JP2006509750A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006509750A5 JP2006509750A5 JP2004554224A JP2004554224A JP2006509750A5 JP 2006509750 A5 JP2006509750 A5 JP 2006509750A5 JP 2004554224 A JP2004554224 A JP 2004554224A JP 2004554224 A JP2004554224 A JP 2004554224A JP 2006509750 A5 JP2006509750 A5 JP 2006509750A5
- Authority
- JP
- Japan
- Prior art keywords
- mol
- liposome
- lipid
- molar ratio
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 25
- 238000009472 formulation Methods 0.000 claims 24
- 239000002502 liposome Substances 0.000 claims 21
- -1 anionic lipid Chemical class 0.000 claims 13
- 150000002632 lipids Chemical class 0.000 claims 8
- 230000007935 neutral effect Effects 0.000 claims 7
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 6
- 239000003862 glucocorticoid Substances 0.000 claims 4
- 238000007910 systemic administration Methods 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 3
- 235000012000 cholesterol Nutrition 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 2
- 229960001231 choline Drugs 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 claims 1
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 1
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 1
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- BIABMEZBCHDPBV-MPQUPPDSSA-N 1,2-palmitoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-MPQUPPDSSA-N 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- JLPULHDHAOZNQI-JLOPVYAASA-N [(2r)-3-hexadecanoyloxy-2-[(9e,12e)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC JLPULHDHAOZNQI-JLOPVYAASA-N 0.000 claims 1
- NXLTXRVPGUCAHF-JNQJZLCISA-N a3xwk6919f Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)COP(O)(O)=O)[C@@]1(C)C[C@@H]2O NXLTXRVPGUCAHF-JNQJZLCISA-N 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960004833 dexamethasone phosphate Drugs 0.000 claims 1
- VQODGRNSFPNSQE-CXSFZGCWSA-N dexamethasone phosphate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)COP(O)(O)=O)(O)[C@@]1(C)C[C@@H]2O VQODGRNSFPNSQE-CXSFZGCWSA-N 0.000 claims 1
- 229960003724 dimyristoylphosphatidylcholine Drugs 0.000 claims 1
- CSVGEMRSDNSWRF-UHFFFAOYSA-L disodium;dihydrogen phosphate Chemical compound [Na+].[Na+].OP(O)([O-])=O.OP(O)([O-])=O CSVGEMRSDNSWRF-UHFFFAOYSA-L 0.000 claims 1
- 229930182470 glycoside Natural products 0.000 claims 1
- 150000002338 glycosides Chemical class 0.000 claims 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- JDOZJEUDSLGTLU-VWUMJDOOSA-N prednisolone phosphate Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COP(O)(O)=O)[C@@H]4[C@@H]3CCC2=C1 JDOZJEUDSLGTLU-VWUMJDOOSA-N 0.000 claims 1
- 229960004786 prednisolone phosphate Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10255106A DE10255106A1 (de) | 2002-11-24 | 2002-11-24 | Liposomale Glucocorticoide |
| PCT/DE2003/003893 WO2004047792A2 (de) | 2002-11-24 | 2003-11-24 | Liposomale glucocorticoide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006509750A JP2006509750A (ja) | 2006-03-23 |
| JP2006509750A5 true JP2006509750A5 (https=) | 2007-01-25 |
Family
ID=32308712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004554224A Pending JP2006509750A (ja) | 2002-11-24 | 2003-11-24 | リポソームグルココルチコイド |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060147511A1 (https=) |
| EP (1) | EP1581185B1 (https=) |
| JP (1) | JP2006509750A (https=) |
| CN (1) | CN1731981B (https=) |
| AT (1) | ATE445389T1 (https=) |
| AU (1) | AU2003294635B8 (https=) |
| CA (1) | CA2507316A1 (https=) |
| DE (2) | DE10255106A1 (https=) |
| WO (1) | WO2004047792A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004257375A1 (en) * | 2003-07-21 | 2005-01-27 | Vasogen Ireland Limited | Liposomes containing phosphate glycerol groups for treating acute inflammatory condition |
| EP1793805A1 (en) * | 2004-09-09 | 2007-06-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposomal formulations comprising an amphipathic weak base like tempamine for treatment of neurodegenerative conditions |
| US7744920B2 (en) * | 2004-09-09 | 2010-06-29 | Hadasit Medical Research Services & Development Limited | Use of liposomal glucocorticoids for treating inflammatory states |
| AU2006256351B2 (en) | 2005-06-10 | 2011-08-04 | Pola Chemical Industries Inc. | Novel triterpenic acid derivative and preparation for external application for skin comprising the same |
| JP4980634B2 (ja) * | 2006-03-17 | 2012-07-18 | ポーラ化成工業株式会社 | 肌荒れの予防、改善に好適な皮膚外用剤 |
| US20080027371A1 (en) * | 2006-07-26 | 2008-01-31 | Higuchi John W | Method and device for minimally invasive site specific ocular drug delivery |
| ES2599630T3 (es) * | 2006-09-28 | 2017-02-02 | Hadasit Medical Research Services & Development Limited | Uso de glicerofosfolípidos para lubricación de las articulaciones |
| JP5424885B2 (ja) * | 2006-10-13 | 2014-02-26 | マリーナ バイオテック，インコーポレイテッド | 両性リポソームにおけるまたは両性リポソームに関する改善、両性リポソームを処方する方法および両性リポソームに充填する方法 |
| CA2702103A1 (en) * | 2007-10-12 | 2009-04-16 | Novosom Ag | Improvements in or relating to amphotaric liposomes comprising neutral lipids |
| EP2127639A1 (en) * | 2008-05-26 | 2009-12-02 | Universiteit Utrecht Holding B.V. | Corticosteroid containing liposomes for treatment of cardiovascular diseases |
| EP2415464B1 (en) * | 2009-03-30 | 2017-05-10 | Eisai R&D Management Co., Ltd. | Method for producing liposome composition |
| ES2593027T3 (es) | 2009-03-30 | 2016-12-05 | Eisai R&D Management Co., Ltd. | Composición liposomal |
| CN102366411B (zh) * | 2011-09-14 | 2012-12-19 | 海南灵康制药有限公司 | 一种地塞米松棕榈酸酯脂质体注射液 |
| PT2773325T (pt) * | 2011-11-04 | 2018-12-19 | Enceladus Pharmaceuticals B V | Corticosteróides lipossômicos para o tratamento de transtornos inflamatórios em humanos |
| EP3095440B1 (en) | 2015-05-19 | 2020-01-15 | PLS-Design GmbH | Antigen-specific immunotherapy using tolerizing liposomes |
| CN106177959A (zh) * | 2016-04-01 | 2016-12-07 | 北京大学 | 抗癌组合物及其制剂和应用 |
| US12029724B2 (en) | 2016-04-28 | 2024-07-09 | Eisai R&D Management Co., Ltd. | Method for inhibiting tumor growth |
| JP2019515925A (ja) * | 2016-04-29 | 2019-06-13 | エンセラドゥス ファーマセウティカルス べー．フェー． | 炎症性病変又は領域に局所注射するためのリポソーム化コルチコステロイド |
| CN111065423B (zh) * | 2017-08-22 | 2022-04-12 | 莫比斯医疗有限公司 | 用于关节润滑的脂质体制剂 |
| EP3787670A1 (en) | 2017-10-18 | 2021-03-10 | Luxembourg Institute of Health (LIH) | Induction of allergen-specific tregs prior to oral or sublingual immunotherapy of food allergy |
| WO2019076478A1 (en) | 2017-10-18 | 2019-04-25 | Luxembourg Institute Of Health (Lih) | OLIGODESOXYNUCLEOTIDES INCORPORATED IN HYDROGEL AS TOLEROGENEOUS ADJUVANT FOR SUB-CUTANEOUS IMMUNOTHERAPY |
| US12083138B2 (en) * | 2018-07-09 | 2024-09-10 | Taiwan Liposome Co., Ltd. | Methods to reduce complications of intra-articular steroid |
| US11083705B2 (en) | 2019-07-26 | 2021-08-10 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| US12036204B2 (en) | 2019-07-26 | 2024-07-16 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| CN110974954B (zh) * | 2019-12-24 | 2021-03-16 | 珠海丽凡达生物技术有限公司 | 一种用于增强核酸疫苗免疫效果的脂质纳米颗粒及其制备方法 |
| CN111494320A (zh) * | 2020-04-24 | 2020-08-07 | 上海交通大学医学院附属仁济医院 | 一种载糖皮质激素的纳米载体及其制备和应用 |
| EP4522178A1 (en) | 2023-01-19 | 2025-03-19 | Moebius Medical Ltd. | A long-acting liposomal composition for treatment of pain in articular disorders |
| CN117357480B (zh) * | 2023-12-08 | 2024-03-29 | 北京中科利华医药研究院有限公司 | 无针经皮注射用组合物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1523965A (en) * | 1976-03-19 | 1978-09-06 | Ici Ltd | Pharmaceutical compositions containing steroids |
| JPS59222410A (ja) * | 1983-06-01 | 1984-12-14 | Terumo Corp | 薬物保持リポソ−ム製剤 |
| JPS61197513A (ja) * | 1985-02-25 | 1986-09-01 | Ichimaru Fuarukosu Kk | 主薬物を内包した安定なリポソ−ムの製剤化法 |
| US5192528A (en) * | 1985-05-22 | 1993-03-09 | Liposome Technology, Inc. | Corticosteroid inhalation treatment method |
| CA2120197A1 (en) * | 1993-04-02 | 1994-10-03 | Kenji Endo | Stable aqueous dispersions containing liposomes |
| US6391336B1 (en) * | 1997-09-22 | 2002-05-21 | Royer Biomedical, Inc. | Inorganic-polymer complexes for the controlled release of compounds including medicinals |
| US6120800A (en) * | 1997-09-25 | 2000-09-19 | Nexstar Pharmaceuticals, Inc. | Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties |
| EP1073425A1 (en) * | 1998-04-30 | 2001-02-07 | The University Of Cincinnati | Fibrinogen coated droplets of liquid hydrophobic phases |
| EP1046394A3 (en) * | 1999-04-19 | 2001-10-10 | ImaRx Pharmaceutical Corp. | Novel compositions useful for delivering compounds into a cell |
| ES2327025T3 (es) * | 1999-06-25 | 2009-10-23 | Terumo Kabushiki Kaisha | Liposomas. |
| DE10109897A1 (de) * | 2001-02-21 | 2002-11-07 | Novosom Ag | Fakultativ kationische Liposomen und Verwendung dieser |
| NZ527832A (en) * | 2001-03-13 | 2006-03-31 | Penwest Pharmaceuticals Co | Chronotherapeutic dosage forms |
| EP1371362A1 (en) * | 2002-06-12 | 2003-12-17 | Universiteit Utrecht Holding B.V. | Composition for treatment of inflammatory disorders |
-
2002
- 2002-11-24 DE DE10255106A patent/DE10255106A1/de not_active Withdrawn
-
2003
- 2003-11-24 WO PCT/DE2003/003893 patent/WO2004047792A2/de not_active Ceased
- 2003-11-24 CN CN2003801074820A patent/CN1731981B/zh not_active Expired - Fee Related
- 2003-11-24 DE DE50312034T patent/DE50312034D1/de not_active Expired - Lifetime
- 2003-11-24 AU AU2003294635A patent/AU2003294635B8/en not_active Ceased
- 2003-11-24 AT AT03785534T patent/ATE445389T1/de not_active IP Right Cessation
- 2003-11-24 CA CA002507316A patent/CA2507316A1/en not_active Abandoned
- 2003-11-24 EP EP03785534A patent/EP1581185B1/de not_active Expired - Lifetime
- 2003-11-24 US US10/536,200 patent/US20060147511A1/en not_active Abandoned
- 2003-11-24 JP JP2004554224A patent/JP2006509750A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006509750A5 (https=) | ||
| Holland et al. | Poly (ethylene glycol)− lipid conjugates promote bilayer formation in mixtures of non-bilayer-forming lipids | |
| DE60126072T2 (de) | Auf lipiden basierende arzneistoffabgabesysteme zur topischen anwendung | |
| US5585109A (en) | Cosmetic delivery system for salicylic acid and process for preparation of same | |
| ES2643938T3 (es) | Liposoma transpulmonar para controlar la llegada del fármaco | |
| DE60318227T2 (de) | Aggregate mit erhöhter verformbarkeit, aus mindestens drei amphiphilen bestehend, zum verbesserten transport durch teildurchlässige barrieren und zur nichtinvasiven verabreichung von medikamenten in vivo, insbesondere durch die haut | |
| US20090155235A1 (en) | Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin | |
| IL278079B2 (en) | Inhalable liposomal sustained release composition for use in treating pulmonary diseases | |
| US20020048596A1 (en) | Preparation for the transport of an active substance across barriers | |
| JP2017048188A5 (https=) | ||
| JP2021522163A5 (https=) | ||
| JP7708388B2 (ja) | 荷電物質を送達する脂質、その製剤、およびその製造方法 | |
| JP2015519383A5 (https=) | ||
| EP1764091A3 (en) | Improvements in or relating to amphoteric liposomes | |
| JP2018184470A5 (https=) | ||
| JP2008512445A5 (https=) | ||
| CN107427482A (zh) | 凝血酸的多囊脂质体制剂 | |
| HUP9903363A2 (hu) | Készítmény hatóanyag biológiai határfelületeken történő átjuttatására | |
| Gardikis et al. | New chimeric advanced Drug Delivery nano Systems (chi-aDDnSs) as doxorubicin carriers | |
| CA2430897A1 (en) | Liposomal composition comprising water-soluble corticosteroids for the treatment of inflammatory disorders | |
| Shabbir et al. | Lipid vesicles and nanoparticles for non-invasive topical and transdermal drug delivery | |
| TR201818978T4 (tr) | İnsanlardaki İnflamatuvar Rahatsızlıkların Tedavisine Yönelik Lipozomal Kortikosteroidler | |
| Fenske et al. | Cationic poly (ethyleneglycol) lipids incorporated into pre-formed vesicles enhance binding and uptake to BHK cells | |
| WO2018020903A1 (ja) | 皮膚外用剤 | |
| EP1610763A2 (en) | Stable liposomes or micelles comprising a sphingolipid and a peg-lipopolymer |