BR0317397A - Derivados de guanidina variadamente substituìdos e seu uso como medicamentos com atividade antidiabetes e/ou antiobesidade - Google Patents

Derivados de guanidina variadamente substituìdos e seu uso como medicamentos com atividade antidiabetes e/ou antiobesidade

Info

Publication number
BR0317397A
BR0317397A BR0317397-6A BR0317397A BR0317397A BR 0317397 A BR0317397 A BR 0317397A BR 0317397 A BR0317397 A BR 0317397A BR 0317397 A BR0317397 A BR 0317397A
Authority
BR
Brazil
Prior art keywords
diabetes
guanidine derivatives
substituted guanidine
obesity
obesity drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
BR0317397-6A
Other languages
English (en)
Inventor
Fabio Gianessi
Emanuela Tassoni
Maria Ornella Tinti
Pompeo Pessotto
Maurizio Botta
Federico Corelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma-Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma-Tau Industrie Farmaceutiche Riunite SpA
Publication of BR0317397A publication Critical patent/BR0317397A/pt
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

"DERIVADOS DE GUANIDINA VARIADAMENTE SUBSTìTUIDOS E SEU USO COMO MEDICAMENTOS COM ATIVIDADE ANTIDIABETES E/OU ANTIOBESIDADE". A presente invenção refere-se a compostos da fórmula (I), onde os grupos são conforme identificado no texto, e seu uso como medicamentos, particularmente como agentes antidiabetes, para a diminuição de glicose no soro e antiobesidade. Os referidos medicamentos são úteis para a profilaxia e tratamento de diabetes, particularmente diabetes do tipo 2, e suas complicações, síndrome X, as várias formas de resistência à insulina e hiperlipidemias, bem como para o tratamento de obesidade.
BR0317397-6A 2002-12-17 2003-12-01 Derivados de guanidina variadamente substituìdos e seu uso como medicamentos com atividade antidiabetes e/ou antiobesidade Withdrawn BR0317397A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000625A ITRM20020625A1 (it) 2002-12-17 2002-12-17 Derivati di guanidine variamente sostituite, loro uso come medicamenti ad attivita' antidiabetica e/o antiobesita'.
PCT/IT2003/000792 WO2004054967A1 (en) 2002-12-17 2003-12-01 Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity

Publications (1)

Publication Number Publication Date
BR0317397A true BR0317397A (pt) 2005-11-16

Family

ID=32587901

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0317397-6A Withdrawn BR0317397A (pt) 2002-12-17 2003-12-01 Derivados de guanidina variadamente substituìdos e seu uso como medicamentos com atividade antidiabetes e/ou antiobesidade

Country Status (12)

Country Link
US (1) US7368605B2 (pt)
EP (1) EP1575912A1 (pt)
JP (1) JP2006509816A (pt)
KR (1) KR20050089058A (pt)
CN (1) CN1729172A (pt)
AU (1) AU2003288534B2 (pt)
BR (1) BR0317397A (pt)
CA (1) CA2506685A1 (pt)
IT (1) ITRM20020625A1 (pt)
MX (1) MXPA05006326A (pt)
PL (1) PL378416A1 (pt)
WO (1) WO2004054967A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873368B1 (fr) * 2004-07-26 2008-01-04 Merck Sante Soc Par Actions Si Derives de guanidine et leurs utilisations en therapeutique
CN101062906B (zh) * 2006-04-26 2012-02-08 中国人民解放军军事医学科学院毒物药物研究所 胍丁胺硫酸盐水合物及其用于戒毒,抗炎,降血糖以及胍丁胺代谢异常所致疾病的用途
CN101121677B (zh) * 2006-08-09 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 胍丁胺硫酸盐二水合物及其医药用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190639B (en) * 1983-12-12 1986-09-29 Gyogyszerkutato Intezet Kv,Hu Process for production of new aminoguanidin derivatives
IT1219846B (it) * 1988-02-24 1990-05-24 Consiglio Nazionale Ricerche Nuovi derivati guandinici ad attivita' ipotensia,composizione che li contengono e relativo procedimento di estrazione e purificazione da materiale botanico
CA2113817A1 (en) 1991-08-27 1993-02-04 Jerry R. Colca A method for treatment of metabolic disorders
GB9511757D0 (en) * 1995-05-19 1995-08-02 Univ Strathclyde Agents for reducing weight
CZ198798A3 (cs) * 1995-12-22 1999-06-16 Smithkline Beecham Plc Způsob glykace proteinu, jeho použití a farmaceutický přípravek s jeho obsahem

Also Published As

Publication number Publication date
KR20050089058A (ko) 2005-09-07
AU2003288534B2 (en) 2009-07-02
WO2004054967A1 (en) 2004-07-01
JP2006509816A (ja) 2006-03-23
CN1729172A (zh) 2006-02-01
AU2003288534A1 (en) 2004-07-09
PL378416A1 (pl) 2006-04-03
US7368605B2 (en) 2008-05-06
ITRM20020625A1 (it) 2004-06-18
EP1575912A1 (en) 2005-09-21
US20060069100A1 (en) 2006-03-30
MXPA05006326A (es) 2005-08-26
CA2506685A1 (en) 2004-07-01

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.