JP2006510571A5 - - Google Patents

Download PDF

Info

Publication number
JP2006510571A5
JP2006510571A5 JP2003573017A JP2003573017A JP2006510571A5 JP 2006510571 A5 JP2006510571 A5 JP 2006510571A5 JP 2003573017 A JP2003573017 A JP 2003573017A JP 2003573017 A JP2003573017 A JP 2003573017A JP 2006510571 A5 JP2006510571 A5 JP 2006510571A5
Authority
JP
Japan
Prior art keywords
tyr
ser
lys
peptide
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003573017A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006510571A (ja
JP4477881B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/006657 external-priority patent/WO2003074551A2/en
Publication of JP2006510571A publication Critical patent/JP2006510571A/ja
Publication of JP2006510571A5 publication Critical patent/JP2006510571A5/ja
Application granted granted Critical
Publication of JP4477881B2 publication Critical patent/JP4477881B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2003573017A 2002-03-01 2003-03-03 治療剤または細胞毒性剤と生物活性ペプチドとの抱合体 Expired - Lifetime JP4477881B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36083102P 2002-03-01 2002-03-01
PCT/US2003/006657 WO2003074551A2 (en) 2002-03-01 2003-03-03 Conjugates of therapeutic or cytotoxic agents and biologically active peptides

Publications (3)

Publication Number Publication Date
JP2006510571A JP2006510571A (ja) 2006-03-30
JP2006510571A5 true JP2006510571A5 (https=) 2006-07-20
JP4477881B2 JP4477881B2 (ja) 2010-06-09

Family

ID=27789031

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003573017A Expired - Lifetime JP4477881B2 (ja) 2002-03-01 2003-03-03 治療剤または細胞毒性剤と生物活性ペプチドとの抱合体

Country Status (21)

Country Link
US (2) US7771727B2 (https=)
EP (1) EP1487493B1 (https=)
JP (1) JP4477881B2 (https=)
KR (1) KR101003622B1 (https=)
CN (2) CN1649625A (https=)
AT (1) ATE455561T1 (https=)
AU (1) AU2003220011B2 (https=)
BR (1) BR0308090A (https=)
CA (1) CA2476182A1 (https=)
CO (1) CO5611160A2 (https=)
DE (1) DE60331049D1 (https=)
DK (1) DK1487493T3 (https=)
ES (1) ES2339934T3 (https=)
IL (1) IL163573A0 (https=)
IS (1) IS7431A (https=)
MX (1) MXPA04008419A (https=)
NO (1) NO20044039L (https=)
NZ (1) NZ534719A (https=)
PL (1) PL373567A1 (https=)
WO (1) WO2003074551A2 (https=)
ZA (1) ZA200406614B (https=)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1545613T3 (da) 2002-07-31 2011-11-14 Seattle Genetics Inc Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
CN1761485B (zh) * 2003-03-20 2010-04-28 日本化药株式会社 含略微水溶性抗癌剂和新型嵌段共聚物的胶束制剂
AU2003225410A1 (en) 2003-03-21 2004-10-11 Academisch Ziekenhuis Leiden Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
CN101791409A (zh) * 2003-04-22 2010-08-04 研究及应用科学协会股份有限公司 肽载体
US20060281897A1 (en) * 2003-08-22 2006-12-14 Andre Trouet Potentialization of the activation of high molecular weight prodrugs
US9011880B2 (en) 2003-10-21 2015-04-21 Igf Oncology, Llc Compounds and methods for treating cancer
CA2542834C (en) 2003-10-21 2012-04-24 Igf Oncology, Llc Conjugates or co-administration of igf-1 receptor ligands with anti-cancer chemotherapeutic agents
JP4820758B2 (ja) 2004-09-22 2011-11-24 日本化薬株式会社 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
WO2006047214A2 (en) 2004-10-21 2006-05-04 Igf Oncology, Llc Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer
KR100897915B1 (ko) * 2004-11-03 2009-05-18 포휴먼텍(주) 경피전달을 위한 약제 조성물
ATE535529T1 (de) 2005-08-09 2011-12-15 Millennium Pharm Inc Verfahren zur acylierung von maytansinol mit chiralen aminosäuren
WO2007123391A1 (en) 2006-04-20 2007-11-01 Academisch Ziekenhuis Leiden Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene.
RU2447095C2 (ru) * 2006-05-18 2012-04-10 Ниппон Каяку Кабусики Кайся Высокомолекулярный конъюгат подофиллотоксинов
EP1857548A1 (en) 2006-05-19 2007-11-21 Academisch Ziekenhuis Leiden Means and method for inducing exon-skipping
EP2046954A2 (en) 2006-07-31 2009-04-15 Curevac GmbH NUCLEIC ACID OF FORMULA (I): GIXmGn, OR (II): CIXmCn, IN PARTICULAR AS AN IMMUNE-STIMULATING AGENT/ADJUVANT
SI2049664T1 (sl) 2006-08-11 2012-04-30 Prosensa Technologies Bv Enojna veriga oligonukleotidov, komplementarna repetitivnim elementom, za zdravljenje genetskih bolezni, povezanih z nestabilnostjo dnk ponovitev
JP5548364B2 (ja) * 2006-10-03 2014-07-16 日本化薬株式会社 レゾルシノール誘導体の高分子結合体
CA2693742A1 (en) 2007-07-12 2009-01-15 Prosensa Technologies B.V. Molecules for targeting compounds to various selected organs, tissues or tumor cells
WO2009008727A2 (en) * 2007-07-12 2009-01-15 Prosensa Technologies B.V. Molecules for targeting compounds to various selected organs or tissues
WO2009030254A1 (en) 2007-09-04 2009-03-12 Curevac Gmbh Complexes of rna and cationic peptides for transfection and for immunostimulation
JP5349318B2 (ja) 2007-09-28 2013-11-20 日本化薬株式会社 ステロイド類の高分子結合体
ES2639852T3 (es) 2007-10-26 2017-10-30 Academisch Ziekenhuis Leiden Medios y métodos para contrarrestar los trastornos musculares
USRE48468E1 (en) 2007-10-26 2021-03-16 Biomarin Technologies B.V. Means and methods for counteracting muscle disorders
DK2176408T5 (en) 2008-01-31 2015-12-14 Curevac Gmbh Nucleic acids comprising FORMULA (NuGiXmGnNv) a AND DERIVATIVES AS IMMUNE STIMULATING AGENTS / ADJUVANTS.
WO2009099326A1 (en) 2008-02-08 2009-08-13 Prosensa Holding Bv Methods and means for treating dna repeat instability associated genetic disorders
CN101977631A (zh) * 2008-03-18 2011-02-16 日本化药株式会社 生理活性物质的高分子量偶联物
JP5366940B2 (ja) 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
EP2119783A1 (en) 2008-05-14 2009-11-18 Prosensa Technologies B.V. Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
WO2010037408A1 (en) 2008-09-30 2010-04-08 Curevac Gmbh Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
CN101439182B (zh) * 2008-12-18 2012-02-01 北京大学 一种生长抑素受体介导的肿瘤靶向药物组合物
WO2010096394A2 (en) 2009-02-17 2010-08-26 Redwood Biosciences, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
EP2421971B1 (en) 2009-04-24 2016-07-06 BioMarin Technologies B.V. Oligonucleotide comprising an inosine for treating dmd
JP5544357B2 (ja) 2009-05-15 2014-07-09 日本化薬株式会社 水酸基を有する生理活性物質の高分子結合体
US20110053829A1 (en) 2009-09-03 2011-03-03 Curevac Gmbh Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
WO2011078672A1 (en) 2009-12-24 2011-06-30 Prosensa Technologies B.V. Molecule for treating an inflammatory disorder
KR101761388B1 (ko) 2010-07-30 2017-07-25 큐어백 아게 트랜스펙션 및 면역 자극을 위한 이황화-크로스링크된 양이온 성분 및 핵산의 복합체
KR20140024833A (ko) 2010-11-17 2014-03-03 니폰 가야꾸 가부시끼가이샤 신규한 시티딘계 대사길항제의 고분자 유도체
WO2012097333A2 (en) 2011-01-14 2012-07-19 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and method of use thereof
WO2012112792A2 (en) 2011-02-17 2012-08-23 The Administrators Of The Tulane Educational Fund Multicomponent compositions and their uses
CN103874722B (zh) 2011-09-11 2016-06-29 日本化药株式会社 嵌段共聚物的制造方法
NZ627896A (en) 2012-01-27 2016-11-25 Biomarin Technologies B V Rna modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy
WO2013113326A1 (en) 2012-01-31 2013-08-08 Curevac Gmbh Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
US9056910B2 (en) 2012-05-01 2015-06-16 Genentech, Inc. Anti-PMEL17 antibodies and immunoconjugates
CN104640572B (zh) * 2012-05-15 2018-04-27 索伦托医疗有限公司 药物偶联物，偶联方法，及其用途
JP6847388B2 (ja) * 2013-03-15 2021-03-31 レゲネロン ファーマシューティカルス，インコーポレーテッド 生物活性分子、そのコンジュゲート、及び治療用途
BR112016003361A2 (pt) 2013-08-21 2017-11-21 Curevac Ag vacina do vírus sincicial respiratório (rsv)
CA2936675C (en) 2014-01-12 2023-06-27 Igf Oncology, Llc Fusion proteins containing insulin-like growth factor-1 and epidermal growth factor and variants thereof and uses thereof
US10369216B2 (en) 2014-04-01 2019-08-06 Curevac Ag Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant
CN105198966B (zh) * 2014-06-26 2019-06-21 中国人民解放军军事医学科学院毒物药物研究所 GnRH类似物-细胞毒分子缀合物、其制备方法及用途
MX379365B (es) 2014-06-30 2025-03-11 Tarveda Therapeutics Inc Conjugados y partículas direccionados y formulaciones de estos.
US11633487B2 (en) * 2014-08-06 2023-04-25 Ascendis Pharma A/S Prodrugs comprising an aminoalkyl glycine linker
CN113912705B (zh) * 2015-07-27 2023-12-22 上海贺普药业股份有限公司 一种肿瘤抑制肽
CN113201048B (zh) 2015-08-05 2022-10-04 陕西麦科奥特科技有限公司 有抗凝血和抗血小板活性的多靶点化合物及制法和用途
CN106466485B (zh) * 2015-08-11 2021-05-04 同宜医药（苏州）有限公司 一种具有细胞内吞介导功能的靶向配体-药物偶联体
US11160871B2 (en) 2015-10-28 2021-11-02 Tarveda Therapeutics, Inc. SSTR-targeted conjugates and particles and formulations thereof
CN109311910B (zh) 2016-03-24 2022-02-01 杜兰教育基金委员会 他克莫司偶联物、其组合物、及其用途
JP2019515677A (ja) 2016-04-26 2019-06-13 アール．ピー．シェーラー テクノロジーズ エルエルシー 抗体複合体ならびにそれを作製および使用する方法
CN106492226A (zh) * 2016-10-13 2017-03-15 武汉大学苏州研究院 肿瘤靶向性多肽—蒽环类衍生物
CN117442747A (zh) 2017-05-21 2024-01-26 Igf肿瘤公司 胰岛素样生长因子——用于治疗骨髓增生异常综合症的化学治疗缀合物
WO2019034176A1 (zh) * 2017-08-18 2019-02-21 四川百利药业有限责任公司 一种喜树碱-抗体偶联物
AU2018321825A1 (en) * 2017-08-19 2020-03-05 Ohio State Innovation Foundation Novel peptide-based cancer imaging agents
CN110357947B (zh) * 2019-03-08 2023-05-26 南京恒远科技开发有限公司 一种combretastatin A4衍生物
US11555019B2 (en) 2019-07-10 2023-01-17 Cybrexa 3, Inc. Peptide conjugates of microtubule-targeting agents as therapeutics
MX2022000449A (es) 2019-07-10 2022-04-25 Cybrexa 2 Inc Conjugados peptídicos de citotoxinas como terapéuticos.
RU2727924C1 (ru) * 2019-08-20 2020-07-27 Открытое акционерное общество "Всероссийский научный центр молекулярной диагностики и лечения" (ОАО "ВНЦМДЛ") Высокоэффективный способ получения лекарственной формы адресного действия для терапии злокачественных новообразований
CN117377495A (zh) * 2021-06-09 2024-01-09 克林提克斯医药股份有限公司 非肽靶向治疗剂及其用途
WO2024069235A2 (en) 2022-09-30 2024-04-04 Sixfold Bioscience Ltd. Compositions containing oligonucleotides with theranostic applications
KR102821945B1 (ko) * 2022-12-02 2025-06-17 성균관대학교산학협력단 광화학적 전환 가능한 펩티드-소분자 복합체
TW202440164A (zh) 2022-12-13 2024-10-16 美商克林提克斯醫藥股份有限公司 生長抑素亞型-2受體（sst2r）靶向治療劑及其用途
CN118252943B (zh) * 2023-10-25 2024-09-20 常州市智态生创科技有限公司 一种短肽偶联药物及其制备方法和应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663306A (en) * 1984-08-09 1997-09-02 Chiron Corporation Method of conjugating an activated ester to an amine-containing biological material
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4812590A (en) * 1987-06-25 1989-03-14 Merck & Co., Inc. Carbamates of 4-hydroxyanisole as prodrugs for chemotherapy of melanoma
US5073541A (en) 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
US5633263A (en) * 1989-04-26 1997-05-27 The Administrators Of The Tulane Educational Fund Linear somatostatin analogs
DK0436005T3 (da) 1989-07-20 1995-07-03 Sandoz Ltd Mærkede polypeptidderivater
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5411943A (en) * 1992-02-25 1995-05-02 Biomeasure, Inc. Hepatoma treatment with somatostatin analogs
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US6326353B1 (en) * 1993-03-23 2001-12-04 Sequus Pharmaceuticals, Inc. Enhanced circulation effector composition and method
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5770687A (en) * 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
US6051554A (en) * 1995-06-07 2000-04-18 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
US5708135A (en) * 1995-09-29 1998-01-13 Biomeasure Incorporated Cyclic peptide analogs of somatostatin
US5750499A (en) * 1995-10-18 1998-05-12 The Salk Institute For Biological Studies Receptor-selective somatostatin analogs
US5843903A (en) 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
US6156725A (en) * 1996-08-16 2000-12-05 National Institute Of Immunology Drug for the treatment of cancer
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US5919934A (en) * 1997-02-19 1999-07-06 The George Washington University Compounds, compositions, and methods for cancer imaging and therapy
EP0977579B1 (en) 1997-04-22 2009-03-11 Curator Of The University Of Missouri Gastrin receptor-avid peptide conjugates
US6465613B1 (en) * 1998-11-19 2002-10-15 Tulane University Hydrophilic somatostatin analogs
AU1607501A (en) 1999-11-15 2001-05-30 Drug Innovation & Design, Inc. Selective cellular targeting: multifunctional delivery vehicles
AU4267700A (en) * 2000-01-13 2001-07-19 Academia Sinica Application of somatostatin analogs to specific delivery of anti-tumor drugs into tumor cells
US6608026B1 (en) * 2000-08-23 2003-08-19 Board Of Regents, The University Of Texas System Apoptotic compounds
CN1589151A (zh) * 2001-09-21 2005-03-02 图兰恩教育基金管理人 诊断或治疗性促生长素抑制素或铃蟾肽类似物的连接物及其用途

Similar Documents

Publication Publication Date Title
JP2006510571A5 (https=)
US8877715B2 (en) Cytotoxic conjugates having neuropeptide Y receptor binding compound
JP2022133360A (ja) Ａｐｊ受容体アゴニストおよびその使用
RU2557654C2 (ru) Терапевтические агенты для снижения уровней паратиреоидного гормона
USRE42274E1 (en) Cyclic peptide CXCR4 antagonists
US9073974B2 (en) RGD-containing cyclic peptides
AU2003220011B2 (en) Conjugates of therapeutic or cytotoxic agents and biologically active peptides
AU648037B2 (en) Therapeutic peptides
AU638423B2 (en) Therapeutic peptides
US7576175B2 (en) Alpha-4 beta-1 integrin ligands for imaging and therapy
JP2005505580A (ja) 診断用もしくは治療用ソマトスタチンまたはボンベシン類似体の結合体およびその使用法
CN116888146A (zh) 胰高血糖素样肽-1受体拮抗剂
JP2927936B2 (ja) ペプチド類
JP3514754B2 (ja) 肝臓癌の治療
CN118679179B (zh) 一种长效glp-1多肽化合物、组合物及其应用
US20150174207A1 (en) Methods for treating cancer with ghrh agonists
JP2009519945A5 (https=)
US6949513B2 (en) Polypeptides of covalently linked synthetic bioactive peptide analog(s) for treatment of cancer
KR20260016965A (ko) 성장 억제호르몬 수용체 타겟팅용 펩타이드, 컨주게이트 약물 및 용도
JP3040166B2 (ja) ノナペプチドのボンベシン拮抗薬
CA2008454A1 (en) Linear analog of biologically active mammalian grp or amphibian bombesin
CN110078811A (zh) 一种具有抗肿瘤活性的多肽imb-p1及其应用