KR20050089058A - 구아니딘의 다양하게 치환된 유도체, 및 당뇨병 치료및/또는 비만 억제 활성을 갖는 약제로서의 그의 용도 - Google Patents
구아니딘의 다양하게 치환된 유도체, 및 당뇨병 치료및/또는 비만 억제 활성을 갖는 약제로서의 그의 용도 Download PDFInfo
- Publication number
- KR20050089058A KR20050089058A KR1020057011435A KR20057011435A KR20050089058A KR 20050089058 A KR20050089058 A KR 20050089058A KR 1020057011435 A KR1020057011435 A KR 1020057011435A KR 20057011435 A KR20057011435 A KR 20057011435A KR 20050089058 A KR20050089058 A KR 20050089058A
- Authority
- KR
- South Korea
- Prior art keywords
- guanidine
- dimethylallyl
- aminobutyl
- mmol
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 description 1
- NNBBQNFHCVVQHZ-UHFFFAOYSA-N methyl carbamimidothioate;sulfuric acid Chemical compound CSC(N)=N.OS(O)(=O)=O NNBBQNFHCVVQHZ-UHFFFAOYSA-N 0.000 description 1
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- 229930029653 phosphoenolpyruvate Natural products 0.000 description 1
- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000625A ITRM20020625A1 (it) | 2002-12-17 | 2002-12-17 | Derivati di guanidine variamente sostituite, loro uso come medicamenti ad attivita' antidiabetica e/o antiobesita'. |
| ITRM2002A000625 | 2002-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20050089058A true KR20050089058A (ko) | 2005-09-07 |
Family
ID=32587901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057011435A Ceased KR20050089058A (ko) | 2002-12-17 | 2003-12-01 | 구아니딘의 다양하게 치환된 유도체, 및 당뇨병 치료및/또는 비만 억제 활성을 갖는 약제로서의 그의 용도 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7368605B2 (https=) |
| EP (1) | EP1575912A1 (https=) |
| JP (1) | JP2006509816A (https=) |
| KR (1) | KR20050089058A (https=) |
| CN (1) | CN1729172A (https=) |
| AU (1) | AU2003288534B2 (https=) |
| BR (1) | BR0317397A (https=) |
| CA (1) | CA2506685A1 (https=) |
| IT (1) | ITRM20020625A1 (https=) |
| MX (1) | MXPA05006326A (https=) |
| PL (1) | PL378416A1 (https=) |
| WO (1) | WO2004054967A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2873368B1 (fr) * | 2004-07-26 | 2008-01-04 | Merck Sante Soc Par Actions Si | Derives de guanidine et leurs utilisations en therapeutique |
| CN101062906B (zh) * | 2006-04-26 | 2012-02-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 胍丁胺硫酸盐水合物及其用于戒毒,抗炎,降血糖以及胍丁胺代谢异常所致疾病的用途 |
| CN101121677B (zh) * | 2006-08-09 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 胍丁胺硫酸盐二水合物及其医药用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU190639B (en) * | 1983-12-12 | 1986-09-29 | Gyogyszerkutato Intezet Kv,Hu | Process for production of new aminoguanidin derivatives |
| IT1219846B (it) * | 1988-02-24 | 1990-05-24 | Consiglio Nazionale Ricerche | Nuovi derivati guandinici ad attivita' ipotensia,composizione che li contengono e relativo procedimento di estrazione e purificazione da materiale botanico |
| JPH06510760A (ja) * | 1991-08-27 | 1994-12-01 | ジ・アップジョン・カンパニー | 代謝障害および代謝の治療法 |
| GB9511757D0 (en) * | 1995-05-19 | 1995-08-02 | Univ Strathclyde | Agents for reducing weight |
| KR19990076594A (ko) * | 1995-12-22 | 1999-10-15 | 피터 존 기딩스 | Niddm 치료용 아미노구아니딘 |
-
2002
- 2002-12-17 IT IT000625A patent/ITRM20020625A1/it unknown
-
2003
- 2003-12-01 BR BR0317397-6A patent/BR0317397A/pt not_active IP Right Cessation
- 2003-12-01 PL PL378416A patent/PL378416A1/pl not_active Application Discontinuation
- 2003-12-01 KR KR1020057011435A patent/KR20050089058A/ko not_active Ceased
- 2003-12-01 AU AU2003288534A patent/AU2003288534B2/en not_active Ceased
- 2003-12-01 EP EP03780657A patent/EP1575912A1/en not_active Withdrawn
- 2003-12-01 JP JP2004560183A patent/JP2006509816A/ja active Pending
- 2003-12-01 CN CNA2003801067329A patent/CN1729172A/zh active Pending
- 2003-12-01 WO PCT/IT2003/000792 patent/WO2004054967A1/en not_active Ceased
- 2003-12-01 MX MXPA05006326A patent/MXPA05006326A/es not_active Application Discontinuation
- 2003-12-01 US US10/537,269 patent/US7368605B2/en not_active Expired - Fee Related
- 2003-12-01 CA CA002506685A patent/CA2506685A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1729172A (zh) | 2006-02-01 |
| WO2004054967A1 (en) | 2004-07-01 |
| AU2003288534B2 (en) | 2009-07-02 |
| PL378416A1 (pl) | 2006-04-03 |
| US7368605B2 (en) | 2008-05-06 |
| JP2006509816A (ja) | 2006-03-23 |
| ITRM20020625A1 (it) | 2004-06-18 |
| EP1575912A1 (en) | 2005-09-21 |
| US20060069100A1 (en) | 2006-03-30 |
| BR0317397A (pt) | 2005-11-16 |
| AU2003288534A1 (en) | 2004-07-09 |
| CA2506685A1 (en) | 2004-07-01 |
| MXPA05006326A (es) | 2005-08-26 |
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