JP2006512366A - ピラゾロ［３，４−ｄ］ピリミジン誘導体及び処置におけるその使用 - Google Patents

ピラゾロ［３，４−ｄ］ピリミジン誘導体及び処置におけるその使用 Download PDF

Info

Publication number
JP2006512366A
JP2006512366A JP2004562221A JP2004562221A JP2006512366A JP 2006512366 A JP2006512366 A JP 2006512366A JP 2004562221 A JP2004562221 A JP 2004562221A JP 2004562221 A JP2004562221 A JP 2004562221A JP 2006512366 A JP2006512366 A JP 2006512366A
Authority
JP
Japan
Prior art keywords
alkyl
het
methyl
optionally substituted
pyrazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004562221A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006512366A5 (enExample
Inventor
バサラブ，グレゴリー
アイアーマン，ジョーゼフ
ゴウラヴァラム，マドフスダン
グリーン，オルインカ
マックファーソン，ローレンス
モーニングスター，マーシャル
ングエン，タン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of JP2006512366A publication Critical patent/JP2006512366A/ja
Publication of JP2006512366A5 publication Critical patent/JP2006512366A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2004562221A 2002-12-20 2003-12-19 ピラゾロ［３，４−ｄ］ピリミジン誘導体及び処置におけるその使用 Pending JP2006512366A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0203825A SE0203825D0 (sv) 2002-12-20 2002-12-20 Novel fused heterocycles and uses thereof
PCT/SE2003/002033 WO2004056831A1 (en) 2002-12-20 2003-12-19 PYRAZOLO [3,4-d] PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF H.PYLORI INFECTION

Publications (2)

Publication Number Publication Date
JP2006512366A true JP2006512366A (ja) 2006-04-13
JP2006512366A5 JP2006512366A5 (enExample) 2006-09-28

Family

ID=20289974

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004562221A Pending JP2006512366A (ja) 2002-12-20 2003-12-19 ピラゾロ［３，４−ｄ］ピリミジン誘導体及び処置におけるその使用

Country Status (9)

Country Link
US (1) US20070004761A1 (enExample)
EP (1) EP1585748B1 (enExample)
JP (1) JP2006512366A (enExample)
AT (1) ATE349448T1 (enExample)
AU (1) AU2003288869A1 (enExample)
DE (1) DE60310767T2 (enExample)
ES (1) ES2278211T3 (enExample)
SE (1) SE0203825D0 (enExample)
WO (1) WO2004056831A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012510996A (ja) * 2008-12-06 2012-05-17 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2459161A1 (en) 2001-08-31 2003-03-13 The Rockefeller University Phosphodiesterase activity and regulation of phosphodiesterase 1b-mediated signaling in brain
EP2023729B1 (en) 2006-06-06 2016-05-04 Intra-Cellular Therapies, Inc. Organic compounds
EP2081431B1 (en) 2006-11-13 2013-01-16 Intra-Cellular Therapies, Inc. Organic compounds
EP2240028B1 (en) 2007-12-06 2016-07-20 Intra-Cellular Therapies, Inc. Pyrazolopyrimidine-4,6-dione derivatives and their use as pharmaceutical
US8008327B2 (en) 2008-04-29 2011-08-30 Boehringer Ingelheim International Gmbh Indazole compounds as CCR1 receptor antagonists
CA2722811C (en) * 2008-05-06 2016-07-05 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
CA2737472A1 (en) 2008-09-26 2010-04-01 Boehringer Ingelheim International Gmbh Azaindazole compounds as ccr1 receptor antagonists
WO2010065152A1 (en) 2008-12-06 2010-06-10 Intra-Cellular Therapies, Inc. Organic compounds
AU2009322899A1 (en) 2008-12-06 2010-06-10 Intra-Cellular Therapies, Inc. Organic compounds
EP2461673A4 (en) 2009-08-05 2013-08-07 Intra Cellular Therapies Inc NEW REGULATOR PROTEINS AND HEMMER
WO2011049917A1 (en) 2009-10-21 2011-04-28 Boehringer Ingelheim International Gmbh Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists
US8927550B2 (en) 2009-10-27 2015-01-06 Boehringer Ingelheim International Gmbh Heterocyclic compounds as CCR1 receptor antagonists
AU2010328480A1 (en) * 2009-12-08 2012-05-17 Boehringer Ingelheim International Gmbh Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds
US8871786B2 (en) 2010-04-30 2014-10-28 Boehringer Ingelheim International Gmbh Azaindazole amide compounds as CCR1 receptor antagonists
US9371327B2 (en) 2010-05-31 2016-06-21 Intra-Cellular Therapies, Inc. PDE1 inhibitor compounds
US9434730B2 (en) 2010-05-31 2016-09-06 Intra-Cellular Therapies, Inc. PDE1 inhibitor compounds
WO2012087782A1 (en) 2010-12-23 2012-06-28 Boehringer Ingelheim International Gmbh Pyrazolopiperidine compounds as ccr1 receptor antagonists
US9546175B2 (en) 2014-08-07 2017-01-17 Intra-Cellular Therapies, Inc. Organic compounds
WO2019233994A1 (en) 2018-06-04 2019-12-12 Exscientia Ltd Pyrazolopyrimidine compounds as adenosine receptor antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3839839A1 (de) * 1988-11-25 1990-05-31 Henning Berlin Gmbh Mittel zur behandlung von chronisch entzuendlichen darmerkrankungen
SE0102315D0 (sv) * 2001-06-28 2001-06-28 Astrazeneca Ab Compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6010004125, Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ，Ｐｅｒｋｉｎ Ｔｒａｎｓａｃｔｉｏｎｓ １，（１９７７），（７），ｐ．７６５−７ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012510996A (ja) * 2008-12-06 2012-05-17 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物

Also Published As

Publication number Publication date
SE0203825D0 (sv) 2002-12-20
AU2003288869A1 (en) 2004-07-14
ATE349448T1 (de) 2007-01-15
WO2004056831A1 (en) 2004-07-08
EP1585748B1 (en) 2006-12-27
ES2278211T3 (es) 2007-08-01
US20070004761A1 (en) 2007-01-04
EP1585748A1 (en) 2005-10-19
DE60310767D1 (de) 2007-02-08
DE60310767T2 (de) 2007-10-11

Similar Documents

Publication Publication Date Title
US7371757B2 (en) Fused heterocycles as inhibitors of glutamate racemase(MURI)
JP2006512366A (ja) ピラゾロ［３，４−ｄ］ピリミジン誘導体及び処置におけるその使用
CN113527293B (zh) Kras g12c突变蛋白抑制剂及其药物组合物、制备方法和用途
ES2706745T3 (es) Compuestos de aminopiridazinona como inhibidores de proteína cinasa
ES2770693T3 (es) Derivados de imidazopiridazina como inhibidores de caseína quinasa 1 delta/épsilon
CN115279763A (zh) Rip1抑制化合物以及制备和使用所述化合物的方法
PT1689751E (pt) Novas 5,7-diaminopirazolo[4,3-d]pirimidinas com actividade inibidora de pde-5
HUE025223T2 (en) Quinoline and quinoxaline derivatives as kinase inhibitors
EP1686999A1 (en) Pyrazole derivatives as inhibitors of receptor tyrosine kinases
HK1054034B (en) Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors
PT819129E (pt) Derivados pirazole e processos para a sua preparacao
WO2019090158A1 (en) Substituted pyrrolopyrimidine jak inhibitors and methods of making and using the same
CN112292374B (zh) 一种新型磷酸肌醇3-激酶抑制剂及其制备方法和用途
WO2016192132A1 (zh) 作为alk抑制剂的嘧啶衍生物
ES2324837T3 (es) Derivados de piridina utiles como inhibidores de la pkc-theta.
ES2837018T3 (es) Ligandos del receptor D3 de dopamina de 6,7,8,9-tetrahidro-5H-pirido[2,3-d]azepina
EP3625234B1 (en) Hexahydropyrazolo [1,2-a] diazepinones and related heterocycles as inhibitors of rip-1 kinase
KR20240168922A (ko) 방향족 헤테로사이클릭 화합물, 그의 제조 방법 및 그의 용도
WO2018133875A1 (zh) Jak酶抑制剂及其制备方法和用途
WO2018121774A1 (zh) 一种选择性抑制激酶化合物及其用途
US20070275954A1 (en) Novel Fused Heterocycles and Uses Thereof
ES2223008T3 (es) Compuestos utiles como ingrediente activo de un medicamento para el tratamiento preventivo y/o terapeutico de enfermedades neurodegenerativas.
JP2011529085A (ja) 抗ウイルス化合物
JP2010540422A (ja) チエノピリミジン化合物類
CN115894376B (zh) 一种芳香族酰胺类化合物、药物组合物及其用途

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060808

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060808

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100128

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100427

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100510

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100528

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100604

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100628

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100705

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20101018