pending legal-status Critical Current

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102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title claims abstract description 29
108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 title claims abstract description 29
229940043355 kinase inhibitor Drugs 0.000 title abstract description 3
239000003757 phosphotransferase inhibitor Substances 0.000 title abstract description 3
GTKIGDZXPDCIKR-UHFFFAOYSA-N 2-phenylbenzamide Chemical class NC(=O)C1=CC=CC=C1C1=CC=CC=C1 GTKIGDZXPDCIKR-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 claims abstract description 24
150000001875 compounds Chemical class 0.000 claims description 139
125000000217 alkyl group Chemical group 0.000 claims description 89
-1 R 2 is OH Chemical group 0.000 claims description 41
239000001257 hydrogen Substances 0.000 claims description 40
229910052739 hydrogen Inorganic materials 0.000 claims description 40
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 34
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238000000034 method Methods 0.000 claims description 25
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 22
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 20
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QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 17
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125000001424 substituent group Chemical group 0.000 claims description 17
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 16
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CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 16
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
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