JP2006511563A - 選択的ｋｄｒ及びｆｇｆｒインヒビターとしてのピリジノ［２，３−ｄ］ピリミジン誘導体 - Google Patents

選択的ｋｄｒ及びｆｇｆｒインヒビターとしてのピリジノ［２，３−ｄ］ピリミジン誘導体 Download PDF

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Publication number
JP2006511563A
JP2006511563A JP2004561276A JP2004561276A JP2006511563A JP 2006511563 A JP2006511563 A JP 2006511563A JP 2004561276 A JP2004561276 A JP 2004561276A JP 2004561276 A JP2004561276 A JP 2004561276A JP 2006511563 A JP2006511563 A JP 2006511563A
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substituted
lower alkyl
pyrimidin
phenyl
propionic acid
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JP2006511563A5 (https=
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リウ，ジン−ジュン
ルク，キン−チュン
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2004561276A 2002-12-20 2003-12-11 選択的ｋｄｒ及びｆｇｆｒインヒビターとしてのピリジノ［２，３−ｄ］ピリミジン誘導体 Pending JP2006511563A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43496902P 2002-12-20 2002-12-20
US51361503P 2003-10-23 2003-10-23
PCT/EP2003/014067 WO2004056822A1 (en) 2002-12-20 2003-12-11 Pyridino `2, 3-d! pyrimidine derivatives as selective kdr and fgfr inhibitors

Publications (2)

Publication Number Publication Date
JP2006511563A true JP2006511563A (ja) 2006-04-06
JP2006511563A5 JP2006511563A5 (https=) 2009-07-30

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JP2004561276A Pending JP2006511563A (ja) 2002-12-20 2003-12-11 選択的ｋｄｒ及びｆｇｆｒインヒビターとしてのピリジノ［２，３−ｄ］ピリミジン誘導体

Country Status (15)

Country Link
US (1) US7098332B2 (https=)
EP (1) EP1581531B1 (https=)
JP (1) JP2006511563A (https=)
KR (1) KR100763298B1 (https=)
AR (1) AR042532A1 (https=)
AT (1) ATE387445T1 (https=)
AU (1) AU2003294830B2 (https=)
BR (1) BR0317480A (https=)
CA (1) CA2508951A1 (https=)
DE (1) DE60319430T2 (https=)
ES (1) ES2300639T3 (https=)
MX (1) MXPA05006437A (https=)
PL (1) PL377661A1 (https=)
RU (1) RU2345077C2 (https=)
WO (1) WO2004056822A1 (https=)

Cited By (7)

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JP2009537520A (ja) * 2006-05-15 2009-10-29 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｆｇｆ受容体キナーゼ阻害剤のための組成物および方法
JP2016519673A (ja) * 2013-03-15 2016-07-07 セルジーン アビロミクス リサーチ， インコーポレイテッド ヘテロアリール化合物およびそれらの使用
JP2016534072A (ja) * 2013-10-25 2016-11-04 ノバルティス アーゲー Ｆｇｆｒ４阻害剤としての縮環二環式ピリジル誘導体
JP2017530154A (ja) * 2014-10-03 2017-10-12 ノバルティス アーゲー Ｆｇｆｒ４阻害剤としての縮環二環式ピリジル誘導体の使用
KR20170129758A (ko) * 2015-03-25 2017-11-27 노파르티스 아게 N-(5-시아노-4-((2-메톡시에틸)아미노)피리딘-2-일)-7-포르밀-6-((4-메틸-2-옥소피페라진-1-일)메틸)-3,4-디히드로-1,8-나프티리딘-1(2h)-카르복스아미드의 입자
US10065966B2 (en) 2013-03-15 2018-09-04 Celgene Car Llc Substituted pyrido[2,3-d]pyrimidines as inhibitors of protein kinases
US10189794B2 (en) 2013-03-15 2019-01-29 Celgene Car Llc Heteroaryl compounds and uses thereof

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BRPI0413018B8 (pt) * 2003-07-30 2021-05-25 Rigel Pharmaceuticals Inc composto, e, uso de um composto
ATE373659T1 (de) * 2004-05-04 2007-10-15 Warner Lambert Co Pyrrolylsubstituierte pyrido(2,3-d)pyrimidin-7- one und derivate davon als therapeutische mittel
EP1814878B1 (en) * 2004-11-24 2012-01-04 Rigel Pharmaceuticals, Inc. Spiro-2, 4-pyrimidinediamine compounds and their uses
EP1883302A4 (en) * 2005-05-03 2009-05-20 Rigel Pharmaceuticals Inc JAK KINASE HEMMER AND ITS USE
DK2074122T5 (da) * 2006-09-15 2014-03-17 Pfizer Prod Inc Pyrido (2, 3-d) pyrimidin0n-forbindelser og anvendelse deraf som pi3 inhibitorer
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US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
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ES2704744T3 (es) 2012-06-13 2019-03-19 Incyte Holdings Corp Compuestos tricíclicos sustituidos como inhibidores de FGFR
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AR094812A1 (es) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd Derivado de piridina monocíclico como inhibidor del fgfr
EA035095B1 (ru) 2013-04-19 2020-04-27 Инсайт Холдингс Корпорейшн Бициклические гетероциклы в качестве ингибиторов fgfr
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
JP6752715B2 (ja) 2014-03-26 2020-09-09 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 組合せ
MX373150B (es) 2014-03-26 2020-04-21 Astex Therapeutics Ltd Combinaciones de un inhibidor del factor de crecimiento de fibroblasto (fgfr) y un inhibidor del receptor del factor de crecimiento 1 similar a insulina (igf1r).
KR102344105B1 (ko) 2014-08-18 2021-12-29 에자이 알앤드디 매니지먼트 가부시키가이샤 모노시클릭 피리딘 유도체의 염 및 이의 결정
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
TWI719960B (zh) 2015-02-10 2021-03-01 英商阿斯迪克治療公司 新穎組成物
MX373169B (es) 2015-02-20 2020-04-24 Incyte Holdings Corp Heterociclos bicíclicos como inhibidores de receptores del factor de crecimiento fibroblástico (fgfr).
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
ES2887148T3 (es) 2015-03-25 2021-12-21 Nat Cancer Ct Agente terapéutico contra el cáncer de vías biliares
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
DK3353177T3 (da) 2015-09-23 2020-08-24 Janssen Pharmaceutica Nv Tricykliske heterocykler til behandling af cancer
AU2016328693B2 (en) 2015-09-23 2021-03-11 Janssen Pharmaceutica Nv Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
US12414945B2 (en) 2015-12-17 2025-09-16 Eisai R&D Management Co., Ltd. Therapeutic agent for breast cancer
AU2018229148B2 (en) * 2017-03-03 2022-08-04 Auckland Uniservices Limited FGFR kinase inhibitors and pharmaceutical uses
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CN110914267B (zh) * 2017-07-19 2022-07-12 江苏奥赛康药业有限公司 嘧啶并吡啶酮或者吡啶并吡啶酮类化合物及其应用
SG11202007591RA (en) 2018-03-28 2020-09-29 Eisai R&D Man Co Ltd Therapeutic agent for hepatocellular carcinoma
CR20200590A (es) 2018-05-04 2021-04-26 Incyte Corp Formas sólidas de un inhibidor de fgfr y procesos para prepararlas
MA52493A (fr) 2018-05-04 2021-03-10 Incyte Corp Sels d'un inhibiteur de fgfr
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WO2020123395A1 (en) 2018-12-10 2020-06-18 Ideaya Biosciences, Inc. 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors
MA54608B1 (fr) 2018-12-27 2023-02-28 Servier Lab Inhibiteurs aza-hétérobicycliques de mat2a et procédés d'utilisation pour le traitement du cancer
WO2020140055A1 (en) * 2018-12-28 2020-07-02 Spv Therapeutics Inc. Cyclin-dependent kinase inhibitors
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
WO2020180959A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
US20220143049A1 (en) 2019-03-21 2022-05-12 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
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Cited By (14)

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Publication number Priority date Publication date Assignee Title
JP2009537520A (ja) * 2006-05-15 2009-10-29 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｆｇｆ受容体キナーゼ阻害剤のための組成物および方法
US10189794B2 (en) 2013-03-15 2019-01-29 Celgene Car Llc Heteroaryl compounds and uses thereof
JP2016519673A (ja) * 2013-03-15 2016-07-07 セルジーン アビロミクス リサーチ， インコーポレイテッド ヘテロアリール化合物およびそれらの使用
US10774052B2 (en) 2013-03-15 2020-09-15 Celgene Car Llc Heteroaryl compounds and uses thereof
US10618902B2 (en) 2013-03-15 2020-04-14 Celgene Car Llc Substituted pyrido[2,3-d]pyrimidines as inhibitors of protein kinases
US10065966B2 (en) 2013-03-15 2018-09-04 Celgene Car Llc Substituted pyrido[2,3-d]pyrimidines as inhibitors of protein kinases
JP2016534072A (ja) * 2013-10-25 2016-11-04 ノバルティス アーゲー Ｆｇｆｒ４阻害剤としての縮環二環式ピリジル誘導体
JP2017214411A (ja) * 2013-10-25 2017-12-07 ノバルティス アーゲー Ｆｇｆｒ４阻害剤としての縮環二環式ピリジル誘導体
US10507201B2 (en) 2014-10-03 2019-12-17 Novartis Ag Use of ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors
JP2019218398A (ja) * 2014-10-03 2019-12-26 ノバルティス アーゲー Ｆｇｆｒ４阻害剤としての縮環二環式ピリジル誘導体の使用
JP2017530154A (ja) * 2014-10-03 2017-10-12 ノバルティス アーゲー Ｆｇｆｒ４阻害剤としての縮環二環式ピリジル誘導体の使用
JP2018509446A (ja) * 2015-03-25 2018-04-05 ノバルティス アーゲー Ｎ−（５−シアノ−４−（（２−メトキシエチル）アミノ）ピリジン−２−イル）−７−ホルミル−６−（（４−メチル−２−オキソピペラジン−１−イル）メチル）−３，４−ジヒドロ−１，８−ナフチリジン−１（２ｈ）−カルボキサミドの粒子
KR20170129758A (ko) * 2015-03-25 2017-11-27 노파르티스 아게 N-(5-시아노-4-((2-메톡시에틸)아미노)피리딘-2-일)-7-포르밀-6-((4-메틸-2-옥소피페라진-1-일)메틸)-3,4-디히드로-1,8-나프티리딘-1(2h)-카르복스아미드의 입자
KR102606643B1 (ko) 2015-03-25 2023-11-28 노파르티스 아게 N-(5-시아노-4-((2-메톡시에틸)아미노)피리딘-2-일)-7-포르밀-6-((4-메틸-2-옥소피페라진-1-일)메틸)-3,4-디히드로-1,8-나프티리딘-1(2h)-카르복스아미드의 입자

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Publication number Publication date
RU2005122901A (ru) 2006-02-27
KR100763298B1 (ko) 2007-10-04
EP1581531A1 (en) 2005-10-05
MXPA05006437A (es) 2005-08-19
WO2004056822A1 (en) 2004-07-08
PL377661A1 (pl) 2006-02-06
ATE387445T1 (de) 2008-03-15
US7098332B2 (en) 2006-08-29
KR20050088202A (ko) 2005-09-02
AU2003294830A1 (en) 2004-07-14
US20040122029A1 (en) 2004-06-24
AR042532A1 (es) 2005-06-22
ES2300639T3 (es) 2008-06-16
BR0317480A (pt) 2005-11-16
EP1581531B1 (en) 2008-02-27
DE60319430D1 (de) 2008-04-10
RU2345077C2 (ru) 2009-01-27
AU2003294830B2 (en) 2009-06-11
DE60319430T2 (de) 2009-02-26
CA2508951A1 (en) 2004-07-08

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