JP2006510571A5 - - Google Patents

Download PDF

Info

Publication number
JP2006510571A5
JP2006510571A5 JP2003573017A JP2003573017A JP2006510571A5 JP 2006510571 A5 JP2006510571 A5 JP 2006510571A5 JP 2003573017 A JP2003573017 A JP 2003573017A JP 2003573017 A JP2003573017 A JP 2003573017A JP 2006510571 A5 JP2006510571 A5 JP 2006510571A5
Authority
JP
Japan
Prior art keywords
tyr
ser
lys
peptide
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003573017A
Other languages
English (en)
Japanese (ja)
Other versions
JP4477881B2 (ja
JP2006510571A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/006657 external-priority patent/WO2003074551A2/en
Publication of JP2006510571A publication Critical patent/JP2006510571A/ja
Publication of JP2006510571A5 publication Critical patent/JP2006510571A5/ja
Application granted granted Critical
Publication of JP4477881B2 publication Critical patent/JP4477881B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2003573017A 2002-03-01 2003-03-03 治療剤または細胞毒性剤と生物活性ペプチドとの抱合体 Expired - Lifetime JP4477881B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36083102P 2002-03-01 2002-03-01
PCT/US2003/006657 WO2003074551A2 (en) 2002-03-01 2003-03-03 Conjugates of therapeutic or cytotoxic agents and biologically active peptides

Publications (3)

Publication Number Publication Date
JP2006510571A JP2006510571A (ja) 2006-03-30
JP2006510571A5 true JP2006510571A5 (https=) 2006-07-20
JP4477881B2 JP4477881B2 (ja) 2010-06-09

Family

ID=27789031

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003573017A Expired - Lifetime JP4477881B2 (ja) 2002-03-01 2003-03-03 治療剤または細胞毒性剤と生物活性ペプチドとの抱合体

Country Status (21)

Country Link
US (2) US7771727B2 (https=)
EP (1) EP1487493B1 (https=)
JP (1) JP4477881B2 (https=)
KR (1) KR101003622B1 (https=)
CN (2) CN102133407A (https=)
AT (1) ATE455561T1 (https=)
AU (1) AU2003220011B2 (https=)
BR (1) BR0308090A (https=)
CA (1) CA2476182A1 (https=)
CO (1) CO5611160A2 (https=)
DE (1) DE60331049D1 (https=)
DK (1) DK1487493T3 (https=)
ES (1) ES2339934T3 (https=)
IL (1) IL163573A0 (https=)
IS (1) IS7431A (https=)
MX (1) MXPA04008419A (https=)
NO (1) NO20044039L (https=)
NZ (1) NZ534719A (https=)
PL (1) PL373567A1 (https=)
WO (1) WO2003074551A2 (https=)
ZA (1) ZA200406614B (https=)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1545613T1 (sl) 2002-07-31 2011-11-30 Seattle Genetics Inc Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni
RU2324701C2 (ru) * 2003-03-20 2008-05-20 Ниппон Каяку Кабусики Кайся Мицеллярный препарат, содержащий малорастворимый в воде противораковый агент, содержащее его противораковое средство и новый блок-сополимер
CA2524255C (en) 2003-03-21 2014-02-11 Academisch Ziekenhuis Leiden Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
NZ564694A (en) * 2003-04-22 2009-11-27 Sod Conseils Rech Applic Peptide vectors
US20060281897A1 (en) * 2003-08-22 2006-12-14 Andre Trouet Potentialization of the activation of high molecular weight prodrugs
EP1680073B1 (en) 2003-10-21 2013-01-02 IGF Oncology, LLC Compounds and method for treating cancer
US9011880B2 (en) 2003-10-21 2015-04-21 Igf Oncology, Llc Compounds and methods for treating cancer
JP4820758B2 (ja) * 2004-09-22 2011-11-24 日本化薬株式会社 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
CA2582552A1 (en) 2004-10-21 2006-05-04 Igf Oncology, Llc Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer
EP1809291A4 (en) * 2004-11-03 2012-04-04 Forhumantech Co Ltd PHARMACEUTICAL COMPOSITIONS FOR TRANSDERMAL LEVY
WO2007021674A2 (en) * 2005-08-09 2007-02-22 Millennium Pharmaceuticals, Inc. Method of acylating maytansinol with chiral amino acids
WO2007123391A1 (en) 2006-04-20 2007-11-01 Academisch Ziekenhuis Leiden Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene.
KR20090009241A (ko) * 2006-05-18 2009-01-22 니폰 가야꾸 가부시끼가이샤 포도필로톡신류의 고분자 결합체
EP1857548A1 (en) 2006-05-19 2007-11-21 Academisch Ziekenhuis Leiden Means and method for inducing exon-skipping
AU2007280690C1 (en) 2006-07-31 2012-08-23 Curevac Gmbh Nucleic acid of formula (I): GIXmGn, or (II): CIXmCn, in particular as an immune-stimulating agent/adjuvant
AU2007282224B2 (en) 2006-08-11 2013-08-29 Vico Therapeutics B.V. Methods and means for treating DNA repeat instability associated genetic disorders
ES2584840T3 (es) * 2006-10-03 2016-09-29 Nippon Kayaku Kabushiki Kaisha Compuesto de un derivado de resorcinol con un polímero
CA2693742A1 (en) * 2007-07-12 2009-01-15 Prosensa Technologies B.V. Molecules for targeting compounds to various selected organs, tissues or tumor cells
WO2009008727A2 (en) 2007-07-12 2009-01-15 Prosensa Technologies B.V. Molecules for targeting compounds to various selected organs or tissues
WO2009030254A1 (en) 2007-09-04 2009-03-12 Curevac Gmbh Complexes of rna and cationic peptides for transfection and for immunostimulation
US8703878B2 (en) * 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
USRE48468E1 (en) 2007-10-26 2021-03-16 Biomarin Technologies B.V. Means and methods for counteracting muscle disorders
AU2008317566B2 (en) 2007-10-26 2014-05-01 Academisch Ziekenhuis Leiden Means and methods for counteracting muscle disorders
EP2176408B9 (en) 2008-01-31 2015-11-11 Curevac GmbH NUCLEIC ACIDS COMPRISING FORMULA (NuGiXmGnNv)a AND DERIVATIVES THEREOF AS AN IMMUNOSTIMULATING AGENTS /ADJUVANTS
NZ587178A (en) 2008-02-08 2011-11-25 Prosensa Holding Bv Methods and means for treating dna repeat instability associated genetic disorders
WO2009116509A1 (ja) * 2008-03-18 2009-09-24 日本化薬株式会社 生理活性物質の高分子結合体
WO2009136572A1 (ja) 2008-05-08 2009-11-12 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
EP2119783A1 (en) 2008-05-14 2009-11-18 Prosensa Technologies B.V. Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
WO2010037408A1 (en) 2008-09-30 2010-04-08 Curevac Gmbh Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
CN101439182B (zh) * 2008-12-18 2012-02-01 北京大学 一种生长抑素受体介导的肿瘤靶向药物组合物
US9238878B2 (en) 2009-02-17 2016-01-19 Redwood Bioscience, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
CA2759899A1 (en) 2009-04-24 2010-10-28 Prosensa Technologies B.V. Oligonucleotide comprising an inosine for treating dmd
EP2431403B1 (en) 2009-05-15 2016-09-28 Nipponkayaku Kabushikikaisha Polymer conjugate of bioactive substance having hydroxy group
US20110053829A1 (en) 2009-09-03 2011-03-03 Curevac Gmbh Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
WO2011078672A1 (en) 2009-12-24 2011-06-30 Prosensa Technologies B.V. Molecule for treating an inflammatory disorder
CA2801523C (en) 2010-07-30 2021-08-03 Curevac Gmbh Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation
EP2641605B1 (en) 2010-11-17 2018-03-07 Nippon Kayaku Kabushiki Kaisha Polymer derivative of cytidine metabolism antagonist
AU2012205301B2 (en) 2011-01-14 2017-01-05 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and method of use thereof
CA2862798C (en) 2011-02-17 2021-04-06 The Administrators Of The Tulane Educational Fund Multicomponent compositions and their uses
KR101849142B1 (ko) 2011-09-11 2018-04-16 니폰 가야꾸 가부시끼가이샤 블록 공중합체의 제조방법
CN112251436A (zh) 2012-01-27 2021-01-22 比奥马林技术公司 治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸
WO2013113326A1 (en) 2012-01-31 2013-08-08 Curevac Gmbh Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
AU2013256596A1 (en) * 2012-05-01 2014-10-09 Genentech, Inc. Anti-PMEL17 antibodies and immunoconjugates
US9981046B2 (en) 2012-05-15 2018-05-29 Concortis Biosystems, Corp., a wholly owned Subsidiary of Sorrento Therapeutics, Inc. Drug-conjugates, conjugation methods, and uses thereof
MX379256B (es) * 2013-03-15 2025-03-10 Regeneron Pharma Moleculas biologicamente activas, conjugados de las mismas, y usos terapeuticos.
BR112016003361A2 (pt) 2013-08-21 2017-11-21 Curevac Ag vacina do vírus sincicial respiratório (rsv)
JP6835590B2 (ja) 2014-01-12 2021-02-24 アイジーエフ オンコロジー、 エルエルシー インスリン様成長因子−１および上皮増殖因子を含む融合タンパク質およびそのバリアントならびにその使用
CA2936286A1 (en) 2014-04-01 2015-10-08 Curevac Ag Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant
CN105198966B (zh) * 2014-06-26 2019-06-21 中国人民解放军军事医学科学院毒物药物研究所 GnRH类似物-细胞毒分子缀合物、其制备方法及用途
CA2953371C (en) 2014-06-30 2021-08-24 Tarveda Therapeutics, Inc. Targeted conjugates and particles and formulations thereof
CA2955569C (en) * 2014-08-06 2023-02-14 Ascendis Pharma A/S Prodrugs comprising an aminoalkyl glycine linker
JP6903633B2 (ja) * 2015-07-27 2021-07-14 上海吉貝医薬科技有限公司Ｇ−Ｂｉｏ Ｐｈａｒｍａ Ｔｅｃｈ Ｃｏ．， Ｌｔｄ． 腫瘍抑制ペプチド
WO2017020282A1 (zh) * 2015-08-05 2017-02-09 陕西麦科奥特科技有限公司 有抗凝血和抗血小板活性的多靶点化合物及制法和用途
CN106466485B (zh) * 2015-08-11 2021-05-04 同宜医药（苏州）有限公司 一种具有细胞内吞介导功能的靶向配体-药物偶联体
JP7057278B2 (ja) 2015-10-28 2022-04-19 ターベダ セラピューティクス インコーポレイテッド Ｓｓｔｒ標的化コンジュゲート及び粒子並びにその製剤
US10913780B2 (en) 2016-03-24 2021-02-09 The Administrators Of The Tulane Educational Fund Conjugates, their compositions, their uses, and their methods of making
AU2017257504A1 (en) 2016-04-26 2018-10-25 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
CN106492226A (zh) * 2016-10-13 2017-03-15 武汉大学苏州研究院 肿瘤靶向性多肽—蒽环类衍生物
WO2018217669A1 (en) 2017-05-21 2018-11-29 Igf Oncology, Llc An insulin-like growth factor-chemotherapeputic conjugate for treating myelodysplastic syndrome
CN109106951A (zh) * 2017-08-18 2019-01-01 四川百利药业有限责任公司 一种喜树碱-抗体偶联物
JP7267998B2 (ja) * 2017-08-19 2023-05-02 オハイオ・ステイト・イノベーション・ファウンデーション 新規ペプチド系癌造影剤
CN110357947B (zh) * 2019-03-08 2023-05-26 南京恒远科技开发有限公司 一种combretastatin A4衍生物
CN114341162B (zh) 2019-07-10 2025-10-17 赛博克萨2公司 作为治疗剂的细胞毒素的肽缀合物
TW202116356A (zh) 2019-07-10 2021-05-01 美商斯布雷克薩三號公司 作為治療劑之微管靶向藥劑之肽結合物
RU2727924C1 (ru) * 2019-08-20 2020-07-27 Открытое акционерное общество "Всероссийский научный центр молекулярной диагностики и лечения" (ОАО "ВНЦМДЛ") Высокоэффективный способ получения лекарственной формы адресного действия для терапии злокачественных новообразований
EP4351653A4 (en) * 2021-06-09 2025-11-12 Radionetics Oncology Inc Non-peptide targeted therapeutic agents and their uses
WO2024069235A2 (en) 2022-09-30 2024-04-04 Sixfold Bioscience Ltd. Compositions containing oligonucleotides with theranostic applications
KR102821945B1 (ko) * 2022-12-02 2025-06-17 성균관대학교산학협력단 광화학적 전환 가능한 펩티드-소분자 복합체
JP2026500913A (ja) 2022-12-13 2026-01-09 クリネティックス ファーマシューティカルズ，インク． ソマトスタチンサブタイプ－２受容体（ｓｓｔ２ｒ）標的化治療薬及びその使用
CN118252943B (zh) * 2023-10-25 2024-09-20 常州市智态生创科技有限公司 一种短肽偶联药物及其制备方法和应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663306A (en) * 1984-08-09 1997-09-02 Chiron Corporation Method of conjugating an activated ester to an amine-containing biological material
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4812590A (en) 1987-06-25 1989-03-14 Merck & Co., Inc. Carbamates of 4-hydroxyanisole as prodrugs for chemotherapy of melanoma
US5073541A (en) 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
US5633263A (en) * 1989-04-26 1997-05-27 The Administrators Of The Tulane Educational Fund Linear somatostatin analogs
ES2070329T3 (es) 1989-07-20 1995-06-01 Sandoz Ltd Derivados de polipeptidos.
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5411943A (en) * 1992-02-25 1995-05-02 Biomeasure, Inc. Hepatoma treatment with somatostatin analogs
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US6326353B1 (en) * 1993-03-23 2001-12-04 Sequus Pharmaceuticals, Inc. Enhanced circulation effector composition and method
US5597894A (en) 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5770687A (en) * 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
US6051554A (en) * 1995-06-07 2000-04-18 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
US5708135A (en) * 1995-09-29 1998-01-13 Biomeasure Incorporated Cyclic peptide analogs of somatostatin
US5750499A (en) * 1995-10-18 1998-05-12 The Salk Institute For Biological Studies Receptor-selective somatostatin analogs
US5843903A (en) 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
US6156725A (en) * 1996-08-16 2000-12-05 National Institute Of Immunology Drug for the treatment of cancer
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US5919934A (en) * 1997-02-19 1999-07-06 The George Washington University Compounds, compositions, and methods for cancer imaging and therapy
CA2283854A1 (en) 1997-04-22 1998-10-29 The Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
US6465613B1 (en) * 1998-11-19 2002-10-15 Tulane University Hydrophilic somatostatin analogs
WO2001036003A2 (en) 1999-11-15 2001-05-25 Drug Innovation & Design, Inc. Selective cellular targeting: multifunctional delivery vehicles
AU4267700A (en) * 2000-01-13 2001-07-19 Academia Sinica Application of somatostatin analogs to specific delivery of anti-tumor drugs into tumor cells
US6608026B1 (en) * 2000-08-23 2003-08-19 Board Of Regents, The University Of Texas System Apoptotic compounds
BR0212897A (pt) * 2001-09-21 2004-08-24 Univ Tulane Conjugados de análogos de somatostatina ou bombesina diagnóstica ou terapêutica e usos dos mesmos

Similar Documents

Publication Publication Date Title
JP2006510571A5 (https=)
US8877715B2 (en) Cytotoxic conjugates having neuropeptide Y receptor binding compound
JP2022133360A (ja) Ａｐｊ受容体アゴニストおよびその使用
RU2557654C2 (ru) Терапевтические агенты для снижения уровней паратиреоидного гормона
USRE42274E1 (en) Cyclic peptide CXCR4 antagonists
US9073974B2 (en) RGD-containing cyclic peptides
AU2003220011B2 (en) Conjugates of therapeutic or cytotoxic agents and biologically active peptides
AU648037B2 (en) Therapeutic peptides
AU638423B2 (en) Therapeutic peptides
US7576175B2 (en) Alpha-4 beta-1 integrin ligands for imaging and therapy
JP2005505580A (ja) 診断用もしくは治療用ソマトスタチンまたはボンベシン類似体の結合体およびその使用法
CN116888146A (zh) 胰高血糖素样肽-1受体拮抗剂
JP2927936B2 (ja) ペプチド類
JP3514754B2 (ja) 肝臓癌の治療
CN118679179B (zh) 一种长效glp-1多肽化合物、组合物及其应用
US20150174207A1 (en) Methods for treating cancer with ghrh agonists
JP2009519945A5 (https=)
US6949513B2 (en) Polypeptides of covalently linked synthetic bioactive peptide analog(s) for treatment of cancer
KR20260016965A (ko) 성장 억제호르몬 수용체 타겟팅용 펩타이드, 컨주게이트 약물 및 용도
JP3040166B2 (ja) ノナペプチドのボンベシン拮抗薬
CA2008454A1 (en) Linear analog of biologically active mammalian grp or amphibian bombesin
CN110078811A (zh) 一种具有抗肿瘤活性的多肽imb-p1及其应用