JP2009513562A5 - - Google Patents
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- Publication number
- JP2009513562A5 JP2009513562A5 JP2008521463A JP2008521463A JP2009513562A5 JP 2009513562 A5 JP2009513562 A5 JP 2009513562A5 JP 2008521463 A JP2008521463 A JP 2008521463A JP 2008521463 A JP2008521463 A JP 2008521463A JP 2009513562 A5 JP2009513562 A5 JP 2009513562A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- salt
- alkoxy
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 42
- 150000001875 compounds Chemical class 0.000 claims 31
- 150000003839 salts Chemical class 0.000 claims 28
- 125000003545 alkoxy group Chemical group 0.000 claims 25
- 125000003118 aryl group Chemical group 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000001424 substituent group Chemical group 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000006239 protecting group Chemical group 0.000 claims 5
- 208000005176 Hepatitis C Diseases 0.000 claims 4
- 238000010511 deprotection reaction Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 239000005022 packaging material Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 238000007363 ring formation reaction Methods 0.000 claims 3
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 2
- -1 carbamoyloxy Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 108010069514 Cyclic Peptides Proteins 0.000 claims 1
- 102000001189 Cyclic Peptides Human genes 0.000 claims 1
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 238000006462 rearrangement reaction Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 0 CC(*)N(C)*1CC1 Chemical compound CC(*)N(C)*1CC1 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73001105P | 2005-10-26 | 2005-10-26 | |
| US60/730,011 | 2005-10-26 | ||
| US75120405P | 2005-12-19 | 2005-12-19 | |
| US60/751,204 | 2005-12-19 | ||
| PCT/JP2006/321924 WO2007049803A1 (en) | 2005-10-26 | 2006-10-26 | New cyclic peptide compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009513562A JP2009513562A (ja) | 2009-04-02 |
| JP2009513562A5 true JP2009513562A5 (https=) | 2009-11-19 |
| JP5218051B2 JP5218051B2 (ja) | 2013-06-26 |
Family
ID=37847219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008521463A Expired - Fee Related JP5218051B2 (ja) | 2005-10-26 | 2006-10-26 | 新規環状ペプチド化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7872097B2 (https=) |
| EP (1) | EP1957518B1 (https=) |
| JP (1) | JP5218051B2 (https=) |
| KR (1) | KR101273681B1 (https=) |
| CN (1) | CN101305019B (https=) |
| AU (1) | AU2006306974B2 (https=) |
| BR (1) | BRPI0617781A2 (https=) |
| CA (1) | CA2623898C (https=) |
| ES (1) | ES2557477T3 (https=) |
| IL (1) | IL190286A0 (https=) |
| NO (1) | NO20082354L (https=) |
| PL (1) | PL1957518T3 (https=) |
| PT (1) | PT1957518E (https=) |
| RU (1) | RU2423377C2 (https=) |
| TW (1) | TWI391403B (https=) |
| WO (1) | WO2007049803A1 (https=) |
| ZA (1) | ZA200803525B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008250254B2 (en) * | 2007-05-02 | 2012-08-16 | Astellas Pharma Inc. | New cyclic peptide compounds |
| JP5625910B2 (ja) * | 2008-09-24 | 2014-11-19 | アステラス製薬株式会社 | ペプチド化合物およびその製造方法 |
| WO2010088573A1 (en) * | 2009-01-30 | 2010-08-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis c infection |
| US8481483B2 (en) | 2009-02-19 | 2013-07-09 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| AU2010248206A1 (en) * | 2009-05-15 | 2011-12-01 | Stichting Het Nederlands Kanker Instituut | Lysine compounds and their use in site- and chemoselective modification of peptides and proteins |
| US8349312B2 (en) | 2009-07-09 | 2013-01-08 | Enanta Pharmaceuticals, Inc. | Proline substituted cyclosporin analogues |
| US8685917B2 (en) | 2009-07-09 | 2014-04-01 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8367053B2 (en) | 2009-07-09 | 2013-02-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| KR20120125610A (ko) * | 2009-12-30 | 2012-11-16 | 싸이넥시스, 인크. | 시클로스포린 유사체 |
| WO2014035707A1 (en) * | 2012-08-25 | 2014-03-06 | The Johns Hopkins University | Gapdh cascade inhibitor compounds and methods of use and treatment of stress induced disorders including mental illness |
| EP2900684A2 (en) | 2012-09-29 | 2015-08-05 | Novartis AG | Cyclic peptides and use as medicines |
| WO2014085623A1 (en) | 2012-11-28 | 2014-06-05 | Enanta Pharmaceuticals, Inc. | Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues |
| WO2015031381A1 (en) | 2013-08-26 | 2015-03-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis c |
| US9669095B2 (en) | 2014-11-03 | 2017-06-06 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis C infection |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05271267A (ja) * | 1991-04-23 | 1993-10-19 | Fujisawa Pharmaceut Co Ltd | Ｆｒ９０１４５９物質、その製法及び用途 |
| PT1091975E (pt) | 1998-07-01 | 2006-05-31 | Debiopharm Sa | Nova ciclosporina com um perfil de actividade melhorado |
| AR031010A1 (es) | 2000-10-19 | 2003-09-03 | Fujisawa Pharmaceutical Co | Una composicion farmaceutica, util para inhibir el dano celular |
| EP1816138A1 (en) * | 2001-10-19 | 2007-08-08 | Isotechnika,Inc. | Cyclosporine analogue mixtures and their use as immunomodulating agents |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| JP2007015926A (ja) * | 2003-10-06 | 2007-01-25 | Fujisawa Pharmaceut Co Ltd | Ｃ型肝炎治療剤 |
| BRPI0515494A (pt) | 2004-10-01 | 2008-07-29 | Debiopharm Sa | uso de [d-meala] 3-[etval] 4-ciclosporina para o tratamento de infecção por hepatite c e composição farmacêutica compreendendo a referida [d-meala] 3-[etval] 4-ciclosporina |
| KR101309409B1 (ko) | 2004-10-01 | 2013-09-23 | 싸이넥시스, 인크. | Ｃ형 간염 바이러스 감염의 치료 및 예방을 위한 ３-에테르및 ３-티오에테르 치환된 시클로스포린 유도체 |
| US7696167B2 (en) | 2004-11-22 | 2010-04-13 | Astellas Pharma Inc. | Cyclic peptide compound |
-
2006
- 2006-10-26 KR KR1020087012431A patent/KR101273681B1/ko not_active Expired - Fee Related
- 2006-10-26 US US12/083,551 patent/US7872097B2/en active Active
- 2006-10-26 PT PT68228444T patent/PT1957518E/pt unknown
- 2006-10-26 BR BRPI0617781-6A patent/BRPI0617781A2/pt not_active Application Discontinuation
- 2006-10-26 TW TW095139941A patent/TWI391403B/zh not_active IP Right Cessation
- 2006-10-26 JP JP2008521463A patent/JP5218051B2/ja not_active Expired - Fee Related
- 2006-10-26 AU AU2006306974A patent/AU2006306974B2/en not_active Ceased
- 2006-10-26 ES ES06822844.4T patent/ES2557477T3/es active Active
- 2006-10-26 PL PL06822844T patent/PL1957518T3/pl unknown
- 2006-10-26 RU RU2008116674/04A patent/RU2423377C2/ru not_active IP Right Cessation
- 2006-10-26 EP EP06822844.4A patent/EP1957518B1/en active Active
- 2006-10-26 CA CA2623898A patent/CA2623898C/en not_active Expired - Fee Related
- 2006-10-26 WO PCT/JP2006/321924 patent/WO2007049803A1/en not_active Ceased
- 2006-10-26 CN CN2006800390294A patent/CN101305019B/zh not_active Expired - Fee Related
-
2008
- 2008-03-19 IL IL190286A patent/IL190286A0/en unknown
- 2008-04-22 ZA ZA2008/03525A patent/ZA200803525B/en unknown
- 2008-05-23 NO NO20082354A patent/NO20082354L/no not_active Application Discontinuation
-
2010
- 2010-07-21 US US12/840,488 patent/US8252895B2/en not_active Expired - Fee Related
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