JP2008512446A5 - - Google Patents
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- Publication number
- JP2008512446A5 JP2008512446A5 JP2007530850A JP2007530850A JP2008512446A5 JP 2008512446 A5 JP2008512446 A5 JP 2008512446A5 JP 2007530850 A JP2007530850 A JP 2007530850A JP 2007530850 A JP2007530850 A JP 2007530850A JP 2008512446 A5 JP2008512446 A5 JP 2008512446A5
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- pharmaceutical composition
- liposome
- use according
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003862 glucocorticoid Substances 0.000 claims 55
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 239000002502 liposome Substances 0.000 claims 15
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 8
- 150000003904 phospholipids Chemical class 0.000 claims 8
- JIPTVEJKXDVECY-GQCTYLIASA-N (e)-3-(2-chloro-3,4-dimethoxyphenyl)prop-2-enoic acid Chemical compound COC1=CC=C(\C=C\C(O)=O)C(Cl)=C1OC JIPTVEJKXDVECY-GQCTYLIASA-N 0.000 claims 4
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 230000002378 acidificating effect Effects 0.000 claims 4
- 235000012000 cholesterol Nutrition 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- LVNGJLRDBYCPGB-UHFFFAOYSA-N 1,2-distearoylphosphatidylethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)OCC[NH3+])OC(=O)CCCCCCCCCCCCCCCCC LVNGJLRDBYCPGB-UHFFFAOYSA-N 0.000 claims 2
- HHZQLQREDATOBM-CODXZCKSSA-M Hydrocortisone Sodium Succinate Chemical compound [Na+].O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COC(=O)CCC([O-])=O)[C@@H]4[C@@H]3CCC2=C1 HHZQLQREDATOBM-CODXZCKSSA-M 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- JLPULHDHAOZNQI-JLOPVYAASA-N [(2r)-3-hexadecanoyloxy-2-[(9e,12e)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC JLPULHDHAOZNQI-JLOPVYAASA-N 0.000 claims 2
- 210000001124 body fluid Anatomy 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- APGDTXUMTIZLCJ-CGVGKPPMSA-N prednisolone succinate Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COC(=O)CCC(O)=O)[C@@H]4[C@@H]3CCC2=C1 APGDTXUMTIZLCJ-CGVGKPPMSA-N 0.000 claims 2
- 229950004597 prednisolone succinate Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 230000000717 retained effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60814004P | 2004-09-09 | 2004-09-09 | |
| US60/608,140 | 2004-09-09 | ||
| PCT/IL2005/000963 WO2006027787A1 (en) | 2004-09-09 | 2005-09-11 | Liposomal compositions of glucocorticoid and glucocorticoid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008512446A JP2008512446A (ja) | 2008-04-24 |
| JP2008512446A5 true JP2008512446A5 (https=) | 2008-10-30 |
| JP5355890B2 JP5355890B2 (ja) | 2013-11-27 |
Family
ID=35432741
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530849A Pending JP2008512445A (ja) | 2004-09-09 | 2005-09-11 | 炎症状態の治療のためのリポソーム性グルココルチコイドの使用 |
| JP2007530850A Expired - Fee Related JP5355890B2 (ja) | 2004-09-09 | 2005-09-11 | グルココルチコイドおよびグルココルチコイド誘導体のリポソーム性組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530849A Pending JP2008512445A (ja) | 2004-09-09 | 2005-09-11 | 炎症状態の治療のためのリポソーム性グルココルチコイドの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8932627B2 (https=) |
| EP (2) | EP1793804A2 (https=) |
| JP (2) | JP2008512445A (https=) |
| CN (2) | CN101043875B (https=) |
| AU (2) | AU2005281351B2 (https=) |
| CA (2) | CA2579786A1 (https=) |
| WO (2) | WO2006027787A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7635463B2 (en) * | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
| AU2004233873B2 (en) | 2003-04-25 | 2010-11-18 | The Penn State Research Foundation | Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds |
| WO2006027787A1 (en) * | 2004-09-09 | 2006-03-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposomal compositions of glucocorticoid and glucocorticoid derivatives |
| DE102007060198A1 (de) | 2007-12-14 | 2009-06-18 | Osram Gesellschaft mit beschränkter Haftung | Konversions-LED |
| DE102007060199A1 (de) | 2007-12-14 | 2009-06-18 | Osram Gesellschaft mit beschränkter Haftung | Leuchtstoff und Beleuchtungssystem mit derartigem Leuchtstoff |
| KR101975843B1 (ko) * | 2008-05-23 | 2019-05-09 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 리포좀 나노입자에 사용하기 위한 변형된 약물 |
| EP2127639A1 (en) * | 2008-05-26 | 2009-12-02 | Universiteit Utrecht Holding B.V. | Corticosteroid containing liposomes for treatment of cardiovascular diseases |
| CN101601652B (zh) * | 2008-06-11 | 2012-07-04 | 天津金耀集团有限公司 | 糠酸莫米松脂质体乳膏 |
| TR201908314T4 (tr) * | 2009-02-20 | 2019-06-21 | 2 Bbb Medicines B V | Glutatyon bazlı ilaç dağıtım sistemi. |
| EP2531175A2 (en) * | 2010-02-01 | 2012-12-12 | Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. | Liposomes comprising amphipathic drugs and method for their preparation |
| JP2011246464A (ja) * | 2010-04-28 | 2011-12-08 | Wakamoto Pharmaceutical Co Ltd | ジクロフェナクナトリウムを封入した後眼部到達用ポリマーコーティングリポソーム |
| CA2834968C (en) | 2011-01-05 | 2018-01-09 | Livon Laboratories | Methods of making liposomes, liposome compositions made by the methods, and methods of using the same |
| WO2013059922A1 (en) | 2011-10-25 | 2013-05-02 | The University Of British Columbia | Limit size lipid nanoparticles and related methods |
| JP5456802B2 (ja) * | 2012-01-23 | 2014-04-02 | 株式会社Ｃａｃ | 細胞遊走促進剤及び創傷治療用の経皮吸収剤 |
| SI2854769T1 (sl) * | 2012-07-05 | 2023-09-29 | Taiwan Liposome Company, Ltd. | Postopki za zdravljenje artritisa |
| CN103083239B (zh) * | 2012-12-26 | 2015-11-25 | 中国人民解放军第四军医大学 | 一种蟾毒灵脂质体及其制备方法和应用 |
| CN105143456A (zh) | 2013-03-15 | 2015-12-09 | 不列颠哥伦比亚大学 | 用于转染的脂质纳米粒子和相关方法 |
| JP6151786B2 (ja) * | 2013-09-30 | 2017-06-21 | 富士フイルム株式会社 | 医療支援装置、医療支援装置の制御方法、医療支援プログラム及び医療支援システム |
| US20150132369A1 (en) * | 2013-11-09 | 2015-05-14 | Exir Nano Sina Company | Nanoliposomal cyclosorin formulations for immunosuppresion and methods for the production thereof |
| CN103720658B (zh) * | 2014-01-07 | 2015-10-07 | 中国药科大学 | 肝素修饰的阿霉素脂质体制剂及其制备方法 |
| WO2017105344A1 (en) * | 2015-12-17 | 2017-06-22 | Nanyang Technological University | Nanoliposomes comprising corticosteroid as medicaments and methods to prepare them |
| TWI754659B (zh) * | 2016-08-08 | 2022-02-11 | 台灣微脂體股份有限公司 | 用於製備含有弱酸性劑之微脂體組合物的傳輸載體、方法及套組 |
| TWI728255B (zh) | 2017-07-24 | 2021-05-21 | 國邑藥品科技股份有限公司 | 包含弱酸藥物之脂質體組成物及其用途 |
| ES2971091T3 (es) * | 2017-08-30 | 2024-06-03 | Bristol Myers Squibb Co | Un método para supervisar las respuestas farmacodinámicas mediadas por la administración de glucocorticoides in vivo |
| IL278513B (en) | 2018-05-07 | 2022-09-01 | Pharmosa Biopharm Inc | A pharmaceutical preparation for the controlled release of treprostinil |
| TWI755629B (zh) * | 2018-09-13 | 2022-02-21 | 台灣微脂體股份有限公司 | 含鎮靜藥物之緩釋藥物組合物及其用途 |
| AU2019339401B9 (en) * | 2018-09-14 | 2022-11-03 | Pharmosa Biopharm Inc. | Pharmaceutical composition for controlled release of weak acid drugs and uses thereof |
| KR102164260B1 (ko) * | 2018-10-30 | 2020-10-12 | (주)유에이치에이 | 메틸프레드니솔론 및 줄기세포를 유효성분으로 포함하는 다발성 경화증의 예방 또는 치료용 조성물 |
| CN113827738B (zh) * | 2020-06-08 | 2024-04-09 | 沈阳药科大学 | 唾液酸修饰地塞米松棕榈酸酯脂质体及其制备和应用 |
| CN116077465B (zh) * | 2022-02-25 | 2024-05-24 | 中南大学湘雅医院 | 用于关节镇痛的纳米制剂及其制备方法和应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56161317A (en) * | 1980-05-15 | 1981-12-11 | Green Cross Corp:The | Pharmaceutical preparation of fatty corpuscle of steroid |
| US4757056A (en) * | 1984-03-05 | 1988-07-12 | Hepar Industries, Inc. | Method for tumor regression in rats, mice and hamsters using hexuronyl hexosaminoglycan-containing compositions |
| IL91664A (en) * | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| WO1990006775A1 (en) | 1988-12-14 | 1990-06-28 | Liposome Technology, Inc. | A novel nonphospholipid liposome composition for sustained release of drugs |
| US5356633A (en) * | 1989-10-20 | 1994-10-18 | Liposome Technology, Inc. | Method of treatment of inflamed tissues |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5189018A (en) * | 1991-08-19 | 1993-02-23 | Wayne State University | Method for reduction of central nervous system (cns) edema resulting from head and spinal cord trauma |
| US5395619A (en) * | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| WO1996032930A1 (en) * | 1995-04-18 | 1996-10-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
| US5817856A (en) * | 1995-12-11 | 1998-10-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Radiation-protective phospholipid and method |
| DE19607722A1 (de) * | 1996-02-29 | 1997-09-04 | Freisleben H J Dr | Tetraetherlipide und diese enthaltende Liposomen sowie deren Verwendung |
| ATE252372T1 (de) | 1996-08-23 | 2003-11-15 | Sequus Pharm Inc | Liposome enthaltend cisplatin |
| JP2001503396A (ja) * | 1996-10-11 | 2001-03-13 | アルザ コーポレイション | 治療用リポソーム組成物および方法 |
| US5948822A (en) * | 1996-12-17 | 1999-09-07 | Lidak Pharmaceuticals | Treatment of hyperproliferative skin disorders with C18 to C26 alphatic alcohols |
| US6090800A (en) * | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| US20030059471A1 (en) * | 1997-12-15 | 2003-03-27 | Compton Bruce Jon | Oral delivery formulation |
| US20030185826A1 (en) * | 1999-02-24 | 2003-10-02 | Tobinick Edward L. | Cytokine antagonists for the treatment of localized disorders |
| US6696038B1 (en) * | 2000-09-14 | 2004-02-24 | Expression Genetics, Inc. | Cationic lipopolymer as biocompatible gene delivery agent |
| US20030129222A1 (en) * | 2000-11-21 | 2003-07-10 | Gabriel Lopez-Berestein | Liposomal imexon |
| DK1347743T3 (da) | 2000-12-07 | 2006-07-03 | Univ Utrecht Holding Bv | Præparat til behandling af inflammatoriske lidelser |
| IL156976A0 (en) * | 2001-02-13 | 2004-02-08 | Yissum Res Dev Co | Carotenoid-loaded liposomes |
| EP2664233B1 (en) | 2001-07-11 | 2014-10-08 | Max Co., Ltd. | Gardening binder |
| AU2002334358B2 (en) | 2001-09-06 | 2008-02-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | A method for preparing liposome formulations with a predefined release profile |
| US20040219201A1 (en) | 2001-12-06 | 2004-11-04 | Yechezkel Barenholz | Tempamine compositions and methods of use |
| AU2003259028A1 (en) * | 2002-06-10 | 2003-12-22 | Combinatorx, Incorporated | Combinations for the treatment of rheumatoid arthritis |
| EP1371362A1 (en) * | 2002-06-12 | 2003-12-17 | Universiteit Utrecht Holding B.V. | Composition for treatment of inflammatory disorders |
| US20060093595A1 (en) * | 2002-07-05 | 2006-05-04 | Mahesh Jayachandra | Methods, compositions and kits for treating damage to excitable tissue |
| EP1393720A1 (en) | 2002-08-27 | 2004-03-03 | Universiteit Utrecht | Vesicle-encapsulated corticosteroids for treatment of cancer |
| DE10255106A1 (de) | 2002-11-24 | 2004-06-09 | Novosom Ag | Liposomale Glucocorticoide |
| US20060025446A1 (en) * | 2004-07-27 | 2006-02-02 | Jeffrey Sterling | Propargyl nitroxides and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders |
| WO2006027787A1 (en) * | 2004-09-09 | 2006-03-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposomal compositions of glucocorticoid and glucocorticoid derivatives |
| PL2308514T3 (pl) * | 2007-03-23 | 2013-11-29 | To Bbb Holding B V | Koniugaty do ukierunkowanego dostarczania leku poprzez barierę krew-mózg |
-
2005
- 2005-09-11 WO PCT/IL2005/000963 patent/WO2006027787A1/en not_active Ceased
- 2005-09-11 US US11/662,172 patent/US8932627B2/en not_active Expired - Fee Related
- 2005-09-11 JP JP2007530849A patent/JP2008512445A/ja active Pending
- 2005-09-11 CA CA002579786A patent/CA2579786A1/en not_active Abandoned
- 2005-09-11 CN CN200580035942.2A patent/CN101043875B/zh not_active Expired - Fee Related
- 2005-09-11 EP EP05779415A patent/EP1793804A2/en not_active Withdrawn
- 2005-09-11 EP EP05778422A patent/EP1791525A1/en not_active Withdrawn
- 2005-09-11 US US11/662,174 patent/US7744920B2/en not_active Expired - Fee Related
- 2005-09-11 WO PCT/IL2005/000962 patent/WO2006027786A2/en not_active Ceased
- 2005-09-11 JP JP2007530850A patent/JP5355890B2/ja not_active Expired - Fee Related
- 2005-09-11 CN CN2005800359742A patent/CN101048138B/zh not_active Expired - Fee Related
- 2005-09-11 CA CA002579695A patent/CA2579695A1/en not_active Abandoned
- 2005-09-11 AU AU2005281351A patent/AU2005281351B2/en not_active Ceased
- 2005-09-11 AU AU2005281352A patent/AU2005281352B2/en not_active Ceased
-
2014
- 2014-12-04 US US14/560,045 patent/US20150093434A1/en not_active Abandoned
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