JP2006514684A - Ｒｏｃｋおよび他のプロテインキナーゼとして有用な組成物 - Google Patents

Ｒｏｃｋおよび他のプロテインキナーゼとして有用な組成物 Download PDF

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Publication number
JP2006514684A
JP2006514684A JP2005502202A JP2005502202A JP2006514684A JP 2006514684 A JP2006514684 A JP 2006514684A JP 2005502202 A JP2005502202 A JP 2005502202A JP 2005502202 A JP2005502202 A JP 2005502202A JP 2006514684 A JP2006514684 A JP 2006514684A
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phenyl
compound
independently
occurrence
hydrogen
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Japanese (ja)
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JP2006514684A5 (https=
Inventor
カオ，　ジンロン
ファーイ カオ，
ジェレミー グリーン，
クライグ マーヘフカ，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Organic Chemistry (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
JP2005502202A 2002-10-30 2003-10-30 Ｒｏｃｋおよび他のプロテインキナーゼとして有用な組成物 Withdrawn JP2006514684A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42244102P 2002-10-30 2002-10-30
US47643303P 2003-06-06 2003-06-06
US47669103P 2003-06-06 2003-06-06
US47990303P 2003-06-19 2003-06-19
PCT/US2003/034319 WO2004041813A1 (en) 2002-10-30 2003-10-30 Compositions useful as inhibitors of rock and other protein kinases

Publications (2)

Publication Number Publication Date
JP2006514684A true JP2006514684A (ja) 2006-05-11
JP2006514684A5 JP2006514684A5 (https=) 2006-12-21

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ID=32314959

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JP2005502202A Withdrawn JP2006514684A (ja) 2002-10-30 2003-10-30 Ｒｏｃｋおよび他のプロテインキナーゼとして有用な組成物

Country Status (14)

Country Link
US (1) US20040122016A1 (https=)
EP (1) EP1558607B1 (https=)
JP (1) JP2006514684A (https=)
KR (1) KR20050088283A (https=)
AR (1) AR043057A1 (https=)
AT (1) ATE466855T1 (https=)
AU (1) AU2003288956A1 (https=)
CA (1) CA2504320A1 (https=)
DE (1) DE60332475D1 (https=)
MX (1) MXPA05004689A (https=)
NO (1) NO20052595L (https=)
NZ (1) NZ540161A (https=)
TW (1) TW200416221A (https=)
WO (1) WO2004041813A1 (https=)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007531757A (ja) * 2004-03-30 2007-11-08 カイロン コーポレイション 抗癌剤としての置換チオフェン誘導体
JP2007535551A (ja) * 2004-04-28 2007-12-06 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ｒｏｃｋおよび他のプロテインキナーゼの阻害剤として有用な組成物
WO2008050600A1 (en) * 2006-10-25 2008-05-02 Neugen Pharma Inc. Therapeutic or preventive agent for intractable disease based on oxidative stress-mediated cell death as molecular background
JP2009544755A (ja) * 2006-07-28 2009-12-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を変調する化合物
JP2011529458A (ja) * 2008-07-30 2011-12-08 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト 置換ピリジン類およびｇｓｋ３阻害剤としてのそれらの使用
JP2012521407A (ja) * 2009-03-23 2012-09-13 グレンマーク ファーマシューティカルズ， エセ．アー． Ｔｒｐａ１調節因子としてのチエノピリミジンジオン誘導体
JP2013536818A (ja) * 2010-09-01 2013-09-26 バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー 除草活性を有するケトスルタム類及びジケトピリジン類
JP2015164927A (ja) * 2009-12-14 2015-09-17 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 癌などの疾患を処置するためのチアゾール誘導体
JP2017516859A (ja) * 2014-05-30 2017-06-22 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ １，３，４−チアジアゾール化合物および癌を治療する際のその使用
JP2017537948A (ja) * 2014-12-17 2017-12-21 ジャンキョテックス スイス エスアーＧｅｎｋｙｏｔｅｘ Ｓｕｉｓｓｅ Ｓａ Ｎａｄｐｈオキシダーゼ阻害剤としてのアミドチアジアゾール誘導体
JP2019504900A (ja) * 2016-02-16 2019-02-21 コリア・インスティテュート・オブ・サイエンス・アンド・テクノロジー プロテインキナーゼ阻害剤である新規な２，３，５−置換チオフェン化合物
JP2020527560A (ja) * 2017-07-12 2020-09-10 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｒｏｃｋ阻害剤としてのフェニルアセトアミド
JP2023510743A (ja) * 2020-01-07 2023-03-15 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１の阻害剤

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196106B2 (en) * 2002-11-05 2007-03-27 Merck & Co., Inc Cyanothiophene derivatives, compositions containing such compounds and methods of use
AR044519A1 (es) 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
CA2536253A1 (en) 2003-08-20 2005-03-03 Vertex Pharmaceuticals Incorporated Aminofurazan compounds useful as protein kinase inhibitors
ZA200602755B (en) * 2003-09-06 2007-06-27 Vertex Pharma Modulators of ATP-binding cassette transporters
US20050085531A1 (en) * 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
JP4638355B2 (ja) * 2003-12-26 2011-02-23 協和発酵キリン株式会社 チアゾール誘導体
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
MXPA06008606A (es) 2004-01-30 2007-04-13 Vertex Pharma Moduladores de transportadores con casete de union a atp.
US20070293484A1 (en) * 2004-05-20 2007-12-20 Sugen, Inc. Thiophene Heteroaryl Amines
CA2575466A1 (en) * 2004-08-13 2006-02-23 Genentech, Inc. Thiazole based inhibitors of atp-utilizing enzymes
EP1809282B1 (en) * 2004-10-18 2013-01-09 Amgen, Inc Thiadiazole compounds and methods of use
WO2006058120A1 (en) * 2004-11-22 2006-06-01 Vertex Pharmaceuticals Incorporated Bicyclic inhibitors or rho kinase
EP1824835A1 (en) * 2004-12-03 2007-08-29 Novo Nordisk A/S Heteroaromatic glucokinase activators
EP1894930A4 (en) 2005-06-23 2010-06-23 Kyowa Hakko Kirin Co Ltd THIAZOLE DERIVATIVE
WO2007037543A1 (ja) * 2005-09-29 2007-04-05 Banyu Pharmaceutical Co., Ltd. ビアリールアミド誘導体
CA2627813A1 (en) * 2005-11-01 2007-05-10 Janssen Pharmaceutica N.V. Substituted pyrrolones as allosteric modulators of glucokinase
EP1951706A1 (en) * 2005-11-01 2008-08-06 Janssen Pharmaceutica N.V. Dihydroisoindolones as allosteric modulators of glucokinase
EP1960386A2 (en) * 2005-11-01 2008-08-27 Janssen Pharmaceutica N.V. Substituted cycloalkylpyrrolones as allosteric modulators of glucokinase
CN101316836A (zh) 2005-11-01 2008-12-03 詹森药业有限公司 作为葡萄糖激酶变构调节剂的取代的二氢异吲哚酮类
WO2007084391A2 (en) 2006-01-18 2007-07-26 Amgen Inc. Thiazole compounds as protein kinase b ( pkb) inhibitors
WO2007125105A2 (en) 2006-04-28 2007-11-08 Transtech Pharma, Inc. Benzamide glucokinase activators
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