JP2006509816A5 - - Google Patents
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- Publication number
- JP2006509816A5 JP2006509816A5 JP2004560183A JP2004560183A JP2006509816A5 JP 2006509816 A5 JP2006509816 A5 JP 2006509816A5 JP 2004560183 A JP2004560183 A JP 2004560183A JP 2004560183 A JP2004560183 A JP 2004560183A JP 2006509816 A5 JP2006509816 A5 JP 2006509816A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethylallyl
- compound
- guanidine
- aminobutyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- HBCFTQKFAADPMS-UHFFFAOYSA-N carbamimidoylazanium;methanesulfonate Chemical compound NC(N)=N.CS(O)(=O)=O HBCFTQKFAADPMS-UHFFFAOYSA-N 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 6
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 6
- -1 amino-imino Chemical group 0.000 claims 5
- 229910052736 halogen Chemical group 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 5
- NFQOVGIVNTWBCQ-UHFFFAOYSA-N 1-(4-aminobutyl)-2-(3-phenylpropyl)guanidine Chemical compound NCCCCNC(=N)NCCCC1=CC=CC=C1 NFQOVGIVNTWBCQ-UHFFFAOYSA-N 0.000 claims 4
- LBNJFBKCTWQRNP-UHFFFAOYSA-N 1-(4-aminobutyl)-2-[(4-fluorophenyl)methyl]guanidine chloro hypochlorite Chemical compound ClOCl.NCCCCNC(=N)NCC1=CC=C(F)C=C1 LBNJFBKCTWQRNP-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- VACJHYSOFQSYAC-UHFFFAOYSA-N N-prenylagmatine Natural products CC(C)=CCNC(=N)NCCCCN VACJHYSOFQSYAC-UHFFFAOYSA-N 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Chemical group 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- UVMLHMAIUVSYOL-UHFFFAOYSA-N prenylagmatine Natural products CC(C)=CCN=C(N)N UVMLHMAIUVSYOL-UHFFFAOYSA-N 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 229910052717 sulfur Chemical group 0.000 claims 2
- 239000011593 sulfur Chemical group 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- 125000004417 unsaturated alkyl group Chemical group 0.000 claims 2
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 239000007902 hard capsule Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
- 239000007901 soft capsule Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 0 CC*NC(C)=N Chemical compound CC*NC(C)=N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000625A ITRM20020625A1 (it) | 2002-12-17 | 2002-12-17 | Derivati di guanidine variamente sostituite, loro uso come medicamenti ad attivita' antidiabetica e/o antiobesita'. |
| PCT/IT2003/000792 WO2004054967A1 (en) | 2002-12-17 | 2003-12-01 | Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006509816A JP2006509816A (ja) | 2006-03-23 |
| JP2006509816A5 true JP2006509816A5 (https=) | 2007-01-25 |
Family
ID=32587901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004560183A Pending JP2006509816A (ja) | 2002-12-17 | 2003-12-01 | 抗糖尿病性および／または肥満抑制性作用を有する、グアニジンの種々の置換誘導体、および医薬としてのその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7368605B2 (https=) |
| EP (1) | EP1575912A1 (https=) |
| JP (1) | JP2006509816A (https=) |
| KR (1) | KR20050089058A (https=) |
| CN (1) | CN1729172A (https=) |
| AU (1) | AU2003288534B2 (https=) |
| BR (1) | BR0317397A (https=) |
| CA (1) | CA2506685A1 (https=) |
| IT (1) | ITRM20020625A1 (https=) |
| MX (1) | MXPA05006326A (https=) |
| PL (1) | PL378416A1 (https=) |
| WO (1) | WO2004054967A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2873368B1 (fr) * | 2004-07-26 | 2008-01-04 | Merck Sante Soc Par Actions Si | Derives de guanidine et leurs utilisations en therapeutique |
| CN101062906B (zh) * | 2006-04-26 | 2012-02-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 胍丁胺硫酸盐水合物及其用于戒毒,抗炎,降血糖以及胍丁胺代谢异常所致疾病的用途 |
| CN101121677B (zh) * | 2006-08-09 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 胍丁胺硫酸盐二水合物及其医药用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU190639B (en) * | 1983-12-12 | 1986-09-29 | Gyogyszerkutato Intezet Kv,Hu | Process for production of new aminoguanidin derivatives |
| IT1219846B (it) * | 1988-02-24 | 1990-05-24 | Consiglio Nazionale Ricerche | Nuovi derivati guandinici ad attivita' ipotensia,composizione che li contengono e relativo procedimento di estrazione e purificazione da materiale botanico |
| JPH06510760A (ja) * | 1991-08-27 | 1994-12-01 | ジ・アップジョン・カンパニー | 代謝障害および代謝の治療法 |
| GB9511757D0 (en) * | 1995-05-19 | 1995-08-02 | Univ Strathclyde | Agents for reducing weight |
| KR19990076594A (ko) * | 1995-12-22 | 1999-10-15 | 피터 존 기딩스 | Niddm 치료용 아미노구아니딘 |
-
2002
- 2002-12-17 IT IT000625A patent/ITRM20020625A1/it unknown
-
2003
- 2003-12-01 BR BR0317397-6A patent/BR0317397A/pt not_active IP Right Cessation
- 2003-12-01 PL PL378416A patent/PL378416A1/pl not_active Application Discontinuation
- 2003-12-01 KR KR1020057011435A patent/KR20050089058A/ko not_active Ceased
- 2003-12-01 AU AU2003288534A patent/AU2003288534B2/en not_active Ceased
- 2003-12-01 EP EP03780657A patent/EP1575912A1/en not_active Withdrawn
- 2003-12-01 JP JP2004560183A patent/JP2006509816A/ja active Pending
- 2003-12-01 CN CNA2003801067329A patent/CN1729172A/zh active Pending
- 2003-12-01 WO PCT/IT2003/000792 patent/WO2004054967A1/en not_active Ceased
- 2003-12-01 MX MXPA05006326A patent/MXPA05006326A/es not_active Application Discontinuation
- 2003-12-01 US US10/537,269 patent/US7368605B2/en not_active Expired - Fee Related
- 2003-12-01 CA CA002506685A patent/CA2506685A1/en not_active Abandoned
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