NO20082354L - Nye sykliske forbindelser - Google Patents

Nye sykliske forbindelser

Info

Publication number
NO20082354L
NO20082354L NO20082354A NO20082354A NO20082354L NO 20082354 L NO20082354 L NO 20082354L NO 20082354 A NO20082354 A NO 20082354A NO 20082354 A NO20082354 A NO 20082354A NO 20082354 L NO20082354 L NO 20082354L
Authority
NO
Norway
Prior art keywords
hepatitis
cyclic compounds
new cyclic
virus
replication
Prior art date
Application number
NO20082354A
Other languages
English (en)
Inventor
Masahiro Neya
Seiji Yoshimura
Kazunori Kamijyo
Takuya Makino
Minoru Yasuda
Toshio Yamanaka
Eisaku Tsujii
Yukiko Yamagishi
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of NO20082354L publication Critical patent/NO20082354L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Foreliggende oppfinnelse angår en ny, syklisk peptidforbindelse eller et salt derav, som har antihepatitt C-virusaktivitet basert på inhiberende aktivitet mot RNA replikasjon av hepatitt Cvirusreplikon, fremgangsmåte for fremstilling derav omfattende en omleiringsreaksjon under en mild, sur betingelse og de etterfølgende aminosyreforandringsreaksjoner, etc., et farmasøytisk preparat omfattende den samme, og en metode for profylaktisk og/eller terapeutisk behandling av hepatitt C i et menneske eller et dyr.
NO20082354A 2005-10-26 2008-05-23 Nye sykliske forbindelser NO20082354L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73001105P 2005-10-26 2005-10-26
US75120405P 2005-12-19 2005-12-19
PCT/JP2006/321924 WO2007049803A1 (en) 2005-10-26 2006-10-26 New cyclic peptide compounds

Publications (1)

Publication Number Publication Date
NO20082354L true NO20082354L (no) 2008-07-01

Family

ID=37847219

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082354A NO20082354L (no) 2005-10-26 2008-05-23 Nye sykliske forbindelser

Country Status (17)

Country Link
US (2) US7872097B2 (no)
EP (1) EP1957518B1 (no)
JP (1) JP5218051B2 (no)
KR (1) KR101273681B1 (no)
CN (1) CN101305019B (no)
AU (1) AU2006306974B2 (no)
BR (1) BRPI0617781A2 (no)
CA (1) CA2623898C (no)
ES (1) ES2557477T3 (no)
IL (1) IL190286A0 (no)
NO (1) NO20082354L (no)
PL (1) PL1957518T3 (no)
PT (1) PT1957518E (no)
RU (1) RU2423377C2 (no)
TW (1) TWI391403B (no)
WO (1) WO2007049803A1 (no)
ZA (1) ZA200803525B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2150269B1 (en) * 2007-05-02 2012-11-21 Astellas Pharma Inc. New cyclic peptide compounds
CA2738280A1 (en) * 2008-09-24 2010-04-01 Astellas Pharma Inc. Peptide compound and method for producing the same
MX2011008000A (es) * 2009-01-30 2011-09-15 Enanta Pharm Inc Analogos de ciclosporina para la prevención o tratamiento de la infeccion de hepatitis c.
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
EP2429988A2 (en) * 2009-05-15 2012-03-21 Stichting Het Nederlands Kanker Instituut Lysine compounds and their use in site- and chemoselective modification of peptides and proteins
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
KR20120125610A (ko) * 2009-12-30 2012-11-16 싸이넥시스, 인크. 시클로스포린 유사체
JP2015529206A (ja) * 2012-08-25 2015-10-05 ザ・ジョンズ・ホプキンス・ユニバーシティ Ｇａｐｄｈカスケードインヒビター化合物ならびに使用の方法および精神病を含むストレス誘導障害の処置
WO2014049540A2 (en) 2012-09-29 2014-04-03 Novartis Ag Cyclic peptides and use as medicines
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
KR20160045136A (ko) * 2013-08-26 2016-04-26 이난타 파마슈티칼스, 인코포레이티드 C형 간염을 예방 또는 치료하기 위한 사이클로스포린 유사체
WO2016073480A1 (en) 2014-11-03 2016-05-12 Enanta Pharmaceuticals, Inc. Novel cyclosporin analogues for preventing or treating hepatitis c infection

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271267A (ja) * 1991-04-23 1993-10-19 Fujisawa Pharmaceut Co Ltd Ｆｒ９０１４５９物質、その製法及び用途
USRE40987E1 (en) 1998-07-01 2009-11-17 Debiopharm S.A. Cyclosporin with improved activity profile
AR031010A1 (es) * 2000-10-19 2003-09-03 Fujisawa Pharmaceutical Co Una composicion farmaceutica, util para inhibir el dano celular
GB0320638D0 (en) * 2003-09-03 2003-10-01 Novartis Ag Organic compounds
JP2007015926A (ja) * 2003-10-06 2007-01-25 Fujisawa Pharmaceut Co Ltd Ｃ型肝炎治療剤
PT1802650E (pt) 2004-10-01 2011-12-30 Scynexis Inc Derivados da ciclosporina 3-éter e 3-tioéter substituída para o tratamento e prevenção da infecção de hepatite c
EA012650B1 (ru) 2004-10-01 2009-12-30 Дебиофарм С.А. ПРИМЕНЕНИЕ [D-MeAla]-[EtVal]-ЦИКЛОСПОРИНА ДЛЯ ЛЕЧЕНИЯ ИНФЕКЦИИ ГЕПАТИТА С И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ [D-MeAla]-[EtVal]-ЦИКЛОСПОРИН
US7696167B2 (en) 2004-11-22 2010-04-13 Astellas Pharma Inc. Cyclic peptide compound

Also Published As

Publication number Publication date
US7872097B2 (en) 2011-01-18
BRPI0617781A2 (pt) 2011-08-09
JP5218051B2 (ja) 2013-06-26
TWI391403B (zh) 2013-04-01
CN101305019B (zh) 2012-12-12
KR20080065297A (ko) 2008-07-11
ES2557477T3 (es) 2016-01-26
CN101305019A (zh) 2008-11-12
AU2006306974B2 (en) 2011-09-22
TW200732351A (en) 2007-09-01
CA2623898A1 (en) 2007-05-03
KR101273681B1 (ko) 2013-06-25
IL190286A0 (en) 2011-08-01
US8252895B2 (en) 2012-08-28
US20100286033A1 (en) 2010-11-11
PT1957518E (pt) 2016-02-26
RU2008116674A (ru) 2009-10-27
CA2623898C (en) 2013-12-24
JP2009513562A (ja) 2009-04-02
PL1957518T3 (pl) 2016-07-29
US20090170755A1 (en) 2009-07-02
AU2006306974A1 (en) 2007-05-03
WO2007049803A1 (en) 2007-05-03
ZA200803525B (en) 2009-08-26
EP1957518A1 (en) 2008-08-20
RU2423377C2 (ru) 2011-07-10
EP1957518B1 (en) 2015-12-09

Similar Documents

Publication Publication Date Title
NO20082354L (no) Nye sykliske forbindelser
MX2009011512A (es) Nuevos compuestos peptidos ciclicos.
ATE365213T1 (de) Aminosäuresequenzen die die fähigkeit besitzen, die durchdringung durch eine biologische barriere erleichtern
CY1112115T1 (el) Παραγωγα φαινοξυοξικου οξεος χρησιμα για τη θεραπευτικη αντιμετωπιση ασθενειων του αναπνευστικου
BRPI0409227A (pt) composto, composição farmacêutica, uso de um composto, intermediário, e, processo para a preparação de um composto
CY1110318T1 (el) Παραγωγα φαινοξυοξικου οξεος
BRPI0718586A2 (pt) Composto, processo para a sua preparação, composição farmacêutica contendo o mesmo, usos deste e método de tratamento ou prevenção de doenças
NO20080745L (no) Nye peptider for anvendelse i behandling av fedme
BRPI0513819A (pt) inibidores de hsp90
DE60323090D1 (de) 1h-imidazoä4,5-cüchinolinderivate zur behandlung von protein kinase-abhängigen krankheiten
MX341883B (es) Composicion farmaceutica para el tratamiento y prevencion de canceres.
BRPI0514133A (pt) compostos de fórmula i, processo para a sua fabricação, composições farmacêuticas, método para o tratamento e/ou profilaxia de doença que são mediadas por inibidores de cetp e uso dos compostos de fórmula i
DE602004017174D1 (de) Phenoxyessigsäure-derivate zur behandlung von störungen der atemwege
NO330888B1 (no) Benzensylfonamidderivater, fremgangsmate for fremstilling av slike, terapeutisk preparatinneholdende slike samt anvendelse av slike for fremstilling av preparat for behandling av sykdom
NO20072290L (no) Organiske forbindelser.
WO2005002526A3 (en) Method and compositions for treatment of viral infections
WO2008124176A3 (en) Soluble and membrane-anchored forms of lassa virus subunit proteins
DE502004008819D1 (de) Medikament zur wachstumsinhibierung von tumoren
DE112004000961D2 (de) Verwendung von Wirksubstanzen zur Vorbeugung oder Behandlung von Viruserkrankungen sowie Testsystem zum Auffinden solcher Wirksubstanzen
NO20070665L (no) Derivater av 1-fenylalkankarboksylsyrer for behandlingen av neurodegenerative sykdommer
NO20081681L (no) N-[1,3,4]-tiadiazol-2-yl-benzensulfonamider, fremgangsmate for fremstilling derav og deres anvendelse som farmasoytika
TW200510352A (en) Cycloalkyl substituted amino acid derivatives, processes for their freparation and their use as pharmaceuticals
BRPI0415781A (pt) método para o tratamento de diabetes em um paciente e kit farmacêutico
BRPI0512951A (pt) compostos, processo para sua fabricação, composições farmacêuticas contendo os mesmos, uso e método para tratamento e/ou prevenção de doenças que são moduladas pelos agonistas de ppar(delta) e/ou ppar(alpha)
BRPI0911159A2 (pt) compostos derivados de ácido 4-dimetilaminobutírico, processo para a sua preparação, composições farmacêuticas que os compreendem, método para o tratamento terapêutico ou profilático de enfermidades que são moduladas por inibidres de cpt2 e uso destes compostos

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application