KR101273681B1 - 신규 시클릭 펩티드 화합물 - Google Patents

신규 시클릭 펩티드 화합물 Download PDF

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Publication number
KR101273681B1
KR101273681B1 KR1020087012431A KR20087012431A KR101273681B1 KR 101273681 B1 KR101273681 B1 KR 101273681B1 KR 1020087012431 A KR1020087012431 A KR 1020087012431A KR 20087012431 A KR20087012431 A KR 20087012431A KR 101273681 B1 KR101273681 B1 KR 101273681B1
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KR
South Korea
Prior art keywords
solution
compound
methyl
vacuo
reaction
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KR1020087012431A
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English (en)
Korean (ko)
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KR20080065297A (ko
Inventor
마사히로 네야
세이지 요시무라
가즈노리 가미죠
다쿠야 마키노
미노루 야스다
도시오 야마나카
에이사쿠 쯔지
유키꼬 야마기시
Original Assignee
아스텔라스세이야쿠 가부시키가이샤
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Publication of KR20080065297A publication Critical patent/KR20080065297A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020087012431A 2005-10-26 2006-10-26 신규 시클릭 펩티드 화합물 Expired - Fee Related KR101273681B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US73001105P 2005-10-26 2005-10-26
US60/730,011 2005-10-26
US75120405P 2005-12-19 2005-12-19
US60/751,204 2005-12-19
PCT/JP2006/321924 WO2007049803A1 (en) 2005-10-26 2006-10-26 New cyclic peptide compounds

Publications (2)

Publication Number Publication Date
KR20080065297A KR20080065297A (ko) 2008-07-11
KR101273681B1 true KR101273681B1 (ko) 2013-06-25

Family

ID=37847219

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087012431A Expired - Fee Related KR101273681B1 (ko) 2005-10-26 2006-10-26 신규 시클릭 펩티드 화합물

Country Status (17)

Country Link
US (2) US7872097B2 (https=)
EP (1) EP1957518B1 (https=)
JP (1) JP5218051B2 (https=)
KR (1) KR101273681B1 (https=)
CN (1) CN101305019B (https=)
AU (1) AU2006306974B2 (https=)
BR (1) BRPI0617781A2 (https=)
CA (1) CA2623898C (https=)
ES (1) ES2557477T3 (https=)
IL (1) IL190286A0 (https=)
NO (1) NO20082354L (https=)
PL (1) PL1957518T3 (https=)
PT (1) PT1957518E (https=)
RU (1) RU2423377C2 (https=)
TW (1) TWI391403B (https=)
WO (1) WO2007049803A1 (https=)
ZA (1) ZA200803525B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100017547A (ko) 2007-05-02 2010-02-16 아스텔라스세이야쿠 가부시키가이샤 신규 시클릭 펩티드 화합물
CN102164947A (zh) * 2008-09-24 2011-08-24 安斯泰来制药有限公司 肽化合物及其制备方法
KR20110111321A (ko) * 2009-01-30 2011-10-10 이난타 파마슈티칼스, 인코포레이티드 Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
SG176085A1 (en) * 2009-05-15 2011-12-29 Stichting Nl Kanker Inst Lysine compounds and their use in site- and chemoselective modification of peptides and proteins
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
WO2011082289A1 (en) * 2009-12-30 2011-07-07 Scynexis Inc. Cyclosporine analogues
JP2015529206A (ja) 2012-08-25 2015-10-05 ザ・ジョンズ・ホプキンス・ユニバーシティ Ｇａｐｄｈカスケードインヒビター化合物ならびに使用の方法および精神病を含むストレス誘導障害の処置
EP2900684A2 (en) 2012-09-29 2015-08-05 Novartis AG Cyclic peptides and use as medicines
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
JP2016538317A (ja) 2013-08-26 2016-12-08 エナンタ ファーマシューティカルズ インコーポレイテッド Ｃ型肝炎を防止または治療するための新規シクロスポリン類似体
US9669095B2 (en) 2014-11-03 2017-06-06 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032576A1 (ja) * 2003-10-06 2005-04-14 Astellas Pharma Inc. Ｃ型肝炎治療剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271267A (ja) * 1991-04-23 1993-10-19 Fujisawa Pharmaceut Co Ltd Ｆｒ９０１４５９物質、その製法及び用途
AU759480B2 (en) 1998-07-01 2003-04-17 Debiopharm S.A. Novel cyclosporin with improved activity profile
AU2001295966A1 (en) * 2000-10-19 2002-04-29 Fujisawa Pharmaceutical Co. Ltd. Cell damage inhibitor
CN100344648C (zh) * 2001-10-19 2007-10-24 伊索泰克尼卡股份有限公司 环孢菌素类似物混合物及其在制备免疫调节剂中的用途
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
DK1793844T3 (da) 2004-10-01 2011-03-21 Debiopharm Sa Anvendelse af [D-MeAla]3-[EtVal]4-cyklosporin til behandling af hepatitis C-infektion
SI1802650T1 (sl) 2004-10-01 2012-03-30 Scynexis Inc Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c
ES2314731T3 (es) * 2004-11-22 2009-03-16 Astellas Pharma Inc. Analogo de ciclosporina.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032576A1 (ja) * 2003-10-06 2005-04-14 Astellas Pharma Inc. Ｃ型肝炎治療剤

Also Published As

Publication number Publication date
JP2009513562A (ja) 2009-04-02
US8252895B2 (en) 2012-08-28
PL1957518T3 (pl) 2016-07-29
RU2008116674A (ru) 2009-10-27
CN101305019A (zh) 2008-11-12
TW200732351A (en) 2007-09-01
CN101305019B (zh) 2012-12-12
NO20082354L (no) 2008-07-01
US7872097B2 (en) 2011-01-18
IL190286A0 (en) 2011-08-01
EP1957518A1 (en) 2008-08-20
RU2423377C2 (ru) 2011-07-10
ES2557477T3 (es) 2016-01-26
CA2623898C (en) 2013-12-24
EP1957518B1 (en) 2015-12-09
WO2007049803A1 (en) 2007-05-03
AU2006306974A1 (en) 2007-05-03
AU2006306974B2 (en) 2011-09-22
US20100286033A1 (en) 2010-11-11
US20090170755A1 (en) 2009-07-02
PT1957518E (pt) 2016-02-26
CA2623898A1 (en) 2007-05-03
JP5218051B2 (ja) 2013-06-26
KR20080065297A (ko) 2008-07-11
BRPI0617781A2 (pt) 2011-08-09
ZA200803525B (en) 2009-08-26
TWI391403B (zh) 2013-04-01

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KR20100017547A (ko) 신규 시클릭 펩티드 화합물
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