JP2006523214A5 - - Google Patents
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- Publication number
- JP2006523214A5 JP2006523214A5 JP2006507309A JP2006507309A JP2006523214A5 JP 2006523214 A5 JP2006523214 A5 JP 2006523214A5 JP 2006507309 A JP2006507309 A JP 2006507309A JP 2006507309 A JP2006507309 A JP 2006507309A JP 2006523214 A5 JP2006523214 A5 JP 2006523214A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- compound
- methyl
- leucine
- proline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 40
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 238000010276 construction Methods 0.000 claims 6
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 6
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 5
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 239000004474 valine Substances 0.000 claims 5
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 claims 4
- 229940043131 pyroglutamate Drugs 0.000 claims 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- 125000006242 amine protecting group Chemical group 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 210000003850 cellular structure Anatomy 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical group [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000002650 immunosuppressive therapy Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000001243 protein synthesis Methods 0.000 claims 1
- 230000014616 translation Effects 0.000 claims 1
- 230000005740 tumor formation Effects 0.000 claims 1
- 0 CC(C)C[C@@](C(N(*)[C@@](*)C(N(C)[C@@](*)C(*C[C@](C)C(N[C@@]([C@](*)C1)*#C)=O)=O)=O)=O)N*[C@](C(C)C)NC1=O Chemical compound CC(C)C[C@@](C(N(*)[C@@](*)C(N(C)[C@@](*)C(*C[C@](C)C(N[C@@]([C@](*)C1)*#C)=O)=O)=O)=O)N*[C@](C(C)C)NC1=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45696703P | 2003-03-21 | 2003-03-21 | |
| PCT/US2004/008275 WO2004084812A2 (en) | 2003-03-21 | 2004-03-19 | Tamandarin analogs and fragments thereof and methods of making and using |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006523214A JP2006523214A (ja) | 2006-10-12 |
| JP2006523214A5 true JP2006523214A5 (https=) | 2007-05-10 |
Family
ID=33098178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006507309A Pending JP2006523214A (ja) | 2003-03-21 | 2004-03-19 | タマンダリン類似物およびこれらのフラグメントそして製造方法および使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8030279B2 (https=) |
| EP (1) | EP1613338A4 (https=) |
| JP (1) | JP2006523214A (https=) |
| CN (1) | CN1819837A (https=) |
| AU (1) | AU2004224418A1 (https=) |
| CA (1) | CA2519234A1 (https=) |
| MX (1) | MXPA05010064A (https=) |
| WO (1) | WO2004084812A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ302498B6 (cs) * | 1999-11-15 | 2011-06-15 | Pharma Mar, S. A. | Farmaceutický prípravek obsahující aplidin pro lécení rakovinových onemocnení |
| CA2405779A1 (en) * | 2000-04-07 | 2001-10-18 | The Trustees Of The University Of Pennsylvania | Tamandarin and didemnin analogs and methods of making and using them |
| US6509315B1 (en) | 2000-04-07 | 2003-01-21 | The Trustees Of The University Of Pennsylvania | Didemnin analogs and fragments and methods of making and using them |
| US20050158294A1 (en) | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
| US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
| AU2006253007B2 (en) | 2005-05-31 | 2012-12-20 | Alimentary Health Ltd | Feline probiotic Bifidobacteria |
| EP2261323A1 (en) | 2005-05-31 | 2010-12-15 | The Iams Company | Feline probiotic lactobacilli |
| JP4935675B2 (ja) | 2005-08-25 | 2012-05-23 | 宇部興産株式会社 | 光学活性（Ｓ又はＲ）−α−アミノ酸及び光学活性（Ｒ又はＳ）−α−アミノ酸エステルの製造方法 |
| WO2007101235A2 (en) | 2006-02-28 | 2007-09-07 | Pharma Mar, S.A. | Improved antitumoral treatments |
| RU2436581C2 (ru) | 2007-02-01 | 2011-12-20 | Дзе Иамс Компани | Способ уменьшения воспаления и снижения стресса у млекопитающего |
| JP5396016B2 (ja) * | 2007-03-26 | 2014-01-22 | 学校法人青山学院 | 化合物又はその薬理上許容される塩若しくはエステル誘導体及び制癌剤 |
| AU2008313627A1 (en) * | 2007-10-19 | 2009-04-23 | Pharma Mar, S.A. | Improved antitumoral treatments |
| US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
| US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
| WO2011020913A2 (en) | 2009-08-21 | 2011-02-24 | Pharma Mar, S.A. | Cyclodepsipeptide antiviral compounds |
| CN104003908B (zh) * | 2014-01-17 | 2016-08-17 | 宁波北仑大港科技创新服务中心 | 一种保护羟基的丝氨酸的制备方法 |
| KR102491180B1 (ko) | 2017-04-27 | 2023-01-20 | 파르마 마르 에스.에이. | 항종양 화합물 |
| CN115461067A (zh) | 2020-03-02 | 2022-12-09 | 法马马有限公司 | 用于炎症的化合物 |
| US20230158104A1 (en) | 2020-03-02 | 2023-05-25 | Pharma Mar, S.A. | Compounds for use in autoimmune conditions |
| US20230158102A1 (en) | 2020-03-02 | 2023-05-25 | Pharma Mar, S.A. | Compounds for use in the treatment of coronavirus infection |
| EP4433462A4 (en) * | 2021-11-16 | 2025-07-16 | Prodeg Llc | USP9X INHIBITORS |
| US12168640B2 (en) | 2021-11-16 | 2024-12-17 | ProDeg, LLC | USP9X inhibitors |
| WO2024165764A1 (en) | 2023-02-10 | 2024-08-15 | Pharma Mar, S.A. | Plitidepsin for use in the treatment of non-integrated dna viral infections |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4256108A (en) * | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4160452A (en) * | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
| US4265874A (en) * | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4782135A (en) * | 1980-09-12 | 1988-11-01 | Board Of Trustees, University Of Illinois | Composition of matter and process |
| US5137870A (en) * | 1980-09-12 | 1992-08-11 | The Board Of Trustees Of The University Of Illinois | Didemnins and nordidemnins |
| US4493796A (en) * | 1980-09-12 | 1985-01-15 | Board Of Trustees, Univ. Of Ill. | Didemnins A, B, C, and derivatives thereof, as antiviral agents |
| DE4120327A1 (de) * | 1991-06-20 | 1992-12-24 | Basf Ag | Neue peptide, ihre herstellung und verwendung |
| ES2102322B1 (es) | 1995-07-13 | 1998-03-01 | Pharma Mar Sa | Procedimiento de preparacion de didemnina a. |
| US6380156B1 (en) | 1996-10-24 | 2002-04-30 | The Board Of Trustees Of The University Of Illnois | Total synthesis of the amino hip analogue of didemnin A |
| DE69735583T2 (de) | 1996-10-24 | 2007-04-05 | The Board Of Trustees Of The University Of Illinois, Urbana | Semisynthetisches verfahren zur herstellung von didemninanalogen |
| CA2405779A1 (en) * | 2000-04-07 | 2001-10-18 | The Trustees Of The University Of Pennsylvania | Tamandarin and didemnin analogs and methods of making and using them |
| US6509315B1 (en) * | 2000-04-07 | 2003-01-21 | The Trustees Of The University Of Pennsylvania | Didemnin analogs and fragments and methods of making and using them |
| UA76718C2 (uk) | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
| SE0300461L (sv) * | 2003-02-21 | 2004-04-06 | Water Treat Construction I Mot | Metod och anordning för att avskilja miljöfarliga ämnen ur en förorenad massa |
-
2004
- 2004-03-19 JP JP2006507309A patent/JP2006523214A/ja active Pending
- 2004-03-19 CA CA002519234A patent/CA2519234A1/en not_active Abandoned
- 2004-03-19 WO PCT/US2004/008275 patent/WO2004084812A2/en not_active Ceased
- 2004-03-19 MX MXPA05010064A patent/MXPA05010064A/es unknown
- 2004-03-19 CN CNA2004800133883A patent/CN1819837A/zh active Pending
- 2004-03-19 AU AU2004224418A patent/AU2004224418A1/en not_active Abandoned
- 2004-03-19 US US10/550,196 patent/US8030279B2/en not_active Expired - Fee Related
- 2004-03-19 EP EP04757804A patent/EP1613338A4/en not_active Withdrawn
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