CN1729172A - 胍的不同取代的衍生物及其作为具有抗糖尿病和/或抗肥胖活性的药物的用途 - Google Patents

胍的不同取代的衍生物及其作为具有抗糖尿病和/或抗肥胖活性的药物的用途 Download PDF

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Publication number
CN1729172A
CN1729172A CNA2003801067329A CN200380106732A CN1729172A CN 1729172 A CN1729172 A CN 1729172A CN A2003801067329 A CNA2003801067329 A CN A2003801067329A CN 200380106732 A CN200380106732 A CN 200380106732A CN 1729172 A CN1729172 A CN 1729172A
Authority
CN
China
Prior art keywords
guanidine
amino
group
allyl
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2003801067329A
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English (en)
Chinese (zh)
Inventor
F·吉安尼斯
E·塔索尼
M·O·丁迪
P·佩索托
M·伯塔
F·克雷利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of CN1729172A publication Critical patent/CN1729172A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
CNA2003801067329A 2002-12-17 2003-12-01 胍的不同取代的衍生物及其作为具有抗糖尿病和/或抗肥胖活性的药物的用途 Pending CN1729172A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000625A ITRM20020625A1 (it) 2002-12-17 2002-12-17 Derivati di guanidine variamente sostituite, loro uso come medicamenti ad attivita' antidiabetica e/o antiobesita'.
ITRM2002A000625 2002-12-17

Publications (1)

Publication Number Publication Date
CN1729172A true CN1729172A (zh) 2006-02-01

Family

ID=32587901

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2003801067329A Pending CN1729172A (zh) 2002-12-17 2003-12-01 胍的不同取代的衍生物及其作为具有抗糖尿病和/或抗肥胖活性的药物的用途

Country Status (12)

Country Link
US (1) US7368605B2 (https=)
EP (1) EP1575912A1 (https=)
JP (1) JP2006509816A (https=)
KR (1) KR20050089058A (https=)
CN (1) CN1729172A (https=)
AU (1) AU2003288534B2 (https=)
BR (1) BR0317397A (https=)
CA (1) CA2506685A1 (https=)
IT (1) ITRM20020625A1 (https=)
MX (1) MXPA05006326A (https=)
PL (1) PL378416A1 (https=)
WO (1) WO2004054967A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008019594A1 (fr) * 2006-08-09 2008-02-21 Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China Dihydrate de sulfate d'agmatine, et son utilisation médicale
CN101062906B (zh) * 2006-04-26 2012-02-08 中国人民解放军军事医学科学院毒物药物研究所 胍丁胺硫酸盐水合物及其用于戒毒,抗炎,降血糖以及胍丁胺代谢异常所致疾病的用途

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873368B1 (fr) * 2004-07-26 2008-01-04 Merck Sante Soc Par Actions Si Derives de guanidine et leurs utilisations en therapeutique

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190639B (en) * 1983-12-12 1986-09-29 Gyogyszerkutato Intezet Kv,Hu Process for production of new aminoguanidin derivatives
IT1219846B (it) * 1988-02-24 1990-05-24 Consiglio Nazionale Ricerche Nuovi derivati guandinici ad attivita' ipotensia,composizione che li contengono e relativo procedimento di estrazione e purificazione da materiale botanico
JPH06510760A (ja) * 1991-08-27 1994-12-01 ジ・アップジョン・カンパニー 代謝障害および代謝の治療法
GB9511757D0 (en) * 1995-05-19 1995-08-02 Univ Strathclyde Agents for reducing weight
KR19990076594A (ko) * 1995-12-22 1999-10-15 피터 존 기딩스 Niddm 치료용 아미노구아니딘

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101062906B (zh) * 2006-04-26 2012-02-08 中国人民解放军军事医学科学院毒物药物研究所 胍丁胺硫酸盐水合物及其用于戒毒,抗炎,降血糖以及胍丁胺代谢异常所致疾病的用途
WO2008019594A1 (fr) * 2006-08-09 2008-02-21 Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China Dihydrate de sulfate d'agmatine, et son utilisation médicale
CN101121677B (zh) * 2006-08-09 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 胍丁胺硫酸盐二水合物及其医药用途

Also Published As

Publication number Publication date
WO2004054967A1 (en) 2004-07-01
AU2003288534B2 (en) 2009-07-02
PL378416A1 (pl) 2006-04-03
US7368605B2 (en) 2008-05-06
JP2006509816A (ja) 2006-03-23
KR20050089058A (ko) 2005-09-07
ITRM20020625A1 (it) 2004-06-18
EP1575912A1 (en) 2005-09-21
US20060069100A1 (en) 2006-03-30
BR0317397A (pt) 2005-11-16
AU2003288534A1 (en) 2004-07-09
CA2506685A1 (en) 2004-07-01
MXPA05006326A (es) 2005-08-26

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