ATE355265T1 - Biphenylcarboxamidderivate und ihre verwendung als p38 kinase inhibitoren - Google Patents

Biphenylcarboxamidderivate und ihre verwendung als p38 kinase inhibitoren

Info

Publication number
ATE355265T1
ATE355265T1 AT04726155T AT04726155T ATE355265T1 AT E355265 T1 ATE355265 T1 AT E355265T1 AT 04726155 T AT04726155 T AT 04726155T AT 04726155 T AT04726155 T AT 04726155T AT E355265 T1 ATE355265 T1 AT E355265T1
Authority
AT
Austria
Prior art keywords
kinase inhibitors
derivatives
biphenylcarboxamide
biphenylcarboxamide derivatives
pharmaceuticals
Prior art date
Application number
AT04726155T
Other languages
German (de)
English (en)
Inventor
Nicola Mary Aston
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE355265T1 publication Critical patent/ATE355265T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
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  • Pulmonology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
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  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
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AT04726155T 2003-04-09 2004-04-07 Biphenylcarboxamidderivate und ihre verwendung als p38 kinase inhibitoren ATE355265T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0308201.3A GB0308201D0 (en) 2003-04-09 2003-04-09 Novel compounds

Publications (1)

Publication Number Publication Date
ATE355265T1 true ATE355265T1 (de) 2006-03-15

Family

ID=9956489

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04726155T ATE355265T1 (de) 2003-04-09 2004-04-07 Biphenylcarboxamidderivate und ihre verwendung als p38 kinase inhibitoren

Country Status (8)

Country Link
US (1) US7626055B2 (enExample)
EP (1) EP1611085B1 (enExample)
JP (1) JP2006523192A (enExample)
AT (1) ATE355265T1 (enExample)
DE (1) DE602004005016T2 (enExample)
ES (1) ES2282857T3 (enExample)
GB (1) GB0308201D0 (enExample)
WO (1) WO2004089875A1 (enExample)

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KR101475115B1 (ko) * 2012-06-15 2014-12-23 중앙대학교 산학협력단 탐식작용 억제 효과를 가지는 자가 면역질환의 예방 또는 치료용 화합물
CA3127373A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
KR102298450B1 (ko) * 2021-01-29 2021-09-08 (주)프레이저테라퓨틱스 p38 MAP 키나아제 억제제로 항염증 활성을 나타내는 신규 화합물

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US20070105850A1 (en) 2007-05-10
DE602004005016T2 (de) 2007-10-31
EP1611085A1 (en) 2006-01-04
ES2282857T3 (es) 2007-10-16
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WO2004089875A1 (en) 2004-10-21
JP2006523192A (ja) 2006-10-12

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