KR101273681B1 - 신규 시클릭 펩티드 화합물 - Google Patents

신규 시클릭 펩티드 화합물 Download PDF

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Publication number
KR101273681B1
KR101273681B1 KR1020087012431A KR20087012431A KR101273681B1 KR 101273681 B1 KR101273681 B1 KR 101273681B1 KR 1020087012431 A KR1020087012431 A KR 1020087012431A KR 20087012431 A KR20087012431 A KR 20087012431A KR 101273681 B1 KR101273681 B1 KR 101273681B1
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KR
South Korea
Prior art keywords
solution
compound
methyl
vacuo
reaction
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KR1020087012431A
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English (en)
Korean (ko)
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KR20080065297A (ko
Inventor
마사히로 네야
세이지 요시무라
가즈노리 가미죠
다쿠야 마키노
미노루 야스다
도시오 야마나카
에이사쿠 쯔지
유키꼬 야마기시
Original Assignee
아스텔라스세이야쿠 가부시키가이샤
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Publication of KR20080065297A publication Critical patent/KR20080065297A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020087012431A 2005-10-26 2006-10-26 신규 시클릭 펩티드 화합물 Expired - Fee Related KR101273681B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US73001105P 2005-10-26 2005-10-26
US60/730,011 2005-10-26
US75120405P 2005-12-19 2005-12-19
US60/751,204 2005-12-19
PCT/JP2006/321924 WO2007049803A1 (en) 2005-10-26 2006-10-26 New cyclic peptide compounds

Publications (2)

Publication Number Publication Date
KR20080065297A KR20080065297A (ko) 2008-07-11
KR101273681B1 true KR101273681B1 (ko) 2013-06-25

Family

ID=37847219

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087012431A Expired - Fee Related KR101273681B1 (ko) 2005-10-26 2006-10-26 신규 시클릭 펩티드 화합물

Country Status (17)

Country Link
US (2) US7872097B2 (https=)
EP (1) EP1957518B1 (https=)
JP (1) JP5218051B2 (https=)
KR (1) KR101273681B1 (https=)
CN (1) CN101305019B (https=)
AU (1) AU2006306974B2 (https=)
BR (1) BRPI0617781A2 (https=)
CA (1) CA2623898C (https=)
ES (1) ES2557477T3 (https=)
IL (1) IL190286A0 (https=)
NO (1) NO20082354L (https=)
PL (1) PL1957518T3 (https=)
PT (1) PT1957518E (https=)
RU (1) RU2423377C2 (https=)
TW (1) TWI391403B (https=)
WO (1) WO2007049803A1 (https=)
ZA (1) ZA200803525B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008250254B2 (en) * 2007-05-02 2012-08-16 Astellas Pharma Inc. New cyclic peptide compounds
JP5625910B2 (ja) * 2008-09-24 2014-11-19 アステラス製薬株式会社 ペプチド化合物およびその製造方法
WO2010088573A1 (en) * 2009-01-30 2010-08-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
AU2010248206A1 (en) * 2009-05-15 2011-12-01 Stichting Het Nederlands Kanker Instituut Lysine compounds and their use in site- and chemoselective modification of peptides and proteins
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
KR20120125610A (ko) * 2009-12-30 2012-11-16 싸이넥시스, 인크. 시클로스포린 유사체
WO2014035707A1 (en) * 2012-08-25 2014-03-06 The Johns Hopkins University Gapdh cascade inhibitor compounds and methods of use and treatment of stress induced disorders including mental illness
EP2900684A2 (en) 2012-09-29 2015-08-05 Novartis AG Cyclic peptides and use as medicines
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
WO2015031381A1 (en) 2013-08-26 2015-03-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c
US9669095B2 (en) 2014-11-03 2017-06-06 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032576A1 (ja) * 2003-10-06 2005-04-14 Astellas Pharma Inc. Ｃ型肝炎治療剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271267A (ja) * 1991-04-23 1993-10-19 Fujisawa Pharmaceut Co Ltd Ｆｒ９０１４５９物質、その製法及び用途
PT1091975E (pt) 1998-07-01 2006-05-31 Debiopharm Sa Nova ciclosporina com um perfil de actividade melhorado
AR031010A1 (es) 2000-10-19 2003-09-03 Fujisawa Pharmaceutical Co Una composicion farmaceutica, util para inhibir el dano celular
EP1816138A1 (en) * 2001-10-19 2007-08-08 Isotechnika,Inc. Cyclosporine analogue mixtures and their use as immunomodulating agents
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
BRPI0515494A (pt) 2004-10-01 2008-07-29 Debiopharm Sa uso de [d-meala] 3-[etval] 4-ciclosporina para o tratamento de infecção por hepatite c e composição farmacêutica compreendendo a referida [d-meala] 3-[etval] 4-ciclosporina
KR101309409B1 (ko) 2004-10-01 2013-09-23 싸이넥시스, 인크. Ｃ형 간염 바이러스 감염의 치료 및 예방을 위한 ３-에테르및 ３-티오에테르 치환된 시클로스포린 유도체
US7696167B2 (en) 2004-11-22 2010-04-13 Astellas Pharma Inc. Cyclic peptide compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032576A1 (ja) * 2003-10-06 2005-04-14 Astellas Pharma Inc. Ｃ型肝炎治療剤

Also Published As

Publication number Publication date
CA2623898A1 (en) 2007-05-03
JP2009513562A (ja) 2009-04-02
US7872097B2 (en) 2011-01-18
EP1957518A1 (en) 2008-08-20
CA2623898C (en) 2013-12-24
IL190286A0 (en) 2011-08-01
RU2008116674A (ru) 2009-10-27
JP5218051B2 (ja) 2013-06-26
TWI391403B (zh) 2013-04-01
NO20082354L (no) 2008-07-01
ES2557477T3 (es) 2016-01-26
PT1957518E (pt) 2016-02-26
CN101305019B (zh) 2012-12-12
BRPI0617781A2 (pt) 2011-08-09
AU2006306974A1 (en) 2007-05-03
AU2006306974B2 (en) 2011-09-22
US20100286033A1 (en) 2010-11-11
WO2007049803A1 (en) 2007-05-03
CN101305019A (zh) 2008-11-12
KR20080065297A (ko) 2008-07-11
EP1957518B1 (en) 2015-12-09
US8252895B2 (en) 2012-08-28
ZA200803525B (en) 2009-08-26
TW200732351A (en) 2007-09-01
US20090170755A1 (en) 2009-07-02
RU2423377C2 (ru) 2011-07-10
PL1957518T3 (pl) 2016-07-29

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