JP2006509816A - 抗糖尿病性および／または肥満抑制性作用を有する、グアニジンの種々の置換誘導体、および医薬としてのその使用 - Google Patents

抗糖尿病性および／または肥満抑制性作用を有する、グアニジンの種々の置換誘導体、および医薬としてのその使用 Download PDF

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Publication number
JP2006509816A
JP2006509816A JP2004560183A JP2004560183A JP2006509816A JP 2006509816 A JP2006509816 A JP 2006509816A JP 2004560183 A JP2004560183 A JP 2004560183A JP 2004560183 A JP2004560183 A JP 2004560183A JP 2006509816 A JP2006509816 A JP 2006509816A
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JP
Japan
Prior art keywords
guanidine
dimethylallyl
compound
aminobutyl
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004560183A
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English (en)
Japanese (ja)
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JP2006509816A5 (https=
Inventor
ファビオ・ジャンネッシ
エマヌエラ・タッソーニ
マリア・オルネッラ・ティンティ
ポンペオ・ペッソット
マウリツィオ・ボッタ
フェデリコ・コレッリ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of JP2006509816A publication Critical patent/JP2006509816A/ja
Publication of JP2006509816A5 publication Critical patent/JP2006509816A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2004560183A 2002-12-17 2003-12-01 抗糖尿病性および／または肥満抑制性作用を有する、グアニジンの種々の置換誘導体、および医薬としてのその使用 Pending JP2006509816A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000625A ITRM20020625A1 (it) 2002-12-17 2002-12-17 Derivati di guanidine variamente sostituite, loro uso come medicamenti ad attivita' antidiabetica e/o antiobesita'.
PCT/IT2003/000792 WO2004054967A1 (en) 2002-12-17 2003-12-01 Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity

Publications (2)

Publication Number Publication Date
JP2006509816A true JP2006509816A (ja) 2006-03-23
JP2006509816A5 JP2006509816A5 (https=) 2007-01-25

Family

ID=32587901

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004560183A Pending JP2006509816A (ja) 2002-12-17 2003-12-01 抗糖尿病性および／または肥満抑制性作用を有する、グアニジンの種々の置換誘導体、および医薬としてのその使用

Country Status (12)

Country Link
US (1) US7368605B2 (https=)
EP (1) EP1575912A1 (https=)
JP (1) JP2006509816A (https=)
KR (1) KR20050089058A (https=)
CN (1) CN1729172A (https=)
AU (1) AU2003288534B2 (https=)
BR (1) BR0317397A (https=)
CA (1) CA2506685A1 (https=)
IT (1) ITRM20020625A1 (https=)
MX (1) MXPA05006326A (https=)
PL (1) PL378416A1 (https=)
WO (1) WO2004054967A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008507571A (ja) * 2004-07-26 2008-03-13 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング グアニジン誘導体および治療でのその使用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101062906B (zh) * 2006-04-26 2012-02-08 中国人民解放军军事医学科学院毒物药物研究所 胍丁胺硫酸盐水合物及其用于戒毒,抗炎,降血糖以及胍丁胺代谢异常所致疾病的用途
CN101121677B (zh) * 2006-08-09 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 胍丁胺硫酸盐二水合物及其医药用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH023661A (ja) * 1988-02-24 1990-01-09 Consiglio Nazi Ricerche 血圧降下活性を有するグアニジン誘導体
JPH06510760A (ja) * 1991-08-27 1994-12-01 ジ・アップジョン・カンパニー 代謝障害および代謝の治療法
JPH11505240A (ja) * 1995-05-19 1999-05-18 ユニヴァーシティー オヴ ストラスクライド 減量用薬剤
JP2000502667A (ja) * 1995-12-22 2000-03-07 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー Ｎｉｄｄｍの治療のためのアミノグアニジン

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190639B (en) * 1983-12-12 1986-09-29 Gyogyszerkutato Intezet Kv,Hu Process for production of new aminoguanidin derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH023661A (ja) * 1988-02-24 1990-01-09 Consiglio Nazi Ricerche 血圧降下活性を有するグアニジン誘導体
JPH06510760A (ja) * 1991-08-27 1994-12-01 ジ・アップジョン・カンパニー 代謝障害および代謝の治療法
JPH11505240A (ja) * 1995-05-19 1999-05-18 ユニヴァーシティー オヴ ストラスクライド 減量用薬剤
JP2000502667A (ja) * 1995-12-22 2000-03-07 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー Ｎｉｄｄｍの治療のためのアミノグアニジン

Non-Patent Citations (9)

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JPN5005013564, Ｊ． Ｌ． ＷＩＬＫＩＮＳＯＮ−ＢＥＲＫＡ, ＤＩＡＢＥＴＥＳ, 200211, Ｖ５１, Ｐ３２８３−３２８９ *
JPN6009014600, Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｒｅｓｅａｒｃｈ, 2002, Ｖｏｌ．１１， Ｎｏ．６, ｐ．３０９−３２１ *
JPN6009014601, Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ, 2001, Ｖｏｌ．４４， Ｎｏ．１８, ｐ．２９５０−２９５８ *
JPN6009014602, Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ, 1993, Ｖｏｌ．３６， Ｎｏ．２０, ｐ．２９５６−２９６３ *
JPN6009014603, Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ, 1999, Ｖｏｌ．９， Ｎｏ．２２, ｐ．３２４９−３２５４ *
JPN6009014604, Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ, 1996, Ｖｏｌ．６， Ｎｏ．６, ｐ．６５３−６５８ *
JPN6010030351, Ｃａｎａｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｐｈｙｓｉｏｌｏｇｙ ａｎｄ Ｐｈａｒｍａｃｏｌｏｇｙ, 2000, ７８（２）, ｐ．１０８−１１５ *
JPN6010030353, Ｔｅｎｓｉｄｅ Ｄｅｔｅｒｇｅｎｔｓ, 1983, ２０（１）, ｐ．２７−２９ *
JPN6010030355, Ａｃｔａ Ｍｅｄｉｃａ Ｕｎｉｖｅｒｓｉｔａｔｉｓ Ｋａｇｏｓｈｉｍａｅｎｓｉｓ, 1975, １７（２）, ｐ．９９−１１１ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008507571A (ja) * 2004-07-26 2008-03-13 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング グアニジン誘導体および治療でのその使用

Also Published As

Publication number Publication date
CN1729172A (zh) 2006-02-01
WO2004054967A1 (en) 2004-07-01
AU2003288534B2 (en) 2009-07-02
PL378416A1 (pl) 2006-04-03
US7368605B2 (en) 2008-05-06
KR20050089058A (ko) 2005-09-07
ITRM20020625A1 (it) 2004-06-18
EP1575912A1 (en) 2005-09-21
US20060069100A1 (en) 2006-03-30
BR0317397A (pt) 2005-11-16
AU2003288534A1 (en) 2004-07-09
CA2506685A1 (en) 2004-07-01
MXPA05006326A (es) 2005-08-26

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