CN101305019B - 新的环肽化合物 - Google Patents

新的环肽化合物 Download PDF

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Publication number
CN101305019B
CN101305019B CN2006800390294A CN200680039029A CN101305019B CN 101305019 B CN101305019 B CN 101305019B CN 2006800390294 A CN2006800390294 A CN 2006800390294A CN 200680039029 A CN200680039029 A CN 200680039029A CN 101305019 B CN101305019 B CN 101305019B
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CN
China
Prior art keywords
compound
salt
brd
reaction
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800390294A
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English (en)
Chinese (zh)
Other versions
CN101305019A (zh
Inventor
闺正博
吉村诚司
上条一纪
牧野拓也
安田实
山中敏夫
辻井荣作
山岸幸子
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of CN101305019A publication Critical patent/CN101305019A/zh
Application granted granted Critical
Publication of CN101305019B publication Critical patent/CN101305019B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2006800390294A 2005-10-26 2006-10-26 新的环肽化合物 Expired - Fee Related CN101305019B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US73001105P 2005-10-26 2005-10-26
US60/730,011 2005-10-26
US75120405P 2005-12-19 2005-12-19
US60/751,204 2005-12-19
PCT/JP2006/321924 WO2007049803A1 (en) 2005-10-26 2006-10-26 New cyclic peptide compounds

Publications (2)

Publication Number Publication Date
CN101305019A CN101305019A (zh) 2008-11-12
CN101305019B true CN101305019B (zh) 2012-12-12

Family

ID=37847219

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800390294A Expired - Fee Related CN101305019B (zh) 2005-10-26 2006-10-26 新的环肽化合物

Country Status (17)

Country Link
US (2) US7872097B2 (https=)
EP (1) EP1957518B1 (https=)
JP (1) JP5218051B2 (https=)
KR (1) KR101273681B1 (https=)
CN (1) CN101305019B (https=)
AU (1) AU2006306974B2 (https=)
BR (1) BRPI0617781A2 (https=)
CA (1) CA2623898C (https=)
ES (1) ES2557477T3 (https=)
IL (1) IL190286A0 (https=)
NO (1) NO20082354L (https=)
PL (1) PL1957518T3 (https=)
PT (1) PT1957518E (https=)
RU (1) RU2423377C2 (https=)
TW (1) TWI391403B (https=)
WO (1) WO2007049803A1 (https=)
ZA (1) ZA200803525B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100017547A (ko) 2007-05-02 2010-02-16 아스텔라스세이야쿠 가부시키가이샤 신규 시클릭 펩티드 화합물
CN102164947A (zh) * 2008-09-24 2011-08-24 安斯泰来制药有限公司 肽化合物及其制备方法
KR20110111321A (ko) * 2009-01-30 2011-10-10 이난타 파마슈티칼스, 인코포레이티드 Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
SG176085A1 (en) * 2009-05-15 2011-12-29 Stichting Nl Kanker Inst Lysine compounds and their use in site- and chemoselective modification of peptides and proteins
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
WO2011082289A1 (en) * 2009-12-30 2011-07-07 Scynexis Inc. Cyclosporine analogues
JP2015529206A (ja) 2012-08-25 2015-10-05 ザ・ジョンズ・ホプキンス・ユニバーシティ Ｇａｐｄｈカスケードインヒビター化合物ならびに使用の方法および精神病を含むストレス誘導障害の処置
EP2900684A2 (en) 2012-09-29 2015-08-05 Novartis AG Cyclic peptides and use as medicines
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
JP2016538317A (ja) 2013-08-26 2016-12-08 エナンタ ファーマシューティカルズ インコーポレイテッド Ｃ型肝炎を防止または治療するための新規シクロスポリン類似体
US9669095B2 (en) 2014-11-03 2017-06-06 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271267A (ja) * 1991-04-23 1993-10-19 Fujisawa Pharmaceut Co Ltd Ｆｒ９０１４５９物質、その製法及び用途
AU759480B2 (en) 1998-07-01 2003-04-17 Debiopharm S.A. Novel cyclosporin with improved activity profile
AU2001295966A1 (en) * 2000-10-19 2002-04-29 Fujisawa Pharmaceutical Co. Ltd. Cell damage inhibitor
CN100344648C (zh) * 2001-10-19 2007-10-24 伊索泰克尼卡股份有限公司 环孢菌素类似物混合物及其在制备免疫调节剂中的用途
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
JP2007015926A (ja) * 2003-10-06 2007-01-25 Fujisawa Pharmaceut Co Ltd Ｃ型肝炎治療剤
DK1793844T3 (da) 2004-10-01 2011-03-21 Debiopharm Sa Anvendelse af [D-MeAla]3-[EtVal]4-cyklosporin til behandling af hepatitis C-infektion
SI1802650T1 (sl) 2004-10-01 2012-03-30 Scynexis Inc Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c
ES2314731T3 (es) * 2004-11-22 2009-03-16 Astellas Pharma Inc. Analogo de ciclosporina.

Also Published As

Publication number Publication date
JP2009513562A (ja) 2009-04-02
US8252895B2 (en) 2012-08-28
PL1957518T3 (pl) 2016-07-29
RU2008116674A (ru) 2009-10-27
CN101305019A (zh) 2008-11-12
KR101273681B1 (ko) 2013-06-25
TW200732351A (en) 2007-09-01
NO20082354L (no) 2008-07-01
US7872097B2 (en) 2011-01-18
IL190286A0 (en) 2011-08-01
EP1957518A1 (en) 2008-08-20
RU2423377C2 (ru) 2011-07-10
ES2557477T3 (es) 2016-01-26
CA2623898C (en) 2013-12-24
EP1957518B1 (en) 2015-12-09
WO2007049803A1 (en) 2007-05-03
AU2006306974A1 (en) 2007-05-03
AU2006306974B2 (en) 2011-09-22
US20100286033A1 (en) 2010-11-11
US20090170755A1 (en) 2009-07-02
PT1957518E (pt) 2016-02-26
CA2623898A1 (en) 2007-05-03
JP5218051B2 (ja) 2013-06-26
KR20080065297A (ko) 2008-07-11
BRPI0617781A2 (pt) 2011-08-09
ZA200803525B (en) 2009-08-26
TWI391403B (zh) 2013-04-01

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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20121212

CF01 Termination of patent right due to non-payment of annual fee